ライフサイエンスコーパス: bacteriocin

1 minosarum and was previously known as 'small bacteriocin'.

2 mately 20 kDa, termed dendritiformis sibling bacteriocin.

3 chromosomal locus for lactacin B, a class II bacteriocin.

4 an Erwinia carotovora carotovoricin Er-like bacteriocin.

5 in altering host specificity for a putative bacteriocin.

6 genotype or resistance to metronidazole and bacteriocin.

7 enotype, and resistance to metronidazole and bacteriocin.

8 ain via secretion of surfactants and a toxic bacteriocin.

9 he antimicrobial activity of the full-length bacteriocin.

10 The second is resistant to the bacteriocin.

11 rse family of microbial defense systems: the bacteriocins.

12 ts, numerous types of protein exotoxins, and bacteriocins.

13 SS); contact dependent inhibition (CDI); and bacteriocins.

14 is of class I (lantibiotic) or some class II bacteriocins.

15 produce small antibacterial peptides called bacteriocins.

16 systems, insecticidal protein complexes, and bacteriocins.

17 categories-antimicrobial, antibacterial and bacteriocins.

18 y and for protection against exogenous DNase bacteriocins.

19 roduced antimicrobial peptide from class IIa bacteriocins.

20 rent kinds of lantibiotic and nonlantibiotic bacteriocins.

21 e of the conjugative plasmid pPD1 expressing bacteriocin 21 in enterococcal colonization.

22 Bacteriocin 41 (Bac41) is produced by certain E. faecali

23 ablishes that the thiopeptides are a type of bacteriocin, a family of genetically encoded antimicrobi

24 bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicro

25 that usually mediates translocation of these bacteriocins across the outer membrane, containing only

26 e recombinant BacL1 and BacA showed complete bacteriocin activity against E. faecalis, but neither Ba

27 n the Bac41 operon, coordinately express the bacteriocin activity against E. faecalis.

28 nt type 19A background was deficient in both bacteriocin activity and immunity.

29 mportantly, bile acids strongly enhance this bacteriocin activity in vivo, leading to greater SGG col

30 a, a distribution inconsistent with putative bacteriocin activity.

31 ther BacL1 nor BacA protein alone showed the bacteriocin activity.

32 t as is found for colicin Ia, these H. alvei bacteriocins (alveicins) lack lysis genes.

33 level constitutive expression system for the bacteriocin and immunity genes of channel-forming colici

34 s a transcription activator for a variety of bacteriocins and bacteriocin-related genes.

35 artial unfolding of TolAIII, suggesting that bacteriocins and bacteriophages parasitize E. coli using

36 ribution of the blp locus, encoding putative bacteriocins and cognate immunity peptides, to intraspec

37 We provide a novel dataset of predicted bacteriocins and context genes.

38 egulated genes associated with production of bacteriocins and downregulated colonization-associated g

39 he phenotypic characteristics, production of bacteriocins and H2O2 are regulated by environmental con

40 ltifunctionality of FepA: toxic ligands like bacteriocins and phage penetrate the outer membrane by p

41 alis, disulfide bonds are formed in secreted bacteriocins and required for activity.

42 XIP to stimulate production of antimicrobial bacteriocins and to induce development of competence for

43 sequence within the central domain of these bacteriocins and to involve residues present in the shor

44 etitors, via the release of chemicals (e.g., bacteriocins ) and via the release of parasites (e.g., t

45 Bacterial toxins (e.g. bacteriocins) and viruses (bacteriophages) targeting Gra

46 These bacteriocins appear to be chimeras consisting of translo

47 and the expression of virulence factors and bacteriocins are all controlled by this important transc

48 Bacteriocins are an abundant class of antimicrobial mole

49 one-responsive conjugative plasmids encoding bacteriocins are common among enterococcal strains and c

50 Recent discoveries have shown that bacteriocins are highly diverse and widely distributed a

51 r-binding parts of LsbB and sequence-related bacteriocins are located in their C-terminal halves.

