ライフサイエンスコーパス: bHLH

1 e identification and characterization of 175 bHLH transcription factors from apple (Malus x domestica

2 -encoding genes-and therefore distinct HLH-2:bHLH dimers-and formulate a "bHLH code" hypothesis for r

3 hese results uncover a novel mechanism for a bHLH transcription factor to recognize a unique spatial

4 ith inhibition of the Notch effector Hey1, a bHLH transcription factor that we here characterize as a

5 echanism by which a dimerization domain in a bHLH factor behaves as a switch that permits distinct co

6 TWIST is a bHLH transcription factor that promotes epithelial-mesen

7 his question, we focused on Atoh1 (Math1), a bHLH transcription factor that specifies distinct neuron

8 iption factor complex consisting of a MYB, a bHLH and a WD repeat-containing protein (the MBW complex

9 s an example of target gene specificity of a bHLH protein being controlled allosterically by a domain

10 a nonsynonymous SNP mutation on exon 5 of a bHLH transcription factor was found to elevate the propo

11 Here, we describe the role of a bHLH transcription factor, Tcf21 (epicardin/Pod1/capsuli

12 Here, we characterize Sage, a bHLH transcription factor expressed exclusively in the D

13 vonol-4-reductase (DFR) in leaves, whereas a bHLH transcription factor was highly correlated with fla

14 distinct HLH-2:bHLH dimers-and formulate a "bHLH code" hypothesis for regulatory cell identity.

15 odule feedback regulates PIFs and additional bHLH factors that interact with ARF6, and thereby modula

16 as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors PIFs, would partially explain

17 s deduced where targets, such as AP2/ERF and bHLH transcription factors and chromatin remodelers form

18 there are approximately 339 and 162 MYB and bHLH genes, respectively, in Arabidopsis, and approximat

19 specific gain-of-function alleles of MYB and bHLH proteins had an additive effect on GSL levels, as d

20 A complex of R2R3-MYB and bHLH transcription factors, stabilized by WD40 repeat pr

21 network that identifies the set of bZIPs and bHLHs that are most predictive of the expression of gene

22 Phylogenetic analysis of apple bHLH (MdbHLH) genes and their Arabidopsis thaliana (Arab

23 g the composition and diversity of the apple bHLH transcription factor family that will provide a pla

24 Functional analysis of ATOH7 bHLH domain substitutions, by electrophoretic mobility s

25 n of sT and the cell fate-determinant atonal bHLH transcription factor 1 (ATOH1) leads to development

26 1 interacts with several inhibitory atypical bHLHs, which likely keep HBI1 under negative control.

27 ) demonstrate unsuspected cross-talk between bHLH transcription factors, important regulators of orga

28 indicate that PREs activate the DNA binding bHLH factor HBI1 by sequestering its inhibitor IBH1.

29 FERONIA and THESEUS1 and the non-DNA binding bHLH protein KIDARI, are functionally validated in Arabi

30 PAS domains, extending above the DNA-binding bHLH domain.

31 f a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains at 2.3 A resolution.

32 enesis and depends upon the function of both bHLH transcription factors, notably Hand2, and homeodoma

33 yase and pectinesterase, are targets of both bHLH transcription factors.

34 prevent neuronal differentiation induced by bHLH neurogenic transcription factors in P19 cells and i

35 mbinatorial control of photomorphogenesis by bHLH proteins in response to light in Arabidopsis.

36 ulation of different biological processes by bHLH proteins.

37 ts into the mechanisms of DNA recognition by bHLH dimers as well as a blueprint for system-level stud

38 ories, whereas R sites mediate repression by bHLH repressors, which serves to restrict expression spe

39 y PHYTOCHROME-INTERACTING FACTOR (PIF)-class bHLH transcription factors in darkness, but light-activa

40 eins, which are characterized by a conserved bHLH domain, comprise one of the largest families of tra

41 endent, per ARNT-sim (PAS) domain containing bHLH transcription factor that mediates adaptive respons

42 ered that it encodes a PAS-domain-containing bHLH transcription factor, and that it is expressed in a

43 ication is achieved through few well-defined bHLH transcription factors.

44 n in ms32 anthers, which possess a different bHLH defect.

45 olecular level that neuronal differentiation bHLH transcription factors have distinct lineage-specifi

46 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and mu

47 s for expression of Notch and the hes family bHLH transcription factor (HES1) in colon tissues from m

48 a complex with the Notch effector hes family bHLH transcription factor 1 (HES1) and the protein deace

49 iscovered that the gene single minded family bHLH transcription factor 1a (sim1a) is dynamically expr

50 epends on Olig2, one of the five Olig family bHLH transcription factors.

