ライフサイエンスコーパス: barrier

1 t more accurate response with the asymmetric barrier.

2 eropathogens may circumvent this physiologic barrier.

3 state (TS) and transfers the H(+) after the barrier.

4 a 6-kcal/mol higher dissociation free energy barrier.

5 lysis owing to the significant thermodynamic barrier.

6 ogenesis and in ensuring a tight blood-brain barrier.

7 unction in maintaining the kidney filtration barrier.

8 t complete the disruption of the blood-brain barrier.

9 egrity in AR, maintaining a leaky epithelial barrier.

10 the denuded basement membrane to reseal the barrier.

11 ing multiple spin states having little or no barrier.

12 ue compartment across the intact blood-brain barrier.

13 important relevance of an intact intestinal barrier.

14 s not anticipated to have a role in vascular barrier.

15 amine-N-oxide (TMAO) crosses the blood-brain barrier.

16 ional sliding away from transcription factor barriers.

17 change models and strategies to target these barriers.

18 emale life expectancy will break the 90 year barrier, a level that was deemed unattainable by some at

19 ss was examined under both favorable (energy barrier absent) and unfavorable (energy barrier present)

20 lso involved in the impairment of intestinal barrier after FMT.

21 cts, while concurrently providing a critical barrier against colonization by harmful bacteria.

22 nactivation in cancer removes an antioxidant barrier against DNA double strand breaks induced by TGFb

23 nsplantation (HSCT), posing as a significant barrier against the widespread use of HSCTs as a curativ

24 ally complete circumvention of the diffusion barrier, an array of 100 pores in 0.2cm(2) area of nail

25 , a polypeptide that crosses the blood-brain barrier and acts as a cognitive enhancer.

26 s a powerful means to bypass the blood-brain barrier and drive widespread distribution of therapeutic

27 his pathway has a force-sensitive activation barrier and is significantly accelerated by force.

28 Teflon membrane used as an additional proton barrier and light scattering layer.

29 oE is associated with an abnormal epithelial barrier and postulates that CS therapy, by reducing inna

30 interaction may protect kidney's filtration barrier and preserve kidney function.

31 PGA2 enhanced the EC barrier and protected against barrier dysfunction caused

32 m DFT calculations, and the simulated energy barrier and rate constants are consistent with experimen

33 ld be absorbed intact through the intestinal barrier and reach the blood stream to exert their physio

34 sport: the softer bonds lower the activation barrier and simultaneously decrease the prefactor of the

35 As) across the damaged glomerular filtration barrier and subsequent reabsorption by the downstream pr

36 oxymethyl cellulose film increased the water barrier and the TPC.

37 nsory neurons lie outside of the blood-brain barrier and therefore, compared to central neurons, may

38 The endothelium serves as a size-selective barrier and tightly controls the fluid exchange from the

39 R-143 and miR-145 on the cervical epithelial barrier and to elucidate the mechanisms by which these m

40 essantly swimming trypanosomes cross various barriers and confined surroundings, with concurrently oc

41 ing technologies, including current adoption barriers and expanded future demands based on demographi

42 t; perceived gaps in training provision; and barriers and facilitators to implementation of relevant

43 ) conducted a nationwide survey to determine barriers and opportunities for women and physicians with

44 l transfer of immunity can cross MHC class I barriers and that Th1 immunity can be imparted to Th2-bi

45 ssential for epithelia to function as tissue barriers and to control active tissue dynamics during mo

46 2Se3/graphene, exhibiting a tunable Schottky barrier, and In2Se3/WSe2, showing a significant band gap

47 ombined with the Zhang formula and parabolic barrier approximation) and spin-dependent drift-diffusio

48 mmadelta T cells located near the epithelial barrier are integral components of local inflammatory an

49 mposed by the formation of a simple physical barrier around the seed through which gas exchange and t

50 creening examination and patient navigation (barrier assessment and motivational education for patien

51 ation decreased the expression of urothelial barrier-associated protein, altered HA production, and i

52 integrity of the putative microtubule-based barrier at the filopodium base.

