ライフサイエンスコーパス: bacterial RNA

1 ey has adapted to a role in the digestion of bacterial RNA.

2 creased demands for the enzyme for digesting bacterial RNA.

3 ll RNAs in the cell and is relatively stable bacterial RNA.

4 RNAs are homologous (of common ancestry) to bacterial RNA.

5 ently, PKR has been found to be activated by bacterial RNA.

6 (FnCas9) is capable of targeting endogenous bacterial RNA.

7 ated by cytosolic poly I:C, reoviral RNA, or bacterial RNA.

8 -1beta induction and caspase-1 activation by bacterial RNA.

9 able on mechanisms underlying recognition of bacterial RNA.

10 l features in this RNA, which are typical of bacterial RNAs, activate PKR in TRAP-free and TRAP/l-Trp

11 onsistent with highly base-paired regions in bacterial RNA activating PKR.

12 Here we describe two reproducible methods of bacterial RNA amplification that will allow previously i

13 ways involved in innate immune activation by bacterial RNA and analyze the physiological relevance of

14 dying small molecules that can interact with bacterial RNA and interrupt cellular activities is a pro

15 une responses, the stimulatory properties of bacterial RNA and its role during infections have just b

16 We report that IFN-gamma suppressed bacterial RNA and LPS induced IL-1beta transcription in

17 iRNA) array analysis revealed an increase in bacterial RNA and multiple host miRNAs (miR-145, miR-146

18 h rifampin or chloramphenicol, inhibitors of bacterial RNA and protein synthesis, respectively, showe

19 IL-1beta and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 an

20 I cleaves double-stranded (ds) structures in bacterial RNAs and participates in diverse RNA maturatio

21 gh cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammaso

22 RNase P RNAs of eukaryotes, in contrast to bacterial RNAs, are not catalytically active in vitro wi

23 tion factor Rho associates with most nascent bacterial RNAs as they emerge from RNA polymerase.

24 Hfq is a bacterial RNA binding protein that facilitates small RNA

25 storage regulator A) is a widely distributed bacterial RNA binding protein that regulates translation

26 Hfq, a bacterial RNA-binding protein, was recently shown to con

27 The functions of many bacterial RNA-binding proteins remain obscure because of

28 Bacterial RNA (bRNA) can induce cytokine production in m

29 hat contain all of the catalytic core of the bacterial RNA but lack phylogenetically variable, stabil

30 RNA contains a core structure similar to the bacterial RNA but lacks specific features that in bacter

31 The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landm

32 sults propose a wide repertoire of potential bacterial RNA capping molecules, and provide mechanistic

33 Hfq is a bacterial RNA chaperone involved in the posttranscriptio

34 f the proteins from different organisms, the bacterial RNA component, and a bacterial RNase P holoenz

35 rial RNA but lacks specific features that in bacterial RNAs contribute to catalysis and global stabil

36 Hfq also plays a key role in bacterial RNA decay by binding tightly to polyadenylate

37 results, together with recent insights into bacterial RNA decay, suggest a unifying model for the bi

38 Bacterial RNA degradation often begins with conversion o

39 Bacterial RNA degradation often begins with conversion o

40 Nase that digests the high concentrations of bacterial RNA derived from symbiotic microflora.

41 Bacterial RNA-directed Cas9 endonuclease is a versatile

42 d little effect on invasion, indicating that bacterial RNA, DNA, and de novo protein synthesis are no

43 A method was developed to detect 5' ends of bacterial RNAs expressed at low levels and to differenti

44 and blood was extracted at 8 hours to purify bacterial RNA for RNA-Seq with an Illumina platform.

45 The ability to identify and isolate bacterial RNA from animals or humans with infections has

46 In this study, we report that bacterial RNA from both Gram-positive and Gram-negative

47 a protocol for isolation of microarray-grade bacterial RNA from Escherichia coli K1 interacting with

48 tome, and examine the pitfalls in extracting bacterial RNA from the infected host compartment.

49 Bacterial RNA from the loops was retrieved at different

50 eloped a technique for specific isolation of bacterial RNA from within infected murine macrophages, a

51 dvent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and p

52 d genome-engineering approaches based on the bacterial RNA-guided nuclease Cas9.

53 unambiguously identify TLR8 as receptor for bacterial RNA in primary human monocyte-derived macropha

54 l-length protein in Escherichia coli package bacterial RNAs in amounts equivalent to the viral pregen

55 ically sequences all RNA, including host and bacterial RNA, in stool specimens.

56 racellular nucleic acid receptor involved in bacterial RNA-induced inflammasome activation and releas

57 Bacterial RNA is a strong inducer of type I IFN and NF-k

58 Bacterial RNA is an important trigger of inflammasome ac

59 ions are to be studied where the recovery of bacterial RNA is limited.