51 Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important role

52 tivation protein Ascl1 (achaete-scute family bHLH transcription factor 1) in proliferating hippocampa

53 sion of either Twist1 (encoding twist family bHLH transcription factor 1, known as Twist) or Snai1 (e

54 alidating the importance of the Twist-family bHLH dimer pool in limb morphogenesis.

55 EFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT)/bHLH heterodimer that has been shown to induce known iro

56 conserved domains needed for their function (bHLH and PAS) and regulation (ODD and TAD).

57 is governed by GLABRA1 (GL1; R2R3MYB), GL3 (bHLH), and transparent TESTA GLABRA1 (TTG1; WD40).

58 (TF) [11, 12] subfamily of basic loop helix (bHLH) proteins by comparing gene function in early diver

59 n of phy-interacting basic Helix Loop Helix (bHLH) transcription factors (PIFs), such as PIF3, thereb

60 liana and associated basic helix-loop-helix (bHLH) and MYB transcription factors activate a variety o

61 in pathway genes and basic-helix-loop-helix (bHLH) ANTHOCYANIN1 (AN1), itself an essential component

62 enorhabditis elegans basic helix-loop-helix (bHLH) dimers using protein binding microarrays.

63 a membrane-localized basic helix-loop-helix (bHLH) DNA-binding transcription factor now renamed Glyci

64 F-1, HdHIF-1 has one basic helix-loop-helix (bHLH) domain and two Per-Arnt-Sim (PAS) domains, and HdH

65 cooperates with the basic helix-loop-helix (bHLH) factor R to activate the expression of anthocyanin

66 signaling regulates basic helix-loop-helix (bHLH) factors as an evolutionarily conserved module, but

67 ption factors of the basic helix-loop-helix (bHLH) family are required to commit cells to a neural fa

68 Members of the basic helix-loop-helix (bHLH) family of transcription factors have been shown to

69 ) are members of the basic helix-loop-helix (bHLH) family of transcription factors in Arabidopsis.

70 The basic helix-loop-helix (bHLH) family of transcription factors orchestrates cell-

71 We analyzed the basic helix-loop-helix (bHLH) family of transcription factors, many of which are

72 s of the subgroup lb basic helix-loop-helix (bHLH) genes that are known to regulate the strategy I re

73 cription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, development, and st

74 We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that univers

75 heterodimer via its basic helix-loop-helix (bHLH) motif, little is known about the conformational sa

76 the Ascl1 and Neurog basic helix-loop-helix (bHLH) proneural factors are expressed in a mosaic patter

77 under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key role

78 s ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pitt-Hopkins syndrome, int

79 Expression of the basic helix-loop-helix (bHLH) protein NeuroD1 is restricted to endocrine cells i

80 onal analysis of the basic helix-loop-helix (bHLH) protein SPEECHLESS, one of three closely related t

81 of a plant-specific basic helix-loop-helix (bHLH) protein, FEHLSTART (FST), a defect in which leads

82 g Factor 1 (PIF1), a basic helix-loop-helix (bHLH) protein, functions as a negative regulator of vari

83 hibits a DNA binding basic helix-loop-helix (bHLH) protein, HBI1, in Arabidopsis thaliana.

84 on is induced by the basic helix-loop-helix (bHLH) protein, Pho4p, in response to phosphate depletion

85 The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcrip

86 Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved b

87 demonstrate that two basic helix-loop-helix (bHLH) proteins-HEB and E2A-bind the SCA motif at regions

88 tor (P) proteins and basic helix-loop-helix (bHLH) repressor (R) factors (a "P+R" regulatory code), w

89 pinal cord, Ptf1a, a basic helix-loop-helix (bHLH) transcription activator, maintains this delicate b

90 Atoh1, a basic helix-loop-helix (bHLH) transcription factor (TF), is essential for the di

91 We identified a basic helix-loop-helix (bHLH) transcription factor at chickpea's B locus that co

92 he expression of the basic helix-loop-helix (bHLH) transcription factor Atoh1.

