ライフサイエンスコーパス: basal lamina

1 e intestine and remodeling of the intestinal basal lamina.

2 ry for regulation of the turnover of the RPE basal lamina.

3 to blood vessels, Bruch's membrane, and RPE basal lamina.

4 e involved in anchoring ColQ to the synaptic basal lamina.

5 ons affect anchoring of ColQ to the synaptic basal lamina.

6 essential for anchoring ColQ to the synaptic basal lamina.

7 owman's gland cells, which pile up above the basal lamina.

8 " endings directly contacting the epithelial basal lamina.

9 entripetally while remaining attached to the basal lamina.

10 and hippocampus, and show disruption of the basal lamina.

11 or protein constituents of the chick retinal basal lamina.

12 echanism for localizing AChE to the synaptic basal lamina.

13 sions but did not appear to have invaded the basal lamina.

14 binds free matrix that is not organized in a basal lamina.

15 XVIII are major constituents of the retinal basal lamina.

16 ed by SCs contacting axons in the absence of basal lamina.

17 defining the signaling pathway activated by basal lamina.

18 play additional roles in assembling synaptic basal lamina.

19 is to anchor asymmetric AChE in the synaptic basal lamina.

20 lar smooth muscle-like cells and a thickened basal lamina.

21 ring to an axon destined for myelination and basal lamina.

22 cells of the neural plate to the underlying basal lamina.

23 to contact both the lumenal surface and the basal lamina.

24 mes, hemidesmosomes, and the production of a basal lamina.

25 was observed uniformly in the microvascular basal lamina.

26 nd type VII collagen in basal epithelium and basal lamina.

27 tended footplates 6 hours after plating onto basal lamina.

28 s catalytic subunits of AChE to the synaptic basal lamina.

29 y binding epithelial cells to laminin in the basal lamina.

30 turn are closely associated with the gonadal basal lamina.

31 n localization in basal epithelial cells and basal lamina.

32 terized by thinning and fragmentation of the basal lamina.

33 here its collagenic tail anchors it into the basal lamina.

34 ipheral retina, however, generated an intact basal lamina.

35 his likely prevents their insertion into the basal lamina.

36 Q to ACHET or the insertion of ColQ into the basal lamina.

37 showed decreased invasion of a reconstituted basal lamina.

38 to be important for binding to the synaptic basal lamina.

39 retract from their usual positions along the basal lamina.

40 reased neural occupation of the perivascular basal lamina.

41 attach normal basal cells to the underlying basal lamina.

42 the bile ductule lumen or to the surrounding basal lamina.

43 elective and more permanent retention on the basal lamina.

44 holinesterase (AChE) molecules from skeletal basal lamina.

45 ynaptic regions that are in contact with the basal lamina.

46 gregate or engage axons and form only patchy basal lamina.

47 ch are major constituents of skeletal muscle basal lamina.

48 in which one daughter loses contact with the basal lamina.

49 in as well as invasive migration through the basal lamina.

50 oss of collagen IV, a principal component of basal lamina.

51 nd then develop into an oocyst on the midgut basal lamina.

52 ing the Schwann cell surface membrane to the basal lamina.

53 a fibronectin-rich stroma to a laminin-rich basal lamina.

54 s associated with a breach in the underlying basal lamina.

55 enic stem cells located beneath the myofiber basal lamina.

56 l transmission to other hosts is hindered by basal lamina, a tightly interwoven and virus-impenetrabl

57 Rather, our results indicate that the mature basal lamina acts as a physical barrier to HSV-1 infecti

58 ound that whereas the thickness of the outer basal lamina adjacent to the glial limiting membrane inc

59 Laminin, a component of the muscle fiber basal lamina, also induces AChR clustering.

60 al epithelial cellular interactions with the basal lamina and adjoining cells.

61 g cell requires concurrent interactions with basal lamina and an axon destined for myelination.

62 that colocalize with a robust deposition of basal lamina and basal lamina streamers, 7 days after in

63 reases in the integrity of the microvascular basal lamina and blood-brain barrier leakage.

