ライフサイエンスコーパス: bacterial toxin

1 the cytotoxic effects of a unique bipartite bacterial toxin.

2 ms that regulate GCC activity in response to bacterial toxin.

3 ne for the GBS haemolysin/cytolysin, a novel bacterial toxin.

4 kely to contribute to cytotoxicity from this bacterial toxin.

5 thogenic human virus can be neutralized by a bacterial toxin.

6 on, cell-surface proteolytic activity, for a bacterial toxin.

7 tion that is reduced in cells exposed to the bacterial toxin.

8 dded by other enzymes, including sirtuins or bacterial toxins.

9 ne-targeting domains found in multiple large bacterial toxins.

10 nd its application to the detection of these bacterial toxins.

11 tidrug tolerance, and are highly enriched in bacterial toxins.

12 stor for several receptor-binding domains of bacterial toxins.

13 prerequisite for the toxicity of a number of bacterial toxins.

14 he RTX (repeats in toxin) family of secreted bacterial toxins.

15 n to be required for endosome escape by many bacterial toxins.

16 y be a generalized response to lumen-derived bacterial toxins.

17 is a novel pore-forming lectin homologous to bacterial toxins.

18 , microRNA processing, and susceptibility to bacterial toxins.

19 rious endo- and exogenous factors, including bacterial toxins.

20 host and exposes the tissue cells to various bacterial toxins.

21 of the photoregulated gene by phytochrome or bacterial toxins.

22 us to the homologous pore-forming domains of bacterial toxins.

23 cytolethal distending toxin (CDT) family of bacterial toxins.

24 on by DD RT-PCR of cellular genes induced by bacterial toxins.

25 ylation of proteins catalyzed by a number of bacterial toxins.

26 r of the thiol-activated cytolysin family of bacterial toxins.

27 l as ITs prepared with a variety of plant or bacterial toxins.

28 antially different from those of other known bacterial toxins.

29 post-translational modification catalyzed by bacterial toxins.

30 he structures of the pore-forming domains of bacterial toxins.

31 forms an active inflammasome in response to bacterial toxins.

32 from other well-recognized ADP-ribosylating bacterial toxins.

33 l products including several antibiotics and bacterial toxins.

34 Kretschmann-configured plasmonic sensing of bacterial toxins.

35 satile platform to measure the activities of bacterial toxins.

36 l G proteins by perturbations using siRNA or bacterial toxins.

37 tin cytoskeleton is an attractive target for bacterial toxins.

38 pathogenic Escherichia coli 536 (EC536) is a bacterial toxin 28 (Ntox28) domain that only exhibits ri

39 . difficile infection (CDI) is mediated by 2 bacterial toxins, A and B; neutralizing these toxins wit

40 Many bacterial toxins act on conserved components of essentia

41 Many plant and bacterial toxins act upon cytosolic targets and must the

42 Advances in our understanding of bacterial toxin action parallel the development of bioph

43 sease processes including cancer metastasis, bacterial toxin activation (e.g. anthrax and Pseudomonas

44 tes that enzymatic cross talk exists between bacterial toxin ADP-ribosyltransferases and host ADP-rib

45 d complement or with the GPI-anchor-reactive bacterial toxin aerolysin enriched for the GPI-anchor- p

46 ontained consensus regions common to several bacterial toxin and mammalian transferases and NAD glyco

47 red into cells via the transport domain of a bacterial toxin and may be used to induce apoptosis.

48 This mechanism of action is novel for a bacterial toxin and provides a model for the generation

49 shown here to be a cellular substrate for a bacterial toxin and represents the identification of a m

50 and cellular effects of the ADP-ribosylating bacterial toxin and reveal that mutants defective in bin

51 tic extract obtained from pineapple stems on bacterial toxin and second-messenger agonist-induced int

52 ces similar to those found in several of the bacterial toxin and vertebrate ADP-ribosyltransferases.

