ライフサイエンスコーパス: azidothymidine

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1 sence of the reverse-transcriptase inhibitor azidothymidine.

2 inhibitors have been approved for human use: azidothymidine; 2'3'-dideoxycytidine; 2'3'-dideoxyinosin

3 tudy to demonstrate the on-demand release of azidothymidine 5'-triphosphate, an anti-human immunodefi

4 Several other substrates, azidothymidine, 9-(2-phosphonylmethoxyethyl)adenine, and

5 found that pre-incubation of the cells with azidothymidine, a pro-oxidant drug, significantly improv

6 omal cell-derived factor-1 (for HIVIIIB), or azidothymidine added during the HIV pulse, as well as by

7 ely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs.

8 thymidine (d4T) >> (+)3TC >> (-)3TC > PMPA > azidothymidine (AZT) >> Carbovir (CBV).

9 We have found that Azidothymidine (AZT) alone induces apoptosis in Epstein

10 kitt's lymphoma (BL) responded to parenteral azidothymidine (AZT) and IFN-alpha.

11 Sensitivity of radA recG mutants to azidothymidine (AZT) can be rescued by blocking recombin

12 Azidothymidine (AZT) caused progressive telomere shorten

13 ilylated nucleoside scaffold derived from 3'-azidothymidine (AZT) consistently and selectively inhibi

14 bination of interferon alpha (IFN-alpha) and azidothymidine (AZT) induces apoptosis in PEL cell lines

15 The antiviral thymidine analog azidothymidine (AZT) is used to treat several virus-asso

16 between muscle performance and CD4+ count or azidothymidine (AZT) use.

17 replication inhibitors hydroxyurea (HU) and azidothymidine (AZT) was suppressed by alleles of dnaA t

18 3'-Azidothymidine (AZT) was the first approved antiviral fo

19 ons to anti-HIV/AIDS pharmaceuticals such as azidothymidine (AZT), anti-malarial compounds and novel

20 stic interactions is with the antiviral drug azidothymidine (AZT).

21 troviral combinations that do not include 3'-azidothymidine (AZT).

22 as steeper in patients receiving zidovudine (azidothymidine [AZT], -3.64 g/dL vs. no AZT, -2.08 g/dL)

23 iency virus type 1 (HIV-1) to zidovudine (3'-azidothymidine; AZT) and appear to approximate the templ

24 lex formation, and primer terminated with 3'-azidothymidine formed dead-end complex with 25-fold elev

25 creased the cell toxicity of ganciclovir and azidothymidine in PEL cells but had no significant effec

26 M184V suppressed the excision of 3'-deoxy-3'-azidothymidine monophosphate (AZTMP) to a greater extent

27 EA (9-(2-phosphonylmethoxyethyl)adenine) and azidothymidine monophosphate from cells and, thus, with

28 e nucleoside reverse transcriptase inhibitor azidothymidine or the protease inhibitor indinavir to th

29 The combination of 6-TG and a RT inhibitor, azidothymidine, provided partial protection.

30 RNase H activity, in addition to the loss of azidothymidine resistance.

31 trains, and reverse transcriptase-resistant, azidothymidine-resistant, ddC/ddI-resistant, nivirapine-

32 se), which can phosphorylate ganciclovir and azidothymidine, respectively.

33 in some patients receiving 2',3'-dideoxy-3'-azidothymidine therapy in combination with 2',3'-dideoxy

34 violet light or 2,2'-dithiodipyridine and in azidothymidine-treated mice.

35 and the two nucleoside analog RT inhibitors (azidothymidine triphosphate or ddCTP), whereas two non-n

36 TP approximately alpha-thio-dTTP < dUTP < 3'-azidothymidine triphosphate).

37 ivity of several mutants was resistant to 3'-azidothymidine triphosphate.

38 When the reverse transcriptase inhibitor azidothymidine was added to the DCs during exposure to H

39 Azidothymidine was studied as an antineoplastic in the 1

40 the phosphorylated forms of ganciclovir and azidothymidine, we found that PEL cells exposed to hypox

41 ideoxyinosine, 2',3'-dideoxycytidine, and 3'-azidothymidine, which are known inhibitors of N1 or N2,

42 the accurate assessment of HIV inhibition by azidothymidine (zidovudine), dideoxycytidine (zalcytibin

43 vents, this study defines such a mutagen, 3'-azidothymidine [zidovudine (AZT)], used widely in the tr

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