53 ptor dystroglycan forms a membrane diffusion barrier at the neck of the protrusion, which enables pro

54 framework demonstrates a lowered free energy barrier at the solid-solution interface in the presence

55 lysis indicates that the rectifying Schottky barrier at the tip-sample interface plays a critical rol

56 ivery to the brain, bypasses the blood-brain-barrier (BBB) and eliminates systemic side effects.

57 crobubbles (MB) causes localized blood-brain barrier (BBB) disruption that is currently being advocat

58 s are predictive for post-stroke blood brain barrier (BBB) disruption.

59 lls (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the leas

60 (11)C]-(R)-3 readily crosses the blood-brain barrier (BBB) in rodents and selectively binds to TrkB/C

61 Culture-based blood-brain barrier (BBB) models are crucial tools to enable rapid s

62 The blood-brain barrier (BBB) protects the brain from inflammation but t

63 vous system (CNS) compromise the blood-brain barrier (BBB) via increased vascular permeability, with

64 rs by direct delivery inside the blood brain barrier (BBB).

65 as border-like cells) provide an expendable barrier between roots and the environment.

66 cific role of mountain ranges as a dispersal barrier between South and Central American lowland plant

67 synchronization, which could remove temporal barriers between species and create novel interactions.

68 tural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular e

69 Here, by studying functional blood-retinal barrier (BRB) formation in mice, we found that immature

70 activation, iron deposition, and blood-brain barrier breakdown.

71 junction disassembly leading to endothelial barrier breakdown.

72 ptomatic G93A mice towards blood-spinal cord barrier (BSCB) repair.

73 cell death, ATG16L1 maintains the intestinal barrier by inhibiting necroptosis in the epithelium.

74 etina, endothelial cells form a blood-retina barrier by virtue of tight junctions and low transcytosi

75 mation and its correlation with clinical and barrier characteristics.

76 Three-dimensional Ehrlich-Schwoebel barriers converge as the step height is three atomic lay

77 vian fear conditioning under the blood-brain barrier crossing MMP inhibitor doxycyline in a pre-regis

78 ound lipid envelope leading to a severe skin barrier defect and premature death of newborn animals.

79 imal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitizat

80 Both mitochondrial and barrier defects were largely corrected by targeting Star

81 okine IL-22 plays a critical role in mucosal barrier defense, but the mechanisms that promote IL-22 e

82 The integrity of the barrier depends on spatial control of dynamics of actin

83 rature plasma probe (LTP) and the dielectric barrier discharge for soft ionization (DBDI).

84 In an atmospheric pressure surface barrier discharge the inherent physical separation betwe

85 Blood-brain barrier disruption (BBB) and release of toxic blood mole

86 of grey/white matter injury and blood-brain barrier disruption after ICH can be assessed with multim

87 in expression and processing contributing to barrier disruption and AD, and therefore we present nove

88 e (ARDS) is caused by widespread endothelial barrier disruption and uncontrolled cytokine storm.

89 for by age- or disease-specific blood-brain barrier disruption is unclear, and this is an important

90 E holoprotein does not cross the blood-brain barrier due to its size.

91 Finally, Rif1 acts as a barrier during somatic cell reprogramming, and its deple

92 nhanced the EC barrier and protected against barrier dysfunction caused by vasoactive peptide thrombi

93 transcriptomes demonstrated that epithelial barrier dysfunction in asthma is characterized by persis

94 clude that the complex nature of blood-brain barrier dysfunction in psychosis might be relevant to ma

95 ly could reverse alcohol-induced endothelial barrier dysfunction using both cultured endothelial cell

96 ced ABL1 activation in human VE cells and VE barrier dysfunction was ABL1-dependent.

97 nal pathology, as indicated by inflammation, barrier dysfunction, and visceral hypersensitivity (VH).

98 restored the TH1- and TH2-induced epithelial barrier dysfunction, respectively.

