ライフサイエンスコーパス: baccatin III

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1 old greater than the microtubule affinity of baccatin III.

2 2'-deoxy-PTX, N-debenzoyl-2'-deoxy-PTX, and baccatin III.

3 he fact that it is essentially a substituted baccatin III.

4 ion step to protect three hydroxyl groups of baccatin III (1), followed by hydride ester cleavage and

5 In contrast to 2-m-azido baccatin III, 2-p-azido baccatin III was similar to bacc

6 f 500 nL of taxol (20 mM) and its precursor, baccatin III (30 mM), is separated using such a column w

7 clitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidi

8 measured for two forms of solid 10-deacetyl baccatin III: a dimethyl sulfoxide (DMSO) solvate and an

9 Baccatin III, an analogue of Taxol lacking the C-13 side

10 X-ray analysis of six baccatin III analogues supports the suggested changes in

11 55 degrees C; the k' values for 10-deacetyl baccatin III and 10-deacetyl taxol go through a maximum

12 While there was no interference from the baccatin III and 10-deacetylbaccatin III, cephalomannine

13 st other naturally occurring taxanes such as baccatin III and 10-deacetylbaccatin III.

14 4-O-acetylation of 4-deacetylbaccatin III to baccatin III and 13-acetyl-4-deacetylbacatin III to 13-a

15 .4 +/- 0.5 microM and 4.9 +/- 0.3 microM for baccatin III and beta-phenylalanoyl-CoA, respectively.

16 he enantiopure side chain precursor to 7-TES-baccatin III and subsequent silyl ether deprotection aff

17 One interpretation of these data is that baccatin III and Taxol differ in their abilities to nucl

18 ural difference in microtubules formed using baccatin III and Taxol.

19 (1)H-NMR and MS verification of the product baccatin III derived from 10-deacetylbaccatin III and ac

20 cient synthesis of 13-epi-7-O-(triethylsilyl)baccatin III from 13-deoxybaccatin III is described.

21 The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III

22 n III, 2-p-azido baccatin III was similar to baccatin III, having no Taxol-like activity, further ind

23 h SmI(2), produced 13-epi-7-O-(triethylsilyl)baccatin III in good overall yield.

24 ibrium constants for the growth reaction for baccatin III-induced GTP-tubulin and GDP-tubulin assembl

25 Baccatin III-induced microtubules were routinely much lo

26 2-m-Azido baccatin III inhibited the proliferation of human cancer

27 Baccatin III is widely considered to be an inactive deri

28 than Taxol, we questioned whether 2-m-azido baccatin III might be active.

29 es at C4, suggesting that the C7 hydroxyl of baccatin III must remain deacylated for enzyme function.

30 The effect of baccatin III on in vitro microtubule assembly was quanti

31 ated using the X-ray geometry of 10-deacetyl baccatin III supports the contention that the B, C, and

32 We found baccatin III to be active in all circumstances in which

33 mical coupling of 10-deacetylbaccatin III or baccatin III to C-13 paclitaxel side chain has been summ

34 )baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and

35 ere semisynthesized from the natural product baccatin III via silyl protecting group manipulation, re

36 ontrast to 2-m-azido baccatin III, 2-p-azido baccatin III was similar to baccatin III, having no Taxo

37 Taxol, even when very high concentrations of baccatin III were employed.

38 at catalyzes the selective 13-O-acylation of baccatin III with beta-phenylalanoyl CoA as the acyl don

39 Oxidation of 13-deoxy-7-O-(triethylsilyl)baccatin III with tert-butyl peroxide, followed by reduc

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