ライフサイエンスコーパス: barrier function

1 mpaired permeability to 100=complete loss of barrier function).

2 CCM1 is an established regulator of vascular barrier function.

3 ance of epithelial cell properties including barrier function.

4 modulate RPE tight junctions and enhance RPE barrier function.

5 e in IBD development by enhancing intestinal barrier function.

6 and that Gc induced an increase in podocyte barrier function.

7 play a major role in the acute regulation of barrier function.

8 6, and a concomitant reduction in glycocalyx barrier function.

9 ria in both ileum and colon, and improve gut barrier function.

10 Nups are necessary but insufficient for NPC barrier function.

11 tribute to the inner vs. outer blood-retinal barrier function.

12 into airways, reflecting loss of epithelial barrier function.

13 play a major role in the acute regulation of barrier function.

14 r microenvironment while decreasing vascular barrier function.

15 to UC inflammation by disrupting epithelial barrier function.

16 ithelial integrity in vitro, and FP restored barrier function.

17 part of C12-HSL's effect on intestinal mucus barrier function.

18 orption, secretion, digestion and intestinal barrier function.

19 nd sphingosine-1-phosphate, which stabilizes barrier function.

20 required for receptor-regulated endothelial barrier function.

21 e deleterious effects of alcohol on alveolar barrier function.

22 assembly of adherens junctions and establish barrier function.

23 t mucosa, is an important contributor to gut barrier function.

24 and their possible influences on epithelial barrier function.

25 Claudins have a paracellular barrier function.

26 sociated with immune response and epithelial barrier function.

27 profilaggrin processing and normal epidermal barrier function.

28 of neutrophils, and improved the epithelial barrier function.

29 d changes in human microvascular endothelial barrier function.

30 ls in endothelial cells compromises vascular barrier function.

31 ular migration, ion transport and epithelial barrier function.

32 n angiography indicated normal blood-retinal barrier function.

33 These results suggest EMD may enhance barrier function.

34 structural proteins that contribute to skin barrier function.

35 regulates endothelial cell-cell adhesion and barrier function.

36 ne phosphatase 2, known to maintain vascular barrier function.

37 litis by promoting disruption of the mucosal barrier function.

38 n of apoptosis, and rapid and lethal loss of barrier function.

39 that either disrupt or stabilize endothelial barrier function.

40 al junctional complex and loss of epithelial barrier function.

41 duce villus injury and compromise intestinal barrier function.

42 otease overexpression and disruption of skin barrier function.

43 MD induced a significant increase of TER and barrier function.

44 ions (SSJ) which are required for intestinal barrier function.

45 , resulting in the disruption of endothelial barrier function.

46 merular capillary bed to maintain filtration barrier function.

47 desmosomes and contributes to the intestinal barrier function.

48 phology, reduces cell shedding, and improves barrier function.

49 ge may contribute to impaired ocular surface barrier function.

50 rphological abnormalities and restoration of barrier function.

51 r inflammation associated with decreased PEC barrier function.

52 which may in turn alter the protective skin barrier function.

53 derived cells contributed to IL-1R-dependent barrier function.

54 maintained vessel integrity, with no loss of barrier function.

55 maturation of the mucus layer, and improved barrier function.

56 genes that promote epidermal/epithelial cell barrier function.

57 r the inside-out or outside-in physical skin barrier function.

58 pression of N-cadherin in CHO cells promoted barrier function.

59 d-type controls did not differ in intestinal barrier function.

60 irectly coupled to NLS-cargo release and NPC barrier function.

61 ty is pivotal for the maintenance of mucosal barrier function.

62 olonic epithelium renewal and the epithelial barrier function.

63 had a direct, protective effect on podocyte barrier function.

64 wered regarding mechanisms disrupting normal barrier function.

65 GC-A/cGMP/PDE2 signaling impairs endothelial barrier functions.

66 s AJ localization and compromised epithelial barrier functions.

67 erved endothelial anticoagulant and vascular barrier functions.

68 hus span the entire timescales of biological barrier functioning.

69 is required for GPCR-mediated disruption of barrier function, a causal link between GPCR-induced cyt

70 e mucosa and delayed the recovery of the gut barrier function after exposure to mesenteric ischemia/r

71 Regeneration of skin's barrier function after injury requires temporally coordi

72 e glycosylation is thought to be involved in barrier function against microbes at mucosal surfaces.

