ライフサイエンスコーパス: baboon

1 ons upstream of the type-I TGF-beta receptor Baboon.

2 was tested in a nonhuman primate model, the baboon.

3 onkey, one Old World macaque monkey, and one baboon.

4 tic effects on gene expression levels in the baboons.

5 naturally transmitted in a colony of captive baboons.

6 but an asymptomatic, persistent infection in baboons.

7 parable to that of allogeneic skin grafts in baboons.

8 immature neurons than socially dominant-like baboons.

9 ymokidney xenograft survival of >2 months in baboons.

10 iviruses are actively circulating in captive baboons.

11 lec-9) orthologs in humans, chimpanzees, and baboons.

12 a after xenogeneic kidney transplantation in baboons.

13 s and 3 Sm-p80-based vaccine formulations in baboons.

14 recent transmission of SWBV-1 among captive baboons.

15 l neurons compared with the two nonepileptic baboons.

16 imaging cerebral beta2-containing nAChRs in baboons.

17 treat the early symptoms of acquired TTP in baboons.

18 enografts survival in specific pathogen free baboons.

19 d from the leukocytes of rhesus macaques and baboons.

20 pig xenoantigens could be achieved in infant baboons.

21 inding potential and rapid brain kinetics in baboons.

22 sine-blocking studies of 4 male Papio anubis baboons.

23 R deltaREC-psiJalpha rearrangement occurs in baboons.

24 the tax sequences present in two individual baboons.

25 t approaches conferred 38%-47% protection in baboons.

26 ls of antibody titers in vaccinated mice and baboons.

27 anti-CD3 rIT could be a useful TCD agent in baboons.

28 ving preexistent acute TTP signs in mice and baboons.

29 trol but strongly correlated in OLD and IUGR baboons.

30 ats and an intravenous dose of 0.06 mg/kg in baboons.

31 acept (n=5) in kidney allotransplantation in baboons.

32 TKO.hCD46.hTBM), that were transplanted into baboons.

33 A total of 68 lesions were identified in 64 baboons.

34 osition in a well-studied population of wild baboons.

35 ve index decreased (only significant for the baboon, -0.001 D/y), and as a result the total isolated

36 age range isolated lens thickness decreased (baboon: -0.04, cyno: -0.05, and rhesus: -0.06 mm/y) and

37 Tx of genetically engineered pig livers into baboons (1) many parameters of hepatic function, includi

38 ed lens refractive power decreased with age (baboon: -1.26, cyno: -0.97, and rhesus: -1.76 D/y).

39 (3324 pg/mL), in comparison to naive control baboons (214 pg/mL).

40 M, 8 F, 5.6 years), and normal elderly (OLD) baboons (6 M, 6 F, mean 15.9 years) revealed long-term L

41 ximately 25 years), and normal elderly (OLD) baboons (6 male, 6 female, mean 15.9 years).

42 r left ventricular (LV) CMRI studies in IUGR baboons (8 M, 8 F, 5.7 years - human equivalent approxim

43 We studied IUGR baboons (8 male, 8 female, 5.7 years), control offspring

44 ood vessel sizes, and distensibility in IUGR baboons (8 males, 8 females, 8.8 years, similar to 35 hu

45 show that loss of Smad2 permits promiscuous Baboon activity, which represses genes subject to contro

46 was calibrated using experimental data from baboons administered a two-hour infusion of E coli and f

47 socially dominant- or subordinate-like (SL) baboons administered the antidepressant fluoxetine or ve

48 Nonetheless, in both mice and baboons, administration of NAC was not effective in reso

49 ere we describe cellular immune responses in baboons against a closely related virus, STLV-1.

50 L1 sequence in modern and archaic humans and baboons along with geographic distribution in present da

51 (3) these appeared to function adequately in baboons although interspecies compatibility of such prot

52 nar distributions of [3H]CUMI-101 binding in baboon and human brain sections matched the known distri

53 tative autoradiography studies in postmortem baboon and human brain sections using the 5-HT1AR antago

54 ing and rapid and reversible kinetics in the baboon and human brain.

55 R ligand for in vivo and in vitro studies in baboon and human brain.

56 the activated partial thromboplastin time of baboon and human plasmas.