60 The amplification of bacterial RNA is required if complex host-pathogen inter

61 Bacterial RNA is the main driver of L lactis G121-mediat

62 RNA to generate the probes, especially when bacterial RNA is used for hybridization (50 microg of ba

63 the eucaryal RNase P RNA, in contrast to the bacterial RNA, is catalytically inactive in the absence

64 In fact, none of the bacterial RNA isolation methods, including the commercia

65 l role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and prov

66 has been considered an important feature of bacterial RNA metabolism.

67 direct entry by RNase E has a major role in bacterial RNA metabolism.

68 se) plays synthetic and degradative roles in bacterial RNA metabolism; it is also suggested to partic

69 The bacterial RNA polymeras holoenzyme consists of a catalyt

70 mechanistic function similarity between the bacterial RNA polymerase (RNAP) "switch region" and the

71 ntibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center 'i' and 'i

72 a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacteri

73 ocrosslinking to define interactions between bacterial RNA polymerase (RNAP) and promoter DNA in the

74 x was tracked by mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or te

75 Myxopyronin inhibits bacterial RNA polymerase (RNAP) by an unknown mechanism.

76 Rifamycin antibacterial agents inhibit bacterial RNA polymerase (RNAP) by binding to a site adj

77 proach was used to investigate inhibition of bacterial RNA polymerase (RNAP) by sorangicin (Sor), a m

78 ads to rapid and selective inhibition of the bacterial RNA polymerase (RNAP) by the 7 kDa T7 protein

79 anism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid ant

80 e resonance energy transfer, we have defined bacterial RNA polymerase (RNAP) clamp conformation at ea

81 The sigma subunit of bacterial RNA polymerase (RNAP) confers on the enzyme th

82 Bacterial RNA polymerase (RNAP) containing the major var

83 e transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associa

84 to complete its infection in the absence of bacterial RNA polymerase (RNAP) enzyme activity.

85 The multisubunit bacterial RNA polymerase (RNAp) enzyme, which catalyses

86 nt of data on initiation of transcription by bacterial RNA polymerase (RNAP) has been obtained.

87 majority of biochemical characterizations of bacterial RNA polymerase (RNAP) have been focused; the p

88 The bacterial RNA polymerase (RNAP) holoenzyme consists of a

89 The bacterial RNA polymerase (RNAP) holoenzyme consists of a

90 The bacterial RNA polymerase (RNAP) holoenzyme containing si

91 The bacterial RNA polymerase (RNAP) is a multi-subunit, stru

92 Bacterial RNA polymerase (RNAP) is a validated target fo

93 The bacterial RNA polymerase (RNAP) is a validated target fo

94 uring transcription of protein-coding genes, bacterial RNA polymerase (RNAP) is closely followed by a

95 The sigma subunit of bacterial RNA polymerase (RNAP) is required for promoter

96 The sigma-subunit of bacterial RNA polymerase (RNAP) is required for promoter

97 Bacterial RNA polymerase (RNAP) is the central enzyme of

98 We report that bacterial RNA polymerase (RNAP) is the functional cellul

99 Transcript elongation by bacterial RNA polymerase (RNAP) is thought to be regulat

100 Bacterial RNA polymerase (RNAP) makes extensive contacts

101 Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences codi

102 The bacterial RNA polymerase (RNAP) recognizes promoters thr

103 The sigma subunit of bacterial RNA polymerase (RNAP) regulates gene expressio

104 Sequence-selective transcription by bacterial RNA polymerase (RNAP) requires sigma factor th

105 Bacterial RNA polymerase (RNAP) requires sigma factors t

106 Bacterial RNA polymerase (RNAP) responds to formation of

107 er specificity factor is distinct from other bacterial RNA polymerase (RNAP) sigma factors in that it

108 To explore the domain-scale flexibility of bacterial RNA polymerase (RNAP) throughout its functiona

109 well known that ppGpp and DksA interact with bacterial RNA polymerase (RNAP) to alter promoter activi

110 actors, the key regulatory components of the bacterial RNA polymerase (RNAP), direct promoter DNA bin

111 complex containing the major variant form of bacterial RNA polymerase (RNAP), Esigma(54), requires en

112 In bacterial RNA polymerase (RNAP), the bridge helix and sw

113 'switch region' - has been identified within bacterial RNA polymerase (RNAP), the enzyme that mediate

114 The bacterial RNA polymerase (RNAP), which catalyzes transcr

115 stant homologs of beta and beta' subunits of bacterial RNA polymerase (RNAP).

116 pyrone antibiotic myxopyronin (Myx) inhibits bacterial RNA polymerase (RNAP).

117 factor GreA induces nucleolytic activity of bacterial RNA polymerase (RNAP).