53 domains were first described in subunits of bacterial toxins and are also commonly found in polysacc

54 asis for the differential pathogenicities of bacterial toxins and are relevant to the design of vacci

55 gangliosides mimic cells that are invaded by bacterial toxins and can be used as sensitive probes for

56 Various plant and bacterial toxins and certain viruses hijack this disloca

57 t AB103 will limit inflammatory responses to bacterial toxins and decrease the incidence of organ fai

58 Bacterial toxins and effector proteins hijack eukaryotic

59 del for identification of in vivo targets of bacterial toxins and evaluation of novel candidate thera

60 r small molecules that reduce the actions of bacterial toxins and has been shown to block the retrogr

61 he RTX (repeats in toxin) family of secreted bacterial toxins and is known to target human leukocytes

62 ave uncovered a new mechanism by which large bacterial toxins and proteins deliver catalytic activiti

63 The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although

64 Bacterial toxins and small molecules are useful tools fo

65 Myriad formulations involving radionuclides, bacterial toxins and small-molecule drugs linked to anti

66 hitherto uncharacterized mode of action for bacterial toxins and suggest the possibility that serine

67 ity, which are common in host-cell-targeting bacterial toxins and the venoms of certain insects and r

68 The catalytic sites of bacterial toxins and vertebrate transferases have conser

69 rin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in t

70 ial physico-chemical property shared by many bacterial toxins and viral proteins - the intrinsically

71 The assembly of bacterial toxins and virulence factors is critical to th

72 describe a novel small molecule inhibitor of bacterial toxins and virus trafficking through the endoc

73 ntly, EGA was shown to inhibit the action of bacterial toxins and viruses exhibiting a pH-dependent t

74 s the entry of multiple other acid-dependent bacterial toxins and viruses into mammalian cells.

75 cells, are natural receptors for a number of bacterial toxins and viruses whose sensitive detection i

76 antigen binding fragment, or a fragment of a bacterial toxin) and a library of carbohydrates containi

77 ponse of mouse macrophages to stimulation by bacterial toxin, and a spatially-resolved response to lo

78 amic interaction between intestinal mucus, a bacterial toxin, and a toxin regulatory system.

79 ntigen binding fragment, and a fragment of a bacterial toxin, and their interactions with isomeric ca

80 ariety of host ligands, as well as bacteria, bacterial toxins, and a number of viruses.

81 t concentration, time course, sensitivity to bacterial toxins, and blockade by the B2 receptor antago

82 Bacterial toxins, and especially alpha-toxin, can mediat

83 designed pore formers, antibiotic peptides, bacterial toxins, and lipases.

84 Ribonucleases, antibiotics, bacterial toxins, and viruses inhibit protein synthesis,

85 zation of some plasma membrane constituents, bacterial toxins, and viruses occurs via caveolae; howev

86 e to human innate immunity against bacteria, bacterial toxins, and viruses.

87 ains, relate EAP domains to a large class of bacterial toxins, and will guide the design of future ex

88 vation in response to lipopolysaccharide and bacterial toxins, and yet its role during bacterial infe

89 Examples include bacterial toxins; animal receptors that mediate cell-cel

90 We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very lo

91 tentially universal blockers of three binary bacterial toxins: anthrax toxin of Bacillus anthracis, C

92 proteins HipA and RelE, both members of the bacterial toxin-antitoxin (TA) modules, have the ability

93 Bacterial toxin-antitoxin (TA) systems (or "addiction mo

94 Bacterial toxin-antitoxin (TA) systems are genetic eleme

95 Bacterial toxin-antitoxin (TA) systems regulate key cell

96 Bacterial toxin-antitoxin (TA) systems typically consist

97 Bacterial toxin-antitoxin protein pairs (TA pairs) encod

98 The bacterial toxin-antitoxin system CcdB-CcdA provides a me

99 Using bacterial toxin-antitoxin systems, we demonstrate the pl

100 Bacterial toxins are a major class of virulence factors

101 ns composed of antibodies linked to plant or bacterial toxins are being evaluated in the treatment of

102 Some bacterial toxins are believed to undergo retrograde intr

103 forming toxins (beta-PFT), a large family of bacterial toxins, are generally secreted as water-solubl

104 xoid vaccines--vaccines based on inactivated bacterial toxins--are routinely used to promote antitoxi

105 ically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see sche

106 or that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for SVV.

107 s of anthrax toxin, and perhaps other binary bacterial toxins, assemble into toxic complexes.

108 o understand the host responses to virus and bacterial toxins at the molecular level.