57 diameter increased (logarithmically for the baboon and rhesus, and linearly for cyno: 0.07 mm/y).

58 s with eQTL significantly overlapped between baboons and a comparable human eQTL data set.

59 22 exists as a single copy in the genomes of baboons and high order primates, but not New World monke

60 ial, behaviorally complex animals, including baboons and humans.

61 elaborate greeting rituals among male Guinea baboons and less aggression toward females.

62 n and arterial thrombosis in guinea pigs and baboons and strongly synergized with oral clopidogrel.

63 , no evidence for superinfection within each baboon, and a ready ability of T cells in each baboon to

64 Myoglianin, Baboon, and Ecdysone Receptor-B1 are also required for n

65 observed in mutants for the TGFbeta receptor baboon, and epistasis tests showed that baboon is epista

66 grafts inserted into arteriovenous shunts in baboons, and reduced fibrin and platelet accumulation do

67 owing T cell lines were established from two baboons, animals 12141 and 12752.

68 Rhesus monkey and baboon APC presented HMBPP and 20.1 to human Vgamma2Vdel

69 manage the baboons' space use) revealed that baboons are at risk of being herded out of urban spaces

70 eferentially following dominant individuals, baboons are more likely to follow when multiple initiato

71 ese results justify the use of STLV-infected baboons as a model system for vaccine development effort

72 range of the simian arteriviruses and define baboons as a natural host for these viruses.

73 ersity of the simian arteriviruses, identify baboons as a natural host of these viruses, and provide

74 Twelve anesthetized baboons assigned randomly to recombinant nematode antico

75 of human CD47 were infused into conditioned baboons at 3 time points over a 9-week period.

76 Aggression directed by male baboons at females during the early stages of their bree

77 Pregnant MNR baboons ate 70% of what controls ate from 0.16 to 0.9 ge

78 Baboon-attached motion/GPS tracking collars showed that

79 (n = 61; age, 0.7-13.3 years), and hamadryas baboons (baboon: n = 16; age, 1.7-27.3 years).

80 In the baboon baseline studies, the brain regional volume of di

81 This ability can also be attributed to baboons being able to recognize specific letters (i.e.,

82 Rescue experiments indicate that Baboon binding, but not canonical transcription factor a

83 (18)F-ASEM readily entered the baboon brain and specifically labeled alpha7-nAChR.

84 PET baboon brain distribution paralleled that seen in mouse,

85 l agonist, blocked (18)F-ASEM binding in the baboon brain in a dose-dependent manner, suggesting that

86 of regional binding potential values in the baboon brain was from 3.9 to 6.6.

87 (18)F-AZAN rapidly entered the baboon brain, reached a steady state within 90 min after

88 ted progenitor cells within the SVZ of adult baboon brain.

89 (18)F-AZAN specifically labels nAChRs in baboon brains with a high value of BP(ND) and it require

90 of trapezoid body (MNTB) in preterm and term baboon brainstem slices to study the structural and func

91 In baboon but not macaque cell cultures, SHFV infection upr

92 ontal defects were created bilaterally in 12 baboons by a split-mouth design.

93 s the severity of P. knowlesi coinfection in baboons by mechanisms that may enhance innate immunity t

94 Grainger et al. suggest that baboons can discriminate words from nonwords on the basi

95 results show that, similarly to humans, the baboon CD8(+) T cell response narrowly targeted the Tax

96 Baboons cervically inoculated once with C. trachomatis d

97 flicts arise over the direction of movement, baboons choose one direction over the other when the ang

98 In four baboons, coagulation factors were measured.

99 t of ACT in nasopharyngeal washes (NPW) from baboons, combined with human and in vitro data, would pr

100 cient mice, and pock lesions were smaller in baboons compared with the controls.

101 e complexes detected in the plasma of septic baboons correlated with increase in histones and/or nucl

102 We sought to determine if the baboon could become infected with a single cervical inoc

103 Baboon cultures produced higher levels of IL-10 than mac

104 V infection were observed in macaque but not baboon cultures, suggesting less efficient counteraction

105 e cultures produced higher virus yields than baboon cultures.

106 of innervation was already formed in preterm baboons delivered at 67% of normal gestation.

