ライフサイエンスコーパス: bacteriochlorin

1 optical fine-tuning of meso-aryl-substituted bacteriochlorins.

2 nd contrasted against benchmark chlorins and bacteriochlorins.

3 rted concerning the synthesis of substituted bacteriochlorins.

4 nce the capabilities for tailoring synthetic bacteriochlorins.

5 agents within the optical window of tissue, bacteriochlorins (2,3,12,13-tetrahydroporphyrins) promis

6 Bacteriochlorin 26 under acidic or basic conditions main

7 ring a 1,3-dioxolan-2-yl moiety afforded the bacteriochlorin (30% yield) containing a 2-hydroxyethoxy

8 rins and 13(1)-oxophorbines (603-687 nm) and bacteriochlorins (707-792 nm).

9 Each bacteriochlorin acceptor is equipped with a different se

10 results in relatively strong emission of the bacteriochlorin acceptor, with a quantum yield Phif rang

11 Interestingly all bacteriochlorins accumulate in melanosomes, and subseque

12 Zinc and copper chelates of each bacteriochlorin also were prepared.

13 Bacteriochlorin analogue BC-PMI has more extended spectr

14 prepared and oxidatively stable chlorin and bacteriochlorin analogues with tunable optical spectra t

15 electronic structure of a family of expanded bacteriochlorin analogues.

16 a readily separable mixture of two free base bacteriochlorins and a free base B,D-tetradehydrocorrin.

17 In summary, this simple entry to stable bacteriochlorins and tetradehydrocorrins should facilita

18 comprising a near-IR absorbing and emitting bacteriochlorin, and BODIPY derivatives with different a

19 ent strengths of the porphins, chlorins, and bacteriochlorins are 1.5-2.5 times stronger than for ben

20 The current strengths of the chlorins and bacteriochlorins are 19-24 nA/T depending on whether the

21 Bacteriochlorins are attractive candidates for a wide va

22 Bacteriochlorins are attractive candidates for photodyna

23 operties of mono- and bis-chromene-annulated bacteriochlorins are described.

24 ctra of the mono- and bis-chromene-annulated bacteriochlorins are modulated as a result of the annula

25 Synthetic bacteriochlorins are of interest for fundamental studies

26 Cell killing studies determined that bacteriochlorins are superior at (LD(50) approximately 0

27 Bacteriochlorins are tetrapyrrole compounds with two red

28 , with absorption between 500-700 nm, BODIPY-bacteriochlorin arrays should allow for construction of

29 ergy donor, and a different near-IR emitting bacteriochlorin, as an energy acceptor.

30 of peripheral functional groups makes these bacteriochlorins attractive candidates for diverse appli

31 ion of a free-base chlorin generally forms a bacteriochlorin (BC), while the reduction of the corresp

32 inated chromophores, which include synthetic bacteriochlorins (BC1, BC2) with strong near-infrared ab

33 The target bacteriochlorins bear cationic, lipophilic, or amphipath

34 Ten new bacteriochlorins bearing 0-6 total aryl, alkyl, and carb

35 , Sonogashira, Hartwig-Buchwald) to give six bacteriochlorins bearing functional groups at the 15-pos

36 Five new bacteriochlorins bearing various substituents (alkyl/alk

37 , the characteristic absorbance bands of the bacteriochlorins bound to the polypeptides within the re

38 at the 15-position to give a trans-(5,15)-AB-bacteriochlorin building block.

39 rins are thus excellent models for localized bacteriochlorin chromophore deformations that are sugges

40 of the modulation is due to ruffling of the bacteriochlorin chromophore.

41 s vary the tetrapyrrole (porphyrin, chlorin, bacteriochlorin), chromophore (boron-dipyrrin, perylene,

42 Bacteriochlorins containing anhydride, imide, or isoimid

43 Synthetic bacteriochlorins containing site-specific isotopic subst

44 Each bacteriochlorin contains two geminal dimethyl groups to

45 The absorption spectra of these novel bacteriochlorins demonstrated remarkably red-shifted int

46 The bacteriochlorins display characteristic spectral feature

47 , which in case of the 13-13' ethynyl-linked bacteriochlorin dyad is positioned past 800 nm.

48 Bacteriochlorin dyads exhibit a strong dependence of flu

49 and split for the 13-13' linked chlorin and bacteriochlorin dyads.

50 ongly conjugated hydroporphyrin (chlorin and bacteriochlorin) dyads.

51 id catalysis conditions has afforded diverse bacteriochlorins (e.g., bearing alkyl/ester, aryl/ester,

52 The narrow, tunable emission band of bacteriochlorins enables the selection of a series of th

53 ical properties of a series of novel chlorin-bacteriochlorin energy transfer dyads are described.

54 The bacteriochlorins exhibit absorption spectra typical of b

55 The bacteriochlorins exhibit characteristic bacteriochloroph

56 Each bacteriochlorin exhibits a Q(y) absorption band in the r

57 r, this study expands the scope of available bacteriochlorins for fundamental studies and diverse app

58 describes testing of 12 new stable synthetic bacteriochlorins for PDT activity.