109 ing, bacterial biofilms, bacterial motility, bacterial toxins, bacterial pigments, bacterial enzymes,

110 tic pigs was well tolerated, suggesting that bacterial toxin-based genetic adjuvants may be a safe an

111 Like the bacterial toxins, Bcl-xL can insert into either syntheti

112 Many bacterial toxins bind to and gain entrance to target cel

113 have been demonstrated to neutralize diverse bacterial toxins both in vitro and in vivo, with protein

114 hat human defensins inactivate proteinaceous bacterial toxins by taking advantage of their low thermo

115 tool used to investigate Rho function is the bacterial toxin C3 transferase derived from Clostridium

116 outer membrane transporter called FyuA and a bacterial toxin called pesticin that targets this transp

117 Thus, genomic responses to a bacterial toxin can influence intestinal neoplasia and s

118 Numerous bacterial toxins can cross biological membranes to reach

119 Numerous bacterial toxins catalyze mono(ADP-ribosyl)ation of mamm

120 ng of neutrophil ?-defensin HNP1 to affected bacterial toxins caused their local unfolding, potentiat

121 m that has similarities to those of both the bacterial toxin CcdB and the quinolone antibacterial age

122 er reminiscent of quinolones, Ca(2+), or the bacterial toxin CcdB.

123 k embryo toxin assay was used to investigate bacterial toxins (cell-free extracellular toxins and cel

124 goals of this study were to understand how a bacterial toxin, cholera toxin (CT), modulates Th17-domi

125 on of microarrays for the detection of three bacterial toxins: cholera toxin, staphylococcal enteroto

126 X) of the cytotoxic endonuclease domain from bacterial toxin colicin (E9) in complex with its cognate

127 e Zamaroczy et al. show that cleavage of the bacterial toxin colicin D is required for its ability to

128 erminal cytotoxic endonuclease domain of the bacterial toxin colicin E9.

129 The bacterial toxin, colicin Ia, is one such protein.

130 The enzymatic activity of the RelE bacterial toxin component of the Escherichia coli RelBE

131 xotoxin group that has diverged from related bacterial toxins containing crucial zinc atoms.

132 ation in acd2 plants can be triggered by the bacterial toxin coronatine through a light-dependent pro

133 The bacterial toxin, coronatine, produced by several pathoge

134 rating bacterial membranes, and inactivating bacterial toxins, defensins are known to intercept vario

135 ch may be broadly applicable to the study of bacterial toxins, defining host pathways that can be tar

136 between organelles, protein degradation and bacterial toxin delivery.

137 h may increase the availability of foodborne bacterial toxin diagnostics in regions where there are l

138 Cytokines and bacterial toxins differ in their effects on neutrophil d

139 vity with properties similar to those of the bacterial toxins, diphtheria toxin, and colicins, i.e.,

140 Bacterial toxins (e.g. bacteriocins) and viruses (bacter

141 and is responsible for the toxicity of some bacterial toxins (e.g. cholera toxin and pertussis toxin

142 dynamic proinflammatory cellular response to bacterial toxins (e.g. lipopolysaccharide or LPS) leads

143 fficking of pathogens such as Ebola virus or bacterial toxins (e.g., cholera toxin).

144 million doses of a purified vaccine free of bacterial toxins edema factor and lethal factor from 1 a

145 When HUVECs are exposed to the bacterial toxin EDIN, which can induce spontaneous trans

146 Thus, the ACDs are a family of bacterial toxin effectors that may be evolutionarily rel

147 YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin

148 limits the fever induced by a Gram-negative bacterial toxin (Escherichia coli lipopolysaccharide, LP

149 r details of how two structurally homologous bacterial toxins evolved divergently to bind calmodulin,

150 Whereas all pore-forming bacterial toxins examined previously have been shown to

151 Of the two bacterial toxins examined, shiga-like toxin 1 subunit B

152 ighly conserved repeat toxin (RTX) family of bacterial toxins expressed by a variety of pathogenic ba

153 al disease cholera and a member of the AB(5) bacterial toxin family, provides the opportunity of desi

154 ptor blockers targeting members of the AB(5) bacterial toxin family.