64 erve as both stem cell and niche cell, (2) a basal lamina and concomitant vasculogenesis may be essen

65 inin-1 was essential in reconstituting a new basal lamina and could not be replaced by laminin-2 or c

66 Insoluble macromolecules of the basal lamina and deeper extracellular matrix may act as

67 on of FAK and paxillin increases as SCs form basal lamina and differentiate.

68 iprotein structures that attach epithelia to basal lamina and disassemble during migration and carcin

69 corneal epithelia were isolated without the basal lamina and either transfected with Rho-specific an

70 king the skeletal muscle, via an intervening basal lamina and epidermis (hypodermis), to the cuticle.

71 ved in proteins comprising components of the basal lamina and extracellular matrixes and in cell adhe

72 observed in other protein components of the basal lamina and extracellular matrixes; they may also b

73 e specific changes in the composition of the basal lamina and in astrocytic components of the NVU.

74 ina and matrix-matrix separation between the basal lamina and JCT.

75 separation between the endothelial cell and basal lamina and matrix-matrix separation between the ba

76 e deinhibition of laminin in the endoneurial basal lamina and may play an important role in the regen

77 regenerating muscle fiber to contact the old basal lamina and nerve terminal, growth of the nerve ter

78 Enhanced breakdown of collagen IV in the basal lamina and of fibrillar collagen I in the adjacent

79 physically separated from astrocytes by the basal lamina and responded only weakly to ATP.

80 These include a glia limiting membrane with basal lamina and similar associated organelles, includin

81 with age, namely, the thickness of the outer basal lamina and the increased numbers of splits in this

82 e cells are myogenic cells found between the basal lamina and the sarcolemma of the muscle fibre.

83 and link different skin layers together: the basal lamina and the underlying connective tissue.

84 CHO cells bound well to isolated sea urchin basal lamina and to purified laminin.

85 stroglycan, which anchor the membrane to the basal lamina and underlying cytoskeletal proteins.

86 neutrophils often paused before crossing the basal lamina and underlying pericytes that they also com

87 um that includes specialized taste buds, the basal lamina, and a lamina propria core with matrix mole

88 isplay only a very fragile attachment to the basal lamina, and exhibit signs of degeneration and tiss

89 itx2 expression, supports dissolution of the basal lamina, and prevents coloboma, whereas supplementa

90 hological alterations in uterine epithelial, basal lamina, and stromal endometrial subregions, and as

91 ents of the postsynaptic specialization, the basal lamina, and supporting Schwann cells during the pr

92 ct that all proteins typical for the retinal basal lamina are abundant in the vitreous body and a new

93 Sarcolemmal proteins and basal lamina are associated with the vacuolar membranes.

94 involved in the linkage between SCs and the basal lamina, are severely reduced in nerves of PMP22-de

95 2 may become trapped between the RPE and its basal lamina as sub-RPE deposits, possibly contributing

96 o epithelial skin layers, but not within the basal lamina, as occurs in other organisms.

97 mine their sites of synthesis during de novo basal lamina assembly in vivo, we localized their mRNA e

98 mice, confirming that collagen VI-dependent basal lamina assembly is a critical aspect of vessel dev

99 disruption of the laminin-2 organization and basal lamina assembly on Schwann cell-axon units.

100 Basal lamina assembly was also studied after disrupting

101 its proteins in the eye was determined, and basal lamina assembly was studied in vivo in two assay s

102 that these endfeet are the preferred site of basal lamina assembly.

103 othelial cell maturation, as well as reduced basal lamina assembly.

104 was present at the axon terminal and in the basal lamina associated with the primary gutter region,

105 Thus, basal lamina-associated LN-agrin is required for neuromu

106 Agrin, a basal lamina-associated proteoglycan, is a crucial nerve

107 ogliosis and widespread fragmentation of the basal lamina at the cortical surface.

108 aterals reached the epidermal surface of the basal lamina at the dermal-epidermal junction and then g

109 l cells and astrocyte endfeet separated by a basal lamina at their interface.