107 In contrast, 100% of inoculated baboons developed clinical pertussis.

108 lly protected against disease, whereas naive baboons developed illness (with 1 death) and leukocytosi

109 Naive infant baboons developed severe disease when challenged with B.

110 Recipient baboons died or were euthanized after 4 to 7 days after

111 hus, the social relationships of male Guinea baboons differ markedly from those of other members of t

112 Using a total of 28 baboons, different vaccination strategies were used incl

113 Overall, these raiding baboons display a time-activity balance that is drastica

114 GBR600 treatment of baboons during acute TTP (treatment group) resulted in a

115 s type D betaretrovirus (SERV) sequences and baboon endogenous virus type C gammaretrovirus (BaEV) se

116 of these serotypes, simian virus 19 (SV19), baboon enterovirus (BaEV), enterovirus 112 (EV112), and

117 A total of 81% of baboons exposed to chronic S. mansoni infection with or

118 Individual baboons expressed more gamma interferon and tumor necros

119 osely related STLV-1 genome sequences in two baboons, extremely low heterogeneity of STLV sequences w

120 ying histamine to a dark-adapted, superfused baboon eye cup preparation while making extracellular re

121 Savannah baboons form strong, equitable, and enduring relationshi

122 d an RNA sequencing (RNA-seq)-based study of baboons from an intensively studied wild population.

123 Strikingly, baboon gut microbiota appeared to be highly dynamic such

124 Despite the dynamic nature of baboon gut microbiota, we identified a set of core taxa

125 Overall, the two epileptic baboons had a 37% average reduction in the number of cor

126 SL baboons had lower numbers of proliferating cells and imm

127 mples collected over 13 years, we found that baboons harbour gut microbiota typical of other omnivoro

128 ndividuals' nearest neighbours, we find that baboons have distinct preferences for particular neighbo

129 Gal-knockout cardiac xenografts after pig-to-baboon heterotopic cardiac xenotransplantation when the

130 t to indicate that adult neurogenesis in the baboon hippocampal DG may be functionally relevant in th

131 ced plasma LPS content in E. coli-challenged baboons, implying reduced complement-mediated bacterioly

132 (2.6%), and 29 (12.3%) of 235 newly captured baboons in Kenya, respectively.

133 Baboons in the control group only injected with 3H9 deve

134 lower parasite burdens (P = 0.004) than the baboons in the P. knowlesi-only group and were protected

135 alveolar bone loss measurements from captive baboons indicates that bone loss increases with age and

136 [PAP]), and complement (C3b, C5a, C5b-9) in baboons infused with factor Xa (FXa) and phospholipids (

137 provide clear evidence that epilepsy in the baboon is associated with considerable reduction in the

138 ptor baboon, and epistasis tests showed that baboon is epistatic to Smad2 for disc overgrowth.

139 We find that the Activin receptor Baboon is required in R8 to receive non-redundant signal

140 esponse against STLV-1 in naturally infected baboons is largely directed against the Tax protein.

141 days) versus naked (MRT, 36 days; P < 0.01) baboon islets transplanted in the EFP site.

142 Recent survivals of our pig-to-baboon kidney xenotransplants have been markedly shorter

143 Surgical removal of the native thymus in two baboons led to a significant decrease of sjTREC in perip

144 However, dog-to-pig and pig-to-baboon liver xenotransplant models have resulted in seve

145 f human coagulation factors following pig-to-baboon liver xenotransplantation (LXT) using GalT-KO swi

146 Epistasis experiments show that Baboon, Mad and Schnurri are required to mediate the ect

147 et of natural injuries and illnesses in wild baboon males.

148 e viruses, and provide further evidence that baboons may have played a role in previous outbreaks of

149 FV infected approximately 50% of macaque and baboon mDCs, virus replication was efficient in macaque

150 lication was efficient in macaque but not in baboon mDCs.

151 aternal vaccination confer protection in the baboon model and support further study of these strategi

152 We developed a baboon model for IUGR studies using a moderate 30% globa

153 ur findings suggest that the STLV-1-infected baboon model may recapitulate some of the important aspe

154 oon viruses suggest that the STLV-1-infected baboon model might be useful for developing a vaccine ag

155 efficacy and safety profile of ALX-0681 in a baboon model of acquired TTP.

