ライフサイエンスコーパス: axotomize

1 ory neurons in dissociated cell culture were axotomized.

2 res recorded in rats that had the LG-S nerve axotomized 3 d before data collection.

3 discharge characteristics and synaptology of axotomized abducens internuclear neurons, which mediate

4 tablishment of gap junctional coupling among axotomized adult motor neurons may occur by modulation o

5 ed with axonal regeneration, we have assayed axotomized adult rat DRGs for evidence of jun kinase act

6 levels that benefit the intrinsic ability of axotomized adult rat sensory neurons to undergo axonal r

7 nerve injury at the spinal nerve level, some axotomized afferent neurons develop ongoing discharges (

8 prevented the decline in EPSP amplitude from axotomized afferents (stimulate MG, record LGS) observed

9 itude of LG-S EPSPs evoked by stimulation of axotomized afferents was significantly larger than that

10 ltered probability of transmitter release of axotomized afferents.

11 well as in the contralateral intact side of axotomized aged rats.

12 rsal skin of KC-Tie2 animals were surgically axotomized and beginning 1 day after denervation, CD11c(

13 mTBI that allows for identification of both axotomized and intact neurons in the living cortical sli

14 Both axotomized and intact neurons recorded within injured co

15 e photoreceptor histology was similar in the axotomized and nonaxotomized areas.

16 ded the field of labeled cortical cells into axotomized and unaxotomized groups.

17 observed in reticulospinal neurons that when axotomized are known to be "bad regenerators." Results i

18 spinal regeneration of anterogradely labeled axotomized ascending primary sensory fibers in the adult

19 aration, light-evoked IPSCs could only reach axotomized BC terminals via the lateral feedback pathway

20 ght stimulation evoked ON and OFF L-IPSCs in axotomized BCs, which had distinct onset latencies ( app

21 SNB motoneurons were axotomized bilaterally and BDNF or PBS was applied to th

22 ipolar cells with axon terminals, but not in axotomized bipolar cells.

23 In extracts from ischemic or axotomized brain compartments, c-Jun phosphorylation cor

24 ye-coupled motor neurons were observed among axotomized, but not control, lumbar spinal motor neurons

25 LGN neurons were axotomized by a visual cortex lesion in 31 adult rats.

26 s of adult locusts (Locusta migratoria) were axotomized by crushing the base of the antenna.

27 hese ganglia corresponded to that of neurons axotomized by this procedure.

28 tions of L4/5 DRG neurons in adult rats were axotomized by transection of the sciatic nerve and the L

29 ury, following frequencies were increased in axotomized C-type neurons and decreased in axotomized no

30 ings that macrophages also accumulate around axotomized cell bodies.

31 ic tree of the physiologically characterized axotomized cells was significantly reduced compared with

32 In a subpopulation of the axotomized cells, abnormally high motoneurone excitabili

33 (DPDPE), was without effect on control or on axotomized cells.

34 To examine the mechanism by which axotomized cholinergic neurons die in vivo, lentiviral v

35 These results provide evidence that adult axotomized cholinergic neurons die of apoptotic death th

36 fficient to mediate NGF-promoted survival of axotomized cholinergic neurons in vivo.

37 rophin-3 (NT-3) contributes to the rescue of axotomized Clarke's nucleus (CN) neurons in adult rats.

38 Axotomized CN neurons had also atrophied by 14 days, but

39 sults indicate that even limited exposure of axotomized CN neurons to NT-3 produces permanent rescue

40 Death of axotomized CNS neurons in vivo is prevented when the for

41 ansplants in producing long-term survival of axotomized CNS neurons.

42 nerves treated directly with vehicle; other axotomized controls were administered subcutaneous NT-3.

43 eurons and no evidence for TUNEL staining of axotomized cortical motoneurons.

44 s of apoptotic cell death in a proportion of axotomized cortical motor neurons after SCI, suggesting

45 RNA above background levels was detected for axotomized cortical neurons at 1, 3 or 7 days after inju

46 continuity is a sufficient condition for the axotomized corticospinal neurons to regain some of their

47 injury site and exerts protective effects on axotomized corticospinal projection neurons.