93 The vertebrate basic helix-loop-helix (bHLH) transcription factor ATOH7 (Math5) is specifically

94 ce deficient for the basic helix-loop-helix (bHLH) transcription factor Bhlhe40 (Bhlhe40(-/-)) are re

95 jasmonate-regulated basic helix-loop-helix (bHLH) transcription factor from clade IVa inducing the m

96 We show that basic helix-loop-helix (bHLH) transcription factor genes represented by Glyma04g

97 The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in

98 h sexes requires the basic-helix-loop-helix (bHLH) transcription factor HLH-2, the sole ortholog of t

99 ere, we identify the basic helix-loop-helix (bHLH) transcription factor homolog of brassinosteroid en

100 inhibit the atypical basic helix-loop-helix (bHLH) transcription factor INCREASED LEAF INCLINATION1 B

101 The basic helix-loop-helix (bHLH) transcription factor Math5 (Atoh7) is transiently

102 The Wnt-regulated basic helix-loop-helix (bHLH) transcription factor mesogenin 1 (Msgn1) has been

103 We show that the basic helix-loop-helix (bHLH) transcription factor PIF7 (phytochrome-interacting

104 r-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tapetal differen

105 the function of the basic helix-loop-helix (bHLH) transcription factor SPEECHLESS (SPCH).

106 molog 1 (Atoh1) is a basic helix-loop-helix (bHLH) transcription factor that is essential for the gen

107 h encodes a class II basic helix-loop-helix (bHLH) transcription factor, and causes Saethre-Chotzen s

108 itors expressing the basic helix-loop-helix (bHLH) transcription factor, Atoh7, which is necessary fo

109 in-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase seam cell number va

110 y32 (ms32) encodes a basic helix-loop-helix (bHLH) transcription factor, which functions as an import

111 mologue 2 (Ascl2)--a basic helix-loop-helix (bHLH) transcription factor--is selectively upregulated i

112 YC2a, b, c) encoding basic helix-loop-helix (bHLH) transcription factors (TFs) whose expression is ra

113 f two genes encoding basic-helix-loop-helix (bHLH) transcription factors (TFs), NtMYC2a and NtMYC2b f

114 development through basic-helix-loop-helix (bHLH) transcription factors and promotes astrocytosis.

115 Neural basic helix-loop-helix (bHLH) transcription factors are crucial in regulating th

116 of master regulatory basic-helix-loop-helix (bHLH) transcription factors controls the initiation, pro

117 bers of the group XI basic helix-loop-helix (bHLH) transcription factors encoded by LOTUS JAPONICUS R

118 Class I Basic Helix-Loop-Helix (bHLH) transcription factors form homodimers or heterodim

119 e show that myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression i

120 , we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 as key r

121 ion of the proneural basic helix-loop-helix (bHLH) transcription factors NEUROG1 and NEUROD1.

122 ion of the proneural basic helix-loop-helix (bHLH) transcription factors Neurog2 or Ascl1 downregulat

123 he activity of three basic-helix-loop-helix (bHLH) transcription factors of the PHYTOCHROME INTERACTI

124 Basic helix-loop-helix (bHLH) transcription factors recognize the canonical E-bo

125 Core basic helix-loop-helix (bHLH) transcription factors regulating stomatal developm

126 This includes the basic helix-loop-helix (bHLH) transcription factors SPEECHLESS (SPCH), MUTE, FAM

127 he ability of neural basic helix-loop-helix (bHLH) transcription factors to activate transcriptional

128 Basic helix-loop-helix (bHLH) transcription factors were reduced, while secondar

129 up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effector bind

130 ly by regulating two basic helix-loop-helix (bHLH) transcription factors, Neurog1 and Neurog2.

131 interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional

132 RREN STALK1 (BA1), a basic helix-loop-helix (bHLH) transcriptional regulator necessary for axillary m

133 The proneural basic helix-loop-helix (bHLH) transcriptional regulators are key components for

134 1 and Sohlh2, encode basic helix-loop-helix (bHLH) transcriptional regulators that are essential in s

135 twork are TFs of the basic helix-loop-helix (bHLH), nuclear factor I (NFI), SOX, and FOX families, wi

136 ormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel type o

137 HIF is a basic helix-loop-helix (bHLH)-PAS (PER-ARNT-SIM) heterodimer composed of an oxyg

138 (ARNT) belong to the basic helix-loop-helix (bHLH)-PER-ARNT-SIM (PAS) family of transcription factors

139 modulated by another basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR f

140 The MYB- basic helix-loop-helix (bHLH)-WD40 complexes regulating anthocyanin and proantho

141 ivated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is k

142 he MBW (for R2R3MYB, basic helix-loop-helix [bHLH], and WD40) genes comprise an evolutionarily conser

143 down-regulation can target other basic HLH (bHLH) dimers as well.

