ライフサイエンスコーパス: basal transcription

1 rall bursting pattern of the promoter during basal transcription.

2 eral transcription factor TFIIB) to initiate basal transcription.

3 ogene has been shown to be essential for RET basal transcription.

4 33 binds to the beta flap and represses this basal transcription.

5 including these Sp1 sites was necessary for basal transcription.

6 decreased expression of genes implicated in basal transcription.

7 f putative cis-acting elements essential for basal transcription.

8 the 1,25(OH)2D3 response and is involved in basal transcription.

9 tor-P.85 works mainly by stimulating overall basal transcription.

10 ylation of nonhistone proteins necessary for basal transcription.

11 n, independent of its general stimulation of basal transcription.

12 omoter that uses a canonical Sp1 element for basal transcription.

13 ption-coupled nucleotide excision repair and basal transcription.

14 be a major mechanism of mitotic silencing of basal transcription.

15 hat is unique to the rabbit promoter repress basal transcription.

16 s involved in nucleotide excision repair and basal transcription.

17 element binds homodimeric c-jun and mediates basal transcription.

18 promoter between bp -394 and bp -330 directs basal transcription.

19 riptional activation by ER, without altering basal transcription.

20 he kinase of the P-TEFb complex, involved in basal transcription.

21 was originally identified as an inhibitor of basal transcription.

22 nd a TATA box at -26, which is essential for basal transcription.

23 TTD are the result of a subtle deficiency in basal transcription.

24 deletion of this segment no longer inhibits basal transcription.

25 the probasin promoter elements necessary for basal transcription.

26 articipant in nucleotide excision repair and basal transcription.

27 ied as an inhibitory site for Sp1/Sp3-driven basal transcription.

28 ymerase loaded but unmelted and support only basal transcription.

29 hanism of cell-cycle-dependent regulation of basal transcription.

30 catalytic activity of Cdc28 is important for basal transcription.

31 In this manner, TAFs kinetically repress basal transcription.

32 extensively coat DNA and essentially silence basal transcription.

33 tch between these two pathways by repressing basal transcription.

34 TBP is in effect ambidextrous with regard to basal transcription.

35 naschii (Mja) TBP do not completely abrogate basal transcription.

36 on in the presence of RA and at the level of basal transcription.

37 e and containing tRNA genes and activator of basal transcription 1 (Abt1), a protein-coding gene that

38 ) gp55-RNAP and the T4 late promoter execute basal transcription; (2) gp55-gp33-RNAP and the T4 late

39 TN4 (full length) and ACTN4 (Iso) potentiate basal transcription activity and directly interact with

40 CAK subunit, thereby decreasing the in vitro basal transcription activity of TFIIH itself and impedin

41 all the elements necessary to achieve strong basal transcription activity were located within the pro

42 ansactivation domain and were able to rescue basal transcription after squelching by the AR polypepti

43 anifested as hTAF(II)-mediated inhibition of basal transcription and a consequent TRAP requirement fo

44 proximal sequence element (PSE) required for basal transcription and a distal sequence element (DSE)

45 TFIID supports basal transcription and activated transcription, both of

46 rt site, consists of a core region directing basal transcription and an activating region that recrui

47 coid response element (GRE) of XMRV impaired basal transcription and androgen responsiveness.

48 adiation, while BD-group members show higher basal transcription and are not induced by ionizing radi

49 ition to snRNPs, they are highly enriched in basal transcription and cell cycle factors, the nucleola

50 cated in transcription-coupled repair (TCR), basal transcription and chromatin remodeling.

51 anscription factor TFIIH is involved in both basal transcription and DNA repair.

