ライフサイエンスコーパス: aziridine

1 y the substitution at the C3 position of the aziridine.

2 the allene to a strained bicyclic methylene aziridine.

3 e >99%) from enantiopure trans-disubstituted aziridine.

4 -98 %) and mostly >90 % optically active cis-aziridines.

5 2-azido-aminoalcohols, diaminoalcohols, and aziridines.

6 palladium-catalyzed cross-coupling of intact aziridines.

7 fied Stille conditions to afford substituted aziridines.

8 oenriched 2-arylphenethylamines from racemic aziridines.

9 ctive construction of complex trisubstituted aziridines.

10 tric inductions and higher overall yields of aziridines.

11 ylmethyl imines with diazoesters to give cis-aziridines.

12 y2) generates trans-alpha-lithiated terminal aziridines.

13 tained with both alkyl- and aryl-substituted aziridines.

14 means for the synthesis of alkyl-substituted aziridines.

15 been studied using the structurally similar aziridines.

16 nd application in dynamic systems other than aziridines.

17 xchange are described for carbon-substituted aziridines.

18 dine opening of tosyl-activated cyclopentene aziridine 2 and optical resolution of racemic 1 with 10-

19 A novel rearrangement of 2-vinyl aziridine 2-carboxylates to unusual chiral cyclic sulfox

20 ate and methanediphosphonate anions afforded aziridine 2-methyl diphosphates and methanediphosphonate

21 ment with MeMgBr, gives the corresponding NH-aziridine 2-phosphonate chiral building blocks.

22 no phosphonates to cis- and trans-N-sulfinyl aziridine 2-phosphonates, respectively, with n-BuLi.

23 en developed for the asymmetric synthesis of aziridine 2-phosphonates.

24 nique reactivity of the resulting N-acylated aziridine-2-carbonyl peptides facilitates their subseque

25 ing of unprotected peptide thioacids and N-H aziridine-2-carbonyl peptides is reported.

26 a-GalNAc-Ser linkage via the ring opening of aziridine-2-carboxamides with pyranose C1-O-nucleophiles

27 sters, and unexpectedly, the N-Boc-protected aziridine-2-carboxylate 16b with a phenyl substituent in

28 e the scope of the reductive ring opening of aziridine-2-carboxylates with samarium diiodide.

29 d stereoselective peptide modification using aziridine-2-carboxylic acid-containing peptides is descr

30 mediated by the imino-BOROX catalyst to give aziridine-2-carboxylic esters with very high diastereo-

31 The key aziridine-2-methanol intermediates (6-OH, 7-OH, and 8-OH

32 ion and afforded, upon deprotection, the N-H aziridine 24 in 18-32% overall yield for the three steps

33 ction of the more stable 21 gave the desired aziridine 26.

34 y classes of nitrogen heterocycles including aziridines, 2H-azirines, pyrrolidines, and piperidines.

35 under otherwise identical conditions, vinyl aziridine 3a and aldehydes 2a-2l engage in reductive cou

36 Using enantiomeric iridium catalysts, vinyl aziridine 3a reacts with unprotected chiral 1,3-diols 1m

37 of N-(p-nitrophenylsulfonyl) protected vinyl aziridine 3a with primary alcohols 1a-1l to furnish bran

38 raoxon (13 months), atrazine (5 months), and aziridine (52 h).

39 detritylation of 26, methylation of the N-H aziridine 56, oxidation of the sensitive cyclohexenedion

40 Aziridine 6 is envisioned as a useful biochemical tool b

41 As expected, three-membered aziridine 6 was calculated to be significantly more reac

42 indole fragment, (b) formation of hexacyclic aziridine 80 from the reaction of cyanide with intermedi

43 -opening of the aziridinium ion derived from aziridine 80, and (d) base-promoted skeletal rearrangeme

44 pha-imino ester gave predominantly the trans-aziridine (89:11) in high yield (91%).

45 idue in mutagenized enzyme, as only the beta-aziridine ABP can bind in its absence.

46 ibition of retaining beta-glucosidases, beta-aziridine ABPs do not.

47 use of cyclophellitol beta-epoxide- and beta-aziridine ABPs.

48 A first-order rate dependence on aziridine aldehyde dimer and a zero-order rate dependenc

49 A multicomponent reaction between an aziridine aldehyde dimer, isocyanide, and l-proline to a

50 the reactivity of cis- and trans-configured aziridine aldehyde dimers has been compared.