144 decreased levels of the proneural basic HLH (bHLH) transcriptional regulators TCF4 and NEUROD6 and de

145 f a common downstream helix-loop-helix (HLH)/bHLH network, thus forming an incoherent feed-forward lo

146 PIF4 bound all direct and down-regulated HLH/bHLH targets of IBH1 and IBL1.

147 In addition, a tripartite HLH/bHLH module feedback regulates PIFs and additional bHLH

148 ughterless (Da), the only Drosophila class I bHLH protein, activates Atonal (Ato) expression and reti

149 The four subgroup Ib bHLH genes also showed reduced expression levels in deve

150 n content in single and multiple subgroup Ib bHLH genes, as well as transcript profiling of iron resp

151 ate the expression of these four subgroup Ib bHLH genes.

152 l proliferation/differentiation switch of ID-bHLH factors.

153 Here, we report that a newly identified bHLH factor, Repressor of MYC2 Targets 1 (RMT1), is acti

154 E proteins that heterodimerize with class II bHLH proteins such as TWIST1.

155 orm homodimers or heterodimers with class II bHLH proteins.

156 genome, it has been puzzling how individual bHLH proteins selectively recognize E-box sequences on t

157 itol-mediated regulation via the Ino2p/Ino4p bHLH proteins.

158 ression2 (BEE2) and cryptochrome-interacting bHLH (CIB1) partially inhibits immunity, indicating that

159 MYC2, MYC3 and MYC4 are JAZ-interacting bHLH transcription factors that play a major role in con

160 family of four Phytochrome (phy)-Interacting bHLH transcription Factors (PIFs) collectively promote s

161 Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and G

162 Here, we combine these data with logics, bHLH-DNA co-crystal structures and computational modelin

163 so highlight the residues of other mammalian bHLH-PAS proteins that are likely involved in their homo

164 and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and p

165 Many bHLH proteins act as heterodimers with members of a clas

166 transcription factor now renamed Glycine max bHLH membrane 1 (GmbHLHm1).

167 rabidopsis, a ternary complex formed by MYB, bHLH transcription factors and TTG1 modulates unicellula

168 hocyanin biosynthesis is controlled by a MYB-bHLH-WD40 (MBW) transcriptional activator complex.

169 non-hair cell fates are determined by a MYB-bHLH-WD40 transcription factor complex and are regulated

170 hetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex.

171 ffect between SPLs and the heterogeneous MYB-bHLH factors binding to TTG1.

172 tral to this process are the activity of MYB-bHLH-WD repeat (MBW) complexes that regulate the transcr

173 box DBD), Klf4 (zinc finger DBD), and c-Myc (bHLH DBD), which together reprogram somatic cells to plu

174 recruitment to chromatin by multiple neural bHLH factors to restrict gene expression in specific neu

175 lators of neurogenesis, including neurogenic bHLH transcription factors and dorsal interneuron progen

176 re transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote

177 We found nine bHLHs expressed in stem cells and neurons that are requi

178 h expression domain of Hand1 defines a novel bHLH-dependent activity, and that disruption of establis

179 l structure in association with its obligate bHLH-ZIP partner Max.

180 tion of PRDM13 in repressing the activity of bHLH transcriptional activators that together are requir

181 tory cell expresses a distinct complement of bHLH-encoding genes-and therefore distinct HLH-2:bHLH di

182 ypes simply by loss or ectopic expression of bHLH genes, and male-to-female and female-to-male transf

183 d by specific markers, and the expression of bHLH transcription factors was assessed.

184 invariant association of loss of function of bHLH among the kabuli type, we conclude that the kabuli

185 on resulted from an increase in the level of bHLH transcription factor Atoh1 in response to inhibitio

186 ggest that dimerization-driven regulation of bHLH protein stability may be a conserved mechanism for

187 l cues in the CNS and to examine the role of bHLH transcription factors in adult tissue regeneration.

188 However, there have been very few studies of bHLH proteins from perennial tree species.

189 interaction of Pfr with a small subfamily of bHLH transcription factors, termed Phy-Interacting Facto

190 ults suggest that variation in the timing of bHLH transcription factor gene expression can explain th

191 mechanism that involved the upregulation of bHLH transcription factor, Math1 (mouse Atoh1), differen

192 We find one WD40 and one bHLH gene controlling anthocyanin pigmentation in the en

193 s for rapid dynamic changes between opposing bHLH proteins in cells approaching a terminal differenti

194 , indicating functional replacement by other bHLH genes.

