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1 involves activation of TLR9-ERK signaling by bacterial DNA.
2 y unrecognized potential for the exchange of bacterial DNA.
3 CpG motifs are present at high frequency in bacterial DNA.
4 ge regions, accounting for 2.7% of the total bacterial DNA.
5 (PFGE) of NotI restriction enzyme digests of bacterial DNA.
6 s-specific differences in the recognition of bacterial DNA.
7 through cGAS-STING-dependent recognition of bacterial DNA.
8 ytokine production in response to ISS-ODN or bacterial DNA.
9 bacterial and fungal cell walls, as well as bacterial DNA.
10 amples did not contain significant levels of bacterial DNA.
11 r label-free and ultrasensitive detection of bacterial DNA.
12 8 log10 gene copies (GC)/g, respectively, in bacterial DNA; 5.5 and 4.4 log10 GC/g, respectively, in
16 etermine whether exposure of immune cells to bacterial DNA affects DNA binding and internalization.
17 is required for transient expression of the bacterial DNA, an early step in the transformation proce
18 nicircle' DNA, a vector type that is free of bacterial DNA and capable of high expression in cells, f
19 binding to two distant operator sites on the bacterial DNA and causing the intervening DNA to form a
20 ating the mechanisms of immunostimulation by bacterial DNA and CpG ODN as well as a strategy for prev
21 easingly clear that eukaryotes have acquired bacterial DNA and function through horizontal gene trans
22 o demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that h
26 erein, we demonstrate that administration of bacterial DNA and ISS-ODN to mice lacking the catalytic
28 olled, synergistic induction of TNF-alpha by bacterial DNA and LPS is not mediated at the transcripti
31 ethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and
33 to spacer acquisition from both foreign and bacterial DNA and results in multiple spacers incapable
34 )17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria an
35 a significant correlation between levels of bacterial DNA and serum tumor necrosis factor-alpha (P =
36 cytosolic surveillance pathway, which senses bacterial DNA and signals through STING, TBK1, IRF3 and
38 these, TLR9, is activated intracellularly by bacterial DNA and synthetic oligodeoxynucleotides (ODN),
41 idate the mechanisms of immunostimulation by bacterial DNA and synthetic oligonucleotides, the effect
43 Although the pathways involved in sensing bacterial DNA and viral RNA are now well established, on
44 also resulted in the presence of contaminant bacterial DNA and yielded fewer reads from the known pat
45 ivated by un-methylated CpG motifs, found in bacterial DNA, and beta-glucans, found in the cell wall
46 olysaccharides, lipoproteins, flagellin, and bacterial DNA, and signaling through TLRs leads to the p
47 TNF-alpha message has a longer half-life in bacterial DNA- and LPS-treated macrophages than that in
62 se studies thus identified a novel family of bacterial DNA-binding proteins, developed a model of Spo
63 hii Ptr2, a member of the Lrp/AsnC family of bacterial DNA-binding proteins, is an activator of its e
64 idylate kinase (TMK), an essential enzyme in bacterial DNA biosynthesis, is an attractive therapeutic
65 f 10(4) CFU/ml was correlated with increased bacterial DNA burden (P < 0.01), decreased community div
66 ture-independent indices of infection (total bacterial DNA burden and low bacterial community diversi
68 was ineffective with genomic double stranded bacterial DNA, but it allowed down to 16 amole detection
69 lex amplification and detection of viral and bacterial DNA by a flow-based chemiluminescence microarr
70 ype phages can randomly package and transfer bacterial DNA by a process called generalized transducti
75 CpG motifs and their associated sequences in bacterial DNA causes an immunotoxic response following t
86 Many studies have reported the presence of bacterial DNA contamination in commercial Taq DNA polyme
87 mmon to all four methods, and revealed trace bacterial DNA contamination in TFF-concentrated metageno
89 imulatory unmethylated CpG motifs present in bacterial DNA (CpG DNA) induce expression of cyclooxygen
96 s pathway is a disease-enhancing response to bacterial DNA damage inflicted by the host immune system
101 f the beta, beta', and sigma(70) subunits of bacterial DNA-dependent RNA polymerases (DdRp), combined
102 ssive oligodeoxynucleotides; 3) simulated by bacterial DNA derived from HKBA; and 4) abrogated by DNa
104 g of bacterial 16S rRNA genes to investigate bacterial DNA diversity in milk samples of mastitic and
105 s end joining (NHEJ) is a recently described bacterial DNA double-strand break (DSB) repair pathway t
106 pathway and PriA, suggesting a mechanism of bacterial DNA DSB repair involving the establishment of
110 A ligase D (PaeLigD) exemplifies a family of bacterial DNA end-joining proteins that consist of a lig
111 e-inducible GAL1 promoter joined to PvuII, a bacterial DNA endonuclease gene, are toxic to yeast cell
113 secretion samples were used for analysis of bacterial DNA for Porphyromonas gingivalis (Pg), Prevote
115 teins play a major role in the protection of bacterial DNA from damage by reactive oxygen species.
