ライフサイエンスコーパス: backbone

1 significant contribution of the nucleic acid backbone.

2 -carbon level in a molecule with a pentacene backbone.

3 s 4 times as long as the bond length of C-C backbone.

4 es a methine group of the 1,8-triptycenediyl backbone.

5 ly composed of a hexa-acylated diglucosamine backbone.

6 nces were engineered into an HIV-1 subtype C backbone.

7 henyl rings, further rigidifying the polymer backbone.

8 on transfer from the saturated pincer ligand backbone.

9 sible for tryptorubin A's linear hexapeptide backbone.

10 nction in the context of a recombinant virus backbone.

11 s as the nucleotide is located closer to the backbone.

12 ysis reaction - in the polymer side chain or backbone.

13 rane units connected by a 1,8-triptycenediyl backbone.

14 of non-base-contacting residues with the DNA backbone.

15 idinedione ring oxygen and the CA II protein backbone.

16 gh yields without degradation of the polymer backbone.

17 troduction of functionalities in the polymer backbone.

18 fects from the substituents on the perenosin backbone.

19 tabilization and binding of the heads to the backbone.

20 s from azide attack on the beta-diketiminato backbone.

21 l building block to generate a heterogeneous backbone.

22 9 properly oriented to interact with the DNA backbone.

23 d from oxidative decomposition of the folate backbone.

24 esence of the additional methyl group on the backbone.

25 ities are connected by a 1,8-biphenylenediyl backbone.

26 ed carboxyl functional groups on the polymer backbone.

27 en the allylic hydroxyl group and the BTN3A1 backbone.

28 clash between O8 of 8-oxoG and the phosphate backbone.

29 fer of this label over protons in the target backbone.

30 ve been found to prevail also in non-natural backbones.

31 es, kinks, scale-like interfaces, and curved backbones.

32 ligands, high temperatures, and pi-extended backbones.

33 All six tryptophan indole and eight glycine backbone (15)N-(1)H NMR signals in A2AAR were individual

34 a late-stage glycosylation of heptagalactan backbone acceptors to introduce branching.

35 ices may be designed, in part, to make their backbones accessible for cleavage.

36 Local shifts in the IgG backbone accommodate the introduction of lysine side cha

37 is important for enhancing charge transport, backbone alignment alone does not guarantee charge trans

38 olled growth of nanofibril aggregates and by backbone alignment, with the adjusted R(2) (R(2)adj) cor

39 be reversed by tuning the degree of polymer backbone alignment.

40 In the absence of the carbastannatrane backbone, alkyltin nucleophiles exhibit no activity towa

41 e triarylphosphine ligand moieties along the backbone allowed for the intramolecular crosslinking of

42 and arginine R210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexamers and p

43 is and biological activities of an LM glycan backbone, alpha(1-6)mannans.

44 to address this challenge is the systematic backbone alteration of natural protein sequences, throug

45 shift dispersion, and a large portion of the backbone amide groups are solvent-exposed leading to fas

46 A or T(304)A) investigated, confirm that the backbone amide of at least one Thr (Thr(304)), adjacent

47 Five peptide regions on IL-23 with reduced backbone amide solvent accessibility upon antibody bindi

48 NMR-derived backbone amide temperature coefficients for many residue

49 een the cis and trans conformations of their backbone amides is the major hurdle to overcome for the

50 in relaxation measurements indicate that the backbone amides of [Formula: see text] have significant

51 stabilized by an oxyanion hole formed by the backbone amides of Ala102 and Leu186.

52 Results for 53 backbone amides show narrow clustering with protection o

53 Herein, we describe a practical synthesis of backbone aminated peptides that readily adopt beta-sheet

54 c copper formed provides a high conductivity backbone and cohesive support to accommodate the volume

55 ocated at the external bonds of the glycerol backbone and concentrated polyunsaturated fatty acids (L

56 res of model compounds representative of the backbone and density functional theory (DFT) were used t

57 olecular spoked wheels with an all-phenylene backbone and different alkoxy side chain substitution pa

58 cluding acyl chain positions on the glycerol backbone and double bond positions within acyl chains.