155 Many bacterial toxins form proteinaceous pores that facilitat

156 eurons and nociceptor sensory neurons-detect bacterial toxins, formyl peptides, and lipopolysaccharid

157 is illustrated with the phosphatase YopH, a bacterial toxin from Yersinia pestis.

158 These findings provide insight into how a bacterial toxin functions to specifically impair host si

159 CNF1), the paradigm of Rho GTPase activating bacterial toxins has been shown to promote E. coli invas

160 BCL-XL monomer and several ion-pore-forming bacterial toxins has prompted electrophysiologic studies

161 Recently, several bacterial toxins have been shown in vitro to disrupt imm

162 Certain domains of bacterial toxins have been shown to facilitate transloca

163 Bacterial toxins have been utilized as vaccines, as tool

164 Bacterial toxins have evolved successful strategies for

165 Several bacterial toxins have evolved to efficiently deliver cat

166 they have evolved a remarkable tolerance to bacterial toxins in decaying meat.

167 ave been suggested to mediate the effects of bacterial toxins in intestinal diseases.

168 Our findings highlight the potentials of bacterial toxins in the regulation of human Th17 respons

169 "active" assay technique to the detection of bacterial toxins in water samples from natural sources a

170 cent of the membrane translocation domain of bacterial toxins, in particular diphtheria toxin and the

171 amplify the cell lysis inflicted by certain bacterial toxins including the two RTX toxins alpha-hemo

172 subdomain is present in multiple families of bacterial toxins, including all of the clostridial gluco

173 Many bacterial toxins, including pertussis toxin (PT), exert

174 (ACDs) are distinct domains found in several bacterial toxins, including the Vibrio cholerae MARTX to

175 ansition-state analogue interrogation of the bacterial toxins indicates that CTA gains catalytic effi

176 respiratory epithelial cells contributes to bacterial toxin-induced cell death, fibrosis, and local

177 genetic, drug-induced, immune-mediated, and bacterial toxin-induced experimental kidney diseases wit

178 our knowledge, this is the first report of a bacterial toxin inducing host target cells to increase t

179 Conversely, several bacterial toxins interfere with cellular signalling mech

180 recombinant form of the fourth domain of the bacterial toxin intermedilysin (the recombinant domain 4

181 le-mediated receptor-dependent delivery of a bacterial toxin into a host cell.

182 Bacterial toxins introduce protein modifications such as

183 lecular mechanism by which the activity of a bacterial toxin is regulated by pH.

184 The CDR response of GJ plaques to bacterial toxins is a phenomenon observed for all tested

185 Cytotoxic necrotizing factor 1 (CNF1) is a bacterial toxin known to activate Rho GTPases and induce

186 ilar to viral infection, and the latter is a bacterial toxin known to induce endoplasmic reticulum (E

187 nize endogenous retroviral gene products and bacterial toxins known collectively as superantigens (SA

188 forming toxins and is one of the most potent bacterial toxins known.

189 Two bacterial toxins, lethal toxin and edema toxin, are beli

190 rosis factor-alpha and interferon-gamma, the bacterial toxin lipopolysaccharide, the human immunodefi

191 n neutrophil rheology than the Gram-positive bacterial toxins, LTA, and staphylococcal enterotoxins.

192 Bacterial toxin-mediated diarrheal disease is a major ca

193 In systemic bacterial toxin-mediated inflammation, inhibition of thr

194 identity and showed structural similarity to bacterial toxins: mosquitocidal toxin (MTX2) from Bacill

195 stances known to humankind, but also are the bacterial toxins most frequently used as pharmaceuticals

196 f biological products and those derived from bacterial toxins often rely exclusively on in vivo model

197 ADP-ribosylation (ADP(R)) of eEF2 by bacterial toxins on a unique diphthamide residue inhibit

198 a demonstrate that CrkI inactivation by ExoT bacterial toxin or by mutagenesis blocks vesicle formati

199 nfections in exposed individuals, inactivate bacterial toxins or "correct" hypogammaglobulinemia in i

200 Translocation of bacterial toxins or effectors into host cells using the

201 RhoA (RhoAV14), activation of Rho GTPase by bacterial toxin, or inhibition of Rho kinase by Y-27632

202 Using a soluble cholesterol-binding bacterial toxin, perfringolysin O, we show that choleste

203 ell system in the presence or absence of the bacterial toxin pneumolysin (PLY).

