ライフサイエンスコーパス: barbiturate

1 to physiological dependence on alcohol and a barbiturate.

2 AA Rs) by photolabelling with an anaesthetic barbiturate.

3 blocking GABA(A) receptors and was slowed by barbiturates.

4 se particular residues, as already shown for barbiturates.

5 l and medicinally relevant bi- and tricyclic barbiturates.

6 latile anesthetics, etomidate, propofol, and barbiturates.

7 functional features previously observed for barbiturates.

8 out the structural rearrangements induced by barbiturates.

9 of inhibition, may be important targets for barbiturates.

10 f compounds, including the neurosteroids and barbiturates.

11 arious barbiturate anions such as the parent barbiturate, 1,3-dimethylbarbiturate, 2-thiobarbiturate,

12 sized enantiomers of a novel, photoactivable barbiturate, 1-methyl-5-propyly-5-(m-trifluoromethyldiaz

13 d in detergent with [(3)H]azietomidate and a barbiturate, [(3)H]R-mTFD-MPAB, photoreactive anesthetic

14 nic acetylcholine receptor (nAChR), in which barbiturates act as noncompetitive antagonists.

15 nthase inhibitor oligomycin, indicating that barbiturates act by inhibiting electron transport suffic

16 e agonists, an inverse agonist, as well as a barbiturate agonist.

17 d a rapid block of currents activated by the barbiturate alone or by the barbiturate in the presence

18 Decerebrate unanaesthetized or barbiturate-anaesthetized preparations were used.

19 )) and saline-treated control hemispheres of barbiturate-anaesthetized, critical-period kittens (n =

20 Each of the barbiturate analogs inhibited the binding of [(3)H]tetra

21 he Torpedo californica nAChR and a series of barbiturate analogs to characterize the barbiturate bind

22 Likewise, 17PA did not affect barbiturate and benzodiazepine potentiation.

23 Barbiturates and benzodiazepine receptor agonists, for e

24 atments, including sedative anticonvulsants (barbiturates and benzodiazepines) and ECT.

25 ess central nervous system function, such as barbiturates and benzodiazepines, results in the product

26 many known modulators of GABA(A)Rs, such as barbiturates and benzodiazepines.

27 In both groups, stage 3 treatments (barbiturates and decompressive craniectomy) were used if

28 y drugs, such as the benzodiazepines (BDZs), barbiturates and ethanol.

29 iety of compounds including benzodiazepines, barbiturates and neuroactive steroids.

30 Barbiturates and neurosteroids augment GABA-currents and

31 nd yielded strong maximum effects similar to barbiturates and neurosteroids.

32 ventional bonded phase for the separation of barbiturates and phenylthiohydantoin amino acids (PTH-am

33 tentiating effects (like benzodiazepines and barbiturates), and interactions with dopamine transporte

34 he positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal.

35 Agents such as chloral hydrate, barbiturates, and benzodiazepines that have been used fo

36 ry drugs such as the benzodiazepines (BDZs), barbiturates, and ethanol.

37 We show here that general anesthetics, barbiturates, and local anesthetics all display the same

38 anesthetics, including etomidate, propofol, barbiturates, and neuroactive steroids, as well as volat

39 ic modulation by agents such as anesthetics, barbiturates, and neurosteroids, the cellular mechanisms

40 ng high individual doses of benzodiazepines, barbiturates, and propofol.

41 The results indicate that BZDs, barbiturates, and steroids, as well as GABA itself, are

42 drug proguanil, certain antidepressants and barbiturates, and the prototype substrate S-mephenytoin.

43 ed by anesthetic concentrations of propofol, barbiturates, and the volatile agent isoflurane, at low

44 of GABARs to regulation by benzodiazepines, barbiturates, and Zn2+.

45 ent depending on the ligand, indicating that barbiturate- and GABA-induced channel gating, antagonist

46 ailed to control RSE, the evidence points to barbiturate anesthesia as the next frequently used optio

47 Male rats under barbiturate anesthesia were used to determine whether ne

48 Under barbiturate anesthesia, pigs underwent placement of a) a

49 tensity, could not be obtained in rats under barbiturate anesthesia.