59 dine ring that provides a structurally rigid backbone and facilitates the installation of other donor

60 US binding illustrated the importance of ASO backbone and hydrophobic 2' sugar modifications and reve

61 h two different linkers, one directly to the backbone and one directly to the nucleobase stack.

62 r between Fab' and MORF1 and between polymer backbone and pendant MORF2, and comparison of two Fab' f

63 ylene group is exchanged between the polymer backbone and side chain.

64 NMR spectroscopy was performed for backbone and side-chain chemical-shift assignments of mo

65 Here, we report that ASOs with specific backbone and sugar modifications can become localized to

66 ity, side chains are attached to the peptide backbone and surrounded by other side chains in the prot

67 integration of alkyne groups into the rigid backbone and the delocalized pi-conjugated structure.

68 the positions of acyl chains on the glycerol backbone and the double bonds within the acyl chains.

69 ic acids depends on the composition of their backbone and the linker group to the electrodes.

70 By varying the length of sh-dsDNA backbone and the spacer between two adjacent mCGs, we sy

71 om two adjacent repeating units of the PSIII backbone and two of them from the branched galactose-sia

72 rst time, intricate details of the phosphate backbone and underlying strand conformations.

73 e assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against

74 esized 12 peroxy acids with C8 to C10 carbon backbones and mono- or diperoxy acid functionality.

75 lasmids exhibit remarkable similarity in the backbone, and the major distinction lies in the region c

76 sequences were inserted into an HIV-1 NL4-3 backbone, and the replication capacities of the resultin

77 the electronic structure of the cyanine-type backbone (approach (a)).

78 ion of rhamnogalacturonan-II side chains and backbone are coordinated to overcome steric constraints,

79 two hydroxyl moieties in the flavone A-ring backbone are essential for potent inhibition of LasR/Rhl

80 Their protein backbones are rich in the disordering amino acid proline

81 ntose phosphate pathway, and the RNA and DNA backbone, are largely unknown.

82 ecificity for protein residue side chains vs backbone as well as selectivity for different residue ty

83 ibodies were synthesized on identical murine backbones as either an IgG1 or IgG2a subclass and evalua

84 m bacterial pathogens, modifying the protein backbone at the Calpha atom of a Pro residue to produce

85 egree of structural similarity between their backbone atoms (0.96-A root mean square deviation).

86 e aromatic units are moved along the peptide backbone away from the hydrophobic core, the interaction

87 The negatively charged backbone balanced with extra-framework cations and the p

88 involved in intermediate steps of terpenoid backbone biosynthesis and those related to secondary tra

89 y GT43 glycosyltransferase involved in xylan backbone biosynthesis, while UPEX1 encodes a family GT31

90 ture dissociation (ECD) for cleaving protein backbone bonds while preserving noncovalent interactions

91 ation of polymers bearing heteroatoms in the backbone but with the ease and robustness of a radical p

92 nanostructures or their internal beta-sheet backbone, but must involve accessible adaptive configura

93 e junctions is defined by the oligophenylene backbone, but the conductance is increased by factors of

94 unexpected control of the DNA phosphodiester backbone by electrostatic interactions.

95 itably designed oligomers with >20% modified backbones can form native-like tertiary folds with metal

96 carboxylic acid groups precisely every 21st backbone carbon atom.

97 etween a Cys, Ser, or Thr side chain and the backbone carbonyl carbon to form a thiazoline, oxazoline

98 receptor antagonists identified herein and a backbone carbonyl group in transmembrane domain 4.

99 h-space" scalar couplings between methyl and backbone carbonyl groups in proteins.

100 tif where lysine NH3(+) group interacts with backbone carbonyl.

101 nally important glutamate and three rings of backbone carbonyls.

102 olated features that change as a function of backbone carboxylation (28, 40, 50, 60, 80, and 93 %) fr

103 A bears functional groups inserted along its backbone chain working as active sites.

104 rative interactions of bound water along the backbone chain.