73 and CD11c+ cells in constitutive epithelial barrier function against P. aeruginosa, with details dep

74 eviously we reported that corneal epithelial barrier function against Pseudomonas aeruginosa was MyD8

75 beta), tangle pathology (P-tau), blood-brain-barrier function (albumin ratio), and glial activation (

76 phenotype was associated with impaired skin barrier function and a defective stratum corneum, with S

77 essing, and the mouse had both impaired skin barrier function and a mild proinflammatory phenotype.

78 required for IGPR-1 to regulate endothelial barrier function and angiogenesis.

79 steine (Hcy) alters retinal endothelial cell barrier function and angiogenic potential via activation

80 sting that p120*VE-Cad interaction regulates barrier function and angiogenic sprouting through differ

81 n a quiescent state characterized by dynamic barrier function and antiadhesion against circulating le

82 roaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins fro

83 Barrier function and bacterial permeation studies that h

84 JAM-A serves many roles and contributes to barrier function and cell migration and motility, and it

85 Inhibition of these responses restored barrier function and circle retention and abrogated the

86 ent mice by preventing the disruption of gut barrier function and dampening cytokine-induced inflamma

87 ases associated with the maintenance of skin barrier function and demonstrate that perturbation of th

88 M3Dq mice, and tested the effects on colonic barrier function and electrogenic ion transport in Ussin

89 s (ECs) from Anxa2(-/-) mice display reduced barrier function and excessive Src-related tyrosine phos

90 bial communities, but also modulates mucosal barrier function and expression of pro- and anti-inflamm

91 Intestinal sections were assessed for barrier function and expression of tight junction protei

92 ine the relationship between early life skin barrier function and FA in infancy.

93 We measured epithelial barrier function and gastrointestinal motility in these

94 de polymorphisms in genes involved in tissue barrier function and glucose homeostasis.

95 s suggest that mast cells regulate epidermal barrier function and have a potential protective role in

96 l and mural cells and its impact on vascular barrier function and highlights an in vitro platform to

97 cts as a potent signaling molecule affecting barrier function and host defense.

98 d near or within genes that regulate mucosal barrier function and immune tolerance.

99 2 cell monolayers wherein acrolein decreased barrier function and increased permeability.

100 factors in the regulation of colonic mucosal barrier function and inflammation.

101 pithelial cells, the latter of which provide barrier function and innate immunity.

102 s skin lipids essential for maintaining skin barrier function and loss of ceramides may underlie infl

103 ytes are important for glomerular filtration barrier function and maintenance of size selectivity in

104 Macrophages enhanced barrier function and maturity of enteroid monolayers as

105 d (IA), which promotes intestinal epithelial barrier function and mitigates inflammatory responses.

106 new approaches for improvement of epithelial barrier function and novel biologicals used in the treat

107 es that brain endothelial microRNAs regulate barrier function and orchestrate various phases of the n

108 be tightly linked to cell death to preserve barrier function and prevent tumour formation.

109 entiated epithelial cells spread to maintain barrier function and recruit integrin-linked kinase to a

110 ic pathways predicted to increase intestinal barrier function and reduce intestinal inflammation.

111 stores glomerular endothelial glycocalyx and barrier function and reduces tissue inflammation in the

112 orced Tie2 suppression sufficed to attenuate barrier function and sensitize endothelium to permeabili

113 replicates the disruption of the epithelial barrier function and structure observed in HIOs colonize

114 o examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic

115 rt, we investigated the role of IGPR-1 in EC barrier function and the molecular mechanism of its acti

116 Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular

117 n effective weight-loss program improves gut barrier function and whether obese patients with or with

118 Mast cells perform important barrier functions and help control type 2 immune respons

119 pression of genes associated with intestinal barrier functions and mucosal immunity involved in micro

120 g arterial integrity, preserving endothelial barrier function, and a normal contractile SMC phenotype

121 ILC2 production of IL-13, improved GI tract barrier function, and a preserved graft-versus-leukemia

122 ion of the fecal microbiota, reduced mucosal barrier function, and altered epithelial proliferation m

123 mitochondrial integrity, enhance intestinal barrier function, and decrease inflammation.

124 tTJs are important for the maintenance of barrier function, and disruption of tTJ proteins contrib

125 le cilia and impaired mucociliary clearance, barrier function, and epithelial repair, demonstrating a

126 uction cell-autonomously, impairs epithelial barrier function, and induces immune cell infiltration,

127 ly identify the nature of the injury, repair barrier function, and limit the intrusion of pathogenic

128 in the intestinal immune system, epithelial barrier function, and other host features that are affec

129 N-cadherin in the mural cells led to loss of barrier function, and overexpression of N-cadherin in CH

130 ency led to a loss of endometrial epithelial barrier function, and pharmacological CD73 inhibition in

131 in maintaining lung cell survival, vascular barrier function, and proper host response to airway mic

132 enance of homeostatic signalling, preserving barrier function, and regulating energy production for c

133 bin and histamine, which disrupt endothelial barrier function, and sphingosine-1-phosphate, which sta

134 tibacterial immunity, maintaining epithelial barrier function, and supporting tissue repair.

