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1 elative to two axes: longitudinal and apical-basal.
3 S2 mutation in p85alpha leads to substantial basal activation of p110delta (>300-fold) and disrupts i
4 distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This w
5 eductase, could be involved in restoring GC1 basal activity and NO sensitivity because the Trx/thiore
6 (GABAA) receptor by the transmitter GABA and basal activity employing concatemeric ternary GABAA rece
7 ogical implications of these findings on the basal activity of opsins and the associated dark noise i
8 ting cord blood KIR3DL1 NK cells exhibited a basal alloreactivity against Bw4 target cells that incre
12 ms, we performed patch-clamp recordings from basal amygdala (BA) neurons in brain slices from mice wi
13 over, whole-cell patch clamp analysis of the basal amygdala to CeA projections showed that alcohol co
14 ic excitatory responses in both the mPFC and basal amygdala, indicating that they could convey contex
15 echnique, that wild-type pigs display both a basal and a Toll-like receptor-mediated ASL secretory re
18 This regulatory strategy conferred higher basal and Ca(2+)-dependent activity to CNbeta1, decreasi
19 BF2-bound enhancers and led to a decrease in basal and catecholamine-stimulated expression of brown f
20 ion led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential ro
21 activity in clonal MIN6 beta-cells increases basal and glucose-stimulated insulin secretion and Ca(2+
23 eceptors and IFN-stimulated genes had higher basal and IFN-induced expression in human and mouse cere
24 PAG microglia are sexually dimorphic in both basal and LPS-induced activation and contribute to the s
25 treated with Kindlin-2 siRNA showed enhanced basal and platelet-activating factor (PAF) or lipopolysa
26 nfluencing nTS neuronal activity and thereby basal and reflex cardiorespiratory function is unknown.
27 this study, we combined tree-ring width and basal area increment series from 40 trembling aspen (Pop
28 er deficit (CWD)] and competition (i.e. tree basal area) on tree mortality patterns, using extensive
31 Specific molecular features, including high basal ATPase activity, a unique aggregate binding domain
32 at in Drosophila melanogaster Cdk5 regulates basal autophagy, a key mechanism suppressing neurodegene
36 t that both mutants had wild type numbers of basal bodies and the flagellar motors were functional.
37 as significantly reduced at (tam)Arl13b(-/-) basal bodies, suggesting impairment of intraflagellar tr
38 tion of the maturation of a second flagellar basal body in late G1 phase, DNA replication in S phase,
42 venient alternative to, the labour-intensive basal-bolus insulin regimen for the management of hyperg
43 NOTCH3 signals constitutively in a panel of basal breast cancer cell lines and in more than one thir
44 CRISPR/Cas9 has no effect on the fitness of basal breast cancer cell lines or cell lines from six ot
45 V4 with GSK1016790A reduced viability of two basal breast cancer cell lines with pronounced endogenou
47 ously reported genes acting as activators of basal bud initiation, SPL4 acts as a suppressor for the
49 in both TP53-WT and mutant cells by reducing basal caspase-2 levels and preventing cleavage of MDM2 a
50 , estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid pregnen
51 is also phosphorylated by CDK1, and blocking basal CDK1-mediated S81 phosphorylation markedly suppres
55 he INTU gene is aberrantly elevated in human basal cell carcinoma (BCC), coinciding with increased pr
57 Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin
61 d that the Krt15 promoter marks a long-lived basal cell population able to self-renew, proliferate, a
64 basal-cell carcinomas, including those with basal-cell nevus (Gorlin) syndrome, need extended treatm
65 of two stem cell populations: the horizontal basal cells (HBCs), which are quiescent and held in rese
66 led cells include both proliferative globose basal cells as well as immature OSNs exhibiting the hall
68 ovide evidence that the p63(+)KRT5(+)KRT7(+) basal cells in this zone are the cells of origin for mul
69 ow but intermediate cells still gave rise to basal cells, whereas basal cells divided only into basal
74 matrix (ECM) in vascular homeostasis in the basal chordate Botryllus schlosseri, which has a large,