105 ng has been previously identified in protein backbone chains, for which these mechanical constraints

106 Our results provide insights into how backbone charge and chemical composition assist in the b

107 tailoring the porosity in the holey graphene backbone, charge transport in the composite architecture

108 eriencing a resurgence driven by advances in backbone chemistry and discoveries of novel therapeutic

109 By mapping the location of backbone cleavages associated with c-type ions onto the

110 fferences in the electrical conductance with backbone composition are preserved.

111 By employing tetrasaccharides with different backbone compositions, a library of 47 HS-oligosaccharid

112 trate that minimal alteration to the peptide backbone conformation occurs with aza-glycine incorporat

113 graft distribution on the domain spacing and backbone conformation.

114 ate strongly with a narrow range of tyrosine backbone conformation.

115 These include a bias toward the BI backbone conformation; sugar repuckering, major-groove d

116 tations are local and do not introduce major backbone conformational changes.

117 improved accuracy in generating polypeptide backbone conformational ensembles for intrinsically diso

118 However, methods for backbone conformational search in design have been much

119 This will allow backbone conformations for entire folds and assemblies n

120 ysis of all NES structures show 5-6 distinct backbone conformations where the only conserved secondar

121 Upon removing the backbone connectivity by breaking all peptide bonds in l

122 fferences between nucleic acids of different backbones correlate with differences in backbone structu

123 7 (H9N2) in the A/California/04/2009 (pH1N1) backbone could become better adapted to pigs by serial p

124 Here we used backbone cyclization as a strategy to improve the foldin

125 Overall, this study highlights the value of backbone cyclization in directing folding, improving yie

126 erein, we demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD

127 nsities (x = 1.0, 0.75, 0.5, 0.25) and total backbone degrees of polymerization (n = 167, 133, 100, 6

128 exhibiting highly branched to nearly linear backbones depending on reaction conditions and catalyst

129 ultiple-sequence alignments, and (ii) during backbone design, maintained stabilizing interactions obs

130 , appropriately localized flexibility in the backbone dihedrals varphi and psi as well.

131 including extrusion of consecutive bases and backbone distortions, with a sharp bending of the duplex

132 he ESR measured distance directly reports on backbone DNA distance, without the need for further mode

133 FRAGFOLD-IDP enables better insight into backbone dynamics in IDPs and opens exciting possibiliti

134 nnaschii NCX) system was used to resolve the backbone dynamics in the inward-facing (IF) and outward-

135 The backbone dynamics of the coagulation serine protease, ap

136 rometry (HDX-MS) was employed to analyze the backbone dynamics profiles in proteins, preferentially a

137 ast (approximately picosecond to nanosecond) backbone dynamics to amide hydrogen exchange rates revea

138 Characteristic differences in the backbone dynamics were identified between apo NCX_Mj-WT

139 mine if it had exceptional global stability, backbone dynamics, or amide hydrogen exchange rates.

140 ine the effects of different formulations on backbone dynamics.

141 formationally selective inhibitors on kinase backbone dynamics.

142 in IRX14L, which also plays a role in xylan backbone elongation, indicate the presence of xylan in p

143 s), is complicated by the interplay of chain backbone entropy and salt-dependent electrostatic repuls

144 The large conformational range of NES backbones explains the lack of a fixed pattern for its 3

145 or three architectures which have more rigid backbones (fewer than five rotatable bonds), intramolecu

146 lower in energy than methods with less or no backbone flexibility do.

147 e completely abolished transport and reduced backbone flexibility of the switch loop, which adopted a

148 cing reveals that a subtle interplay between backbone flexibility, steric factors, and ability to hyd

149 ally infeasible when modeled with less or no backbone flexibility.

150 e analyzed by computing secondary structure, backbone fluctuations, tertiary interactions, and radius

151 of peptidomimetic building blocks containing backbone-fluorinated 1,4-disubstituted 1,2,3-triazole mo

152 d molecular dynamic calculations reveal that backbone fluorination of F-P3EHT leads to an extended ro

153 mic simulations, to elucidate the impacts of backbone fluorination on morphology and excitonic coupli

154 se results expand the scope of heterogeneous-backbone foldamer design to a new tertiary structure cla

155 Here we report heterogeneous-backbone foldamers that mimic the zinc finger domain, a

156 table toxicity profile makes it an excellent backbone for study of new agents.