135 e on the endothelium and reduced endothelial barrier function, and this effect was abrogated when Rac

136 1 signalling pathway that regulates vascular barrier function, and thus provide a mechanism by which

137 adhesion molecule that regulates endothelial barrier function, and transmembrane chemokines CX3CL1 an

138 Although defects in intestinal barrier function are a key pathogenic factor in patients

139 ever, the mechanisms that regulate epidermal barrier function are incompletely understood.

140 ew insight into how epithelial integrity and barrier function are maintained throughout cytokinesis i

141 f proteins that that control the endothelial barrier function are the RhoGTPases.

142 n, bowel wall edema, and impaired intestinal barrier function are thought to result in bacterial tran

143 areas further exhibited impaired endothelial barrier function as illuminated by Evans blue leakage.

144 o the formation of monolayers with decreased barrier function (as assessed by transendothelial electr

145 xpression in mural cells plays a key role in barrier function, as CRISPR-mediated knockout of N-cadhe

146 Skin barrier function, as measured by corneometry, pH, and tr

147 iquid interface cultures resulted in reduced barrier function, as measured by decreased transepitheli

148 Impairment of skin barrier function at birth and at 2 months precedes clini

149 y evaluated with parallel assessment of skin barrier function at disease flare, during antimicrobial

150 pathogenic sequence of disturbances in skin barrier function before or during the early development

151 n endothelial function by not only improving barrier function, but also inhibiting CC formation both

152 s a critical role in maintaining endothelial barrier function, but how this occurs remains unknown.

153 M did not affect tight junction integrity or barrier function, but it dose-dependently increased acet

154 that can induce cell contraction and loss of barrier function, but only if Galphai-mediated signaling

155 The transmembrane domain restores barrier function by catalysing the formation of a recept

156 The glomerulus exercises its filtration barrier function by establishing a complex filtration ap

157 s pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxyd

158 d sufficient to diminish alveolar epithelial barrier function by impairing the ability of claudin-18

159 Regulation of brain endothelial barrier function by microRNAs in health and neuroinflamm

160 Alterations in barrier function by OSM were reversible, and the viabili

161 ole in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA

162 However, disruption of endothelial barrier function by thrombin and histamine requires the

163 chymal transition and facilitated epithelial barrier functions by AJ localization of phosphorylated b

164 We assessed barrier functions by the oral Lac:Man and the fecal zonu

165 soluble permeability factors, and changes in barrier function can exacerbate tissue damage during dis

166 es, and their skin also maintained epidermal barrier function compared with wild-type mice.

167 te-derived macrophages were used to evaluate barrier function, cytokine secretion, and protein expres

168 bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate

169 vitro, they develop damage characterized by barrier function disruption and cell hypotrophy.

170 ts, genes that promoted epidermal/epithelial barrier function (eg, filament-aggregating protein [fila

171 ed in immunological regulation or epithelial barrier function, emphasizing the role of both mechanism

172 , hypermotility and impairment of filtration barrier function equally in primary podocytes derived fr

173 th delay or absence of pathology, and better barrier function, even at old ages.

174 educed their capacity to promote endothelial barrier function ex vivo.

175 ermore, quantification of spatially resolved barrier functions exists within a single assay, providin

176 ermine the role of sirtuin 1 (SIRT1) in skin barrier function, FLG expression, and development of AD.

177 at ROS signaling is critical for the loss of barrier function following genetic deletion of KRIT1.

178 cus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating

179 tic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggri

180 abnormalities in many aspects of epithelial barrier function have been identified.

181 Immunity, intestinal barrier function, host metabolism and host-microbiota co

182 ncy and delivery further impairs normal skin barrier functions (immune suppression, mechanical stress

183 In conjunction with these defensive barrier functions, immunomodulatory cross-talk between t

184 audin-18 was sufficient to impair epithelial barrier function in 16HBE cells and in mouse airways.

185 ent, possibly indicating an impaired mucosal barrier function in allergic children.

186 Impaired endothelial barrier function in apolipoprotein M-deficient mice is d

187 sophageal epithelium by impairing epithelial barrier function in association with loss of desmoglein-

188 ip between the cutaneous microbiome and skin barrier function in atopic dermatitis, show the impact o

189 crobiome diversity, clinical signs, and skin barrier function in atopic dogs before, during, and afte

190 vitro that physiologic levels of OSM impair barrier function in differentiated airway epithelium.