51 l for the three-component reaction driven by aziridine aldehyde dimers has predictive value for diffe

52 syn-stereoselectivity from readily available aziridine aldehyde dimers in the Petasis borono-Mannich

53 he multicomponent conversion of amino acids, aziridine aldehyde dimers, and isocyanides into chiral p

54 rsible dimer dissociation is instrumental in aziridine aldehyde transformations.

55 a range of functionalized isocyanides in the aziridine aldehyde-driven multicomponent synthesis of pi

56 ibitor calpastatin have motivated the use of aziridine aldehyde-mediated peptide macrocyclization tow

57 Unprotected aziridine aldehydes belong to the amphoteric class of mo

58 The cyclization chemistry centers on using aziridine aldehydes in a multicomponent reaction with pe

59 he related macrocyclization of peptides with aziridine aldehydes.

60 y, the synthesis and reactivity of methylene aziridines, allene oxides/spirodiepoxides, methylene sil

61 Here we show that the reduced amidicity of aziridine amide bonds provides an entry point for the si

62 The other aziridine analogues bearing the N-(alpha-methylene)bisho

63 rization of five racemic and two enantiopure aziridine analogues of PSPP and the evaluation of their

64 m the palladium(II) species bearing both the aziridine and aryl groups to form the hindered C-C bond.

65 A series of N-activated aziridines and 2-bromoindole derivatives with different

66 rization of enynes, [3 + 2] cycloaddition of aziridines and alkenes, and [4 + 2] hetero-Diels-Alder c

67 he phosphine-mediated [3 + 3] annulations of aziridines and allenes are experimentally simple reactio

68 ioselective ring-opening of chiral activated aziridines and azetidines with alcohols to nonracemic be

69 ation processes, leading to the synthesis of aziridines and beta-lactams (respectively), and is sugge

70 d cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported.

71 C bond-forming reaction between simple alkyl aziridines and organozinc reagents.

72 vestigated using a variety of functionalized aziridines and phenols to determine the scope of the rea

73 of the substituent in the 3-position of the aziridine, and whether the substituent in the 3-position

74 an), which is known to carbonylate epoxides, aziridines, and beta-lactones, was used to catalyze the

75 es, which induce the direct formation of the aziridines, and stereochemistry of the olefin is retaine

76 to add to the Si-face of the imine when cis-aziridines are formed and both to add to the Re-face of

77 o add to the Re-face of the imine when trans-aziridines are formed.

78 2,2,3-Trisubstituted aziridines are known to undergo ring opening at the more

79 Likewise, N-alkyl aziridines are prepared from N-alkylated DPH derivatives

80 Aziridines are useful precursors to the azomethine ylide

81 ormational transitions, which in the case of aziridines arise from inversion at the nitrogen center.

82 e-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroaceti

83 reactions are the first reported examples of aziridines as reaction partners in nucleophilic phosphin

84 amma-thialysine) using freshly prepared (13C)aziridine at room temperature.

85 er formation was explored with small N-alkyl aziridines, azetidines, pyrrolidines, and piperidines.

86 rently exist: doubly-activated molecules and aziridine based molecules, each of which employs a diffe

87 A water-soluble biocompatible aziridine-based biosensor with pendant anthracene units

88 Aziridine-based cofactor mimics have been synthesized an

89 The fluorescently labeled aziridine-based probes 3 and 4 inhibit the two human ret

90 alpha-Lithiated terminal aziridines bearing N-alkoxycarbonyl (Boc) protection und

91 In contrast, aziridines bearing N-organosulfonyl [tert-butylsulfonyl

92 the stage for future biochemical studies of aziridine biosynthesis and assembly.

93 n rates of cyclophellitol and cyclophellitol aziridine-both covalent retaining beta-glucosidase inhib

94 of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amino alcohol

95 CH(2)OH/CH(3)CN desilylated a simple N-TBDPS aziridine but caused nucleophilic cleavage at C(1) as we

96 Selective labeling with fluorescent beta-aziridine but not beta-epoxide ABPs identifies the acid/

97 onfiguration at the terminal position of the aziridine by way of aziridine ring opening by Ni (invers

98 A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation

99 ohydrins were converted to the corresponding aziridines by primary-selective silylations of four azid

100 st accelerates the ring opening of aliphatic aziridines by trimethylsilylazide, inducing nucleophilic

101 that heterolysis at C(10) is faster than at aziridine C(1), in contrast to the behavior of typical a

102 The consumed enantiomer of aziridine can be further converted to an enantioenriched

103 If necessary, the N-4-nosyl Hough-Richardson aziridine can be isolated by filtration in a very good y

104 The activated aziridines can be converted to beta3-amino esters, and u

105 The aziridines can be derivatized to afford a range of chira

106 direct ring opening at the sp(3)-hybridized aziridine carbon atom (C-3).