204 sualize the structural rearrangements in the bacterial toxin pneumolysin that occur when it assembles

205 to the NALT also required expression of the bacterial toxin pneumolysin.

206 fused and ventilated lungs with the purified bacterial toxin, pneumolysin.

207 Two bacterial toxins, pneumolysin and, to a lesser extent, H

208 zymes involved in phospholipid metabolism, a bacterial toxin, poxvirus envelope proteins, and bacteri

209 reviously, we have shown that IAP detoxifies bacterial toxins, prevents endotoxemia, and preserves in

210 with GPI-APs (detected by the GPI-AP binding bacterial toxin proaerolysin).

211 is the first report of a biologically active bacterial toxin produced with the P. pastoris system.

212 Inhibitors of several bacterial toxins produced by Bacillus anthracis, Staphyl

213 Bacterial toxins produced in the gut enter the circulati

214 rge number of culture conditions influencing bacterial toxin production.

215 ection on host survival outcomes and in vivo bacterial toxin production.

216 The bacterial toxin protein A from Staphylococcus aureus (Sp

217 To our knowledge, BFT is the first bacterial toxin reported to activate T-cell factor-depen

218 biofilm formation by a host-directed protein bacterial toxin represents a novel regulatory mechanism

219 Bacterial toxins require localization to specific intrac

220 To our knowledge, LtxA represents the first bacterial toxin shown to localize to the lysosome where

221 lipopolysaccharide, LPS) and a Gram-positive bacterial toxin (Staphylococcus aureus), when these toxi

222 athogenesis of septic shock is due mainly to bacterial toxin stimulation of the immune system, result

223 nt resealing after permeabilization with the bacterial toxin streptolysin O (SLO) requires endocytosi

224 dysfunction in patients exposed to multiple bacterial toxins such as in sepsis, multiple-system orga

225 e tmRNA, the ribosomal alarmone (p)ppGpp, or bacterial toxins such as RelE which have been shown to s

226 d not require the stringent factor ppGpp, or bacterial toxins such as RelE, which mediates a similar

227 d by glucosyltransferases, including certain bacterial toxins such as Toxins A and B from Clostridium

228 splay structural homology to channel-forming bacterial toxins, such as colicins, transmembrane domain

229 ibrils that resemble a class of pore-forming bacterial toxins, suggesting that inappropriate membrane

230 This study extends the list of thermolabile bacterial toxins, suggesting that this quality is essent

231 ic viruses and for the activation of several bacterial toxins suggests that selective inhibitors of f

232 , as well as the protective effect against a bacterial toxin, suggests that inhibitors of furin or fu

233 are toxin domains of two distinct classes of bacterial toxin systems, namely polymorphic toxins impli

234 We discuss detection of three bacterial toxins-tetanus, botulinum, and cholera toxins

235 that NAD+-glycohydrolase is a novel type of bacterial toxin that acts intracellularly in the infecte

236 Pseudomonas exotoxin A (PE) is a bacterial toxin that arrests protein synthesis and induc

237 366 amino acid residues) is an intracellular bacterial toxin that binds to cells and enters the cytos

238 d markedly in susceptibility to aerolysin (a bacterial toxin that binds to GPI-anchored proteins), th

239 brio cholerae RTX is a large multifunctional bacterial toxin that causes actin crosslinking.

240 The cytolysin of E. faecalis is a novel bacterial toxin that contributes to the severity of dise

241 t infection studies and reveal that SLS is a bacterial toxin that does not require bacterial attachme

242 in SUMOylation induced by listeriolysin O, a bacterial toxin that impairs the host cell SUMOylation m

243 TcdB, an intracellular bacterial toxin that inactivates small GTPases, is a maj

244 at exploits the unique properties of MazF, a bacterial toxin that is an ssRNA- and ACA-specific endor

245 of a mesothelin-specific antibody fused to a bacterial toxin that is presently undergoing phase II te

246 he absence and presence of C3 transferase, a bacterial toxin that specifically inhibits rho.