118 the clinically important antibiotics, target bacterial RNA polymerase (RNAP).

119 rocin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP).

120 rocin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP).

121 therapy, stemming from its inhibition of the bacterial RNA polymerase (RNAP).

122 nds has been attributed to the inhibition of bacterial RNA polymerase activities, although the exact

123 domain that resembles the alphaCTD domain of bacterial RNA polymerase alpha; and this domain preferen

124 Bacterial RNA polymerase and a "sigma" transcription fac

125 Bacterial RNA polymerase and eukaryotic RNA polymerase I

126 e framework of a structure-function model of bacterial RNA polymerase and viral biology.

127 Intrinsic terminators of bacterial RNA polymerase are small (< approximately 30 b

128 Bacterial RNA polymerase arrested at the human site is r

129 act upon the sigma54-containing form of the bacterial RNA polymerase belong to the extensive AAA+ su

130 Bacterial RNA polymerase binds promoters in the form of

131 escribe a structural basis for inhibition of bacterial RNA polymerase by the antibiotic streptolydigi

132 gs highlight how nonconserved regions of the bacterial RNA polymerase can be targets of regulatory fa

133 nt termination of the S box leader region by bacterial RNA polymerase depends on SAM but not on methi

134 We found that in such complexes bacterial RNA polymerase exhibit an intrinsic endonucleo

135 rogen regulatory protein C (NtrC) contacts a bacterial RNA polymerase from distant enhancers by means

136 istance occur in an 81-bp core region of the bacterial RNA polymerase gene, rpoB.

137 o define the three-dimensional structures of bacterial RNA polymerase holoenzyme and the bacterial RN

138 dvance was the high-resolution structures of bacterial RNA polymerase holoenzyme and the holoenzyme i

139 ptional activators that act upon the sigma54 bacterial RNA polymerase holoenzyme belong to the extens

140 The bacterial RNA polymerase holoenzyme consists of a cataly

141 The structures of the bacterial RNA polymerase holoenzyme have provided detail

142 iously reported for the sigma subunit in the bacterial RNA polymerase holoenzyme, consisting of a ser

143 the successive steps of promoter opening by bacterial RNA polymerase holoenzyme.

144 Bacterial RNA polymerase holoenzymes containing the sigm

145 nts on diverse DNA probes were used with two bacterial RNA polymerase holoenzymes that differ in how

146 as become clear that promoter recognition by bacterial RNA polymerase involves interactions not only

147 Bacterial RNA polymerase is a common target for many ant

148 Bacterial RNA polymerase is able to initiate transcripti

149 The dissociable sigma subunit of bacterial RNA polymerase is required for the promoter-sp

150 The sigma subunit of bacterial RNA polymerase is strictly required for promot

151 his study finds that individual molecules of bacterial RNA polymerase move in single base-pair steps

152 The sigma subunits of bacterial RNA polymerase occur in many variant forms and

153 ed the positions of the binding sites within bacterial RNA polymerase of the small-molecule inhibitor

154 The sigma-to-core protein interaction in bacterial RNA polymerase offers a potentially specific t

155 standing of the mechanistic underpinnings of bacterial RNA polymerase regulation.

156 ubtilis, a member of the sigma(70)-family of bacterial RNA polymerase sigma factors, is negatively re

157 The bacterial RNA polymerase sigma subunits are key particip

158 etween termination mechanisms of Pol III and bacterial RNA polymerase suggests that hairpin-dependent

159 entified a few "hot spots" on the surface of bacterial RNA polymerase that mediate its interactions w

160 (sigma(32) in Escherichia coli) directs the bacterial RNA polymerase to promoters of a specific sequ

161 Sigma 54 is a required factor for bacterial RNA polymerase to respond to enhancers and dir

162 Rifampicin, which inhibits bacterial RNA polymerase, provides one of the most effec

163 by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region

164 The clamp closure in bacterial RNA polymerase, the ratcheting of 30S and 50S

165 In bacterial RNA polymerase, this motif, the zinc binding d

166 bacterial RNA polymerase holoenzyme and the bacterial RNA polymerase-promoter open complex in soluti

167 phage-encoded activator protein Mor and the bacterial RNA polymerase.

168 uced by Streptomyces lydicus, which inhibits bacterial RNA polymerase.

169 protoknot antibacterial peptide that targets bacterial RNA polymerase.

170 Peptide microcin J25 (MccJ25) inhibits bacterial RNA polymerase.

171 l domains of the alpha and sigma subunits of bacterial RNA polymerase.

172 the phage-encoded activator protein Mor and bacterial RNA polymerase.

173 cent determination of the X-ray structure of bacterial RNA polymerase.

174 s in the structurally unrelated multisubunit bacterial RNA polymerase.