52 Bacteriocins are peptide-derived molecules produced by b

53 The colicin-like bacteriocins are potent protein antibiotics that have ev

54 ates for context genes which may clarify how bacteriocins are synthesized, and identify new candidate

55 However, bacteriocins are typically freely diffusible, and so of

56 e the fact that closely related colicin-like bacteriocins are widely produced by Gram-negative bacter

57 Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intras

58 ce element sufficient for the binding of the bacteriocin as well as of hybrid indicator proteins to t

59 acteriocin diversity observed and the use of bacteriocins as preservatives in the food industry and a

60 Enzymatic modification of bacteriocins as well as their export is achieved by prot

61 otal synthesis of the three largest circular bacteriocins, AS-48, uberolysin, and garvicin ML, by an

62 ssociator (BOA) that can identify homologous bacteriocin associated gene blocks and predict novel one

63 lling phenotypes revealed two instances of a bacteriocin associated with a bacteriophage gene, the fi

64 from chicken gizzard, was noted to produce a bacteriocin (BacJ1) that inhibited Gram-positive and Gra

65 pacity to colonize human epithelia, owing to bacteriocin-based bacterial interference.

66 ulence factors, and in several regulators of bacteriocin biosynthesis, previously unified in the AgrA

67 pology of the nisin pathway for constitutive bacteriocin biosynthesis.

68 nine-gene GAS locus (sagA-sagI) resembling a bacteriocin biosynthetic operon is necessary and suffici

69 re reductions from steric hindrance when the bacteriocin bound to the receptor protein.

70 not due to expression of a lantibiotic-type bacteriocin, but proteolytically processed derivatives o

71 Bacillus subtilis produces an anionic bacteriocin called subtilosin A that possesses antibacte

72 Steinernema carpocapsae, produces the R-type bacteriocin called xenorhabdicin, which is thought to co

73 a family of ribosomally synthesized peptide bacteriocins called lantibiotics (lanthionine-containing

74 ion of a variable repertoire of pneumococcal bacteriocins called pneumocins and their associated immu

75 Thus, just as bacteriocins can lead to increased diversity via rock-pa

76 Some of these compounds, such as bacteriocins, can affect bacteria of similar or closely

77 id-containing host also produces gelatinase, bacteriocin cannot be detected.

78 y highlights that short peptide ligands from bacteriocin class offer high selectivity in bacterial de

79 We have studied how the bacteriocin colicin E9 (ColE9) assembles a cytotoxic tra

80 e outer membrane protein TolC constitute the bacteriocin colicin V secretion system in Escherichia co

81 by the C-terminal pore-forming domain of the bacteriocin, colicin E1.

82 the lethal, channel-forming activity of the bacteriocin, colicin E1.

83 ailed studies into the biosynthesis of other bacteriocin compounds and the production of these natura

84 Given the heterogeneity of bacteriocin compounds, many tools struggle with identify

85 le Hidden Markov Models from the clusters of bacteriocin context genes, and uses them to identify nov

86 by members of the domain Bacteria: circular bacteriocins, cyanobactins, and circular pilins.

87 llows users to search peptide families (e.g. bacteriocins, cyclotides, or defensins), peptide sources

88 mpetition in the gastrointestinal tract, and bacteriocins, delivered by commensals that occupy a prec

89 results therefore identify LLS as the first bacteriocin described in L. monocytogenes and associate

90 d almost a century ago, our understanding of bacteriocin distribution and prevalence in bacterial pop

91 ecular mechanisms involved in the process of bacteriocin diversification.

92 vide a novel mechanism for the generation of bacteriocin diversity in Klebsiella.

93 sing attention because of the high levels of bacteriocin diversity observed and the use of bacterioci

94 f clinical isolates suggested that the BlpMN bacteriocins divide into two families.

95 Unlike T6SS and CDI systems, bacteriocins do not require contact between bacteria but

96 , many tools struggle with identifying novel bacteriocins due to their vast sequence and structural d

97 Bacteriocins elaborated by S. mutans, termed mutacins, m

98 Bacteriocin encoding genes are frequently found in micro

99 The complete nucleotide sequences of two bacteriocin-encoding plasmids isolated from Hafnia alvei

100 t here the identification of the E. faecalis bacteriocin, EntV, produced from the entV (ef1097) locus

101 sequence homology with five other leaderless bacteriocins, especially at their C-terminal halves wher

102 Therefore, bacteriocin expression by commensal bacteria can influen

103 ighly modified peptides that are part of the bacteriocin family of antimicrobial peptides.