195 Pathways driven by other bHLH-PAS transcription factors have a homologous repress

196 As is the case for other bHLH factors, R harbors several protein-protein interact

197 la genomes reveals that TWIST, but not other bHLH proteins, recognizes a unique double E-box motif wi

198 recently available X-ray structures of other bHLH-PAS protein dimers.

199 form heterodimers with Neurogenin 2 or other bHLH partners, suggesting a molecular basis for the swit

200 forms homodimers and heterodimers with other bHLH transcription factors.

201 through which the expression of a particular bHLH factor influences RPC fate is unclear.

202 ila retina, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) controls photor

203 ophila eye, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) determines a ra

204 We identified 44 planarian bHLH homologs, determined their patterns of expression i

205 ose that mutual inhibition between proneural bHLH proteins and Yap is an important regulator of proli

206 Sox2, it does cause suppression of proneural bHLH gene expression, indicating that PRC2 is crucial fo

207 al ectoderm independently from the proneural bHLH genes.

208 of the highly conserved proneural proteins, bHLH transcriptional regulators.

209 DYSFUNCTIONAL TAPETUM 1 (DYT1), a putative bHLH transcription factor, plays a critical role in regu

210 he classical but rather a briefly extended R bHLH region forms homodimers that bind canonical G-box D

211 , BEE1 and BEE3 genes encode closely related bHLH transcription factors that act redundantly to speci

212 nctions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle

213 Overexpression of the HBI1-related bHLHs brassinosteroid enhanced expression2 (BEE2) and cr

214 how that MYB75, a component of the WD-repeat/bHLH/MYB complex regulating anthocyanin production, is a

215 Two classes of JA-responsive bHLH transcription factor (TF), CrMYC2 and BIS1/BIS2, ar

216 In the mouse retina, bHLH genes Atoh7 and Neurog2 have distinct functions, wi

217 rine 193 (S193) is phosphorylated in Atoh1's bHLH domain in vivo Knock-in mice of both sexes bearing

218 of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1.

219 of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are lin

220 is mechanism is later reinforced by specific bHLH factors.

221 omains has diverged, with the three stomatal bHLHs exhibiting absolute, partial, or no requirements f

222 e three domains in each of the two subunits--bHLH, PAS-A, and PAS-B--tightly intertwined and involved

223 he Single-minded:Tango and Trachealess:Tango bHLH-PAS proteins that also influences link midline and

224 The bHLH code appears to be embedded in a bow-tie regulatory

225 The bHLH factor Twist is among the least well studied of the

226 The bHLH iridoid synthesis 1 (BIS1) transcription factor tra

227 The bHLH transcription factor Olig2 is expressed in cycling

228 The bHLH transcription factors SHARP1 and SHARP2 are partial

229 The bHLH transcription factors that regulate early developme

230 -length protein, and in particular about the bHLH domain-flanking N- and C-terminal segments, which a

231 In petunia petals, AN11 and the bHLH protein AN1 activate, together with the MYB protein

232 as EMT inducers, among them, Snail1 and the bHLH transcription factor E47.

233 (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem c

234 ncreased auxin biosynthesis, mediated by the bHLH transcription factor PHYTOCHROME-INTERACTING FACTOR

235 teracts with two JH receptor candidates, the bHLH-PAS paralogs MET and GCE, in a JH-dependent manner.

236 m by which increasing temperature causes the bHLH transcription factor PHYTOCHROME INTERACTING FACTOR

237 n insects and malacostracan crustaceans, the bHLH-PAS transcription factor single-minded is the maste

238 CF12 mutations identified were in either the bHLH domain, which is important for TCF12 function as a

239 ells proliferate and transiently express the bHLH transcription factor Ngn3.

240 ns share a developmental requirement for the bHLH transcription factor Atoh1.

241 Designer TALEs (dTALEs) for the bHLH transcription factors and the pectate lyase, but no

242 find that these roles are distinct from the bHLH protein Hairy (H), which we show restricts atonal (

243 Prior work has implicated the bHLH transcription factor Tal1 in endocardial tube forma

244 ch-5 allele carrying a point mutation in the bHLH domain that displayed normal growth, but had an ext

245 s insertion of a Tnt1 retrotransposon in the bHLH gene led to reduced nodulation.

246 Of particular interest is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestr

247 wever, the ACT domain remains monomeric, the bHLH region dimerizes and binds to G-boxes present in se

248 cking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da).