175 It inhibits transcription by bacterial RNA polymerase.

176 This technique was used to study the bacterial RNA polymerase/lacUV5 DNA open promoter comple

177 Most bacterial RNA polymerases (RNAP) contain five conserved

178 Bacterial RNA polymerases (RNAPs) are targets for antibi

179 trinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-

180 Transcription initiation complexes formed by bacterial RNA polymerases (RNAPs) exhibit dramatic speci

181 eptolydigin class of antibiotics that target bacterial RNA polymerases (RNAPs).

182 treptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs).

183 pe can be rate-limiting for transcription by bacterial RNA polymerases and RNA polymerase II of highe

184 Sigma subunits of bacterial RNA polymerases are closely involved in many s

185 direct DNA interaction (as sigma subunits of bacterial RNA polymerases do) or indirectly by their act

186 Here we have transcribed with phage and bacterial RNA polymerases, a human DNA sequence previous

187 scription, because unlike the eucaryotic and bacterial RNA polymerases, it is a single subunit enzyme

188 criptional initiation by pol II, pol III and bacterial RNA polymerases: a preformed single-stranded D

189 Screening for bacterial RNAs produced in response to host interactions

190 A and analyze the physiological relevance of bacterial RNA recognition during infections.

191 The significance of bacterial RNA recognition for initiating innate immune r

192 iew the mechanisms and functions of selected bacterial RNA regulators and discuss their importance in

193 argetRNA, that predicts the targets of these bacterial RNA regulators.

194 e, but whether this is a general property of bacterial RNA remains unclear as are the pathways involv

195 Here we report a new bacterial RNA repair complex that performs RNA repair li

196 ase (CthPnk), the 5'-end-healing module of a bacterial RNA repair system, catalyzes reversible phosph

197 ase (CthPnk), the 5' end-healing module of a bacterial RNA repair system, catalyzes reversible phosph

198 ifferent between the eukaryotic RNAi and the bacterial RNA repair.

199 ocess of analyzing RNA-seq data sets, making bacterial RNA-seq analysis a routine process that can be

200 SPARTA is a reference-based bacterial RNA-seq analysis workflow application for sing

201 es based on VLMC were applied to compare the bacterial RNA-Seq and metatranscriptomic datasets.

202 To make bacterial RNA-seq data analysis more accessible, we deve

203 d Rockhopper that supports various stages of bacterial RNA-seq data analysis, including aligning sequ

204 ructures and transcriptomes, for analysis of bacterial RNA-seq data and de novo transcriptome assembl

205 used for efficient and accurate analysis of bacterial RNA-seq data, and that it can aid with elucida

206 nd offers accurate and efficient analysis of bacterial RNA-seq data.

207 SPARTA provides an easy-to-use bacterial RNA-seq transcriptional profiling workflow to

208 Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis (SPARTA).

209 Many tools exist in the analysis of bacterial RNA sequencing (RNA-seq) transcriptional profi

210 However, the role of single bacterial RNA species in immune activation has not been

211 Small, non-coding bacterial RNAs (sRNAs) have been shown to regulate a ple

212 Small non-coding bacterial RNAs (sRNAs) play important regulatory roles i

213 A major class of small bacterial RNAs (sRNAs) regulate translation and mRNA sta

214 In summary, we present a dynamic bacterial RNA structurome and find that the expression o

215 also inhibited transcription/translation of bacterial RNA, suggesting a mechanism for its antibiotic

216 the binding site for compounds that inhibit bacterial RNA synthesis and kill bacteria.

217 polymerase (RNAP), the enzyme that mediates bacterial RNA synthesis.

218 However, the features of bacterial RNA that activate PKR are unknown.

219 ligo-dT primers after polyadenylation of the bacterial RNA, the second using a set of mycobacterial a

220 Moreover, the contribution of bacterial RNA to the induction of innate immune response

221 nstrates that PKR can signal the presence of bacterial RNAs under physiological ionic conditions and

222 eukaryotes and even more distant from known bacterial RNA viruses.

223 Moreover, TLR8-dependent detection of bacterial RNA was critical for triggering monocyte activ

224 l as the priming for caspase-1 activation by bacterial RNA was dependent on UNC93B, an endoplasmic re

225 In addition, bacterial RNA was stained in liver sections using 16sRNA

226 osslinking results and crystal structures of bacterial RNAs, we develop a tertiary structure model of

227 ation and IL-1beta production by transfected bacterial RNA were absent in MyD88-deficient cells but i

228 Thus, TLR13 detects bacterial RNA with exquisite sequence specificity.DOI:ht

229 udy, we show that human monocytes respond to bacterial RNA with secretion of IL-6, TNF, and IFN-beta,

230 Bacterial RNA within streptococci was also a dominant st

231 One physiological change a bacterial RNA would face in a human cell is a decrease i