116 lunteers with liver cirrhosis, 50% contained bacterial DNA from Enterobactericaea, Clostridium leptum
117 n with specific primers and probes to detect bacterial DNA from several oral species and Chlamydia pn
121 ion of WDM for rapid, automated detection of bacterial DNA from whole blood may have an enormous impa
123 ome is facilitated by the directed motion of bacterial DNA generated during chromosome replication, i
124 tomyces sahachiroi AlkZ (previously Orf1), a bacterial DNA glycosylase that protects its host by exci
128 g (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged
131 g the GyrB/ParE ATP-binding sites located on bacterial DNA gyrase and topoisomerase IV and not utiliz
136 es are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the en
139 arin natural product antibiotics that target bacterial DNA gyrase is assembled from tyrosine by nonri
140 A recent study has analysed the action of bacterial DNA gyrase on a single substrate DNA molecule,
141 Albicidin is a nanomolar inhibitor of the bacterial DNA gyrase with a strong activity against vari
142 antibacterial agents that act by inhibiting bacterial DNA gyrase, a target of clinical significance.
146 intracellular bacteria, cytosolic sensing of bacterial DNA has also been implicated in eliciting immu
149 motifs (CpG ODN), which mimic the effects of bacterial DNA, have been shown to enhance type-1 cytokin
152 estimates the relative amounts of fungal and bacterial DNA in a sample in comparison to the endogenou
154 osomal DNA was used to measure the levels of bacterial DNA in blood samples drawn through the CVC in
155 been demonstrated by the presence of similar bacterial DNA in both prostatic secretion and subgingiva
157 6S rDNA PCR analysis reveals the presence of bacterial DNA in incubated blood samples but also in neg
159 recent reports suggest that the presence of bacterial DNA in peritoneal fluid in patients with cirrh
160 on analysis of the reassociation kinetics of bacterial DNA in soil, Gans et al. claimed that millions
162 e provide evidence, for the first time, that bacterial DNA in the context of heat-killed Brucella abo
165 The median value for the total amount of bacterial DNA in thrombi was 16 times higher than that f
169 glycan and double-stranded RNA, but not with bacterial DNA, indicating that Rip2 is downstream of TLR
170 ne-deoxyguanosine dinucleotides, which mimic bacterial DNA, induced hemophagocytosis only in IFN-gamm
171 pG oligodeoxynucleotides (ODNs), which mimic bacterial DNA, inhibit allergic airways disease and prom