48 ls does not enhance the growth of neonatally axotomized DC axons.

49 etected in Schwann cells associated with the axotomized distal stump.

50 )1.3 has been linked to hyperexcitability of axotomized dorsal root ganglion (DRG) neurons, which und

51 ued Kcna2 mRNA and protein expression in the axotomized DRG and attenuated the development of nerve i

52 lar to Na(v)1.3, contactin is upregulated in axotomized DRG neurons and accumulates within the neurom

53 unced suppression of Ca2+ channel current in axotomized DRG neurons by nociceptin led to a reduction

54 howed that 75.6 and 65.1% of the chronically axotomized DRG neurons displaying ectopic discharges enh

55 s in SNS and NaN mRNA and protein levels, in axotomized DRG neurons in vitro.

56 SNS and NaN protein levels, in peripherally axotomized DRG neurons in vivo.

57 ctin and its colocalization with Na(v)1.3 in axotomized DRG neurons may contribute to the hyper-excit

58 rtant in nociception, the effects of GDNF on axotomized DRG neurons may have important implications f

59 st growth factor-inducible-14 (Fn14) mRNA in axotomized DRG neurons was verified by Northern analysis

60 noceptor agonists evoked activity in 7 of 28 axotomized DRG neurons, which did not show ongoing disch

61 through epigenetic silencing of Kcna2 in the axotomized DRG.

62 its post-injury transcriptional activity in axotomized DRGs has been characterized.

63 was used to accurately collect uninjured and axotomized facial motor nuclei of WT and presymptomatic

64 n found to play a crucial role in preventing axotomized fibers from regenerating after adult rat spin

65 Retrograde labeling of axotomized ganglion cells resulted in 5D4+ cells in the

66 Using patch-clamp recordings from axotomized goldfish Mb bipolar cell (BC) terminals with

67 ophin-3 (NT-3) and NT-4/5 on the function of axotomized group Ia afferents and motoneurons comprising

68 limited extent NT-4/5, promotes recovery of axotomized group Ia afferents but not axotomized motoneu

69 smission strength at spinal synapses made by axotomized group IA primary sensory neurons.

70 that the region of cortex within 1 mm of the axotomizing injury had less than 10% of the expected neu

71 the right side of the rostral spinal cord to axotomize ipsilateral reticulospinal (RS) neurons.

72 tors) with SA increased in intact L4 but not axotomized L5 DRGs in SNA and mSNA (to 35%), and in L4/L

73 he mean size of SP-positive neurons from the axotomized L5 ganglia was greater at 2, 4, 7, and 14 dpo

74 ium-sized (30-39 microM) neurons, as well as axotomized L5 or adjacent L4 DRG neurons from hyperalges

75 Among large neurons (>800 microm2) from the axotomized L5, the percentage of SP-positive neurons inc

76 Among small neurons from the axotomized L5, the percentage of SP-positive neurons was

77 ensitive currents, which are reduced in both axotomized (L5) and adjacent (L4) neurons.

78 SNL decreases total I(K(Ca)) in axotomized (L5) neurons, but increases total I(K(Ca)) in

79 y 1 month after injury, the vast majority of axotomized labeled cells appeared to have died.

80 We wished to determine the effect of axotomizing lesions on survival of transcallosally proje

81 The results suggest that axotomized LVN neurons express many genes thought to be

82 The axotomized medial gastrocnemius (MG) nerve was provided

83 ue, we examined the electrical properties of axotomized motoneurons following reinnervation.

84 effect on the morphometric parameters of the axotomized motoneurons in aged rats, but slightly enhanc

85 ery of axotomized group Ia afferents but not axotomized motoneurons or the synapses on them.

86 stripping of synapses from the cell somas of axotomized motoneurons was studied by using synaptophysi

87 round 10% reduction at days 3, 7, and 14) in axotomized motoneurons.

88 Androgens can rescue axotomized motor neurons from cell death.

89 ediated recovery of excitatory synapses onto axotomized motor neurons in adult mice.

