ライフサイエンスコーパス: base analogue

1 ition by 2-aminopurine (2-AP), a fluorescent base analogue.

2 could be successfully performed with several base analogues.

3 mplexes on the regiochemistry of fluorinated base analogues.

4 tners, consistent with previous nonpolar DNA base analogues.

5 ted by alkylation of DNA or incorporation of base analogues.

6 c activity with that of the less acidic urea-based analogue.

7 , but closer pi-pi spacing than does the TPD-based analogue.

8 s of these BN heterocycles with their carbon-based analogues.

9 tovoltaic efficiency in comparison to the Pb-based analogues.

10 nt of the blood-brain barrier for nucleoside-based analogues.

11 ifiers than the univariate feature selection based analogues.

12 no reports on successful synthesis of Cu(I) -based analogues.

13 2 SH2 domain-binding affinity of phosphonate-based analogues.

14 y more active toward ROP than the thiazolium-based analogues.

15 This system utilizes the fluorescent base analogue 1,3-diaza-2-oxophenothiazine (tC) as the F

16 epared oligonucleotides containing the novel base analogue 2'-aminoethoxy,5-propargylamino-U in place

17 The fluorescent base analogue 2-aminopurine (2-AP) is commonly used to s

18 emission in a quartz substrate from the DNA base analogue 2-aminopurine (2-AP).

19 In both cases, the base analogue 2-aminopurine (2AP) proved tremendously us

20 ime, and increase in photostability of a DNA base analogue 2-aminopurine and a coumarin derivative (7

21 Use of the fluorescent base analogue 2-aminopurine has provided a direct demons

22 In this approach, we insert the fluorescent base analogue 2-aminopurine in place of A1492 in an E. c

23 clease I, grow poorly in the presence of the base analogue 2-aminopurine, and exposure to the base an

24 The fluorescent adenine base analogue, 2-aminopurine (2-AP), placed opposite an

25 Two carbohydrate-based analogues, (2-hydroxyethyl)-alpha-D-glucopyranosid

26 en replaced with the NMR-sensitive thymidine base analogue 5-fluoro-2'-deoxyuridine (5-F-dUrd).

27 y fluorescence anisotropy of the fluorescent base analogue, 6-methyl isoxanthopterin, incorporated in

28 We demonstrate that the unnatural base analogue 7-deazaguanine (7dG) will suppress tGTP mi

29 Furthermore, introducing the base analogue 7-deazaguanosine in the ((G/U)AGCC)11 RNAs

30 nt interests, universal/non-hydrogen-bonding base analogues and photochemical backbone cleavage, have

31 stability of triplexes containing different base analogues and to confirm the selectivity of a tripl

32 nuclease resistance among all phosphodiester-based analogues and its RNA binding affinity surpasses t

33 65R) using DNA templates containing nonpolar base analogues, and find that one of these (F61A) is a h

34 obtaining a small library of novel curcumin-based analogues, and a number of potent and balanced dua

35 Fluorescent nucleic acid base analogues are important spectroscopic tools for und

36 =49+/-9 nM) confirmed that the aminothiazole-based analogues are competitive with ATP.

37 Nucleoside-based analogues are mainstays in the treatment of cancer

38 tamer oligonucleotides tailed with different base analogues as primers in cycle sequencing reactions.

39 trategy to prepare a collection of TFOs with base analogues at a defined position.

40 Consequently, our base analogues can now measure base-base FRET between 3

41 Although there have been a number of base analogues described that appear to be promising as

42 ssociated with adverse sensitivity to purine base analogue drugs.

43 Importantly, while the base analogues enhanced probe-target stability, they did

44 ical dNTP production, (ii) inhibition of the base analogue excision from DNA and (iii) enhancement of

45 patterns can emerge and change within agent-based analogues, expecting that those mechanisms may hav

46 ive mapping of the upstream fork junction by base analogue fluorescence and nucleic acids crosslinkin

47 e tC(O) a highly interesting fluorescent RNA base analogue for detailed FRET-based structural measure

48 titution of a single 3-deazzaadenosine (c3A) base analogue for residues A6, A9, A13, A14, or A15.1.

49 the substitution of a single 2-pyridone (2P) base analogue for residues U4, U7, and U16.1.

50 These properties make BAU a useful base analogue for the sequence-specific creation of stab

51 A universal base analogue forms 'base pairs' with each of the natura

52 nt with various methylating agents and other base analogues has been well reported and is believed to

53 binogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxy

54 l nucleotide (position 5) were replaced with base analogues in plus and/or minus strands.