247 CcdB is a bacterial toxin that targets DNA gyrase.

248 late cyclase toxin (ACT), which is a protein bacterial toxin that targets host cells and disarms immu

249 into the cytosol is to fuse them to modified bacterial toxins that are able to enter mammalian cells.

250 cial liposomes as decoy targets to sequester bacterial toxins that are produced during active infecti

251 Lymphostatin represents a new class of large bacterial toxins that blocks lymphocyte activation.

252 Botulinum neurotoxins (BoNTs) are potent bacterial toxins that cause paralysis at femtomolar conc

253 Bacterial toxins that disrupt the stability of contracti

254 dent cytolysins (CDCs) are a large family of bacterial toxins that exhibit a dependence on the presen

255 rum and reduce cellular sensitivity to other bacterial toxins that require the same host proteases.

256 mbrane-bound cholesterol sensors are soluble bacterial toxins that show an identical switch-like spec

257 Evidence from bacterial toxins that specifically inhibit the activity

258 Channel-forming colicins are bacterial toxins that spontaneously insert into the inne

259 The effects (cholera, whooping cough) of bacterial toxins that target G proteins for covalent mod

260 tor type 1 (CNF1), a member of the family of bacterial toxins that target the Rho family of small GTP

261 enic Escherichia coli belongs to a family of bacterial toxins that target the small GTP-binding Rho p

262 C3 thus represents a major family of the bacterial toxins that transfer the ADP-ribose moiety of

263 The Cdt is a family of gram-negative bacterial toxins that typically arrest eukaryotic cells

264 ism, distinct from those described for other bacterial toxins, that disrupts this signaling pathway.

265 e systems and tissue culture, but, like many bacterial toxins, the in vivo targets of TcdB are unknow

266 technique for simultaneous detection of five bacterial toxins: the cholera toxin, the E. coli heat-la

267 Based on crystallography of the bacterial toxins, these regions are believed to form, in

268 rotects the midgut from virus infections and bacterial toxins through death and replacement of affect

269 Certhrax is the first bacterial toxin to add a post-translational modification

270 that fusion of the translocation domain of a bacterial toxin to an antigen may greatly enhance vaccin

271 genicity, demonstrate the novel ability of a bacterial toxin to increase its cytotoxicity, establish

272 et only replicating organisms, thus allowing bacterial toxins to cause unchecked, devastating physiol

273 the target membrane and forms a channel for bacterial toxins to flow from bacteria into the host cel

274 -tagged anthrolysin O, a cholesterol-binding bacterial toxin, to measure accessible cholesterol in hu

275 Although circulating bacterial toxins trigger inflammation in sepsis, little

276 Our results reveal a mechanism by which a bacterial toxin uses constitutively occurring calpain-me

277 protease release, the first description of a bacterial toxin using a lysosomal cell death pathway.

278 electrochemical sensor for the detection of bacterial toxins using an electrochemical enzyme-linked

279 e results define a pathway by which a single bacterial toxin utilizes a widely expressed receptor to

280 ency and clinical immunogenicity testing for bacterial toxin vaccine candidates in development.

281 crofluidic channels, to assay the binding of bacterial toxins via total internal reflection fluoresce

282 tant function in the cellular uptake of some bacterial toxins, viruses and circulating proteins.

283 A flow-based immunoassay for bacterial toxin was developed with 5% GM1/DOPC+ membrane

284 A selection procedure based on a bacterial toxin was used to select for cells in which th

285 Using bacterial toxins, we describe a new approach for discove

286 nous substrates including growth factors and bacterial toxins, we determined that elevated furin-depe

287 nic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule,

288 Here, we made use of bacterial toxins, which directly activate Rho GTPases to

289 Exceptions to this include bacterial toxins, which insert into and cross the lipid

290 , has rarely been described for pore-forming bacterial toxins, which suggests that VacA is a pore-for

291 t specifically mediates the interaction of a bacterial toxin with a cholesterol-rich membrane.

292 on a CMC surface and detection of the bound bacterial toxins with a biotinylated secondary antibodie

293 te interactions, such as the interactions of bacterial toxins with cell-surface receptors.

294 de prolonged prophylactic protection against bacterial toxins without inducing inhibitory immune resp

295 responses to several bacterial pathogens and bacterial toxins, yet respond normally to the presence o