59 nge between 4 A to 11 A and that between two bacteriochlorins from different subunits is more than 20

60 er with near-infrared absorption gives these bacteriochlorins great potential as photosensitizers for

61 Deuterium exchange of both bacteriochlorins (H-BC and MeO-BC) in acidic media (TFA-

62 Altogether 22 free base bacteriochlorins have been prepared.

63 teriochlorin (MeOBC-type), a 5-unsubstituted bacteriochlorin (HBC-type), and a free base B,D-tetradeh

64 s two geminal dimethyl groups to lock-in the bacteriochlorin hydrogenation level, p-tolyl substituent

65 nsequently (3) access to diverse substituted bacteriochlorins including those with substituents at th

66 Each bacteriochlorin is stable to adventitious dehydrogenatio

67 of a bis-chromene-annulated chlorin from the bacteriochlorins is also described, including its X-ray

68 -tune the electronic properties of synthetic bacteriochlorins is important for these purposes.

69 Together, the 24 bacteriochlorin isotopologues should provide valuable be

70 By contrast, the bacteriochlorin lacking the 5-methoxy group (8,8,18,18-t

71 hereby maintaining an 18-atom 18-pi electron bacteriochlorin-like aromatic delocalization pathway.

72 ned and up to 90 nm bathochromically shifted bacteriochlorin-like optical spectra.

73 d dioxabacteriochlorins may have chlorin- or bacteriochlorin-like spectra.

74 Microscopy reveals that the least effective bacteriochlorin localizes predominantly in lysosomes, wh

75 Bacteriochlorophylls contain a bacteriochlorin macrocycle bearing an annulated fifth ri

76 unit attached to pyrroline ring B forms the bacteriochlorin macrocycle, and (ii) Nazarov cyclization

77 manifested by nearly exclusive emission from bacteriochlorin moiety upon BODIPY excitation.

78 parable with that observed for corresponding bacteriochlorin monomer, and is significantly reduced in

79 The novel bacteriochlorins, obtained from chlorophyll-a, have long

80 dination chemistry (e.g., Zn, Cd, Ni), (2) a bacteriochlorin oxidation state of the macrocyclic ring,

81 t energy transfer (>/=0.77) even for chlorin-bacteriochlorin pairs with large (up to 122 nm) separati

82 The 15 new bacteriochlorins prepared herein exhibit a long-waveleng

83 orescent probes show that the most effective bacteriochlorin produces significantly higher levels of

84 es of the isolated porphyrins, chlorins, and bacteriochlorins, related to Bchl a, were assigned on th

85 The bacteriochlorins show relatively low fluorescence quantu

86 pared from commercially available reactants (bacteriochlorin sites): ((13)C)paraformaldehyde (1, 11);

87 tes different sets of bis-chromene-annulated bacteriochlorin stereo- and regioisomers.

88 of synthetic plans for early installation of bacteriochlorin substituents via the dihydrodipyrrin-ace

89 differ in the levels of pigmentation; 3 new bacteriochlorins successfully overcame the resistance.

90 The distances between neighboring bacteriochlorin systems within a subunit range between 4

91 Bacteriochlorins (tetrahydroporphyrins) are attractive f

92 gree of reduction is significantly lower for bacteriochlorins than for Photofrin.

93 single-isotopic substitution gives rise to a bacteriochlorin that contains two isotopic substitutions

94 may provide simple strategies for designing bacteriochlorins that efficiently generate ROS upon phot

95 Among all the bacteriochlorins the triplet states were quenched by gro

96 groups at a specific site enables synthetic bacteriochlorins to be tailored for a variety of applica

97 ties is described, generating inter alia the bacteriochlorin-type chromophores oxazolobacteriochlorin

98 The bacteriochlorin-type optical spectra of the mono- and bi

99 formation of the dihydrodipyrrin-acetal and bacteriochlorin underpins evaluation of synthetic plans

100 A new route to bacteriochlorins via Northern-Southern (N-S) self-conden

101 a building block in the synthesis of diverse bacteriochlorins via Pd-mediated coupling reactions (Son

102 Each bacteriochlorin was prepared in five steps from an alpha

103 The best in vitro performing bacteriochlorin was tested in vivo in a mouse melanoma m

104 A series of new bacteriochlorins was synthesized using 13(2)-oxo-bacteri

105 rties, and skin phototoxicity of some stable bacteriochlorins were investigated.

106 ining PEG-substituted BODIPY and chlorins or bacteriochlorins were prepared and their optical and flu

107 Eight such isotopically substituted bacteriochlorins were prepared from commercially availab

108 tal X-ray structures (two intermediates, two bacteriochlorins) were determined.

109 novo synthesis has been employed to prepare bacteriochlorins wherein each macrocycle contains a pair

110 ring with KOH/propanol produced an "unstable bacteriochlorin", which decomposed in acidic conditions

111 thalene afforded highly conjugated annulated bacteriochlorins with fused quinoxaline, benzimidazole,