52 We also showed that FOXO1 repressed basal transcription and gonadotropin-releasing hormone (

53 the transcription factor Sp1 is required for basal transcription and LPS-induced expression of the Da

54 at Hsf1 nuclear export immediately decreased basal transcription and mRNA expression of 18 genes, whi

55 TFIIH has two functions, in basal transcription and nucleotide excision repair.

56 FIIB can bypass the Mediator requirement for basal transcription and pol II recruitment in nuclear ex

57 (in the reverse ATTGG orientation) repressed basal transcription and progesterone-induced transcripti

58 sed transcriptional factors involved in both basal transcription and signal transduction activation o

59 all three GC boxes are required to maintain basal transcription and to obtain maximal induction of t

60 lso significantly reduces activated, but not basal, transcription and add-back of the highly purified

61 8 to +22 relative to A(+1) are important for basal transcription, and a region from +18 to +27 is suf

62 ) and the TATA box binding protein (TBP) for basal transcription, and are activated by Oct-1.

63 the region from nt -63 to -84 is crucial for basal transcription, and that two upstream regions can a

64 iption and associates with components of the basal transcription apparatus and a number of coactivato

65 adult developmental stages suggest that the basal transcription apparatus can be recruited to a core

66 ate the recruitment of the components of the basal transcription apparatus to the basal promoter with

67 hich module is directing the function of the basal transcription apparatus, and ultimately on the tra

68 ich links various transcriptional factors to basal transcription apparatus, participates in transcrip

69 ivators and the RNA polymerase II-associated basal transcription apparatus.

70 nvolving multiple specific components of the basal transcription apparatus.

71 33 and -318 bp produced a 3-fold increase in basal transcription as compared to the 2.1 kB eIF4E prom

72 ter, which may participate in the control of basal transcription as well as glucose-mediated transcri

73 iption system, we show that HSF-4a represses basal transcription at an early step during preinitiatio

74 resent a kinetic model for a single round of basal transcription at the IL-2 promoter that provides i

75 Here, we studied the kinetic mechanism of basal transcription at the IL-2 promoter using a human i

76 cated between -25 and +10 were essential for basal transcription because mutations of these sequences

77 These studies suggest that HSF-4a inhibits basal transcription both in vivo and in vitro.

78 These nucleosomes, evidently, inhibit basal transcription but are poised to be removed quickly

79 Sp1 expression increased basal transcription but did not cause a further increase

80 ruption of these binding sites did not lower basal transcription but severely reduced the response to

81 a, Mth, and Mma TBPs are interchangeable for basal transcription, but their ability to support Lrp-me

82 mplex, Mediator, and TFIIH, in CTD-dependent basal transcription by either mutation or immunodepletio

83 The repression of basal transcription by HSF-4a occurs through interaction

84 inase subunit of TFIIH, Cdk7 participates in basal transcription by phosphorylating the carboxy-termi

85 have shown that, although not essential for basal transcription by purified RNA polymerase II (pol I

86 tivity of TATA box binding protein (TBP) and basal transcription by RNA polymerase II.

87 mbled by the enhancer was different from the basal transcription complex assembled at the promoter.

88 quired for promoter chromatin remodeling and basal transcription complex communication.

89 RP.PNR complex inhibited the activity of the basal transcription complex from homologous as well as h

90 nd cooperative interactions of PspF with the basal transcription complex influence dynamics of the Ps

91 n the engagement of a multimeric bEBP with a basal transcription complex via several L1s.

92 s independent of the known components of the basal transcription complex.

93 As a consequence, much is now known of the basal transcription complex.

94 ions other than positioning elements for the basal transcription complex.

95 PI and further illustrates the importance of basal transcription components as signal transducers.

96 rogen action but caused an increase in hSlo1 basal transcription; conversely, constitutively active c

97 have shown (i) that Mediator enhancement of basal transcription correlates with Mediator-dependent r

98 (RNA pol II) via direct interaction with the basal transcription/DNA repair factor IIH (TFIIH).