157 They also provide attractive backbones for advanced materials.

158 In this work, we show that the xyloglucan backbone, formed by (1-->4)-linked beta-d-glucopyranosyl

159 The polypeptide backbone forms transient, sparse hydrogen-bonded turns a

160 FM-115a, and MFM-132a, with different linker backbone functionalization.

161 We defined five clinically relevant backbone groups on the basis of established prognostic f

162 Combined with an optimized miR-E backbone, >90% of high-scoring SplashRNA predictions tri

163 ange (HDX) mass spectrometry (MS) reports on backbone H-bond fluctuations.

164 end these studies here by introducing single-backbone H-bond impairing modifications (alpha)N-methyl

165 46% glycine and an interior filled only with backbone H-bonds between six polyproline 2 (PP2) helices

166 ,5'- and 3',5'-linkages, and overcoming this backbone heterogeneity has long been considered a major

167 Polymeric backbone however interferes in the enrichment and thus a

168 Although backbone hydrogen bonds in transmembrane (TM) helices ha

169 embly at elevated temperatures with eventual backbone hydrolysis have not been reported to date.

170 unprecedented view of the selectivity filter backbone in its collapsed deep C-type inactivated confor

171 a geometrical perturbation of the carotenoid backbone in the triplet state induced by the interchromo

172 e reactivity of thymines reveals that strand backbones in open regions of long-lived lambdaPR-discrim

173 The negatively charged phosphate backbone increases (decreases) the DNA surface coverage

174 ciation MS/MS fragmentation, and the peptide backbone information was provided by collision-induced d

175 ndicate that changes in base composition and backbone insertions influence the translocation rates, w

176 rdinates as a function of our new continuous backbone internal coordinates.

177 hylcyclopentadiene monomer into a conjugated backbone is an attractive strategy to high performance s

178 tigations revealed that the GAC polyrhamnose backbone is assembled on GlcNAc-P-P-Und.

179 into the potential region in which the PEDOT backbone is conductive, thus eliminating the need for co

180 The arabinoxylan backbone is decorated with arabinose side chains that ma

181 ron enriched 2,4-(dimethylamino)diketiminato backbone is described, which allowed for the synthesis a

182 When the backbone is flexible (five or more rotatable bonds separ

183 des with different framework attachments and backbone length/structure agree with measurements when d

184 +) metallosupramolecular cages based on long backboned ligands are an attractive approach to increasi

185 nucleoside repeat units, connected via 3',5'-backbone linkages.

186 ver, an additional nick in the donor plasmid backbone markedly improved the gene-editing efficiency.

187 ture class and show that judiciously applied backbone modification can be accompanied by improvement

188 Oligonucleotides containing these backbone modifications show enhanced uptake, relative to

189 RSV F mutant, or combine both RSV F and PIV5 backbone modifications.

190 which is highly atypical in being a protein backbone-modifying activity, rather than a side-chain-mo

191 , the protein displays distinct asymmetrical backbone motions, unlike its homodimeric counterparts th

192 Backbone N-methylation of alpha-peptides has been widely

193 The conformational heterogeneity of backbone N-substituted peptides limits their ability to

194 units close to the N-terminus of the peptide backbone near the hydrophobic core of cylindrical nanofi

195 to be optimized with a combination of sugar, backbone, nucleobase, and 3'- and 5'-terminal modificati

196 agment originating from the phosphorothioate backbone (O2PS-: m/z 94.936) was formed efficiently upon

197 sly by grafting specific sequences along the backbone of a double-stranded DNA carrier.

198 to reduce the conformational disorder in the backbone of a previously developed high-performance acce

199 rotators have been covalently linked to the backbone of a quinquepyridine (QPY) foldamer at the seco

200 wser's publicly accessible databases are the backbone of a rich, integrated bioinformatics tool suite

201 lenetetraimide-vinylene (NDP-V), featuring a backbone of altenating naphthodiperylenetetraimide and v

202 Local governments form the backbone of climate-related public health preparedness.

203 tegy to embed 2,2'-bipyridine units into the backbone of CPPs.