99 A perceived barrier, especially for pediatric oncology patients, is

100 ion that significantly lowers the activation barrier for C-OH bond cleavage from the metallocarboxyli

101 and target selectivity; however, the biggest barrier for its introduction into clinical use is its de

102 +/- 0.04 per cent) decreases the nucleation barrier for precipitation, thus enabling and stabilizing

103 actor, Ptbp1, revealed that it is a critical barrier for the acquisition of cardiomyocyte-specific sp

104 d reactivity of SiH2OO, i.e., the calculated barrier for the cyclization of SiH2OO is only 4.4 kcal/m

105 latent HIV-1 reservoir represents the major barrier for the development of an HIV-1 cure.

106 The calculated activation barrier for the highly exothermic reaction to a classica

107 the potential energy surface; there is a low barrier for the pseudopericylic [1,3]-NO shift, calculat

108 gastric environment creates a physiological barrier for using therapeutic drugs in the stomach.

109 RCCSD(T)/cc-pVDZ//UBLYP/cc-pVDZ free energy barriers for 1,4-H shifts at 298 K are consistently pred

110 tly predicted to be ca. 25 kcal/mol, whereas barriers for 1,5- and 1,6-shifts range from 6 to 28 kcal

111 dation pathway and present smaller enthalpic barriers for both epoxidation and H2O2 decomposition rea

112 inserted pore, yielding a force profile with barriers for membrane exit due to the membrane anchors.

113 This review summarizes the delivery barriers for nano-carriers presented in tumor microenvir

114 10RA expression directly correlates with IEC barrier formation and butyrate represses permeability-pr

115 ar bodies, which are essential for epidermal barrier formation.

116 mor progression, viral replication, and skin barrier formation.

117 The mechanical barrier formed by the polymerization of Si beneath the c

118 is requires the formation of homogeneous and barrier-free interfaces between the superconductor and s

119 s show a reduction in the methane activation barrier from 1.07 eV on Co(0001) to 0.87 eV on Co(2+) /C

120 be tightly linked to cell death to preserve barrier function and prevent tumour formation.

121 Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular

122 areas further exhibited impaired endothelial barrier function as illuminated by Evans blue leakage.

123 s pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxyd

124 audin-18 was sufficient to impair epithelial barrier function in 16HBE cells and in mouse airways.

125 ent, possibly indicating an impaired mucosal barrier function in allergic children.

126 vitro that physiologic levels of OSM impair barrier function in differentiated airway epithelium.

127 jor role for TRPV4 in Ca(2+) homeostasis and barrier function in human retinal capillaries and sugges

128 rtant for development and maintenance of the barrier function of the epidermis.

129 hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively

130 receptor NOTCH1 directly regulates vascular barrier function through a non-canonical, transcription-

131 st colonic epithelium and enhance epithelial barrier function through unclear mechanisms.

132 )physiology; from GI motility and epithelial barrier function to enteric neuroinflammation.

133 heir involvement in epigenetic regulation of barrier function were investigated.

134 n barrier integrity, including supplementing barrier function with moisturizers.

135 mpaired permeability to 100=complete loss of barrier function).

136 Immunity, intestinal barrier function, host metabolism and host-microbiota co

137 e in IBD development by enhancing intestinal barrier function.

138 tribute to the inner vs. outer blood-retinal barrier function.

139 assembly of adherens junctions and establish barrier function.

140 ls in endothelial cells compromises vascular barrier function.

141 which may in turn alter the protective skin barrier function.

142 We assessed barrier functions by the oral Lac:Man and the fecal zonu

143 In conjunction with these defensive barrier functions, immunomodulatory cross-talk between t

144 T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes;

145 hat habitat fragmentation owing to a natural barrier has resulted in strong genetic division of popul

146 NbOx is partly due to insufficient Schottky barrier height originating from interface defects betwee

147 A critical barrier hindering the application of transplantation str

148 lls controls the tissue microenvironment and barrier homeostasis.

149 atures and structural characteristics of low-barrier hydrogen bond (LBHB) formation are well document

150 generalized scaling, erythema, and epidermal barrier impairment.