50 acid (R-mTFD-MPAB), a potent stereospecific barbiturate anesthetic, to photolabel expressed human al

51 ty, we recorded intracellularly in vivo from barbiturate anesthetized rats while increasing the veloc

52 In barbiturate anesthetized rats, microinjection of agonist

53 rized superficial dorsal horn neurons in the barbiturate-anesthetized cat spinal cord, and to determi

54 ts in response to 300 ms tones in the LSO of barbiturate-anesthetized cats using detection theory.

55 cordings in vivo in the barrel cortex of the barbiturate-anesthetized rat.

56 dynamic range and nociceptive specific) from barbiturate-anesthetized rats that were non-inflamed or

57 In seven barbiturate-anesthetized rats, 16 vasomotor presympathet

58 e constants (k2) of the reactions of various barbiturate anions such as the parent barbiturate, 1,3-d

59 The nucleophilic reactivities of barbiturate anions were compared with those of structura

60 The reactivity parameters N and sN of the barbiturate anions were derived from the linear plots of

61 We report that a barbiturate anticonvulsant, phenobarbital, alleviates th

62 Most barbiturates are anaesthetics but a few unexpectedly are

63 Most barbiturates are anaesthetics but unexpectedly a few are

64 The work shows that MMP-inhibitory barbiturates are suitable scaffolds for hybrid design, t

65 Barbiturates are widely used as anesthetics, anticonvuls

66 o general anesthetics and, as shown here, to barbiturates, at clinically relevant concentrations.

67 However, all of the barbiturates attenuated NMDA-induced calcium elevations

68 We describe a new type of barbiturate-based matrix metalloproteinase (MMP) inhibit

69 UT-1 mediated transport, are consistent with barbiturates being noncompetitive inhibitors of Glc tran

70 GABARs are regulated by numerous positive (barbiturates, benzodiazepines, and neurosteroids) and ne

71 receptor distinct from that interacting with barbiturates, benzodiazepines, and steroids.

72 To investigate how electronic effects impact barbiturate binding in bifurcated Hamilton receptors, a

73 Characteristics of the barbiturate binding site on the resting nAChR include: (

74 es helped us unambiguously identify a unique barbiturate binding site within the central ion channel

75 s of barbiturate analogs to characterize the barbiturate binding site(s) on this superfamily member.

76 esthetic that is well-suited for identifying barbiturate binding sites on Cys-loop receptors.

77 Interactions with these two classes of barbiturate binding sites on GABAA Rs underlie the enant

78 Benzodiazepines (BZ) and barbiturates both potentiate chloride currents through G

79 dy, we present the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC

80 steroid anesthetic, reduced sensitivity to a barbiturate, but not propofol.

81 ite of GABA(A) receptors are much safer than barbiturates, but are still liable to abuse.

82 However, unlike barbiturates BZ do not impair autonomic control of heart

83 pentobarbital induces complete uncoupling of barbiturate-BZD site interactions, partial uncoupling of

84 prepared and studied an analogous series of barbiturate C5-alkyl alcohols that were unable to releas

85 ve use of medications containing opioids and barbiturates, caffeine overuse, stressful life events, d

86 Decompressive craniectomy and barbiturate coma are often used as second-tier strategie

87 <20 mm Hg once the conventional therapy and barbiturate coma as outlined above failed to control int

88 of the time and was more cost-effective than barbiturate coma in 78% of cases if our willingness-to-p

89 consultations, mannitol use, treatment with barbiturate coma, decompressive craniectomy, number of n

90 1.5 quality-adjusted life years relative to barbiturate coma, with an incremental cost-effectiveness

91 res decreased in those patients treated with barbiturate coma.

92 alue in terms of costs and health gains than barbiturate coma.

93 nt strategies: decompressive craniectomy and barbiturate coma.

94 ntre trial is currently comparing it against barbiturate coma.

95 Barbiturates completly blocked alpha1G currents with pot

96 ach potentiated NMDA-induced neuron death at barbiturate concentrations relevant to clinical and expe

97 k of NMDA-induced current flux at millimolar barbiturate concentrations.

98 Several derivatives of barbiturates containing anomalous scatterers were synthe

99 AR-null cells indicating that FMR-Red-Dye, a barbiturate derivative, activates GABAAR-mediated outwar

100 phore to nitroalkenes, delivering the chiral barbiturate derivatives in high yields and high enantios

101 lude that the sites for binding steroids and barbiturates do not overlap with the GABA-binding site.

102 d the interactions of gender, adult age, and barbiturate dose on the course of phenobarbital inductio

103 ts into the regulation of gene expression by barbiturate drugs.