249 Targeted deletion of the bHLH DNA-binding protein Hand2 in the neural crest, impa

250 e also show that the C-terminal helix of the bHLH domain is involved in intermolecular interactions,

251 CH target genes require the integrity of the bHLH domain of SPCH.

252 Cs require the postmitotic expression of the bHLH pancreas transcription factor Ptf1a; however, Ptf1a

253 ed allosterically by a domain outside of the bHLH region.

254 ur predictions by functional analysis of the bHLH TF OLIG2.

255 n the temporal and spatial regulation of the bHLH transcription factor Atoh1.

256 n depends on the regulated expression of the bHLH transcription factor Atoh1.

257 gested that the large-scale expansion of the bHLH transcription factor family occurred before the div

258 ing nuclear localization and activity of the bHLH transcription factor Tfe3.

259 ed genes that could be direct targets of the bHLH transcription factors and therefore indirect target

260 retinoblasts, and functions upstream of the bHLH transcription factors ath5/atoh7 and neurod, and th

261 The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of stru

262 Singleminded-2s (SIM2s) is a member of the bHLH/PAS family of transcription factors and a key regul

263 UV-B also stabilizes the bHLH protein LONG HYPOCOTYL IN FAR RED (HFR1), which can

264 yte Physcomitrella patens has shown that the bHLH and EPF components are also required for moss stoma

265 support this hypothesis by showing that the bHLH gene complement is both necessary and sufficient to

266 Here, we show that the bHLH transcription factor Hand2 limits the size of the e

267 We demonstrated that the bHLH transcription factor R1 and hexokinase HEX9 might a

268 Here, we show that the bHLH transcription factors HECATE 1 (HEC1), HEC2 and HEC

269 In summary, we conclude that the bHLH transcription factors SHARP1 and SHARP2 are involve

270 Then the bHLH remains in the monomeric form, allowing it to inter

271 ordinated with phosphate utilization via the bHLH proteins.

272 iptional regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1.

273 mechanisms, including interactions with the bHLH factor Ascl1, to repress Ascl1 activation of Tlx3.

274 e, both display significant overlap with the bHLH transcription factor DIMM, a known neuroendocrine (

275 JAZ13 interacts with the bHLH transcription factor MYC2 and the co-repressor TOPL

276 m, an absence of nested variation within the bHLH gene and invariant association of loss of function

277 gesting that mutual interactions among these bHLH factors could direct the generation of the two cell

278 s identify the first direct targets of these bHLH repressors.

279 nteracting Factors (PIFs) by releasing these bHLH transcription factors from phytochrome B-mediated i

280 Phylogenetic analysis indicates that these bHLH transcription factor genes are orthologous to Arabi

281 This bHLH DNA-binding activity is abolished if the C-terminal

282 igand-binding domain, thus establishing this bHLH-PAS protein as a novel type of an intracellular hor

283 irect target of EZH2, and repression of this bHLH transcription factor is critical for neuronal diffe

284 temporal, and lineage inputs connect through bHLH genes to diverse outputs for terminal features and

285 Here Medicago truncatula bHLH MtTT8 was characterized as a central component of t

286 Two bHLH transcription factors in this network, Olig1 and Ol

287 hange and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

288 Here we show that Arabidopsis lacking two bHLH transcription factors produces pollen without sperm

289 pression is mediated by a heterodimer of two bHLH-PAS proteins-the JH receptor methoprene-tolerant (M

290 Although the group VIII bHLH proteins, AtROOT HAIR DEFECTIVE6 and AtROOT HAIR DE

291 r findings show that the specificity of WD40-bHLH-MYB complexes is in part determined by interacting

292 es and computational modeling to infer which bHLH monomer can interact with which CAN E-box half-site

293 While bHLH heterodimers are known to have diverse roles, littl

294 In summary, Zelda collaborates with bHLH-PAS proteins to directly regulate midline and trach

295 hocyanin MYBs, BvMYB1 will not interact with bHLH members of heterologous anthocyanin MBW complexes b

296 scriptional regulation by PAS domains within bHLH-PAS transcription factors.

297 This study tested the ability of all yeast bHLH proteins to regulate PHO5 expression and identified

298 minal basic helix-loop-helix leucine zipper (bHLH-LZ) domains of the oncoprotein c-Myc.

299 is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein.

300 (SEC14-like 3), bZIP (basic-leucine zipper), bHLH (basic helix-loop-helix) and SBP (SQUAMOSA promoter