99 ites for SREBPs and nuclear factor Y lowered basal transcription drastically but still permitted a 4-

100 The Ets-binding site within the basal transcription element (BTE) of the rat prolactin (

101 t -212 and an EBS that co-localizes with the basal transcription element (BTE, or A-site) located at

102 elements, is divergent in sequence from the basal transcription elements seen in other eukaryotic ge

103 Mediator complexes have defects in enhanced basal transcription, enhanced TFIIH phosphorylation of t

104 utively active c-Src (Y527F) decreased hSlo1 basal transcription even preventing its estrogen/hERalph

105 system and interacted specifically with the basal transcription factor (TFIIE) in HeLa nuclear extra

106 en that LC8 has never been identified with a basal transcription factor and that T. brucei relies on

107 at the ATM protein interacted with the TFIIH basal transcription factor and the XPG protein of the NE

108 e suppressed by mutations that do not affect basal transcription factor binding-DNA contacts.

109 Kin28 is a subunit of the basal transcription factor holo-TFIIH and its trimeric s

110 ecific functional interactions with both the basal transcription factor OsTFIIB and the accessory tra

111 rRNA by inactivation of the RNA polymerase I basal transcription factor RRN3/TIF-IA.

112 report that TAF1B, a subunit of human Pol I basal transcription factor SL1, is structurally related

113 we report that Atgl is down-regulated by the basal transcription factor Sp1 in preadipocytes and that

114 omain protein Brd2 is closely related to the basal transcription factor TAF(II)250, which is essentia

115 ct effect on the interaction of p53 with the basal transcription factor TAF(II)31.

116 Specifically, basal transcription factor Taf4b is down-regulated in th

117 e promoter DNA is recognized and bent by the basal transcription factor TATA-binding protein (TBP).

118 allosteric component and is mitigated by the basal transcription factor TFEalpha/beta.

119 The basal transcription factor TFIID is composed of the TATA

120 the TATA binding protein, a component of the basal transcription factor TFIID.

121 ing protein (TBP), which is a subunit of the basal transcription factor TFIID.

122 y HSF-4a occurs through interaction with the basal transcription factor TFIIF.

123 between a transcriptional repressor with the basal transcription factor TFIIF.

124 preliminary studies, we have identified the basal transcription factor TFIIH as the potential target

125 Further, we show that the basal transcription factor TFIIH is constitutively recru

126 Basal transcription factor TFIIH phosphorylates the RNA

127 nscription by disrupting the assembly of the basal transcription factor TFIIH through sequestration o

128 Pol II CTD is phosphorylated at Ser 5 by the basal transcription factor TFIIH.

129 -dependent kinase 7 (CDK7), a subunit of the basal transcription factor TFIIH.

130 ng protein (TBP), RVFV appears to target the basal transcription factor THIIH to induce shut-off of h

131 TFIIH is a 10-subunit RNA polymerase II basal transcription factor with a dual role in DNA repai

132 regulates transcription as part of the TFIIH basal transcription factor, is an attractive target for

133 in developmental transcription for the TFIID basal transcription factors and for the DNA core promote

134 findings suggest that the core promoter and basal transcription factors are important yet mostly une

135 monstrate the following: 1) pol II and other basal transcription factors are recruited to LCR core hy

136 with as much RNA polymerase II (Pol II) and basal transcription factors as present at the active Gat

137 ling can circumvent the need for a subset of basal transcription factors at specific promoters.

138 oiety itself interferes with the assembly of basal transcription factors at the promoter.

139 the RNAP and the molecular mechanisms of the basal transcription factors E (TFE) and Spt4/5 through c

140 gical function for acetylation in regulating basal transcription factors has not been reported.

141 here were to develop procedures for studying basal transcription factors in the cytosol of M. mazeii

142 ity that altered levels of sequence-specific basal transcription factors may contribute to neurologic

143 d transcription in a reporter assay, and the basal transcription factors OCT1 and SP1 were shown to b

144 It does not include basal transcription factors or chromatin-associated prot

145 tion and architecture, promoter elements and basal transcription factors required for the initiation

146 e promoter lacks canonical binding sites for basal transcription factors such as TATA and CCAAT boxes

147 matin remodeling factor component BRG-1, and basal transcription factors TATA-binding protein (TBP) a

148 complex multisubunit RNA polymerase and the basal transcription factors TBP and TF(II)B, closely res

149 e EICP0 protein interacted directly with the basal transcription factors TFIIB and TBP and that the E