104 ptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure rec

105 iturates on NMDA neurotoxicity and show that barbiturate effects on neuronal mitochondria can be func

106 On the basis of the barbiturate effects we propose a model for the action of

107 ls, chromanes, cyclopentanoids, amino acids, barbiturates, etc., novel synthetic strategies emerge th

108 The structural heterogeneity of barbiturate, etomidate, and propofol derivatives is acco

109 Benzodiazepines (BZDs), anesthetics, and barbiturates exert their CNS actions by binding to GABA(

110 efold increase in the incidence of tumors in barbiturate-exposed rats of both sexes and a three- to f

111 mer concentration increases, selectivity for barbiturate extraction over other cyclic imides becomes

112 nesthetics, isomers of anesthetic ethers and barbiturates have been discovered that act as convulsant

113 When both midazolam and barbiturates have failed, use of isoflurane or ketamine

114 lton's bis(acetamidopyridinyl)isophthalamide-barbiturate hydrogen-bonding host-guest complexes are se

115 zing escalating bolus doses of diazepam, and barbiturates if necessary, significantly reduced the nee

116 activated by the barbiturate alone or by the barbiturate in the presence of 1 microM GABA.

117 arbonyls by SmI2-H2O, convert simple achiral barbiturates in one step to hemiaminal- or enamine-conta

118 ng rhodamine-123 under quenching conditions, barbiturates in this concentration range were shown to d

119 nity complexes of phenobarbital antibody and barbiturates, including the sequential loading, washing,

120 Barbiturates induce anesthesia by modulating the activit

121 he antagonistic effect of the peptide on the barbiturate-induced anesthesia (measure of the activatio

122 Barbiturate-induced anesthesia is a complex mechanism th

123 Barbiturate-induced mitochondrial depolarization was inc

124 In contrast, the same low dose of barbiturate inducing an equal percent increase in CYP2B2

125 th millimolar affinity, whereas propofol and barbiturates inhibit binding but do not bind in a mutual

126 Barbiturates inhibit GLUT-1 mediated hexose transport bo

127 In the present study, the mechanism by which barbiturates inhibit GLUT-1 mediated hexose transport wa

128 omidate in the alpha4 and beta3 subunits and barbiturate-inhibitable labeling by [(3)H]R-mTFD-MPAB in

129 binding site sheds light on the mechanism of barbiturate inhibition of cationic pLGICs and allows the

130 thin the channel, the pyrimidine ring of the barbiturate is located just above the highly conserved l

131 outine use of hyperventilation and high-dose barbiturates is no longer recommended.

132 For example, the barbiturate isobarbital [5-ethyl-5'-(2-methylbutyl) barb

133 ABAA receptor complex to control levels in a barbiturate-like fashion.

134 lecule adamantane, which prefers the TID (or barbiturate) locus instead of the TCP site.

135 were rechallenged with a nominal dose of the barbiturate, males and females neonatally exposed to phe

136 However, barbiturates may also inhibit mitochondrial respiration,

137 Overall, these results imply that barbiturates may more strongly inhibit GLUT-1 mediated G

138 We propose, therefore, that barbiturates may prevent or alter the conformational cha

139 -elements that are thought to be involved in barbiturate-mediated induction of CYP genes.

140 In multivariate models, use of barbiturates, meprobamates, phenothiazines, and lithium

141 ined the effects of propofol, etomidate, the barbiturate methohexital, and the steroid alphaxalone on

142 g AChR, probably by a steric mechanism; (iv) barbiturates modulate CrV binding to the resting AChR by

143 alone, but distinct from that obtained when barbiturates modulate the response to GABA.

144 amely, a stoppered thread (1) with a central barbiturate motif and an optimized doubly anthracene-ter

145 The cell-impermeant barbiturate N-glucoside amobarbital did not influence mi

146 Barbiturates offer an alternative antihypertensive thera

147 Although the effects of barbiturates on alphabetagamma isoforms, thought to domi

148 t cortical cultures to examine the effect of barbiturates on neuronal mitochondria and responses to N

149 Effects of barbiturates on neuronal mitochondria should be consider

150 cile previous reports of opposing effects on barbiturates on NMDA neurotoxicity and show that barbitu

151 We further compared the separation of barbiturates optimized by the T3C approach with that opt

152 ne did not interact with the benzodiazepine, barbiturate, or neurosteroid binding sites in the GABAAR

153 iabetes and subjects taking anticonvulsants, barbiturates, or steroids.