151 the ability of anti-ZIKV drugs to cross the barrier.IMPORTANCE Recent outbreaks of ZIKV, a neglected

152 generate following injury represents a major barrier in cardiovascular medicine.

153 somatic cells overcomes an early epigenetic barrier in cellular reprogramming and facilitates the ge

154 he integrity and cohesion of the blood-brain barrier in several pathophysiological states.

155 recovered the destruction of the epithelial barrier in the differentiated Caco-2 cells in vitro.

156 ignificant role in maintenance of epithelial barrier in the intestine via regulation of apical juncti

157 We also revealed potential barriers in cross-seeding between three-repeat and four-

158 ersions but has to overcome high free-energy barriers in water.

159 kyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a single b

160 Fourth, disruption of the permeability barrier induced similar elevations in epidermal and seru

161 e how S. aureus directly influences the skin barrier integrity by stimulating endogenous proteolytic

162 e host inflammatory response and blood-brain barrier integrity dictate clinical outcomes.

163 d AD clinical strains of S. aureus) inducing barrier integrity impairment and tight junction damage.

164 ells and TH2 cells might decrease epithelial barrier integrity in AR, maintaining a leaky epithelial

165 to prevent AD are focusing on improving skin barrier integrity, including supplementing barrier funct

166 used no defects in epithelial proliferation, barrier integrity, or ultrastructure.

167 As expected, CD14 overexpression increased barrier integrity.

168 vity but do not obviously regulate epidermal barrier integrity.

169 ay critical roles patterning and maintaining barrier integrity.

170 The outer blood-retina barrier is established through the coordinated terminal

171 The glomerular filtration barrier is known as a 'size cutoff' slit, which retains

172 The (H2O)3Ne + H2O ring insertion barrier is sufficiently large, such that evaporative hel

173 ce of this strong collecting duct epithelial barrier is unresolved.

174 Cell invasion across basement membrane barriers is important in both normal development and can

175 (TFMG), which acts as an effective diffusion barrier layer with low electrical contact resistivity, o

176 Our data demonstrate that barrier leakiness in asthmatic patients is induced by TH

177 ES and tight junction disruption, making the barrier leaky), in the testis in vivo We report our find

178 ters in the liquid phase, melting is instead barrier-less and limited by buoyancy-driven convection.

179 The barrier-less route to the cyclic 1,2,4,7-cyclooctatetrae

180 n of physiological functions locally, at the barrier level, and systemically.

181 In conjunction with slight barrier lowering, these two effects are sufficient to ex

182 nate the timing of both vascular pruning and barrier maturation.

183 estimates of Gd-DTPA transport across these barriers might be useful to estimate local DOX concentra

184 -human, in vitro, 3-dimensional, blood-brain barrier model exemplifies tight-junction integrity.

185 Europe, but to achieve this, the identified barriers must be overcome.

186 These barriers need to be addressed to ensure the continued de

187 ntiptycene groups with a much lower rotation barrier of 6.5 kcal mol(-1) at 298 K in spite of the bul

188 rder of 10(-4) s(-1) despite an experimental barrier of Ea =4.8 kcal mol(-1) and with only a shallow

189 The mucous barrier of our digestive tract is the first line of defe

190 as of the C-terminal helix; (iii) the energy barrier of phospholipid extraction from the membrane is

191 We measure the deprotonation/protonation barriers of 0.36 eV and find that molecularly bound wate

192 f protein complexes, mostly due to technical barriers of studying such closely related species.

193 ntrolled by stromal cells that construct the barriers of the CNS.

194 and provided close results for the reaction barriers of the two reaction steps.

195 d as the optimal care model, yet significant barriers often prevent its implementation.

196 nt built-in voltage of the PZT-LSMO Schottky barriers on applied magnetic field.

197 the tissue, it likely overcomes antioxidant barriers only within approximately 30 mum of the wound m

198 ite of damage through a breached blood-brain barrier or via brain lymphatics.

199 over many hours without the use of physical barriers or active drift-correction algorithms.