110 Formation of the synaptic basal lamina at vertebrate neuromuscular junction involv

111 at alpha4beta2gamma1 laminin in the synaptic basal lamina attaches to calcium channel, which in turn

112 Hypertransmission of light below the RPE-basal lamina band correlated with dissociated RPE.

113 e foci was preceded by thickening of the RPE-basal lamina band.

114 and submesothelial cells associated with the basal lamina beneath mesothelial cells and expressing ac

115 owed increasing numbers of splits, the inner basal lamina between endothelial cells and pericytes did

116 ctional peri-implant epithelial sealing with basal lamina (BL) attachment at the interface of the imp

117 quired for the development of SCs when their basal lamina (BL) is fragmentary, but not when it is mat

118 th ammonium hydroxide to expose the RPE cell basal lamina (BL).

119 cells, astrocytes, and pericytes embedded in basal lamina (BL).

120 became confluent 14 days after plating onto basal lamina but did not become confluent up to 21 days

121 were often noted to retain connection to the basal lamina by cytoplasmic stalks.

122 as also studied after disrupting the retinal basal lamina by intraocular injection of collagenase.

123 he present data demonstrate that the retinal basal lamina, by anchoring the neuroepithelial cells to

124 The disruption of the pial basal lamina caused the neuroepithelial cells to retract

125 s typical of smooth muscle cells including a basal lamina, caveolae, subsurface cisterns and dense bo

126 oes ectodomain shedding to become a synaptic basal lamina component.

127 eractions between growing axons and synaptic basal lamina components direct the formation of neuromus

128 uscular junction (NMJ) suggest that synaptic basal lamina components tell the returning axon where to

129 nates, changes in the gene expression of the basal lamina components, adhesion molecules, the tight j

130 tegrins serve as cellular receptors for many basal lamina components, we asked whether agrin interact

131 integrins are a major class of receptors for basal lamina components, we stained muscles with antibod

132 lieved to require ookinete interactions with basal lamina components.

133 This result provides genetic evidence that basal lamina composition is a determinant of integrin di

134 found that disrupting RG endfoot adhesion to basal lamina consistently results in C-R cell displaceme

135 distinct populations, one of which maintains basal lamina contact and temporally precedes the other,

136 neering of skin equivalents as well as other basal lamina-containing tissues.

137 tic insight into how the dystroglycan-linked basal lamina contributes to the maintenance of sarcolemm

138 ons in proteins associated with the synaptic basal lamina, defects in endplate development and mainte

139 Among TNF-alpha-converting MMPs, basal lamina degrading gelatinases are thought to play a

140 hotoreceptor degeneration, multilayered RPE, basal lamina deposits, and accumulations of monocytes/ma

141 ve epithelial-mesenchymal transformation and basal lamina disruption in the rat remnant kidney model

142 Basal lamina disruption of embryonic day 3 to 6 retinae

143 The basal lamina disruption was first detectable 1 hour afte

144 by exaggerated subcapsular spaces, breaks in basal lamina, dissociated cap cells, and an increased in

145 eys, suggesting that thickening of the outer basal lamina does not contribute to cognitive decline.

146 in late VAD embryos, and dissolution of the basal lamina does not occur at the optic fissure margin.

147 We show that in addition to facing the basal lamina, dystroglycan is found near the nodal matri

148 emonstrate that integrins anchor FSCs to the basal lamina, enabling FSCs to maintain their characteri

149 uscular junctions (NMJs) contain specialized basal laminas enriched for proteins not found at high co

150 urites on fibronectin, and motor neurites on basal lamina extract, avoid regions which contain substr

151 l paradigm was devised to remove the retinal basal lamina for defined periods of development: the bas

152 Basal lamina formation was not affected.

153 Par1b overexpression inhibits basal lamina formation, cell spreading, focal adhesion,

154 intracellular mediator of integrin-dependent basal lamina formation.

155 e vitreous body having a function in retinal basal lamina formation.

156 e dy/dy muscle which is defective for normal basal lamina formation.