55 e a new binding model for several of the CPI-based analogues, in which the aromatic secondary rings f

56 araquats and diquat relative to the 30-crown-based analogue; in these systems, 2:1 H:G complexes were

57 By monitoring fluorescent base analogues incorporated at various positions in the

58 Finally we used mutagenesis and base analogue incorporation to show that the non-B DNA s

59 odified DNA, on which EndoV nicking near the base analogues initiates excision repair.

60 nce energy transfer (FRET) using fluorescent base analogues is a powerful means of obtaining high-res

61 the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcri

62 dditionally, a comparison with hydrogen bond-based analogues is provided.

63 However, like most reported base analogues, it has not been thoroughly characterized

64 This new base analogue may find broad applications in biotechnolo

65 Further, a variety of other nucleotide-based analogues, not normally considered antiretrovirals

66 urea (component 3) with nucleic acid bases, base analogues, nucleosides, and nucleotide monophosphat

67 features that closely resemble those of free base analogues of chlorophyll b.

68 By using base analogues of G and T we have explored the functiona

69 elopment of sonogenetics: a non-invasive, US-based analogue of optogenetics.

70 Here we report an aptamer-based analogue of the widely used sandwich enzyme-linked

71 velop more powerful and efficient likelihood-based analogues of "model-free" tests of linkage and/or

72 of the 3 alpha-substituent of the piperidine-based analogues of cocaine and can be used to design nov

73 eries of druglike 3alpha-modified piperidine-based analogues of cocaine were designed, synthesized, a

74 s of novel N- and 3alpha-modified piperidine-based analogues of cocaine were synthesized and tested f

75 A 3D-QSAR CoMFA study of piperidine-based analogues of cocaine with flexible 3 alpha-substit

76 f the 3 alpha-substituents of the piperidine-based analogues of cocaine.

77 tivity of imidazoquinoxalines, benzimidazole-based analogues of indole-based pyrroloiminoquinone mari

78 Recently developed DNA-based analogues of membrane proteins have advanced synth

79 Two configurationally stable carbon-based analogues of pyochelin have been prepared from Boc

80 A variety of 9-substituted, acridine-based analogues of quinacrine were synthesized, which de

81 of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor,

82 A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 w

83 potency of stable fluorinated or phosphonate-based analogues of the tetrahedral reaction intermediate

84 east 20 times faster than that of its carbon-based analogue, presumably a result of Coulombic repulsi

85 ar dichroism and fluorescence spectra of DNA base analogue probes placed site specifically to show th

86 r UV CD and fluorescence spectra of pairs of base analogue probes, substituted either at the primer t

87 rovement in activity of the set, terfenadine-based analogues provide a novel structural class of anti

88 analogue 2-aminopurine, and exposure to the base analogue results in filament formation, indicative

89 Quinoline-based analogues showed lower inhibitory activity and sel

90 rium dissociation constants of wild-type and base-analogue sites were also measured for the weakly ac

91 g reactions of the wild-type enzyme with DNA base-analogue substrates, as it provides identical Delta

92 f EcoRV endonuclease to DNA, for a series of base-analogue substrates, demonstrate that expression of

93 utagenic and toxic effects of N-hydroxylated base analogues, such as 6-N-hydroxylaminopurine (HAP).

94 By using a series of adenosine base analogues tagged with phosphorothioate substitution

95 ed patients contains 6-thioguanine (6-TG), a base analogue that is particularly susceptible to oxidat

96 ion anisotropy approach that utilizes a rare base analogue that retains substantial fluorescence when

97 defined key structural features of the urea-based analogues that contribute to their properties and

98 with fixed orientation, compared to the free-base analogues, the related mono- and di-Zn(II) complexe

99 Compared to the free-base analogue, these complexes showed a remarkable shift

100 t properties of site-specifically introduced base analogues to map and quantify the equilibrium bindi

101 ated derivatives than the corresponding free-base analogues to produce the corresponding excited trip

102 Notably, pairing among the nonpolar base analogues was considerably more stable, and some of

103 A series of omeprazole-based analogues was synthesized and assessed for inhibit

104 Base analogues were used to identify Hoogsteen base pair

105 ory activity of IdeS, but several piperidine-based analogues were identified as inhibitors.

106 Use has been made of base analogues, which delete hydrogen bonds between the

107 rated TNA molecules to include a hydrophobic base analogue with strong fluorescent properties that is

108 relationship studies yielded 84 terfenadine-based analogues with several modifications providing inc

109 ed DNA site was assessed using photoreactive base analogues within specific DNA substrates to allow s

110 rogen-bonding purine derivatives or aromatic base analogues without hydrogen-bonding capabilities.

111 -WN-7 and the previously reported salicylate-based analogue WN-8 are described.

112 A universal, photochemically cleavable DNA base analogue would add desirable versatility to a numbe