ライフサイエンスコーパス: baicalein

1 cells caused by the compound) as compared to baicalein.

2 rils of alpha-synuclein are disaggregated by baicalein.

3 cytotoxicity is less than that observed for baicalein.

4 d in the interaction of alpha-synuclein with baicalein.

5 nificantly activated by EGF and inhibited by baicalein.

6 L), eicosatetraynoic acid (1 micromol/L), or baicalein (10 micromol/L), desensitization of C-fibers u

7 100 microM) and a 12-lipoxygenase inhibitor, baicalein (5 microM), suggesting that opioids acted via

8 Baicalein (5,6,7-trihydroxyflavone), a predominant bioac

9 Its effects were compared with those of baicalein (a flavonoid isolated from Scutellaria baicale

10 Baicalein, a 12-LO enzyme inhibitor, dose-dependently in

11 c acid, a pan inhibitor of lipoxygenases and baicalein, a selective inhibitor of 12-lipoxygenase, red

12 Among the active TCMs, we discovered that baicalein, a specific flavonoid from Scutellaria baicale

13 previously observed inhibition properties of baicalein against alpha-synuclein fibrillation.

14 d 23 is also a more selective inhibitor than baicalein against P-gp 170, because its cytotoxicity is

15 The present study demonstrated that baicalein alleviated the severity of TNBS-induced coliti

16 25 micro M for celecoxib, and 75 micro M for baicalein and indomethacin.

17 e most dominant being p-hydroxybenzoic acid, baicalein and kaempferol (T. aestivum), epicatechin and

18 The effect of two 12-LOX inhibitors, Baicalein and N-benzyl-N-hydroxy-5-phenylpentamide (BHPP

19 Baicalein and phenidone attenuated the increase in 12-HE

20 Both baicalein and phenidone attenuated the protective effect

21 genin and is responsible for biosynthesis of baicalein and scutellarein in roots and aerial parts of

22 These observations suggest that baicalein and similar compounds may have potential as th

23 n the presence of the lipoxygenase inhibitor baicalein and/or exogenous 12(S)HETE.

24 also blocked by inhibitors of lipoxygenases (baicalein) and CYP4A (17-octadecynoic acid), but not of

25 w here that low micromolar concentrations of baicalein, and especially its oxidized forms, inhibit th

26 esence of LOX inhibitors (NDGA, AA-861, CDC, baicalein, and PD146176) vs. vehicle-treated and mock-tr

27 Three compounds, apigenin, baicalein, and quercetin, decreased Gli1 mRNA concentrat

28 Acetylated compounds are more toxic than baicalein, and their potency against cell growth is comp

29 ore propose that resveratrol, genistein, and baicalein are attractive candidates for improved chemoth

30 dy provided evidence for the first time that baicalein attenuated TNBS-induced colitis, at least in p

31 Progressively adapted baicalein (BLN)-resistant parasites (pB(25)R) show overe

32 Baicalein blocked EGF-dependent translocation and activa

33 roxyeicosatetraenoic acid in the presence of Baicalein blocked loss of pRB, whereas 12(S)-HETE alone

34 oncert with these results, apigenin, and not baicalein, blocked the localization of MUC1-C to the nuc

35 At the upstream level, baicalein bound to the hydrophobic region of the myeloid

36 eicosatetraynoic acid) and lipoxygenase (LO; baicalein) but not cyclooxygenase (indomethacin).

37 elivery of inhibitors targeting 12-LOX (CDC, Baicalein), but not 5-LOX (Zileuton) dose-dependently at

38 In disaggregation baicalein causes fragmentation throughout the length of

39 atment and prevention abilities of apigenin, baicalein, curcumin, epigallocatechin 3-gallate (EGCG),

40 notoxic effects, resveratrol, genistein, and baicalein did not cause mutagenesis, which is a major si

41 he results indicate that alkylation of R5 of baicalein does not have a major impact on the interactio

42 In vitro, baicalein down-regulated the TLR4/MyD88 signaling cascad

43 In the presence of baicalein, EGF triggered an asymmetric phosphorylation o

44 s fisetin, luteolin, quercetin, eriodictyol, baicalein, galangin and EGCG, and the synthetic flavonoi

45 of 12(S)-HETE protected both cell lines from Baicalein-induced apoptosis, whereas other LOX metabolit

46 It has been known that baicalein induces the formation of alpha-synuclein oligo

47 The flavonoid baicalein inhibits fibrillation of alpha-synuclein, whic

48 Baicalein is a flavonoid with antioxidant properties; up

49 of SbCYP82D1.1 is knocked down, baicalin and baicalein levels are reduced significantly while chrysin

50 The impact of the baicalein modifications on activity against the growth o

51 However, little is known about the effect of baicalein on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-

52 Baicalein, one of the major flavones, was found to be re

53 , an effect reversed by the 12-LOX inhibitor baicalein or after chemical desensitization of local sen

54 Treatment with Baicalein or BHPP resulted in a dose-dependent decrease

55 Treatment with either Baicalein or BHPP resulted in significant apoptosis in b

56 was markedly abrogated in mice treated with baicalein or mice lacking 12-LOX.

57 Furthermore, Baicalein or N-benzyl-N-hydroxy-5-phenylpentamide, speci

58 They were then treated with either baicalein or phenidone, 2 selective 12-LO inhibitors.

59 with and without the LOX pathway inhibitor, baicalein, or lacking 12-LOX.

60 The 12-lipoxygenase blocker, baicalein, prevents epidermal growth factor (EGF)-induce

61 n molecules have been covalently modified by baicalein quinone to form a Schiff base with a lysine si

62 Furthermore, baicalein reduced NOD-like receptor 3 (NLRP3) inflammaso

63 Baicalein-stabilized oligomers are beta-sheet-enriched a

64 mbrane permeability tests suggested that the baicalein-stabilized oligomers had a mild effect on the

65 These baicalein-stabilized oligomers, added to the solution of

66 der to evaluate the structural properties of baicalein-stabilized oligomers, we purified oligomer spe

67 cts of Scutellaria baicalensis compared with baicalein suggest the synergistic effects among componen

68 well as celecoxib and indomethacin, but not baicalein, suppressed proliferation cell nuclear antigen

69 dants, including resveratrol, genistein, and baicalein, that are currently used or investigated for t

70 an autoinductive loop, and apigenin, but not baicalein, treatment was associated with down-regulation

71 The binding of baicalein was abolished by conversion of the Tyr residue

72 y contrast, the structurally related flavone baicalein was ineffective in blocking the formation of M

73 of micro-opioid inhibition by both 4-AP and baicalein was reduced.

74 The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to asse

75 ne or both, could enhance the interaction of baicalein with P-gp 170 as well as the amount of intrace

76 Baicalein, wogonin, and their glycosides are major bioac