157 Although the focal absence of basal lamina from renal vesicle stages ensures that both

158 ion of dystroglycan causes detachment of the basal lamina from the sarcolemma and renders muscle pron

159 nd shows discontinuities in the pial surface basal lamina (glia limitans) that probably underlie the

160 On shallow basal lamina gradients, the axons also showed a directio

161 The temporary absence of the basal lamina had dramatic effects on retinal histogenesi

162 resent experiments demonstrate that the pial basal lamina has an important function during brain morp

163 dependent defects during the assembly of the basal lamina have negative effects on both pericyte matu

164 ation that are associated with the capillary basal lamina have not yet formed.

165 II is, next to perlecan and agrin, the third basal lamina heparan sulfate proteoglycan (HSPG) and the

166 Perineurial cells produced surface basal lamina; however, endoneurial, epineurial, and meni

167 endent studies suggest may form an assembled basal lamina important for polarization.

168 leprae invasion of Schwann cells through the basal lamina in a laminin-2-dependent pathway.

169 receptor neurons (ORNs) to penetrate the CNS basal lamina in mice.

170 actin-associated complex in SCs adhering to basal lamina in the presence of axons.

171 idely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous sys

172 ating cells in the basal region close to the basal lamina in the sensory epithelium.

173 they are unlikely to have passed through the basal lamina in this form.

174 o investigate the importance of the vascular basal lamina in tumor blood vessel morphogenesis and fun

175 nted myofibers or their position beneath the basal lamina in unperturbed muscle tissue.

176 strated that the mast cells were deep to the basal lamina, in nests of glial processes.

177 integrity and composition of the endothelial basal lamina, inappropriate expression of embryonic vasc

178 r, the packing of epithelial cells along the basal lamina increases, but density is later restored by

179 A narrow sickle-shaped region containing a basal lamina-independent form of laminin exists in and a

180 estored the structural integrity of myofiber basal lamina, inhibited interstitial fibrosis, and ameli

181 ce molecule netrin 1 (Ntn1), which regulates basal lamina integrity in the fusion plate.

182 rtion of coll XVIII in Bruch's membrane, RPE basal lamina, intercapillary septa, and choriocapillaris

183 lie the initial formation of all specialized basal lamina interposed between other cell types.

184 is externalized and attached to the synaptic basal lamina interposed between the nerve terminal and t

185 nocarcinoma cell invasion through the normal basal lamina is attributable in part to metalloproteinas

186 Skeletal muscle basal lamina is linked to the sarcolemma through transme

187 are abundant in the vitreous body and a new basal lamina is only formed when the vitreous body was d

188 Basal lamina is present, neurons are healthy, and the in

189 CB(1)(HIGH) cells are closely related to the basal lamina labyrinths or fractones derived from subepe

190 rly MMP-9 and -2, can digest the endothelial basal lamina leading to BBB opening.

191 tween the intracellular cytoskeleton and the basal lamina, leading to progressive muscle wasting.

192 monstrate that a transient disruption of the basal lamina leads to dramatic and probably irreversible

193 taining alpha5 or beta2 chains are potential basal lamina ligands for these interactions.

194 expression, which prevented formation of the basal lamina-like matrix, resulted in marked reduction i

195 and collagens, which assemble into a unique basal lamina-like network that surrounds these cells.

196 layer of ectodermally-derived cells with the basal lamina lining the lumen of the vessel.

197 effector caspases, leading to remodeling of basal lamina lining tracheal cells associated with the i

198 vivo suggest a model in which Netrins in the basal lamina locally modulate and fine-tune the outgrowt

199 ssic EMT during which the PMCs penetrate the basal lamina, lose adherens junctions and migrate into t

200 e terminal retains contact with the synaptic basal lamina marked by cholinesterase staining even in t

201 tem cell niche formation along a free-moving basal lamina may prompt distorted epithelial morphologie

202 R56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is

203 for the deposition of UNC-52/perlecan in the basal lamina, nor for the initiation of attachment assem

204 choriocapillaris, Bruch's membrane, and RPE basal lamina of AMD choroids (P < 0.05) and completely n

205 are vascular mural cells embedded within the basal lamina of blood micro-vessels.