200 nce, fluorescence microscopy faces a 'colour barrier', owing to the intrinsically broad (about 1,500

201 To identify the effect of the dielectric barrier, ozone production curves corresponding to ten di

202 ding and function and determined blood-brain barrier passage of drugs and demonstrate target involvem

203 We prevent blood-brain barrier passage of DT through PEGylation, which polarize

204 formulation's ability to penetrate the mucus barrier passively.

205 ggest quantitative assessment of blood-brain barrier pathology as a clinically relevant predictive, d

206 enous (IV) route, which requires blood-brain barrier penetration.

207 rointestinal functions, including epithelial barrier permeability and motility.

208 ergy barrier absent) and unfavorable (energy barrier present) conditions in an impinging jet system.

209 Our work illustrates that large energetic barriers, prohibitive toward chemical reaction, may be o

210 Host immune and physical barriers protect against pathogens but also impede the e

211 f, and Heron Island) along Australia's Great Barrier Reef (GBR).

212 Our study in the Great Barrier Reef confirms for the first time that dugongs (D

213 nificant expression of genes related to skin barrier repair.

214 migration and in epidermal wound healing and barrier repair.

215 Thus suggesting barrier restoration has both a biochemical and physical

216 omponent, and both are necessary for optimal barrier restoration.

217 how that loss of PGANT4 disrupts the mucosal barrier, resulting in epithelial expression of the IL-6-

218 e caused damage to the intestinal epithelial barrier, resulting in increased permeability and subsequ

219 disorder of the renal glomerular filtration barrier, results in impairment of glomerular permselecti

220 The blood brain barrier separates the circulating blood from the extrace

221 optimal penetration through the blood-brain barrier should be considered even for patients without n

222 aging studies that have examined blood-brain barrier structure and function in schizophrenia and rela

223 A rotational barrier study was performed on eight tertiary biaryl 2-a

224 found that CRIg(+) TRMs formed a protective barrier surrounding pancreatic islets.

225 eologic formations and clay-based engineered barrier systems.

226 absorption regions separated by an electron barrier that blocks the transport of majority carriers t

227 ary apparatus and by formation of a physical barrier that controls passage of ions and macromolecules

228 f D is the time required to cross the energy barrier that dominates folding kinetics, known as the tr

229 a coli OMPs OmpLA and EspP creates an energy barrier that impedes membrane insertion.

230 n factor MxA represents an effective species barrier that must be overcome by zoonotic viruses.

231 nd pericytes encase the surface, acting as a barrier that regulates transport of molecules.

232 We have identified important barriers that confront academic surgeons pursuing basic

233 cale was associated with construction of 154 barriers that fragment stream habitats, increased depth

234 from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation ca

235 Distinct cellular barriers that protect primary human blood cells are like

236 ating immune surveillance at a specific oral barrier, the gingiva - a constantly stimulated and dynam

237 In considering implementation barriers, the argument is made that decision-makers focu

238 m the phenol to the peroxo ligand before the barrier; the other involves O-O homolysis, where the phe

239 zed according to the mechanical, water vapor barrier, thermal, and biodegradability properties.

240 o suppress leakage is to increase its energy barrier through four-way branch migration.

241 reversibly induced by overcoming the energy barrier through mild heating of the capsid, but little i

242 gh concentrations in the epithelial layer of barrier tissues, is selectively recognized by Mincle (Cl

243 he properties of macrophages in steady-state barrier tissues, outline the factors that shape their di

244 The lower barrier to access of makerspaces ameliorates the otherwi

245 A major barrier to achieving ambitious targets for global contro

246 While traditionally viewed as a barrier to axon regeneration, beneficial functions of th

247 oxic ocean likely, and would be a formidable barrier to biologic survival.

248 These findings identify a second inducible barrier to CNS entry at the GL.

249 ersists in memory CD4(+) T cells, creating a barrier to cure.