156 g in vitro whole-blood assays and an in vivo baboon model of Escherichia coli sepsis.

157 The recently developed baboon model of infection mimics the prolonged cough and

158 The recent development of a baboon model of pertussis, along with the future develop

159 en infected and naive animals, utilizing the baboon model of pertussis.

160 Here, we used a baboon model to test the protective potential of the nov

161 les for periodontal tissue regeneration in a baboon model.

162 TTP signs, using well-established murine and baboon models for TTP.

163 Our juvenile nonhuman primate (Papio baboons) models of endotoxin-free Stx challenge exhibit

164 a process of shared decision-making governs baboon movement.

165 of their habitat to identify key drivers of baboon movement.

166 We find that baboon movements are best predicted by 4 to 6 neighbours

167 caque MPhis but in only approximately 10% of baboon MPhis.

168 Two groups of baboons (n = 8 each) and a schistosomiasis control group

169 age, 0.7-13.3 years), and hamadryas baboons (baboon: n = 16; age, 1.7-27.3 years).

170 Baboons naturally infected with simian T lymphotropic vi

171 heterogeneity of STLV sequences within each baboon, no evidence for superinfection within each baboo

172 o enable translation to humans, we developed baboon offspring cohorts from mothers fed ad libitum (co

173 cidating the rules that maintain cohesion in baboons 'on the move', as well as the different temporal

174 measurably displace [3H]CUMI-101 binding in baboon or human brain sections, thereby ruling out [3H]C

175 es from cages housing rhesus macaques, olive baboons, or hamadryas baboons were positive for a picorn

176 ysis to seven behaviors among 45 wild female baboons over 7 y to determine whether the personality di

177 s have shown significant correlation between baboon (Papio anubis) and human brain.

178 cted a randomized controlled study using the baboon (Papio anubis) to analyze the effect of chronic s

179 The baboon (Papio hamadryas anubis) can be transcervically i

180 a virus closely related to HTLV-1, in olive baboons (Papio anubis).

181 ial-enhanced MR angiography was performed in baboons (Papio anubis; n = 4) by using Mn-PyC3A and Gd-D

182 concentrations in five social groups of wild baboons (Papio cynocephalus) over an 11-y period.

183 d stress in a natural population of savannah baboons (Papio cynocephalus), high-ranking males had hig

184 To this end, 52 baboons (Papio hamadryas) underwent partial pancreatecto

185 with genetic relatedness data of wild Guinea baboons (Papio papio), we show that this species exhibit

186 related species in the vaginal microflora of baboons (Papio spp.).

187 sidency times (PRTs) recorded from 54 chacma baboons (Papio ursinus) across two groups in natural (n

188 oural processes by which raiding male chacma baboons (Papio ursinus) exploit the opportunities and mi

189 Retrospective data from 33 septic baboons (Papio ursinus) subjected to Escherichia coli in

190 functions as sexual coercion in wild chacma baboons (Papio ursinus).

191 n use with experimental food patches in wild baboons (Papio ursinus).

192 venous challenge with purified Stx1 or Stx2, baboons (Papio) developed thrombocytopenia, anemia, and

193 (mDCs), were differentiated from macaque and baboon peripheral blood monocytes and used to compare vi

194 rination reaction to non-human primate (NHP) baboon PET imaging-an important milestone on the path to

195 ere evaluated in DISC1 mice (dissection) and baboons (PET).

196 948, (11)C-RO6931643, and (11)C-RO6924963 to baboons, PET scans indicated good brain entry, rapid was

197 ompound present at 90 min after injection in baboon plasma.