104 products suggest that SLS is related to the bacteriocin family of microbial toxins.

105 achinery to synthesize antibiotic molecules (bacteriocins) for their continuous warfare with other mi

106 It includes a total of 2619 AMPs with 261 bacteriocins from bacteria, 4 AMPs from archaea, 7 from

107 An SGG-specific locus encoding a bacteriocin ("gallocin") is shown to kill enterococci in

108 ntext genes, and uses them to identify novel bacteriocin gene blocks and operons.

109 rsR binds to the promoter regions of several bacteriocin genes and requires the presence of a LytTR f

110 gulator, BlpR, and requires the two putative bacteriocin genes blpM and blpN.

111 t several phyla have a strong preference for bacteriocin genes, suggesting distinct functions for thi

112 The bacteriocin haemocin is produced by most type b strains

113 The first gene to encode a haloarchaeal bacteriocin (halocin H4) has been cloned and sequenced f

114 r binding and species specificities of these bacteriocins has been driven by diversifying selection r

115 One class of antimicrobials, the bacteriocins, has received increasing attention because

116 To date, close to five hundred bacteriocins have been identified and classified.

117 treatment both bacteriophage endolysins and bacteriocins have been shown to possess antimicrobial ef

118 esent in a subset of lineage I strains, is a bacteriocin highly expressed in the intestine of orally

119 hat the inactivation of bip or smbG, another bacteriocin immunity protein gene present within the smb

120 ies resulted from repression of the putative bacteriocin immunity protein gene, bip, which is located

121 s of these observations for the evolution of bacteriocin immunity protein genes as well as for potent

122 ium can be modulated by some of the putative bacteriocin immunity proteins expressed by the organism.

123 encoding homologs of dendritiformis sibling bacteriocin in other bacterial species suggests that thi

124 s of TxeR regulate synthesis of toxins and a bacteriocin in other Clostridium species, TxeR appears t

125 Here, we identify an atypical two-protein bacteriocin in the alpha-proteobacterium Caulobacter cre

126 Production of R-type bacteriocins in a host organism had not been shown previ

127 All bacteriocins in this family have a conserved N-terminal

128 kin, as in poison-antidote systems, such as bacteriocins, in which cells benefit their own kind by p

129 m the C-terminal regions of two LsbB-related bacteriocins inhibited the activity of LsbB, in the same

130 for the penetration of several nuclease-type bacteriocins into target cells.

131 Bacteriocin is an important peptide which can be used as

132 Uptake of the bacteriocin is required for activity in the periplasm le

133 f adaptive prophage-derived elements such as bacteriocins, killer particles, gene transfer agents, or

134 t C. difficile-killing spectrum, with no one bacteriocin killing all C. difficile isolates tested.

135 pathogen that produces a powerful cytolytic bacteriocin known as streptolysin S (SLS).

136 we show that Pseudomonas aeruginosa specific bacteriocins, known as pyocins, show strong efficacy in

137 This unusual bacteriocin lacks the intrinsically unstructured translo

138 n responsible for the synthesis of the novel bacteriocin lacticin 3147; and (iii) the phage resistanc

139 Lacticin 481 is a lanthionine-containing bacteriocin (lantibiotic) produced by Lactococcus lactis

140 trate was developed for direct recovery of a bacteriocin-like inhibitory substance (BLIS) from a cult

141 on was employed for the first time to purify bacteriocin-like inhibitory substance (BLIS) from a ferm

142 oduce a low-molecular-weight, broad-spectrum bacteriocin-like inhibitory substance (BLIS).

143 A new gene, sboX, encoding another bacteriocin-like product was discovered residing in a se

144 The bacteriocin-like proteins CdzC and CdzD harbor glycine-z

145 The product of the tail fiber ORF in the bacteriocin-like region shows a hybrid structure where t

146 peptide supports the designation of SLS as a bacteriocin-like toxin.