191 disease symptoms and disruption of critical barrier function in disorders such as inflammatory bowel

192 We measured skin barrier function in early infancy and related it to the

193 ty, and as a potential target for modulating barrier function in endothelial cells.

194 vo mechanisms involving impaired endothelial barrier function in experimental atherothrombosis.

195 t literature around the topic of hypoxia and barrier function in health and during disease.

196 jor role for TRPV4 in Ca(2+) homeostasis and barrier function in human retinal capillaries and sugges

197 oduction directly contributes to the loss of barrier function in KRIT1 deficient animals and cells, a

198 nd inhibitor of NF-kappaB signaling, rescued barrier function in KRIT1 deficient cells.

199 known as RABEX-5) severely impairs epidermal barrier function in mice and induces an allergic cutaneo

200 sic MYD88 signaling and sustaining epidermal barrier function in mice, and suggest that dysregulation

201 apacity, which may contribute to compromised barrier function in normal-appearing uninvolved psoriati

202 We found impaired nasal epithelial barrier function in patients with HDM-induced AR, with l

203 rotein-coupled receptor known to promote the barrier function in peripheral vessels.

204 mbly, it dramatically altered cell shape and barrier function in response to elevated contractility.

205 ase in permeability and impaired recovery of barrier function in response to tumor necrosis factor (T

206 ion signalling, cytoskeletal remodelling and barrier function in retinal microvasculature in vitro an

207 arch tool to study the mechanisms leading to barrier function in stratified epithelia and may facilit

208 y to evaluate the healing and restoration of barrier function in stratified human corneal epithelial

209 t junctions and preserving cell polarity and barrier function in the face of energetic stress.

210 rom arachidonic acid, decreasing endothelial barrier function in vitro In mice in vivo pharmacologica

211 VE-cadherin trafficking and thus endothelial barrier function, in settings of ALI.

212 by demonstrating that it protects epithelial barrier function independently of inflammasomes.

213 Alterations of the epithelial barrier function induced by EMD were investigated by ana

214 of NOTCH1 is sufficient to rescue defects in barrier function induced by knockout of NOTCH1.

215 ular processes, including loss of epithelial barrier functions, induction of apoptosis, and inflammat

216 haracterized by clinical dermatitis, loss of barrier function, inflammation, and fibrosis.

217 In this model, barrier function is compromised upon exposure to inflamm

218 Understanding endothelial barrier function is critical for vascular homeostasis.

219 sitization through the skin occurs when skin barrier function is disrupted by, for example, genetic p

220 engthens the notion that a proper intestinal barrier function is essential to sustain a healthy pheno

221 Our data indicate that barrier function is impaired and the localization of vas

222 but also in lesional skin with impaired skin barrier function is important, in order to explore the s

223 Epithelial barrier function is maintained by tight junction protein

224 lasmic Ca(2+) increases and acute changes in barrier function is missing.

225 We find that epithelial barrier function is not disrupted during cytokinesis and

226 For dexamethasone, skin barrier function is shown to rely on the combination of

227 Compromised gastrointestinal barrier function is strongly associated with the progres

228 Precise regulation of epithelial barrier function is therefore required for maintaining m

229 Endothelial barrier function is tightly regulated by plasma membrane

230 r this structure is related to the diffusion barrier function is unclear.

231 Impaired blood-retinal barrier function leads to macular edema that is closely

232 However, the skin's protective barrier function limits the delivery of NAs into skin af

233 laggrin mRNA and protein levels, compromised barrier function, marked ultrastructural change, and enh

234 Epithelial integrity and barrier function must be maintained during the complex c

235 fects of these three agonists on endothelial barrier function occur independently of Ca(2+) entry thr

236 The disruption of the intestinal epithelial barrier function occurs commonly in various pathologies,

237 hosphate-mediated enhancement of endothelial barrier function occurs independently of STIM1.

238 onger timeframes are required to restore the barrier function of aged skin following MN insertion, su

239 Strikingly, the epithelial barrier function of differentiated keratinocytes, compri

240 molecules (CAMs) play a central role in the barrier function of ECs.

241 hesive function of IGPR-1 contributes to the barrier function of ECs.

242 in, a critical regulator of the Rho-mediated barrier function of endothelial cells through microtubul

243 duced rapid and prolonged enhancement of the barrier function of epithelial monolayers that was depen

244 at-S specifically impaired the integrity and barrier function of glomerular endothelial cells selecti

245 The aim of this study was to evaluate the barrier function of platelet-induced epithelial sheets o

246 Disruption of the barrier function of skin increases transepidermal water

247 phospholipids to help maintain the essential barrier function of the bacterial OM.