198 A previously unexplored social influence - baboons' preference for locations that other troop membe

199 the inhibitory anti-ADAMTS13 antibody 3H9 to baboons (prevention group) precluded TTP onset as severe

200 To model maternal vaccination, adult female baboons primed with acellular pertussis vaccine were boo

201 IUGR programming in baboons produces myocardial remodelling, reduces systoli

202 Our results demonstrate that the baboon provides an excellent model of clinical pertussis

203 Four baboons received anti-CD3 rIT; the time course of TCD wa

204 After LXT, baboons received no coagulation factors (historical cont

205 artery patch xenotransplantation, recipient baboons received no immunosuppression (IS; n=3), or anti

206 Six baboons received rituximab before transplantation to dep

207 Baboons receiving acellular pertussis vaccine and infant

208 ient chimerism were substantially greater in baboons receiving hematopoietic cells from a pig express

209 TCD levels in baboons receiving the anti-CD3 rIT regimen were 150 to 2

210 250 cells/muL for at least 14 days, whereas baboons receiving the LoCD2 recovered to more than 300 c

211 Baboon recipients of Gal-positive, CD46 pig hearts were

212 Three prospective pig-to-baboon renal transplants using kidneys from swine delive

213 Baboon reovirus (BRV) is a member of the fusogenic subgr

214 Although the social organization of Guinea baboons resembles that of hamadryas baboons, we found st

215 baboon virus 1 (SWBV-1), in wild and captive baboons, respectively, and demonstrate the recent transm

216 ent with MRI findings in rodent, feline, and baboon retinas.

217 rated here high-titer LVs pseudotyped with a baboon retroviral envelope glycoprotein (BaEV-LVs), resi

218 PET imaging in baboons reveals that all organs have a 2-phase (rapid an

219 In contrast, lower primates (baboons, rhesus monkeys) express 12-lipoxygenating enzym

220 y quantitative PCR using primers specific to baboon sequence.

221 Culture of isolated pig podocytes with naive baboon sera, which has preformed antipig natural antibod

222 Similarly, ex vivo incubation of baboon serum with thrombin, plasmin, or FXa did not show

223 Ventilated preterm baboons show activation of the NLRP3 inflammasome with i

224 Baseline PET studies in the pig and baboon showed that (11)C-IMA107 and (11)C-MP-10 displaye

225 xt describe results from free-ranging female baboons showing that individuals who show high rates of

226 Baboon sjTREC can be quantified by quantitative PCR usin

227 Primers, specific to baboon sjTREC sequence were designed and used to quantif

228 A collection of baboon skulls from a pedigreed colony (for which scienti

229 Adult primary baboon smooth muscle cells (SMCs) were seeded in the lum

230 Female baboon social groups were fed ad libitum (control, CTR)

231 ucted with 'rangers' (employed to manage the baboons' space use) revealed that baboons are at risk of

232 xplain the distinct behavioral suites of two baboon species in Awash, Ethiopia, which differ markedly

233 PS tracking collars showed that raiding male baboons spent almost all of their time at the urban edge

234 ed but distinct from each other and from the baboon STLV-1 sequence in the NCBI sequence database.

235 Tax peptides corresponding to the reference baboon STLV-1 sequence.

236 expanded the number of available full-length baboon STLV-1 sequences from one to three and related th

237 ps were detected in a thrombus and plasma of baboons subjected to deep vein thrombosis, an example of

238 ts and regulatory role of H3K4me3 within the baboon SVZ, we developed a technique to purify undiffere

239 the undifferentiated progenitor cells of the baboon SVZ.

240 To quantify the production of baboon T cells by the porcine thymic tissue, we recently

241 assay to measure the excised DNA products of baboon T-cell receptor (TCR) gene rearrangement (signal-

242 ach unique Tax sequence and to the reference baboon Tax sequence were used to analyze recognition by

243 dentified two tentative enterotypes in adult baboons that differ from those of humans and chimpanzees

244 In two thymectomized baboons that received porcine thymokidney xenografts, sj

245 Baboons that received the anti-CD3 rIT died from pneumon

246 gene-knockout pig kidneys transplanted into baboons that were treated with a protocol designed to in

247 d viral sequence heterogeneity in individual baboons, the identity of the viral gene product that is

248 In IUGR baboons there was increased carotid arterial blood flow

249 D-1 and sEH knock-out mice and Papio anubis (baboon) through pretreatment with an sEH inhibitor to bl

250 on regimen (ATG regimen) in a GalT-KO pig-to-baboon thymokidney (TK) model.

251 ,000 cells in thymic biopsies, implying that baboon thymopoiesis had begun to occur in the porcine th

252 Initial results suggest that baboon thymopoiesis occurs in vascularized porcine thymu

253 The ability of a wild baboon to acquire and exploit social information depends

254 boon, and a ready ability of T cells in each baboon to recognize circulating Tax sequences.

