ライフサイエンスコーパス: baccatin

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1 ion step to protect three hydroxyl groups of baccatin III (1), followed by hydride ester cleavage and

2 f 500 nL of taxol (20 mM) and its precursor, baccatin III (30 mM), is separated using such a column w

3 clitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidi

4 X-ray analysis of six baccatin III analogues supports the suggested changes in

5 55 degrees C; the k' values for 10-deacetyl baccatin III and 10-deacetyl taxol go through a maximum

6 While there was no interference from the baccatin III and 10-deacetylbaccatin III, cephalomannine

7 st other naturally occurring taxanes such as baccatin III and 10-deacetylbaccatin III.

8 4-O-acetylation of 4-deacetylbaccatin III to baccatin III and 13-acetyl-4-deacetylbacatin III to 13-a

9 .4 +/- 0.5 microM and 4.9 +/- 0.3 microM for baccatin III and beta-phenylalanoyl-CoA, respectively.

10 he enantiopure side chain precursor to 7-TES-baccatin III and subsequent silyl ether deprotection aff

11 One interpretation of these data is that baccatin III and Taxol differ in their abilities to nucl

12 ural difference in microtubules formed using baccatin III and Taxol.

13 (1)H-NMR and MS verification of the product baccatin III derived from 10-deacetylbaccatin III and ac

14 cient synthesis of 13-epi-7-O-(triethylsilyl)baccatin III from 13-deoxybaccatin III is described.

15 The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III

16 h SmI(2), produced 13-epi-7-O-(triethylsilyl)baccatin III in good overall yield.

17 2-m-Azido baccatin III inhibited the proliferation of human cancer

18 Baccatin III is widely considered to be an inactive deri

19 than Taxol, we questioned whether 2-m-azido baccatin III might be active.

20 es at C4, suggesting that the C7 hydroxyl of baccatin III must remain deacylated for enzyme function.

21 The effect of baccatin III on in vitro microtubule assembly was quanti

22 ated using the X-ray geometry of 10-deacetyl baccatin III supports the contention that the B, C, and

23 We found baccatin III to be active in all circumstances in which

24 mical coupling of 10-deacetylbaccatin III or baccatin III to C-13 paclitaxel side chain has been summ

25 )baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and

26 ere semisynthesized from the natural product baccatin III via silyl protecting group manipulation, re

27 ontrast to 2-m-azido baccatin III, 2-p-azido baccatin III was similar to baccatin III, having no Taxo

28 Taxol, even when very high concentrations of baccatin III were employed.

29 at catalyzes the selective 13-O-acylation of baccatin III with beta-phenylalanoyl CoA as the acyl don

30 Oxidation of 13-deoxy-7-O-(triethylsilyl)baccatin III with tert-butyl peroxide, followed by reduc

31 In contrast to 2-m-azido baccatin III, 2-p-azido baccatin III was similar to bacc

32 Baccatin III, an analogue of Taxol lacking the C-13 side

33 n III, 2-p-azido baccatin III was similar to baccatin III, having no Taxol-like activity, further ind

34 ibrium constants for the growth reaction for baccatin III-induced GTP-tubulin and GDP-tubulin assembl

35 Baccatin III-induced microtubules were routinely much lo

36 old greater than the microtubule affinity of baccatin III.

37 2'-deoxy-PTX, N-debenzoyl-2'-deoxy-PTX, and baccatin III.

38 he fact that it is essentially a substituted baccatin III.

39 measured for two forms of solid 10-deacetyl baccatin III: a dimethyl sulfoxide (DMSO) solvate and an

40 at affect this equilibrium occur between the baccatin portion of the molecule and the binding site.

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