250 One significant barrier to efficacy may be the recruitment of myeloid-de

251 Z2 can penetrate the placental barrier to enter fetal tissues and is safe for use in pr

252 pentene or with the equally large activation barrier to form an alkoxy group via a carbenium-ion tran

253 ergence of resistant cancer cells is a major barrier to full cures.

254 ity responsible for their condition can be a barrier to greater acceptance of anti-obesity drugs as a

255 leading cause of allograft loss, and a major barrier to improving long-term outcomes after intestinal

256 ollen tube to the female gametes, a critical barrier to interspecific hybridization.

257 he endodermal cells and likely function as a barrier to limit transmembrane movement of apoplastic so

258 e model of prostate cancer, SIN3B provides a barrier to malignant progression.

259 hat has overcome the long-standing, stubborn barrier to microliter-scale peak volumes and achieved th

260 nderstood, the extent to which cost may be a barrier to monitoring in different settings is unclear.

261 The p53 transcription factor is a critical barrier to pancreatic cancer progression.

262 sin, native whey proteins present a physical barrier to para-casein aggregation.

263 iral proteins which help lower the energetic barrier to pore expansion.IMPORTANCE Influenza A virus i

264 anergy thus seems to function as activation barrier to prevent unwanted reactions against minor alle

265 ene expression to construct a 'species-like' barrier to reproduction between two otherwise compatible

266 Tuberculosis relapse is a barrier to shorter treatment.

267 s differentiation and, conversely, acts as a barrier to somatic-cell reprogramming.

268 ment of donor atoms, exhibits a large energy barrier to spin reversal (770.8 K) and magnetic blocking

269 ar DNA damage response (DDR) is considered a barrier to successful infection.

270 s that the actin cytoskeleton is the primary barrier to transcellular tunnel formation using a combin

271 ture senescence in primary cells, an initial barrier to tumor development.

272 As commercialization has lowered the barrier to using SRM and the awarding of the Nobel Prize

273 ology is partly implemented, but significant barriers to acceptance and adoption remain.

274 lly; socioeconomic, geographical, and ethnic barriers to accessing PC were observed.

275 as used to explore nurse identified sources, barriers to addressing, and consequences of fatigue.

276 ical concerns were also cited as significant barriers to ATS viability.

277 The barriers to cataract surgery were older age, greater dis

278 with each as well as current limitations and barriers to clinical implementation.

279 patient-, practitioner-, and system-related barriers to diabetes care may help reduce the risk of DR

280 genes, CYP6P9a, CYP6P9b, and CYP6M7, support barriers to gene flow that are shaping the underlying mo

281 The goal of this study was to identify barriers to HCC surveillance, using data from the Vetera

282 dress attitudinal, social, and accessibility barriers to health care.

283 The most frequently perceived barriers to mobilization were hemodynamic instability, h

284 e transitions originate from the presence of barriers to propagation and the excitation of topologica

285 The main barriers to the management of STIs reported were low com

286 commercialization of these devices requires barriers to their development to be overcome, such as th

287 ervention strategy (CIS) targeting prevalent barriers to timely linkage and sustained retention in HI

288 More research is needed to identify barriers to uptake of CBE at home and to develop effecti

289 nally consistent response with the symmetric barrier, to a slower but more accurate response with the

290 itute integral constituents of the NPC whose barrier, transport, and cargo release functionalities es

291 To overcome this barrier, we developed a synthetic-biology approach based

292 To overcome this barrier, we studied a natural experiment involving genet

293 To overcome these barriers, we developed a strategy to macroencapsulate is

294 ted emulsion coatings with improved moisture barrier, wettability and surface adhesion onto fruit sur

295 ical trainee is presented with a significant barrier when he or she attempts to suspend disbelief and

296 r green coffee quality evaluation, but faces barriers when applied to commercial roasted coffees due

297 n of immunoglobulins (Igs) across epithelial barriers, which is achieved via the polymeric immunoglob

298 ction curves corresponding to ten dielectric barriers with different effective thicknesses and therma

299 across both the blood-tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS

300 ells requires overcoming the plasma membrane barrier without harming the cell during the staining pro