107 nation reaction of nonactivated alkynes with aziridines, catalyzed by Lewis or Bronsted acids, to for

108 otecting group could not be achieved without aziridine cleavage.

109 N-Toluenesulfonyl aziridines comprise effective second electrophiles in th

110 Vicinal aziridine-containing diamines have been obtained with hi

111 n deployed to construct the optically active aziridine-containing fragment that is joined to the arom

112 A synthesis of aziridine-containing peptides via the Cu(II)-promoted co

113 Excellent yields of the N-H-aziridines could be obtained with both alkyl- and aryl-s

114 corresponding aziridino complexes, that is, aziridine cross-metathesis.

115 ctive strategies for ring-opening of the new aziridines, deprotection of the Ts group, and subsequent

116 re alpha-acyl-beta-amino acid and 2,2-diacyl aziridine derivatives efficiently from Cu(OTf)(2) + 1,10

117 philic ring-opening reactions of N-activated aziridine derivatives with thiols, beta-thioglycosyl thi

118 repared by iterative opening of epoxides and aziridines derived from homochiral cyclohexadiene cis-di

119 expansion of vinyloxiranes, -thiiranes, and -aziridines described in the literature from 1964 to 2013

120 ridine substitution patterns show that alkyl aziridines display similar reactivity to alkynyl aziridi

121 thesis of such molecules that is amenable to aziridine diversification as well as elaboration of the

122 ubstituent groups on the biologically active aziridine do not function as TbNTR or TbCPR-activated pr

123 tended for the enantioselective synthesis of aziridines (ee up to 92%).

124 kyl azide was converted to the corresponding aziridine employing styrene as a substrate.

125 high asymmetric inductions as seen with cis-aziridines, enabling the development of an unprecedented

126 High yields of aziridines exceeding 90% can be obtained with a 1:1 olef

127 nd to react at accelerated rates relative to aziridine exclusively by means of the a Menshutkin-type

128 the first time, and their reactivity toward aziridines explored.

129 The success with the N-Bus aziridines facilitated the development of a new route to

130 lyzed SN2-type ring-opening of the activated aziridine followed by a concomitant 5-exo-dig cyclizatio

131 alkylation of 2-vinylindoles with activated aziridines followed by an intramolecular aza-Michael rea

132 d selective opening of a cyclic sulfate over aziridines followed by aza-Payne rearrangement.

133 rmation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade react

134 or the synthesis of alkyl-substituted chiral aziridines from achiral starting materials.

135 direct synthesis of N-phosphorus-substituted aziridines from alkenes with dinitrogen as the byproduct

136 ubstituted imines, the optical purity of the aziridines from all of the imine substrates could be enh

137 metric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds.

138 oselective synthesis of trisubstituted vinyl aziridines from these chiral sulfinamides, simply by cha

139 The nitrogen inversion of a N-phenyl aziridine fused to a succinimide ring is influenced by t

140 ed aryl bromides and tertiary organometallic aziridines, generated from sulfinylaziridines by sulfiny

141 idines display similar reactivity to alkynyl aziridines, giving insight into mechanistic possibilitie

142 or the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions f

143 oss-coupling with 1,1-disubstituted styrenyl aziridines has been developed.

144 The coupling of carbon monoxide and aziridines has been shown to be selective for comonomer-

145 A series of novel, highly substituted N-PMP aziridines have been accessed in high yields by palladiu

146 tional methods for producing these activated aziridines have significant drawbacks.

147 nd nitrogen in the formation of oxiranes and aziridines; however, such reactivity is not known betwee

148 iastereoselective, affording the trans-vinyl aziridine in moderate-to-good yields.

149 ehydes were examined and found to give trans-aziridines in 60-88% yield with 60-98% ee and trans/cis

150 h aryl aldehydes were screened to give trans-aziridines in 73-90% yield with 82-99% ee and trans/cis

151 be directly transformed to the corresponding aziridines in a one-pot fashion.