206 Collagen type IV is a major component of the basal lamina of blood vessels.

207 Nerves reach the basal lamina of developing taste papillae at E14 to dens

208 satellite cells were detected underneath the basal lamina of muscle fibers, indicating the self-renew

209 Neuregulin accumulation in the synaptic basal lamina of neuromuscular junctions occurred signifi

210 specifically to the native laminin-2 in the basal lamina of Schwann cell-axon units.

211 Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells

212 ses, MMP-2 and MMP-9, digest the endothelial basal lamina of the BBB, which is essential for maintain

213 s are major constituents of the gliovascular basal lamina of the blood-brain barrier (BBB); however,

214 ises from a tracheal branch that invades the basal lamina of the disc to juxtapose directly with disc

215 d that the collagenase dissolved the retinal basal lamina of the injected eye.

216 es with the degree of separation between the basal lamina of the inner wall endothelium and the JCT.

217 st likely involved virus movement across the basal lamina of the midgut into the hemocoel.

218 linesterase (AChE) molecules attached to the basal lamina of the neuromuscular junction (NMJ) suggest

219 tylcholinesterase (AChE) are anchored in the basal lamina of the neuromuscular junction using a colla

220 hed at later stages of development, the pial basal lamina of the newly developing neuroepithelium in

221 a thin densely packed layer external to the basal lamina of the retinal pigment epithelium (RPE) onl

222 The basal lamina of the RPE, inner collagenous layer, and el

223 gment epithelial cells colocalizing with the basal lamina of the RPE.

224 junction, asymmetric AChE is anchored to the basal lamina of the synaptic cleft, where it hydrolyzes

225 llagen-tailed AChE molecules on the synaptic basal lamina of the vertebrate NMJ and suggest that thes

226 e that c-met receptor is present beneath the basal lamina on presumptive satellite cells in intact mu

227 that as basal keratinocytes migrate from the basal lamina onto the dermal matrix contact with native

228 bers and may be associated with the synaptic basal lamina or the terminal Schwann cell.

229 myofilament proteins within the cell to the basal lamina outside the cell, rendering the sarcolemma

230 the long-range spread of CNS-1 glioma along basal lamina pathways but enhances local infiltration of

231 ated at the NMJ, including components of the basal lamina, post-synaptic membrane and post-synaptic c

232 it the midgut epithelium to reach the midgut basal lamina, processes collectively known as midgut inv

233 The basal lamina produced by peritubular myoid and Sertoli c

234 ase in capillary diameter, remodeling of the basal lamina, proliferation and migration of endothelial

235 The synaptic basal lamina protein agrin is essential for the formatio

236 ent preservation of the cerebral microvessel basal lamina protein laminin, and the tight junction pro

237 showed that the expression pattern of every basal lamina protein mRNA in the developing eye is uniqu

238 The only basal lamina protein that is synthesized by the neural r

239 as evident by the fragmented distribution of basal lamina proteins at the pial surface of the midbrai

240 Laminin and collagen type IV, other basal lamina proteins commonly found colocalized with Pl

241 omplete basal lamina that included all known basal lamina proteins from chick embryos, such as lamini

242 te from extraretinal tissues infers that the basal lamina proteins have to be shed from the lens, opt

243 extraretinal tissues infers that the retinal basal lamina proteins must be shed from their tissues of

244 That most retinal basal lamina proteins originate from extraretinal tissue

245 Integrity of the underlying basal lamina provides cellular signals that maintain the

246 wann cell proliferation and transcription of basal lamina receptor genes, both necessary for radial s

247 The basal lamina regenerated after chasing the collagenase w

248 Finally, basal lamina regeneration was associated with aberrant a

249 nhibitor that did not directly contribute to basal lamina regeneration.

250 When the stem cell niche forms along a rigid basal lamina, relatively regular morphologies are mainta

251 mental and pathogenic processes that involve basal lamina remodeling.