154 3 wt %, the selectivity of the extraction of barbiturates over similar molecules could be improved.

155 The barbiturate pentobarbital binds to gamma-aminobutyric ac

156 At high concentrations, the barbiturate pentobarbital opens GABA(A)R channels with s

157 At saturating GABA concentrations, the barbiturate pentobarbital substantially increased the am

158 TL) with a large effect on predisposition to barbiturate (pentobarbital) withdrawal to a 0.44 Mb inte

159 structural features similar to those of the barbiturate phenobarbital were synthesized; one DHPM use

160 as continued therapy, which was the case for barbiturates, phenytoin and valproate.

161 model of the desensitized state, showed that barbiturates preferentially stabilize the closed state.

162 The barbiturate prevented the increase of intrinsic tryptoph

163 At high concentrations, the barbiturates produce a channel blocking action that limi

164 Propofol, etomidate, and barbiturates produce profound amnesia and hypnosis, but

165 nes, ethanol, clomethiazole, antipsychotics, barbiturates, propofol, and dexmedetomidine) is detailed

166 anesthetic agents, nitrous oxide, ketamine, barbiturates, propofol, pentobarbital, phenobarbital.

167 g of beta3Met-227 in betaM1 by an anesthetic barbiturate, R-[(3)H]methyl-5-allyl-5-(m-trifluoromethyl

168 of a plasticized PVC membrane containing the barbiturate receptor (or host) creates a spatial concent

169 lic imides becomes better in the presence of barbiturate receptor and worse without receptor.

170 A barbiturate receptor has proven effective in improving s

171 r clips, molecular tweezers, and a synthetic barbiturate receptor.

172 Synthetic barbiturate receptors have been utilized for many applic

173 B), a photoreactive analog of the convulsant barbiturate S-MPPB, inhibits alpha1beta3gamma2 but poten

174 ulose use, rifaximin use, and benzodiazepine/barbiturate sedation.

175 Medications containing opioids and barbiturates should be reserved for a few selected cases

176 Barbiturates similarly amplified the effects of NMDA on

177 lline competes for binding at the steroid or barbiturate sites.

178 A difference in the barbiturate solute (substrate or guest) concentration in

179 ic and heteroaromatic systems present in the barbiturate substrates.

180 The barbiturates tested, secobarbital, amobarbital, and thia

181 inylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereoselective anesthe

182 zed and characterized a novel pair of chiral barbiturates that are capable of photolabelling their bi

183 assisted suicide by ingestion of prescribed barbiturates, the second involves withdrawal of artifici

184 s of three randomized trials of prophylactic barbiturate therapy for neonatal hypoxic-ischemic enceph

185 potent than the most potent clinically used barbiturate, thiopental, and its general anesthetic EC(5

186 In conjunction with the effect of a barbiturate to decrease the frequency of gamma oscillati

187 uscle length changes passively after using a barbiturate to suppress gamma-motor firing.

188 ult in fewer deaths, just as the change from barbiturates to benzodiazepines has reduced the number o

189 ic steroid) and pentobarbital (an anesthetic barbiturate) to directly activate recombinant GABAA rece

190 Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be

191 tive of an oxidative damage response only to barbiturate-type induction and probably related to 2B su

192 es to obtain spirocyclopropylpyrazolones and barbiturates, using iodosylbenzene (PhIO) or the combina

193 Potentiation by high concentrations of barbiturates was also reduced by 3beta-hydroxysteroids.

194 The response to the barbiturates was similar to that produced by GABA, altho

195 iatric illness, including benzodiazepines or barbiturates, was associated with chronic prescription o

196 The effects of the barbiturate were dose-dependent.

197 Other barbiturates were found to inhibit sugar flux in human e

198 electivity in solid-phase microextraction of barbiturates when doped into plasticized poly(vinyl chlo

199 Inhibition by barbiturates, which was pharmacologically specific and s

200 bility states in mice, including alcohol and barbiturate withdrawal and convulsions elicited by chemi

201 region as a gene that influences alcohol and barbiturate withdrawal convulsions.

202 CNS hyperexcitability, including alcohol and barbiturate withdrawal, involve MPDZ interaction with 5-

203 n of the unusual charge-separated pyridinium barbiturate zwitterion 2 from 1,3-dimethylbarbituric aci