152 MEDAM imines can be deprotected to give N-H aziridines in all cases except for some electron-rich ar

153 uents leads to the quantitative formation of aziridines in clean solid-to-solid reactions despite ver

154 selective formation of either functionalized aziridines in dimethylformamide (through direct bromide

155 and catalytic Rh(2)(OAc)(4) to give bicyclic aziridines in excellent yield.

156 verted into the corresponding N-H or N-alkyl aziridines in good to excellent yields.

157 ith MeMgBr or TFA/MeOH, which affords the NH-aziridines in good yield.

158 c carbamates into [4.1.0]-carbamate-tethered aziridines in good yields and with ee values of up to 92

159 fast at ambient temperature, furnishing N-H aziridines in good-to-excellent yields.

160 available amines into synthetically valuable aziridines in high enantiomeric ratios.

161 forming the desired N-phosphorus-substituted aziridines in moderate to high yields and good enantiose

162 By employing substituted aziridines in single enantiomeric form, the correspondin

163 by radicalar polymerization of N-substituted aziridines in supercritical carbon dioxide.

164 the copolymerization reaction involves first aziridine insertion into the cobalt-acyl bond, rate dete

165 rforms the second function of activating the aziridine intermediate toward nucleophilic attack.

166 yridinium perchlorate to generate a bicyclic-aziridine intermediate, which is transformed under aziri

167 nolithium-mediated conversion of beta-alkoxy aziridines into substituted allylic sulfonamides, use of

168 N-bound phenyl rings of amines, imines, and aziridine is achieved in the presence of H(2) and B(C(6)

169 s rate-limiting ring closure to form the cis-aziridine is implicated.

170 In the oxidation of 4e, the product aziridine is spectroscopically identical to its parent,

171 Conversion of the triazolines to aziridines is also described.

172 zation reactions of alpha-lithiated terminal aziridines is detailed.

173 n of a range of carbon acids with N-sulfonyl aziridines is reported.

174 diate as the nitrene donor and a symmetrical aziridine-like transition state.

175 ] with Me3SiCl releases the N-functionalized aziridine Me3SiN(CH2CHPh) while simultaneously generatin

176 The aziridine-mediated peptide ligation concept is exemplifi

177 g HSQC NMR peaks were identified in the (13C)aziridine-modified enzyme, corresponding to detection of

178 d that aspartic acid is the precursor of the aziridine moiety.

179 ents, that aspartate is the precursor of the aziridine moiety.

180 Despite the prevalence of the N-H aziridine motif in bioactive natural products and the cl

181 h a N-tosyl group, rendering these alpha-CF3-aziridines much more susceptible to nucleophilic ring op

182 etracyclic aziridinomitosenes containing the aziridine N-H subunit.

183 in E showing that the enzyme functions as an aziridine N-methyltransferase.

184 re the development of a new synthesis of the aziridine necessary for the aziridine--pi-nucleophile cy

185 modified carbohydrates afforded enantiopure aziridines, nitrocyclopropane, and dihydrofuran.

186 to serve as protecting groups for the labile aziridine nitrogen found within the highly sensitive azi

187 In contrast, a nosyl group on the aziridine nitrogen leads efficiently to the bicyclic rin

188 es with three different substitutions on the aziridine nitrogen.

189 bstrate established that ring opening of the aziridine occurs with inversion of stereochemistry.

190 Steric bulk (e.g., mustard rather than aziridine) on the ring can limit the possible binding or

191 ped a short and practical synthesis of 1 via aziridine opening of tosyl-activated cyclopentene azirid

192 trideoxy-L-hex-2-enopyranosides, followed by aziridine opening, leads to 3-amino-3-N-,4-O-carbonyl-2,

193 The initial aziridine opening/cyclodehydration strategy was also dir

194 lization of allyl azidoformates to construct aziridine/oxazolidinone-fused bicyclic structures.

195 Mono- and disubstituted aziridines perform well, with complete retention of ster

196 synthesis of the aziridine necessary for the aziridine--pi-nucleophile cyclization.

197 tion, the effect of fluorine substitution at aziridine positions other than nitrogen was studied.

198 Compound A (CpdA) is a stable analogue of an aziridine precursor from the African shrub Salsola tuber

199 C horizontal lineC bond is maintained in the aziridine product (cis or trans).

200 he starting amino alcohol is retained in the aziridine product.