76 , Nlrp12 deficiency in mice caused increased basal colonic inflammation, which led to a less-diverse
77 r5(+) ISC self-renewal, but instead confer a basal competency by maintaining RSPO receptor expression
79 adiponectin, and NEFA concentrations, under basal conditions and during a hyperinsulinemic-euglycemi
82 Zonda displays an even distribution under basal conditions and, soon after starvation, nucleates i
83 largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and
84 luA2/3s are in a low-conductance state under basal conditions, and although present at synapses they
87 rolonged in PMCA1(cko) atrial myocytes under basal conditions, with Ca(2+) overload leading to even g
92 en, whereas fragmentation of the central and basal contents was seen frequently in larger cuticular d
95 geting alpha1D reduced the migration and the basal cytosolic Ca(2+) concentration of HCT116 colon can
99 s initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into da
100 ment (1% vs 8%, P < .0001) and larger median basal diameter (7 vs 8 mm, P < .0001) and thickness (1 m
102 ter from optic nerve), the mean (SD) largest basal diameter was 18.1 (1.9) mm and mean height was 8.2
103 (1000mg of DL-alpha-tocopheryl acetate/kg of basal diet) on physicochemical and fatty acid stability
104 fected by OSSN (6 vs 4; P = .12), mean tumor basal dimension (13 mm vs 8 mm; P = .11), and mean numbe
105 af with Src family inhibitors blocks growth, basal dimerization, and ERK activation in these cells.
106 among patients who were resistant to R-CHOP, basal DLBCL mutations did not disappear from cfDNA.
107 H-enhancement of evoked dopamine release and basal efflux is dependent on sigma receptor activation.
108 al-mesenchymal transition (EMT) inducers and basal-enriched molecules, while cluster of differentiati
109 l group had significantly higher OSDI score, basal epithelial cells density, stromal reflectivity and
112 y in breast luminal epithelial cells, not in basal epithelial or stromal cells, of BRCA1 mutation car
114 cal ES degeneration) and BTB function (i.e., basal ES and tight junction disruption, making the barri
120 ottle free choice protocol for 8 weeks), the basal firing rate and the excitability of LHb neurons in
122 neurons excite wake-promoting neurons in the basal forebrain (BF), and a reciprocal projection from t
123 neuronal loss in the cortex, hippocampus and basal forebrain and gliosis and microgliosis in the hipp
124 we found that electrical stimulation of the basal forebrain increased cortical choline transporter (
125 ence demonstrated that virtually all ChAT-ir basal forebrain neurons were also p75(NTR) -positive.
126 ally connected with the olfactory system and basal forebrain, as well as with the chemosensory and ba
127 e developed cholinergic neuronal loss in the basal forebrain, GABAergic neuronal loss in the cortex,
129 Among different sub-cortical structures, the basal ganglia (BG) has been investigated as a putative a
131 bjects, patients with PD and MCI had a large basal ganglia and frontoparietal network with decreased
133 ong been considered an interface between the basal ganglia and motor systems, and its ability to regu
135 results suggest that the PCC, thalamus, and basal ganglia are key components of a LC-noradrenergic a
136 hat D2 MSNs and specific circuits within the basal ganglia are preferentially vulnerable to HIV-1.
138 ependent plasticity in songbirds depend on a basal ganglia circuit, which actively generates vocal va
142 earning capacity depends on specific cortico-basal ganglia circuits that are affected by normal agein
143 were accordingly homogenous, with bilateral basal ganglia involvement (98%); the characteristic "put
144 lts reveal static properties of aged cortico-basal ganglia networks that introduce temporal limits to
145 , indicating a possible link between altered basal ganglia neurodevelopment and declined motor perfor
146 s indicate a potential evolutionary shift in basal ganglia neurotransmission in humans that may favor
148 cellular and circuit complexity involving a basal ganglia output structure, the entopeduncular nucle
149 sed in, and regulate the development of, the basal ganglia primodia from which many GABAergic neurons
150 tive, excitatory interneuron in the songbird basal ganglia that makes strong synaptic connections ont
153 nly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices.