150 The known basal transcription factors that support TATA-dependent

151 RNA polymerases (RNAPs) require basal transcription factors to assist them during transc

152 It interacts with variety of basal transcription factors to initiate and elongate tra

153 DNA, there are several reports of RNAPII and basal transcription factors within silenced regions.

154 there is no knowledge about the function of basal transcription factors, and there is an apparent ra

155 zation of coactivator p300, as well as other basal transcription factors, at the nucleosomes for regu

156 ogen receptor alpha (ERalpha) interacts with basal transcription factors, coregulatory proteins, and

157 ORE)) and is stimulated by promoter-specific basal transcription factors, such as two human TFIIB fam

158 atinized templates suppressed recruitment of basal transcription factors, thereby amplifying the effe

159 The basal transcription factors, which act in conjunction wi

160 d eukaryotic RNAPII is assisted by conserved basal transcription factors.

161 e nucleus occurs subsequent to TBP and other basal transcription factors.

162 kinases-7 (Cdk7) and Cdk9, components of two basal transcription factors.

163 FR gene expression through interactions with basal transcription factors.

164 anscriptional activity and with occupancy by basal transcription factors.

165 8 for viability, we identified a plethora of basal transcription factors.

166 enes requires the participation of a host of basal transcription factors.

167 rged kinetoplastids possess a reduced set of basal transcription factors.

168 a single subunit RNA polymerase and a set of basal transcription factors.

169 4 DNA binding domain, dramatically inhibited basal transcription from a Gal4-E1b TATA promoter in a h

170 tor coregulator complex cooperate to enhance basal transcription from core promoters containing both

171 MCMV did not alter basal transcription from IFN gamma-responsive promoters

172 scription factor IIIB (TFIIIB)-alpha governs basal transcription from small nuclear RNA genes by RNA

173 In addition, NPM-RAR decreases basal transcription from some promoters and acts in a do

174 nscription elongation factor (NELF) inhibits basal transcription from the long terminal repeat of the

175 nd their cognate DNA motifs are critical for basal transcription from the minimal promoter region.

176 onia-lyase, caused DNA bending, and enhanced basal transcription from the pal promoter in a TATA box-

177 binding and caused a 10-fold enhancement of basal transcription from the promoter, rather than an in

178 e transcription in trypanosomes and that the basal transcription function of mediator head is a chara

179 that can inhibit both enhancer-activated and basal transcription in a manner that is not dependent up

180 Here, we have studied Mediator effects on basal transcription in an in vitro transcription system

181 or is a direct intermediary of CTD-dependent basal transcription in extracts and that the requirement

182 In eukaryotes, the basal transcription in interphase is orchestrated throug

183 nitiation factors, Mediator is essential for basal transcription in nuclear extracts that contain a m

184 Elevation of basal transcription in sin4 strains or by tethering the

185 f c-Jun was able to derepress TFIID-directed basal transcription in vitro.

186 re, we present evidence that HSF-4a inhibits basal transcription in vivo when it is artificially targ

187 to Sp1 activation, and dramatically reduced basal transcription in vivo.

188 f standard Pol II) in activator-independent (basal) transcription in addition to the previously descr

189 Basal transcription initiates predominantly from the ups

190 TFIIH has roles both in basal transcription initiation and in DNA repair, and se

191 cluding RNA polymerase II itself and general/basal transcription initiation factors, to form a stable

192 on between Sp1/Sp3 at the Sp1-1 site and the basal transcription initiator complex.

193 The initiation of tissue-specific basal transcription is accompanied by the induction of t

194 Low level basal transcription is sustained by gp55-RNAP holoenzyme

195 e effect, observed with activated as well as basal transcription, is eliminated by deletion of Sir3.

196 le depletion of SNAPC1 had a small effect on basal transcription, it diminished the transcriptional r

197 erall effect of the Mediator is to stimulate basal transcription, its initial engagement with the PIC

198 recursor RNA, followed by a decrease back to basal transcription levels at 24 h, consistent with the

199 tion occurs in an hsf1 mutant that maintains basal transcription levels but cannot mediate transcript

200 LSD1 by small interfering RNAs inhibited Cp basal transcription levels, and overexpression of LSD1 a

201 lines, androgen treatment did not influence basal transcription levels.