201 f the starting material and formation of the aziridine product.

202 yst while still maintaining>or=90% ee in the aziridine product.

203 s were utilized to afford the functionalized aziridine products as single diastereoisomers with reten

204 e of regio- and enantiocontrol to afford the aziridine products in good to excellent yields in highly

205 strated through derivatization of the chiral aziridine products to obtain a diverse array of function

206 formed with dirhodium catalysts, which favor aziridine products.

207 s enables the rapid assembly of unique amino aziridine products.

208 yields at room temperature, into valuable NH aziridine products.

209 unique strain and structure of the methylene aziridine promotes a ring-opening/ring-closing cascade t

210 The resulting [3.1.0] bicyclic aziridines prove to be versatile synthons for the prepar

211 N-protected aziridines, pyrrolidines, piperidines, and azepanes bear

212 pid generation of peptides incorporating the aziridine residue has been developed.

213 rine substitution at the carbon positions of aziridine results in profound enhancements of the rate o

214 nd carbenes with strained bicyclic methylene aziridines results in a formal [3+1] ring expansion to y

215 ladium(0) on the less-hindered carbon of the aziridine ring and that alkene insertion occurs in a syn

216 in DMA led to regioselective opening of the aziridine ring at C2 to give the corresponding bicyclic

217 p-TsOH resulted in exclusive opening of the aziridine ring at the most substituted position affordin

218 Kibdelosporangium sp. MJ126-NF4, contain an aziridine ring attached to the polyketide core.

219 tions of these genes, a possible pathway for aziridine ring formation in the azecimicins can now be p

220 odular one-pot, sequential protocol using an aziridine ring opening and intramolecular nucleophilic a

221 terminal position of the aziridine by way of aziridine ring opening by Ni (inversion), transmetalatio

222 kylation to effect regio- and stereospecific aziridine ring opening by oxygen, halogen, sulfur, and n

223 ine intermediate, which is transformed under aziridine ring opening conditions to the key intermediat

224 This aziridine ring opening reaction manifold has demonstrate

225 investigation of a regio- and stereospecific aziridine ring opening reaction presents new synthetic t

226 mpounds to give products derived from either aziridine ring opening, interaction with the cyano group

227 synthesized to change the electronics of the aziridine ring system.

228 ereoselective epoxidation and opening of the aziridine ring with hydrazoic acid afforded the 2-azidoc

229 or nucleophile-dependent ring-opening of the aziridine ring yields functionalized 1,2- and 1,3-diamin

230 oped by utilizing a newly discovered ethynyl aziridine ring-opening reaction in a longest linear sequ

231 The scope of the aziridine ring-opening reaction was substantially broade

232 oups of l-lysine, despite the presence of an aziridine ring.

233 new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functiona

234 ks for tripeptide controls, a small molecule aziridine self-polymer mimetic, and a cysteine-minus con

235 s removal of the noncovalently protein-bound aziridine self-polymer using a novel chelating dialysis

236 ction kinetics showed zero-order in both the aziridine species and the aryl bromide.

237 The attachment of the aziridine structural motif was achieved by application o

238 ctural features such as the nature of the C2 aziridine substituent and the nature of the electrophile

239 tocol displays a broad scope with respect to aziridine substitution and N-protecting groups.

240 Studies to probe the effect of the aziridine substitution patterns show that alkyl aziridin

241 The monodeuterated aziridine syn-(p-CH(3)C(6)H(4)SO(2))NCHDCH-n-Bu (1e) rea

242 l aldehyde gave a 71% yield and 95% ee of an aziridine that was found to be the cis- and not the tran

243 The torquoselectivity of aziridines that lack a plane of symmetry was investigate

244 thetically exploited oxiranes and thiiranes, aziridines that lack electron-withdrawing substituents,

245 ds contain two electronically differentiated aziridines that undergo highly regioselective ring openi

246 of (R)-beta(3)-DOPA and L-DOPA from the same aziridine, the former by SmI2-mediated reductive opening

247 on of the nature of the N-substituent of the aziridine, the nature of the substituent in the 3-positi

248 Comparisons to alkenes, cyclopropanes, aziridines, thiiranes, and phosphiranes are also made.

249 triplet sensitizers that selectively produce aziridines through the spin-selective photogeneration of