90 That GDNF:TTC provided neuroprotection of axotomized motor neurons in neonatal rats further reveal

91 Our findings indicate that: (i). axotomized motor neurons increase expression of estrogen

92 te signaling that maintains the viability of axotomized motor neurons until synaptic connections are

93 onadally intact males have more cells in the axotomized N.IX-X than castrated animals, suggesting tha

94 pressing cells are severely decreased in the axotomized N.IX-X.

95 ays was most prominent in the P stump of the axotomized nerve.

96 Controls were preparations with axotomized nerves treated directly with vehicle; other a

97 approach to periodically photo-stimulate the axotomized neuron, we can enhance its regeneration.

98 eleon to track in vivo calcium fluxes in the axotomized neuron.

99 Within these same axotomized neuronal populations, TAI was also found to i

100 Axotomized neurons (HX) upregulated genes commonly assoc

101 r, these results demonstrate that intact and axotomized neurons are both affected by mTBI, resulting

102 afterhyperpolarization duration decreased in axotomized neurons at 1 and 2 d postinjury.

103 The rheobase is significantly increased in axotomized neurons at 1 d postinjury.

104 In contrast, in the adult all axotomized neurons begin to express HSP27.

105 abeling in the SCG and MICG is restricted to axotomized neurons but that in addition there is extensi

106 A plasmid encoding this gene to determine if axotomized neurons destined to undergo retrograde death

107 esponse to sustained depolarization, whereas axotomized neurons fired a single short burst or short r

108 ggest an initial decrease in excitability in axotomized neurons followed by an increase in excitabili

109 Axotomized neurons from rats made hyperalgesic by SNL lo

110 In axotomized neurons from rats made hyperalgesic by spinal

111 a pseudosubstrate blocker of CaMKII, whereas axotomized neurons from SNL animals that failed to devel

112 After spinal nerve ligation, axotomized neurons had less I(h) compared to control neu

113 Thus, the peptide phenotype of these axotomized neurons is regulated both by the induction of

114 This increase in p55-ir in axotomized neurons may play a pivotal role in the connec

115 r, lasting c-Jun phosphorylation occurred in axotomized neurons negative for Fas-ligand or TUNEL and

116 o induction and phosphorylation in all adult axotomized neurons of the small heat shock protein Hsp27

117 whether apoptotic cell death occurs in these axotomized neurons remains unanswered.

118 However, TTX-S currents in axotomized neurons reprimed four times faster than contr

119 al root ganglion (DRG) neurons as a model of axotomized neurons to investigate early changes in prote

120 There is controversy about whether axotomized neurons undergo death or only severe atrophy

121 monly associated with axonal growth, whereas axotomized neurons whose axons were apposed to the PNG s

122 Axotomized neurons within the damaged CNS are thought to

123 ing axons, a lack of trophic support for the axotomized neurons, and intrinsic neuronal changes that

124 G is dramatically reduced, but all surviving axotomized neurons, as identified by c-jun immunoreactiv

125 to promote the survival and regeneration of axotomized neurons.

126 dult mammals causes atrophy or death of some axotomized neurons.

127 least 2 weeks after injury had clear loss of axotomized neurons.

128 DI was unaffected, but CDF was eliminated in axotomized neurons.

129 ift in gene expression pattern must occur in axotomized neurons.

130 Spinal cord injury axotomizes neurons and induces many of them to die, wher

131 at the tracer predominated in injured (i.e., axotomized) neurons.

132 n axotomized C-type neurons and decreased in axotomized non-inflected A-type neurons.

133 es ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia

134 In the axotomized, non-EAU eyes, 4Di-10ASP-labeled ganglion cel

135 Axotomized optic axons of Xenopus laevis, in contrast to

136 trocytes, and was present in both normal and axotomized optic nerve but not in peripheral nerves.