147 phage endolysin CHAPK and the staphylococcal bacteriocin lysostaphin have been co-administered in a t

148 f this review we focus on the potential role bacteriocins may play in addressing human health concern

149 nd show that colicins (and potentially other bacteriocins) may promote, rather than eliminate, microb

150 The Enterococcus faecalis class IIa bacteriocin MC4-1 encoded by the sex pheromone-respondin

151 This is similar to previously described bacteriocin-mediated effects.

152 ture antibiotics, some of the tricks used by bacteriocins might be exploited for the synthesis of nov

153 competence system and the expression of the bacteriocin mutacin IV of S. mutans, as well as the H(2)

154 nd measure expression of nlmAB (encoding the bacteriocin mutacin IV) within mice to assess its import

155 gate the requirement for ComE to produce the bacteriocin mutacin IV.

156 Production of the bacteriocin, mutacin I, is one such mechanism.

157 The mutant bacteriocin, named subtilosin A1, has a replacement of t

158 The antimicrobial activity of the resultant bacteriocin-nanoclay systems was analyzed using skimmed

159 ov Models for the identification of nuclease bacteriocins (NBs) in bacteria of which, to-date, only a

160 actococcus lactis produce the broad-spectrum bacteriocin nisin, which belongs to the lantibiotic clas

161 LsbB is a class II leaderless lactococcal bacteriocin of 30 amino acids.

162 The bacteriocins of Escherichia coli have served as a model

163 se goals, we have developed a software tool, Bacteriocin Operon and gene block Associator (BOA) that

164 mobilization genes, as well as colicin-like bacteriocin operons.

165 SH3b domains from either lysostaphin (bacteriocin) or LysK (phage endolysin) resulted in a app

166 This novel bacteriophage/bacteriocin organization may provide a novel mechanism f

167 These R-type bacteriocin particles, which have been purified from dif

168 e, we identify a novel ferredoxin-containing bacteriocin pectocin P, which possesses a cytotoxic doma

169 tructurally characterized the colicin M-like bacteriocin, pectocin M2, which is active against strain

170 f Yersinia pestis confers sensitivity to the bacteriocin, pesticin, and is an integral component of a

171 ere also sensitive to the Y. pestis-produced bacteriocin, pesticin.

172 pAD1 is a 60-kb hemolysin-bacteriocin plasmid in Enterococcus faecalis that encode

173 reptococcus pneumoniae encodes a two-peptide bacteriocin, pneumocin MN, which mediates intraspecies c

174 d in a discrete gene cluster proximal to the bacteriocin precursor gene, referred to as context genes

175 all peptides with structural similarities to bacteriocin precursor polypeptides.

176 The two bacteriocin prediction tools, BAGEL3 and BACTIBASE, both

177 o expand this large CPBP (CAAX proteases and bacteriocin-processing enzymes) family to include more t

178 Plantaricin C, a bacteriocin produced by a Lactobacillus plantarum strain

179 Microcin E492 (Mcc), a low molecular weight bacteriocin produced by Klebsiella pneumoniae RYC492, ha

180 a gonorrhoeae WS1 is a spontaneous pyocin (a bacteriocin produced by Pseudomonas aeruginosa)-resistan

181 l-regulated production of chemicals, such as bacteriocins (produced by S. mutans) and hydrogen peroxi

182 For self-protection, a bacteriocin producer strain must possess one or more cog

183 During a screening programme for bacteriocin producers, a new lactic acid bacterium calle

184 e associated with determinants implicated in bacteriocin production and acid tolerance.

185 In Streptococcus mutans, both competence and bacteriocin production are controlled by ComC and the Co

186 ng a 16-gene Tra (transfer) operon; (ii) the bacteriocin production region, including an operon respo

187 biofilm, may utilize the competence-induced bacteriocin production to acquire transforming DNA from

188 each other and ultimately determine whether bacteriocin production will inhibit competitor organisms

189 xtracellular DNA release, biofilm formation, bacteriocin production, and genetic competence.

190 s, mutants in acid tolerance, and mutants in bacteriocin production, at frequencies ranging from 0.1

191 ofilm formation, escape from phagolysosomes, bacteriocin production, toxin activity and protection fr

192 , biofilm formation, genetic competence, and bacteriocin production.