255 PET nuclide and tested in vivo in tau-naive baboons to assess brain uptake, distribution, clearance,

256 e we use prospective data on 196 wild female baboons to show that cumulative early adversity predicts

257 and again in the peri-transplant period; 18 baboons treated only before transplantation served as hi

258 Thymokidney grafts from baboons treated with the LoCD2 regimen were rejected by

259 resolution GPS tracking of members of a wild baboon troop, we test whether collective movement in sta

260 Furthermore, constitutively active Baboon (type I receptor upstream of Smad2) cannot stimul

261 Two additional baboons underwent GalT-KO TK transplantation after treat

262 Papio anubis baboons underwent PET scans of the brain after intraveno

263 measure the kinetics for 14 organs in a male baboon using (86)Y- 6 RESULTS: Compounds (86)Y- 4: - 6:

264 to analyze recognition by T cells from each baboon using intracellular cytokine staining (ICS).

265 sing a yoked control paradigm in mice nor in baboons using a standard paradigm for assessing drug abu

266 lanted in the abdominal aorta in 3-month-old baboons using A/B-incompatible (AB-I) allografts or wild

267 d ejection abnormalities in IUGR young adult baboons using cardiac magnetic resonance imaging.

268 of each labeled drug has been determined in baboons using positron emission tomography (PET).

269 Baboons vaccinated with aP were protected from severe pe

270 and 7% amino acid, respectively), while the baboon variant was substantially more divergent, mirrori

271 arteriviruses related to SHFV, Mikumi yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SW

272 yellow baboon virus 1 (MYBV-1) and Southwest baboon virus 1 (SWBV-1), in wild and captive baboons, re

273 he sequence similarity between the human and baboon viruses suggest that the STLV-1-infected baboon m

274 The metabolism of (18)F-FNDP in baboons was assessed using high-performance liquid chrom

275 f Guinea baboons resembles that of hamadryas baboons, we found stronger male-male affiliation and mor

276 Using shotgun metagenomic data from wild baboons, we found that social group membership and socia

277 onary inflammation and fibrosis in hyperoxic baboons, we hypothesized that ionizing radiation trigger

278 When BPZE1-vaccinated baboons were challenged with a high dose of a highly vir

279 Pregnant baboons were fed control (ad libitum, n=11) or an MNR di

280 stic response was observed when convalescent baboons were infected 6 months following recovery from a

281 rhesus macaques, olive baboons, or hamadryas baboons were positive for a picornavirus, while no picor

282 Ten female baboons were randomized and inoculated cervically with C

283 To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP

284 Baboons were vaccinated with acellular pertussis vaccine

285 , and blood flow pattern in young adult IUGR baboons, which may contribute to cardiac stress.

286 rdiac dysfunction and vascular impairment in baboons who were IUGR at birth because of moderate mater

287 Juvenile offspring of 19 female baboons, whose diets were either restricted [maternal nu

288 Tracking wild baboons with a high-resolution global positioning system

289 models, particularly the infection of infant baboons with B. pertussis, are enabling longstanding que

290 anasal/intratracheal inoculation of juvenile baboons with BPZE1 resulted in transient nasopharyngeal

291 eactivities in post-mortem brains from adult baboons with cerebral hypoperfusive injury, induced by o

292 were co-administered into the peritoneum of baboons with endometriosis, cells in lesions selectively

293 plete extent of the cortex for two epileptic baboons with naturally occurring seizures and two baboon

294 We inoculated rhesus macaques and olive baboons with wild-type B. pertussis strains and evaluate

295 erial concentrations similar to those in the baboons, with 12 to 20 ng/ml ACT.

296 h arterial blood sampling was performed in 3 baboons, with regional tracer binding quantified using d

297 ultaneous, high-resolution, tracking of wild baboons within a troop with a 3-dimensional reconstructi

298 ion activation in induced-heat stroke in the baboon without an effect on fibrinolysis and inflammatio

299 ns with naturally occurring seizures and two baboons without epilepsy.

300 graft survival across the discordant pig-to-baboon xenogeneic barrier.