252 protein of TLR and IL-1R signaling, but the basal lamina represents the final barrier to bacterial p

253 ir apical surfaces laterally relative to the basal lamina, resulting in further laterally directed ev

254 cells that lie between the muscle fiber and basal lamina (satellite cells) are activated, proliferat

255 eccrine gland, and in the basement membrane/basal lamina separating epithelial and mesenchymal compo

256 at has been altered structurally and along a basal lamina sheath to reinnervate synaptic targets.

257 r results were obtained using empty myofiber basal lamina sheaths produced by mechanical or freeze-th

258 sitive cells lose their association with the basal lamina, shift apically, and differentiate into sus

259 he extracellular matrix (ECM) incorporates a basal lamina significantly denser than the loosely organ

260 d by the presence of hemorrhage and vascular basal lamina sleeves lacking endothelial cells.

261 tin filaments but no myosin, a discontinuous basal lamina, sparse rough endoplasmic reticulum, many m

262 with a robust deposition of basal lamina and basal lamina streamers, 7 days after injury within epice

263 complex (DGC) and laminin in skeletal muscle basal lamina, such that disruption of this bridge result

264 ed, and numerous axon-SC profiles show loose basal lamina, suggesting altered interactions of the gli

265 n these mutant mice, the organization of the basal lamina surrounding developing follicles is severel

266 cell bodies of the oligodendrocytes abut the basal lamina surrounding the capillary, so that the norm

267 tained using antibodies directed against the basal lamina surrounding the vasculature as well as anti

268 subchains were also expressed by the de novo basal lamina synthesized by prostate carcinoma, the gamm

269 chase by forming a morphologically complete basal lamina that included all known basal lamina protei

270 l neuromuscular junction is organized by the basal lamina that occupies the synaptic cleft.

271 and concentrated in the small portion of the basal lamina that passes through the synaptic cleft at t

272 Satellite cells are situated beneath the basal lamina that surrounds each myofiber and function a

273 ells: muscle stem cells resident beneath the basal lamina that surrounds each myofiber.

274 lls reside as quiescent cells underneath the basal lamina that surrounds muscle fibres and respond to

275 The assembly of the retinal basal lamina then occurs by the binding of these protein

276 ellular yolk particles penetrate the gonadal basal lamina to directly touch the underlying oocytes.

277 Schwann cells interact with neurons and the basal lamina to myelinate axons using known receptors, s

278 mall pores forming conduits from the gonadal basal lamina to the surface of the oocyte, passing throu

279 Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystroph

280 s and axonal pathways were observed when the basal lamina was disrupted at a later stage of embryonic

281 mina for defined periods of development: the basal lamina was dissolved by injecting collagenase into

282 protein composition of the embryonic retinal basal lamina was investigated, the site of synthesis of

283 milar to the invaginations found in a native basal lamina was laser machined into the surface of a po

284 However, the regenerated basal lamina was located deeper in the retina than norma

285 Although the disrupted basal lamina was not reestablished at later stages of de

286 With further development, the retinal basal lamina was not reestablished; newly developing neu

287 The basal lamina was reconstituted within 6 h.

288 ce of collagen VI, the width of the vascular basal lamina was reduced twofold.

289 The mesh size of the RPE basal lamina was smaller than the particles, and it appe

290 rm, depends on cells losing contact with the basal lamina when they divide.

291 l-2(+) cells were found to reside within the basal lamina, where satellite cells are normally found.

292 sence of basally migrating GC and a weakened basal lamina, whereas GC migration was minimal in DBP-FW

293 apoptosis and extrusion of cells through the basal lamina, which are then engulfed by blood-borne pha

294 B (MMP-9) are able to digest the endothelial basal lamina, which plays a major role in maintaining BB

295 on, exposing the underlying collagen IV-rich basal lamina, which promotes both intravascular thrombos

296 aled that the collagenase disrupted the pial basal lamina, which was evident by the fragmented distri

297 These novel microfabricated analogs of the basal lamina will help to elucidate the influence of top

298 , we test the prediction that removal of the basal lamina will increase the average oscillation perio

299 By correlating the disruptions in the pial basal lamina with changes in the morphology of radial gl

300 ach was used to produce novel analogs of the basal lamina with complex topographic features.