173 The Cancer Genome Atlas (TCGA), we examined bacterial DNA integration into the human somatic genome.
174 foundation for future experiments to test if bacterial DNA integrations alter the transcription of th
175 will lead to the more frequent detection of bacterial DNA integrations in tumors that are in close p
177 ible for the generation and transport of the bacterial DNA into the host cell has resulted in the est
179 patient by a newly developed method in which bacterial DNA is amplified directly from sputum Gram-sta
184 rep Spin miniprep kit [Qiagen] and the urine bacterial DNA isolation kit [Norgen]) for the direct DNA
185 is to identify the structural components of bacterial DNA ligase that interact with NAD(+) and then
186 irement, and widespread existence in nature, bacterial DNA ligases appear to be valuable targets for
191 on 5 of a pyrimidine nucleotide, such as the bacterial DNA m(5)C methyltransferases, utilize their si
193 Mitochondrial DNA that shows similarities to bacterial DNA may be released after tissue damage and ac
194 -function mutations or transient exposure to bacterial DNA may drive persistent inflammatory mononucl
195 ch in guanine nucleotides and the integrated bacterial DNA may have complex transcript secondary stru
197 ing antibiotic stress and suggests targeting bacterial DNA methylation as a viable approach to enhanc
198 e present a binning method that incorporates bacterial DNA methylation signatures, which are detected
199 man DNA methyltransferase 1 (hDNMT1) and the bacterial DNA methyltransferase (M.EcoRII) and that it i
201 Th1 phenotype, raising the possibility that bacterial DNA might play a role in the generation of pat
203 nd examined for epithelial morphology, SIgA, bacterial DNA, nuclear factor-kappaB activation, neutrop
205 ease, bacterial lysate, intact bacteria, and bacterial DNA on proliferation and cytokine production b
209 by unmethylated CpG-containing sequences in bacterial DNA or synthetic oligonucleotides (ODNs) in th
210 23, PMAP-36, and protegrin-1 to complex with bacterial DNA or synthetic RNA molecules and facilitate
212 romote NET formation, as did preparations of bacterial DNA, outer membrane proteins, and lipooligosac
213 expectation, animals receiving alum-GTF plus bacterial DNA (P. gingivalis in particular) demonstrated
214 mass spectrometry and normalized for mass of bacterial DNA per sample to exclude confounding by varyi
217 capacity to inhibit the replication-specific bacterial DNA polymerase IIIC (pol IIIC) and the growth
219 ts of these reactions with several phage and bacterial DNA polymerases capable of strand-displacement
220 tes, consistent with replication by accurate bacterial DNA polymerases in the integrated prophage sta
221 archaeal FEN1 or the 5'-nuclease domains of bacterial DNA polymerases is a double-flap structure con
224 o interact with and facilitate import of the bacterial DNA-protein transport (T) complexes into the p
225 hese pathways represent the main function of bacterial DNA recombination systems, as well as the main
230 plasmid-borne RepA binding sites to inhibit bacterial DNA replication and delay host cell division w
231 on is also evident during the termination of bacterial DNA replication and during the induction of th
233 ilis, in contrast to the prevailing model of bacterial DNA replication based on Escherichia coli DnaA
236 rio extends our fundamental understanding of bacterial DNA replication initiation, and because of the
237 lethal infection in mice, demonstrating that bacterial DNA replication is inhibited during host-patho
241 We propose that DnaA serves to coordinate bacterial DNA replication with the onset of chromosome s
242 to those in eukaryal DNA replication than in bacterial DNA replication, but have some archaeal-specif
246 endosomes, TLR9 is activated by unmethylated bacterial DNA, resulting in proinflammatory cytokine sec
248 this study is to determine the expression of bacterial DNA sensors, including Toll-like receptor 9 (T
251 s from myeloperoxidase, serum amyloid A, and bacterial DNA, shifting the balance of pro- and anti-sur
259 nsive to CpG ODN but are fully responsive to bacterial DNA, thus implying that microbial recognition
261 bined this approach with quantitative PCR of bacterial DNA to normalize the amount of gene expression
265 DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex D
267 robiology, the most commonly used methods of bacterial DNA transfer are conjugation and electroporati
268 ng the viral DNA-packaging motor, beside the bacterial DNA translocases, that uses a revolving mechan
272 lli identified by Gram staining, we isolated bacterial DNA using spin columns (BC-C) and rapid water
273 etic readout of rolling circle products from bacterial DNA utilizing the dynamic properties of MNBs i
275 ve qPCR detection of the extracted S. aureus bacterial DNA was achieved with a detection limit of 5+/
276 Among the 46 samples associated with PTB, bacterial DNA was amplified from all (16/16) of the cult
289 cimens with no culture growth, the amount of bacterial DNA was greater than that in reagent and rinse
297 ment may be systematically contaminated with bacterial DNA, which appears to be sampled by metagenome
298 s were positive for spiroplasma or any other bacterial DNA, while control Spiroplasma mirum genomic D
299 larensis revealed striking colocalization of bacterial DNA with endogenous AIM2 and inflammasome adap
300 how that neighboring transgenic elements and bacterial DNA within the transgene cause profound silenc
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