137 ncreases in galanin expression that occur in axotomized peripheral neurons have functional consequenc

138 ins at the T-junction of C-type neurons with axotomized peripheral processes could enhance the transm

139 ation and cleaved caspase-3 were detected in axotomized PPNs and motoneurons, suggesting apoptosis as

140 In contrast to sham-operated animals, axotomized preparations did not sensitize, reflecting th

141 Axotomized presymptomatic SOD1 FMNs displayed a dynamic

142 of abnormal pain (e.g., ectopic discharge in axotomized primary afferent neurons) that underlie the c

143 Axotomized pyramidal cells, identified by retrograde tra

144 Axotomized rats had near-total loss of PGP9.5(+) innerva

145 e following injury above that present in non-axotomized rats of the same age.

146 Finally, a group of axotomized rats was injected with the S-antigen peptide

147 Another group of such axotomized rats were immunized with S-antigen peptide an

148 The ChAT staining intensity of the axotomized RDLN declined in both age groups after 7 days

149 With regard to axotomized RDLN neurons, 7 days of GM1 restored the cell

150 gnificantly more retrogradely labeled right (axotomized) red nucleus (RN) neurons were seen in Ch'ase

151 sage levels were reduced dramatically in all axotomized reticulospinal neurons, on the basis of semiq

152 h factor (bFGF) on the long-term survival of axotomized retinal ganglion cells (RGCs) were studied in

153 -triggered response from purified intact and axotomized retinal ganglion cells (RGCs).

154 Axotomized retinal ganglion cells were retrograde labele

155 The death of axotomized RGCs can be prevented if they are simultaneou

156 Axotomized RGCs were significantly enlarged and elongate

157 ed and new protein synthesis was impaired in axotomized RGCs, which may contribute to the regeneratio

158 pathways of the unfolded protein response in axotomized RGCs.

159 owth factor-deprived sympathetic neurons and axotomized RGCs.

160 elatively long recovery times (12-16 weeks), axotomized RS neurons displayed firing patterns and afte

161 of lamprey HVA calcium and SKKCa channels in axotomized RS neurons were significantly reduced at shor

162 that the downregulation of Ca2+ channels in axotomized RS neurons, and the associated reduction in c

163 For axotomized RS neurons, the fAHP was significantly larger

164 heral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed

165 at excessive BH4 is produced in mice by both axotomized sensory neurons and macrophages infiltrating

166 results in the death of the majority of the axotomized sensory neurons by 7 d after injury.

167 hibitors were administrated to embryonic and axotomized sensory neurons in vitro to block the activat

168 In axotomized sensory neurons, reduction of SPRR1A function

169 growth factor (NGF) gene transfer protected axotomized septal cholinergic neurons, we injected linea

170 s was increased in both the intact (14%) and axotomized sides (75%).

171 ositive cells was compared in the intact and axotomized sides of N.IX-X of gonadectomized males that

172 AR mRNA in N.IX-X on both the intact and the axotomized sides, suggesting that the increase is indepe

173 Delayed application of BDNF to the axotomized SNB motoneurons restored the AR-LI to the int

174 t of BDNF on androgen receptor expression in axotomized SNB motoneurons, and examined whether delayed

175 diminished mitochondrial Ca(2+) buffering in axotomized SNL L5 neurons but enhanced Ca(2+) buffering

176 ain density of up to 8-fold were measured in axotomized spinal cord motor neurons used as positive co

177 d in reactive CXCR4-positive astrocytes near axotomized spinal cord motor neurons, consistent with au

178 urons remain unknown, and until now death of axotomized spinal-projecting neurons has not been descri

179 For example, axotomized sympathetic, sensory, and motor neurons begin

180 on to study light-evoked IPSCs recorded from axotomized terminals of ON-type mixed rod/cone BCs (Mb)

181 9 transection of the dorsal funiculus, which axotomizes the dorsal CST, and introduction of the retro

182 Axotomized transcallosal neurons were compared with near

183 eneration in Drosophila larval MNs, and when axotomized WD proceeded stereotypically in milton distal

184 dorsal lateral geniculate nucleus (LGN) are axotomized, which leads to their atrophy and death.

185 cantly delayed and propagated more slowly in axotomized Wld(S) RGCs compared with wild-type axons.