204 ranscriptase (RT) inhibitors (NRTIs) are the backbone of current antiretroviral treatments.

205 ated that hZalphaADAR1 recognizes the zigzag backbone of d(GAC)7.d(GAC)7 at the B-Z junction and subs

206 While Boolean logic has been the backbone of digital information processing, there exist

207 modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E.

208 incorporation of these derivatives into the backbone of DNA oligonucleotides is described.

209 yridyloxobutylates nucleobases and phosphate backbone of DNA.

210 o improve on existing INSTI options with the backbone of emtricitabine and tenofovir alafenamide, mig

211 stallation of these building blocks into the backbone of Gram-positive and Gram-negative bacterial PG

212 Hydrogen bonds formed between the backbone of His55 and Cys56 and the Cys56-thiol result i

213 ral plasmids encoding diverse RTs within the backbone of HIV-1 strain NL4-3.

214 se involved in extending the alpha1-6-mannan backbone of LM intermediates.

215 Because the backbone of most organic molecules is composed primarily

216 ritical role in the elongation of the mannan backbone of mycobacterial and corynebacterial LM, furthe

217 osted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors.

218 ling of 2,3,5-triiodobenzaldehyde to the PVA backbone of pre-formed beads yields a uniformly distribu

219 ism between the negatively charged phosphate backbone of RNA and the PIL cation framework were the ma

220 Gangliosides consist of a backbone of sphingoid base and a polar oligosaccharide c

221 G3P forms the backbone of TAGs and membrane glycerolipids and it can b

222 eic acid as a function of "depth" toward the backbone of the brush polymer.

223 are not visible, while ZF8 and ZF9 span the backbone of the DNA duplex, conferring no sequence speci

224 for the prefunctionalization of the aromatic backbone of the electrophile prior to cross-coupling.

225 We traced approximately 80% of the backbone of the viral genome, built atomic models for 16

226 , BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invari

227 hat the use of cyclic peptides as structural backbones offers a promising approach for the treatment

228 en proteins mutate or bind to ligands, their backbones often move significantly, especially in loop r

229 The phosphate backbone oxygen is clearly the most common halogen accep

230 ne (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se su

231 opolysaccharide, peptidoglycan and terpenoid backbone pathways.

232 ess, yet some radical triazole and amide DNA backbones perform surprisingly well, indicating that the

233 without aromatic moieties within the polymer backbone, potentially enhancing electronic delocalizatio

234 zole unit into the poly(9,9-dioctylfluorene) backbone promotes exciton dissociation within the poly(N

235 Here we measure intramolecular polypeptide backbone reconfiguration as a way to understand the mole

236 eful attention to the redox potential of the backbone relative to the organic radical species is need

237 PhF2,5 and PhF2,6 assumed more linear backbones relative to PhF2,3, which in turn impacts self

238 (number of side chains/number of norbornene backbone repeats) could be straightforwardly controlled

239 s that incorporate modifications to the PIV5 backbone, replace native RSV F with a prefusion-stabiliz

240 Since the polymer backbone requires less than a 15% functionalization of i

241 beta-1,4-galactan requiring more than three backbone residues for optimized recognition.

242 a major challenge is the polymer's aliphatic backbone, resulting in a low electronic conductivity.

243 iate molecular models of high accuracy (<3 A backbone RMSD) from models of lower accuracy (>4 A backb

244 ne RMSD) from models of lower accuracy (>4 A backbone RMSD).

245 We conclude that involvement of the peptide backbone's carbonyl and amide groups in hydrogen-bond st

246 d of l- and d-amino acids by near-exhaustive backbone sampling followed by sequence design and energy

247 Its rigid connection to the kalata B1 backbone scaffold, together with the well-defined struct

248 luent) provides opportunities to control the backbone sequence and therefore the side chain distribut

249 least five independent insertions of vector backbone sequences.

250 corresponding to blocky, gradient, or random backbone sequences.

251 ional theory (DFT) were used to estimate the backbone shape for each copolymer.