154 e) generate pacemaker activity that controls basal ganglia, circuitry associated with habitual and co
155 t a novel computational model of the healthy basal ganglia, constrained by single unit recordings fro
156 However, it is known that dysfunctions in basal ganglia, including a reduced number of striatal ch
157 loration is induced by LMAN, the output of a basal ganglia-related circuit that also contributes a co
161 are composed of a single FtsZ, except in the basal glaucophytes, chloroplast division involves two he
164 scales with excess nutrient uptake over the basal growth requirement, and (3) redox production, whic
165 aining dogs underwent a hyperinsulinemic (4x basal) hyperglycemic clamp (arterial blood glucose 146 +
167 Functional SARD4 is required for proper basal immunity to the bacterial pathogen Pseudomonas syr
168 tide, a well-characterized elicitor of plant basal immunity, did not induce closure of hydathode pore
171 vestigate whether and how resveratrol alters basal inhibitory synaptic transmission and cocaine-induc
174 ing electron microscopy) and higher in vitro basal insulin release (2391 +/- 1342 and 1778 +/- 978 mu
175 d the first FXYD homologue in sea lamprey, a basal jawless vertebrate, which suggests small transmemb
176 ctional peri-implant epithelial sealing with basal lamina (BL) attachment at the interface of the imp
179 um that includes specialized taste buds, the basal lamina, and a lamina propria core with matrix mole
180 sence of basally migrating GC and a weakened basal lamina, whereas GC migration was minimal in DBP-FW
182 ar tachycardia substrate concentrated to the basal lateral LV, with marked epicardial predominance.
185 stem cells/progenitor cells residing in the basal layer of the olfactory epithelium are capable of r
192 ptiles, suggesting that it may exemplify the basal layout from which vertebrate pallial architectures
195 evels remained significantly higher than its basal level within the first 24 hours after ischemia ons
199 whereas Twist1 expression is associated with basal-like breast cancer (BLBC) with poor prognosis owin
201 gration and collaboration of Wnt pathways in basal-like breast cancer, where Ror2 provides a spatiote
202 and, in our data set, was highly enriched in basal-like breast cancers in young individuals of Africa
204 eding" was associated with increased risk of basal-like subtype [OR 4.17; 95% confidence interval (CI
205 ynergistically inhibits the proliferation of basal-like TNBC cells in vitro and attenuates tumor grow
209 d in decreased lipid droplet size, increased basal lipolytic rate and alterations in adiponectin and
211 kness in the basal septum (19-31 mm), severe basal LVOTO (70-120 mm Hg), and left atrial dilatation (
212 of H3K27me3 from adjoining areas of elevated basal marking into large well-demarcated genome domains.
213 ventional Dulbecco's modification of Eagle's basal medium (DME) produce no transformed foci when grow
214 m accounts for the fibrous topography of the basal membrane and allows for easy modulation of fiber s
217 Thus, mandelalide cytotoxicity depends on basal metabolic phenotype; cells with an oxidative pheno
218 also allow for maintenance of a normal fetal basal metabolic rate despite low fetal insulin and gluco
219 ntaneous DNA damage by alkaline comet assay, basal micronuclei levels, the number of large-scale chro
224 sts of differentiated luminal epithelial and basal myoepithelial cells, as well as undifferentiated s
225 mammary epithelial stem cell (MaSC) enriched basal/myoepithelial population and an increase in in vit
226 cells density, stromal reflectivity and sub-basal nerve tortuosity (p = 0.000, 0.014, 0.008, 0.002),
227 .002), less GSS score, BUT and number of sub-basal nerves (p = 0.0000, 0.026, 0.003) than controls.