202 tes transcriptional activation by recruiting basal transcription machinery and acetylating histones.

203 absolutely require chromatin to assemble the basal transcription machinery and activate transcription

204 ors and/or various components of the general/basal transcription machinery and are essential for regu

205 gion is crucial for the interaction with the basal transcription machinery and is thus required for p

206 The basal transcription machinery and regulatory components

207 tentiating tissue-selective functions of the basal transcription machinery and reveal intricate netwo

208 d in transduction of cellular signals to the basal transcription machinery and that one of these sign

209 n factors that are sufficient to recruit the basal transcription machinery and therefore activate tra

210 t, together with RNA polymerase II, form the basal transcription machinery at the core promoter.

211 ntacts between gene specific factors and the basal transcription machinery but little is known regard

212 oter-specific regulation of Mediator and the basal transcription machinery by HMGA1.

213 vides a mechanism for how a component of the basal transcription machinery can mark the activators it

214 oylation with novel SUMO substrates found in basal transcription machinery for RNA polymerases I, II,

215 oteins, chromatin modifying enzymes, and the basal transcription machinery govern cellular differenti

216 the ordered recruitment of components of the basal transcription machinery in concert with alteration

217 chromatin remodeling complex, NURF, and the basal transcription machinery near the transcriptional s

218 We also show that Pax5 targets the basal transcription machinery of c-fms by interacting wi

219 with TFIID and assembles with POL II and the basal transcription machinery on promoters in vivo.

220 The archaeal basal transcription machinery resembles the core compone

221 is the minimal DNA region that recruits the basal transcription machinery to direct efficient and ac

222 icular implementations of the interaction of basal transcription machinery with promoter DNA, dependi

223 n (LBD), which leads to interaction with the basal transcription machinery, and ultimately with RNA p

224 between Xeed and a component of the Xenopus basal transcription machinery, TAF(II)32.

225 on and conveys regulatory information to the basal transcription machinery.

226 ese regulatory mechanisms coevolved with the basal transcription machinery.

227 activators that enhance their binding to the basal transcription machinery.

228 nd to interact with TAFII68, a member of the basal transcription machinery.

229 stone deacetylation and interaction with the basal transcription machinery.

230 the activities of components of the general/basal transcription machinery.

231 initiation by preventing recruitment of the basal transcription machinery.

232 volved in the interaction between GR and the basal transcription machinery.

233 s and Sp1/Sp3 complex, and its impact on the basal transcription machinery.

234 ctions between transcription factors and the basal transcription machinery.

235 tin remodeling factors and interact with the basal transcription machinery.

236 ect mechanism involving interaction with the basal transcription machinery.

237 tein complex that nucleates formation of the basal transcription machinery.

238 the recruitment of RNA polymerase II and the basal transcription machinery.

239 idging proteins between the receptor and the basal transcription machinery.

240 s (TRs), chromatin regulators (CRs), and the basal transcription machinery.

241 tly interacting with AR and by targeting the basal transcription machinery.

242 s through the head and middle modules to the basal transcription machinery.

243 furthermore is uniquely associated with the basal transcription machinery.

244 IB-like protein was not evident in the Pol I basal transcription machinery.

245 connect sequence-specific activators to the basal transcription machinery.

246 es ETO to directly inhibit activation of the basal transcription machinery.

247 further chromatin modifying complexes or the basal transcription machinery.

248 of chromatin structure and regulation of the basal transcription machinery.

249 dging factor between NF-kappaB, CBP, and the basal transcription machinery.

250 A random "basal" transcription mechanism for protein-coding genes

251 r NF-Y/CEBP were involved in controlling the basal transcription of AKR1C1 in all the cancer cells st

252 the minimal proximal promoter essential for basal transcription of AKR1C1 in human ovarian (2008 and

253 results indicate that the NF-Y regulates the basal transcription of AKR1C1 in human ovarian, lung and

254 tablishes a protein-DNA complex required for basal transcription of APE1.