250 gle catalyst transforms a racemic mixture of aziridines to a pair of regioisomeric products, each in

251 The hydrofluorination of aziridines to provide beta-fluoroamines using this laten

252 doalanines is prone to rearrangement, via an aziridine, to give predominantly trityl-protected alpha-

253 e we describe a new tool, methylthiocarbonyl-aziridine, to install acetyl-Lys mimics site-specificall

254 were developed for deprotection of the N-DAM-aziridines under acidic conditions without causing an ac

255 N-Sulfonyl aziridines undergo oxidative addition to palladium(0) co

256 The resulting tricyclic aziridines underwent ring opening when treated with vari

257 -, tri-, and tetrasubstituted olefins to N-H aziridines using O-(2,4-dinitrophenyl)hydroxylamine (DPH

258 ne and cyclopentene, yields of corresponding aziridines vary from 44% to 83%.

259 ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be de

260 Subsequent nucleophilic attack of the aziridine was accomplished using RSH, R2NH, N3-, or ROH

261 tions, N-o-(trifluoromethane)benzenesulfonyl aziridine was efficiently ring-opened to afford the amin

262 us reactions between the five components, an aziridine was formed in 85% yield and 98% ee and only tw

263 The expected aziridine was not observed, but rather simultaneous spir

264 Finally, activation of the N-H-aziridines was achieved with Boc, tosyl, and Fmoc groups

265 1-alkyl-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines was developed starting from the corresponding

266 ese newly synthesized nonactivated alpha-CF3-aziridines was evaluated by applying N-protonation or N-

267 Furthermore, nonactivated alpha-CF3-aziridines were easily transformed into their activated

268 Aziridines were formed by copper-catalyzed intramolecula

269 catalyst; however, in those cases where cis-aziridines were formed, the configuration was opposite f

270 ng transfer hydrogenation conditions, the NH-aziridines were regioselectively opened to the correspon

271 N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regios

272 this can be particularly pronounced with cis-aziridines where a nearly equal mixture of the two is ob

273 generate separable, diastereomeric bicyclic-aziridines, which are then independently transformed to

274 the observed absolute stereochemistry of the aziridines, which undergo nucleophilic ring opening to y

275 have found that N-diphenylphospinyl and N-H aziridines, while participating in the initial ring-open

276 ia in situ formed N-4-nosyl Hough-Richardson aziridine with nitrogen nucleophiles under mild conditio

277 lso been synthesized via the ring-opening of aziridines with 2-bromobenzyl alcohols and -mercaptan, r

278 gh an S(N)2-type ring-opening of N-activated aziridines with 2-bromobenzylamine followed by a hithert

279 type ring opening of enantiopure N-activated aziridines with 2-bromoindoles followed by copper-cataly

280 been developed by ring-opening of activated aziridines with 2-hydroxyphenyl acrylates and 2-aminophe

281 ring opening cyclization (DROC) of activated aziridines with 2-vinylindoles is described.

282 s that are the predominant products for most aziridines with an N-activating group.

283 domino ring-opening cyclization of activated aziridines with aryl and alkyl isothiocyanates has been

284 talyzed reductive cross-coupling of styrenyl aziridines with aryl iodides is reported.

285 ing of unsubstituted and 2-alkyl-substituted aziridines with arylboronic acid nucleophiles is present

286 ions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoimidazolylet

287 lyzed S(N)2-type ring opening of substituted aziridines with electron-rich arenes/heteroarenes to pro

288 The preparation of C-iodo-N-Ts-aziridines with excellent cis-diastereoselectivity has b

289 -N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectiv

290 synthetically useful chiral [3.1.0]-bicyclic aziridines with high diastereo- and enantioselectivity.

291 catalyzed SN2-type ring opening of activated aziridines with indoles having substitutions at 3- and o

292 eoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (L

293 ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and ste

294 The intramolecular cyclization reactions of aziridines with pi-nucleophiles can be a useful route to

295 and aliphatic aldehydes both gave the trans-aziridines with the same absolute configuration with the

296 me imines with diazoacetamides to give trans-aziridines with the same high asymmetric inductions as s

297 the C-N cleavage product is observed for all aziridines with the strongly N-activating p-toluene sulf

298 We also report on the cyclization of aziridines with three different substitutions on the azi

299 Several trisubstituted aziridines, with different substitution patterns at the

300 HAT) reaction resulting in H2NTs and lowered aziridine yields.