252 a discussion on molecular engineering (e.g., backbone, side chains, and substituents), then the discu

253 strained cyclooctynes containing a sulfamate backbone (SNO-OCTs) were prepared under mild conditions

254 h a pre-existing chiral center at any of the backbone sp(3)-carbons, the reaction remained highly eff

255 otoactivation, the conjugate cleaves the DNA backbone specifically near the mismatch site on a 27-mer

256 rent backbones correlate with differences in backbone structural flexibility.

257 the carbohydrate scaffold has on the peptide backbone structure and the role of the sugar in molecula

258 ect, and at high force, where details of the backbone structure become important.

259 This property, coupled with a backbone structure that is refractory to nuclease digest

260 on, and the resultant alterations in peptide backbone structure, affect a peptide's conformational la

261 materials, involving modulation of nanoscale backbone structures and number and spacing between ligan

262 ive conformation and that the amide-to-ester backbone substitutions at Gly77 and Tyr78 perturb the hy

263 as it is suppressed following amide-to-ester backbone substitutions at Gly77 and Tyr78, even though t

264 opensities of residues with nonproteinogenic backbones, such as those derived from a beta-amino acid,

265 ugh modifications within the oligonucleotide backbone, sugar and heterocycles.

266 The glucosamine disaccharide-as a backbone surrogate of the bacterial lipid A region-was s

267 rallel bundles of microtubules as structural backbones, surrounded by regularly spaced actin rings te

268 e essential Med14 subunit works as a central backbone that connects the Mediator head, middle and tai

269 N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory.

270 e molecular properties of the phosphodiester backbone that made it the evolutionary choice for the en

271 e moiety is embedded into the chromophore pi-backbone the highest intramolecular charge transfer (ICT

272 nd the regiochemistry of their tetrapeptidic backbones, the anticancer activities of these precursors

273 yrazolo-1,3,5-triazinanes have nearly planar backbones, thereby enhancing the density and thermal sta

274 single-atom, O-to-S modification of peptide backbone thioamidation has the potential to selectively

275 quire direct modification of the fluorophore backbone through complex synthetic considerations to ena

276 nce of charge transport control in a protein backbone through external mutagenesis and a unique nanos

277 survey on 54 analog structures with similar backbone to 2-APB showed that delicate balance between e

278 gradable polymer, which was used as a common backbone to control for the degree of polymerization.

279 ta-sheet assembly, reinforced with a polymer backbone to improve strain stability.

280 r subunits were introduced in the conjugated backbone to modulate the band gap.

281 The prominent role of backbone to side chain electronic interactions (n --> pi

282 he electronic coupling of the oligophenylene backbone to the Au electrodes, consistent with experimen

283 d 12% (2/17) when using the homology-modeled backbones to generate the complexes.

284 rus centered radical (stabilized by the peri-backbone) to the P-P coupled product and a free propyl r

285 nly spaced glycosyl decorations on the xylan backbone, together with minor motifs with consecutive gl

286 3,7-NBA positions strongly modulates polymer backbone torsion and, therefore, intramolecular pi-conju

287 the unprecedented influence of the bicyclic backbone unsaturation for the preparation of the corresp

288 in protein design, namely, how to introduce backbone variability in a controlled manner.

289 charge carrier mobility for the more linear backbones was achieved when using NG substrates.

290 NA folding and structures with heterogeneous backbones, we recently reported two crystal structures o

291 ree ruthenium compounds with 2,2'-bipyrazine backbones were found to oxidize chloride ions in acetone

292 er-order (secondary) conformations of the SP backbone, which may induce functionality that is compara

293 phery of anthracene leads to buckling of the backbone while also dramatically lowering the LUMO energ

294 gion, the chiral peropyrene adopts a twisted backbone with an end-to-end twist angle of 28 degrees th

295 long) containing an alpha1-6-linked mannose backbone with greatly reduced alpha1-2-mannose side chai

296 Each P-MLV has an E-MLV backbone with P- or X-ERV replacements that together cov

297 his supports the crucial role of the polymer backbone with respect to hydration changes in the amide

298 A variety of oligomeric backbones with compositions deviating from biomacromolec

299 strate the immediate need for new antibiotic backbones with novel mechanisms of action.

300 s, sheets) have been produced from unnatural backbones, yet examples of tertiary folds combining seve