255 An Sp1 element was responsible for the basal transcription of AR and significantly enhanced the

256 d macrophages, high p52 expression repressed basal transcription of both canonical and noncanonical N

257 Nrf2 may also play a role in basal transcription of both ferritin H and L.

258 m TSP2 may be responsible for control of the basal transcription of HP1186 alpha-carbonic anhydrase.

259 encoding these factors enhance not only the basal transcription of hsp82-deltaHSE1, but also that of

260 This repressor isoform inhibits basal transcription of hsps 27 and 90 in tissue culture

261 Basal transcription of human mitochondrial DNA (mtDNA) i

262 d that the cis-acting elements necessary for basal transcription of Phgdh are contained within the -1

263 and Pit-1 in CHO cells is required for high basal transcription of prolactin-CAT.

264 on, which prevents senescence and suppresses basal transcription of SASP genes.

265 Thus, NCoRi selectively blocked basal transcription of several thyroid hormone-responsiv

266 function in a negative feedback pathway for basal transcription of some genes, although being a posi

267 (TRs) interact with corepressors and repress basal transcription of target genes in cotransfection an

268 E-26-specific) family and is crucial for the basal transcription of TCR zeta-chain in Jurkat cells.

269 Basal transcription of the HIV LTR is highly repressed a

270 viral entry of CCR5 (R5)-tropic HIV and with basal transcription of the HIV LTR, potently inhibiting

271 Basal transcription of the HIV-1 genome is controlled by

272 Inhibiting PKC delta blocked both basal transcription of the human p53 gene and initiation

273 First, LuxR-independent basal transcription of the luxI promoter was enhanced by

274 ificity protein 1 (Sp1) is essential for the basal transcription of the MnSOD gene.

275 the factor responsible for coordinating the basal transcription of the plastid atp genes and that SI

276 Importantly, HDAC3 promotes the basal transcription of these genes independently of adre

277 Over-expression of EDA neither stimulated basal transcription of Wnt-dependent genes, nor inhibite

278 is a potent repressor of both ER-induced and basal transcription on a promoter containing the pS2 ERE

279 ly transfected cell lines without inhibiting basal transcription or inducing apoptosis.

280 To test mechanistically whether basal transcription or transcription factor binding was

281 the requirement for Mediator and the CTD in basal transcription originates from their ability to com

282 The basal transcription profile revealed that 2,506 of the 2

283 s not respond to calcium limitation, but the basal transcription rate of this operon was lower in del

284 and a high and more physiological activated/basal transcription ratio.

285 support transcription in yeast extracts, but basal transcription reactions reconstituted from highly

286 However, the exact role of Cdc28 in basal transcription remains poorly understood, and a fun

287 ot1, an essential ATP-dependent regulator of basal transcription, removes TATA box-binding protein (T

288 Although basal transcription repression was impaired and the pro-

289 ites (Sp1-A, Sp1-B, and Sp1-C), which confer basal transcription specific activity of NAG-1 expressio

290 t between -133 and +117 base pairs conferred basal transcription specific activity.

291 nding protein-1 and to the Abt1 activator of basal transcription that interacts with the TATA-binding

292 In contrast to their effect on basal transcription, the more severe ewe mutations stron

293 ne binds to the TATA box of DNA and supports basal transcription, the TAFs have essential functions t

294 tic and stochastic models led us to focus on basal transcription to optimize circuit performance and

295 lyze infected M phi responses while allowing basal transcription to proceed.

296 ether, these results suggest a regulation of basal transcription typical of cell cycle-regulated gene

297 a modulator of apoptosis and a repressor of basal transcription, was identified in a two-hybrid scre

298 e-independent, direct function in regulating basal transcription, which does not require its catalyti

299 C/EBPalpha and Pit-1 were required for high basal transcription while insulin sensitivity required E

300 GPS2 potently represses basal transcription, with the repression domain mapped t