193 mulating peptide (CSP) to stimulate mutacin (bacteriocin) production and competence development throu

194 Phage tail-like bacteriocins (PTLBs) are widespread in bacteria, compris

195 as aeruginosa is hijacked to translocate the bacteriocin pyocin S2 (pyoS2) across the outer membrane

196 This bacteriocin (pyocin) that we have named PaeM was crystal

197 Circular bacteriocins, ranging from 35 to 70 amino acids, are the

198 and their prokaryotic homologs with putative bacteriocin-related functions.

199 well as several restriction/modification and bacteriocin-related genes and a number of open reading f

200 activator for a variety of bacteriocins and bacteriocin-related genes.

201 eral stress-related genes and genes encoding bacteriocin-related peptides and many transcription fact

202 Bacteriocins represent a large family of ribosomally pro

203 a seven-gene operon (alb, for antilisterial bacteriocin) residing immediately downstream from the sb

204 of megaplasmid pSsal-K12, which encodes the bacteriocins salivaricin A and salivaricin B; however, i

205 Colicin-like bacteriocins show potential as next generation antibioti

206 e strains and can therefore be classified as bacteriocins, similar to the R-type pyocins of Pseudomon

207 es resistance to the SPbeta prophage-encoded bacteriocin sublancin, and the yknWXYZ operon and yfhL p

208 n contains sboA, the structural gene for the bacteriocin subtilosin, and the alb genes required for s

209 confirmed that the substance was the cyclic bacteriocin subtilosin.

210 lus subtilis 168 derivative JH642 produces a bacteriocin, subtilosin, which possesses activity agains

211 The potency and targeted action of bacteriocins suggests that they could be developed into

212 structure and function of the colicin M-like bacteriocin, syringacin M from Pseudomonas syringae pv.

213 cell-killing that is generally not found in bacteriocins targeting the periplasm, implying a specifi

214 A bacteriocin termed SRCAM 602 previously reported to be p

215 are related to the rapidly growing class of bacteriocins termed lantibiotics.

216 bv. staphylolyticus secretes lysostaphin, a bacteriocin that cleaves pentaglycine cross bridges in t

217 Colicin N is a pore-forming bacteriocin that enters target Escherichia coli cells wi

218 distribution of host interaction factors and bacteriocins that affect their natural and industrial en

219 synthesized, and identify new candidates for bacteriocins that bear no sequence similarity to known t

220 type pyocin particles have been described as bacteriocins that resemble bacteriophage tail-like struc

221 The colicins are bacteriocins that target Escherichia coli and kill bacte

222 It belongs to a family of bacteriocins that, when membrane-associated, is predicte

223 utolysis-related genes and those that encode bacteriocins, the ClpB protease chaperone subunit, pyruv

224 However, paradoxically, import of protein bacteriocins, the mechanisms of which are poorly underst

225 Although bacteriocins themselves are structurally diverse, contex

226 In the case of protein bacteriocins, this is because of high levels of sequence

227 s, the CWT domain of lysostaphin directs the bacteriocin to cross-linked peptidoglycan, which also se

228 in is required for selective binding of this bacteriocin to S. aureus cells; however, the molecular t

229 ed approach using nisin, a FDA-approved safe bacteriocin, to inhibit outgrowth of germinated spores a

230 nsure the proper extracellular activation of bacteriocin toxicity.

231 ng phenotypes that suggest the production of bacteriocin toxins.

232 Many bacteriocins undergo post-translational processing or mo

233 This isolated domain of the PaeM bacteriocin was further shown to kill E. coli cells when

234 , proteases, and leukotoxins, in addition to bacteriocins, was transferrable in vitro to human and an

235 Bacteriocins were intercalated into the interlayer space

236 is mutacin (mutacin IV) is a non-lantibiotic bacteriocin which kills closely related Streptococcal sp

237 AS-48 is a bacteriocin with potential application as food biopreser

238 engineering approaches for obtaining anionic bacteriocins with enhanced and/or altered bactericidal a

239 ld make alveicin B the smallest pore-forming bacteriocin yet discovered.