248 rtant for development and maintenance of the barrier function of the epidermis.

249 ot be indiscriminate because of the critical barrier function of the epithelium.

250 thermore, vancomycin treatment increased the barrier function of the intestinal epithelium, thus prev

251 y-protective mechanisms and the host mucosal barrier function of the lower airways, combined with bot

252 reating transient micropores that bypass the barrier function of the skin.

253 l proteins that are involved in the physical barrier function of the stratum corneum and provide inna

254 inase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly du

255 mural cell-like phenotype that recapitulates barrier function of the vasculature.

256 hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively

257 tigens and by enforcing the integrity of the barrier functions of the gut mucosa.

258 Knowledge of the barrier functions of tricellular junctions (tTJs) are le

259 to deliver medications, its superb intrinsic barrier function often makes this route untenable at tim

260 trix stiffness, we measured endothelial cell barrier function on substrates mimicking the stiffness o

261 tion protein, but its contribution to airway barrier function or asthma is unclear.

262 offer advanced solutions to compromised skin barrier function, pharmaceutical delivery and wound dres

263 Endothelial cell (EC) barrier function plays a prevalent regulatory mechanism

264 ent with an ointment to maintain normal skin barrier function protected mutant mice from dermatitis o

265 ctive as SB203580 in stabilizing endothelial barrier function, reducing inflammation, and mitigating

266 ss of KRIT1 causes the subsequent deficit in barrier function remains undefined.

267 chondria in HCEnCs are critical for pump and barrier function required for corneal hydration and tran

268 icient phagocytosis, and stabilized enteroid barrier function revealed a coordinated response to ente

269 dant roles in various aspects of endothelial barrier function, RhoB specifically inhibits barrier res

270 din-18 is a determinant of airway epithelial barrier function that is downregulated by IL-13 and that

271 n for p190BRhoGAP in control of capillary EC barrier function that may also be important in acquired

272 receptor NOTCH1 directly regulates vascular barrier function through a non-canonical, transcription-

273 in signaling regulates endothelial metabolic barrier function through Cyp1b1 transcription.

274 ed that MCP-1 inhibition restores glomerular barrier function through influencing macrophage cathepsi

275 s critical for the maintenance of intestinal barrier function through promoting antipathogen response

276 S1P promotes cell spreading and endothelial barrier function through S1PR1-Galphai-Rac1 and S1PR1-Ga

277 st colonic epithelium and enhance epithelial barrier function through unclear mechanisms.

278 erin expression, and restored the epithelial barrier function to a nearly normal level.

279 sing agonists that can improve microvascular barrier function to ameliorate trauma-induced hypotensio

280 nstrained Newton's method and designed a log-barrier function to compute analytically intractable, po

281 )physiology; from GI motility and epithelial barrier function to enteric neuroinflammation.

282 dicate that HAT-L4 is important in epidermal barrier function to prevent body fluid loss.

283 Improved endothelial barrier function toward the entry of plasma LDL particle

284 ess impairs colon epithelium homeostasis and barrier function via different mechanisms along the cryp

285 HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675 by altering

286 Mucosal barrier function was measured by uptake of fluorescent d

287 Endothelial barrier function was promoted by CXCL12/CXCR4, which tri

288 nisms of intestinal epithelial transport and barrier function, we discuss how diarrhea can result fro

289 ribution of the Asn-25 glycan to endothelial barrier function, we generated an N25Q mutant form of PE

290 heir involvement in epigenetic regulation of barrier function were investigated.

291 ens and the latter with a role in epithelial barrier function, were DA in patients with SAR and contr

292 gnificantly influence epithelial/endothelial barrier function where increased fiber stiffness/density

293 pha.Kapbeta1 by RanGTP further abrogates NPC barrier function, whereas adding back Kapbeta1 rescues i

294 nregulated many genes involved in epithelial barrier function, which involves structural resistance t

295 y cyst formation and severe defects in renal barrier function, which led to death within 6-8 weeks.

296 TFV-DP concentrations, both equally impaired barrier function, while wound closure was more sensitive

297 phenotype that includes impaired intestinal barrier function with low grade chronic inflammation, hy

298 n barrier integrity, including supplementing barrier function with moisturizers.

299 te the TNF-alpha modulation of intestinal TJ barrier function with the use of in vitro and in vivo in

300 entiation and impaired glomerular filtration barrier function, with development of pericardial edema,