232 t feathering was a significant factor in how basal paravians utilized arm, leg and tail function for
233 14-defficient proteasomes reduced both their basal peptidase activity and the stimulation by ATPgamma
234 The proteasomes lacking Usp14 had higher basal peptidase activity than WT 26S, and this activity
235 PP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and
236 remarkably reduced Ca(2+) leakage and lower basal phosphorylation levels of Ca(2+)-cycling proteins
237 fuse large B-cell lymphoma patients had high basal phosphorylation levels of most measured signaling
238 nesis of the Fn2-Fn2 interface increased the basal phosphorylation of Tie2, suggesting that the Fn2 i
239 ed effort be made into understanding whether basal photosynthetic capacity, Ea , Hd and DeltaS co-acc
241 bserved for the LCO nanoparticles, where the basal plane is greatly diminished to expose the edge sit
242 with an order that resembles the one in the basal plane of ice, it was proposed that lattice matchin
243 bdenum disulfide, where it is shown that the basal plane possesses uniform activity, while surface de
245 tained by subtraction of the activity of the basal-plane sites from results containing both basal-pla
246 on reaction (HER) activities at the edge and basal-plane sites of monolayer molybdenum disulfide (MoS
253 aluronic acid with a deep cave formed in the basal portion of each microneedle, into which BCG powder
254 s to the accumulation of mitochondria at the basal portion of the RPE, as identified by cytochrome C
255 ese biological features of Spirodela and its basal position in the monocot lineage, understanding its
257 tory elements (Atoh1 3' enhancer/beta-globin basal promoter) to direct expression of Clrn1 in hair ce
258 8%; overall survival [OS], 69%), followed by basal prostate cancers (10-year bRFS, 39%; DMFS, 73%; PC
260 rameters, lambda and xi, which represent the basal rate of puff generation and the recovery rate from
261 system presents a unique transition from one basal renewable resource-hydropower-to another based on
262 GCG, octreotide (OCT), and insulin (INS) for basal replacement; B) overnight saline (SAL) infusion fo
263 ts displayed impaired GINS complex assembly, basal replication stress, impaired checkpoint signaling,
265 e effect was observed only for mitochondrial basal respiration but not for the maximum respiratory ca
266 diator that inhibits HDAC activity, enhances basal Rgs10 expression in BV-2 microglia, suggesting tha
268 th maximal left ventricular thickness in the basal septum (19-31 mm), severe basal LVOTO (70-120 mm H
270 Following a 24 h recording to characterize basal sleep/wake parameters, mice were sleep deprived (S
272 mutation had a similar broadening effect on basal spike shape as deletion of Kv1.1; however, spike m
273 -deficient embryos display defects in apical-basal spindle orientation in delaminated embryonic neuro
274 eveals that PHF5A-Y36C has minimal effect on basal splicing but inhibits the global action of splicin
276 y, what signaling pathways are active in the basal state and the functional relevance of the observed
278 in the manifestation of an undifferentiated basal/stem cell-associated phenotype in human keratinocy
279 proximately 100-km-thick denser-than-average basal structure, our results support the hypothesis that
281 r rate of Her2 alterations than those of the basal subtype, suggesting that Her2 activity is also ass
290 nobacteria (class Sericytochromatia) that is basal to the Melainabacteria and Oxyphotobacteria All me
294 cterized HIV riboswitch and demonstrates the basal translation rate of authentic HIV RNA is regulated
297 tial for cochlear amplification in the stiff basal turn, possibly through maintaining cochlear partit
298 We find that Lin28a protein exhibits rapid basal turnover in neurons and that mitogen-activated pro
299 ogrammed necrosis, but not apoptosis, in the basal-type breast cancer cells mostly seen in TNBC tumor
300 the heritability of breast cancer subtypes (basal vs nonbasal) was estimated to be 0.436 (P = 1.5 x
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