ライフサイエンスコーパス: base excision repair

1 ne DNA glycosylase (TDG) in conjunction with base excision repair.

2 g Okazaki fragment maturation and long patch base excision repair.

3 ely during DNA lagging strand maturation and base excision repair.

4 e, two bases that can be removed from DNA by base excision repair.

5 endent dilution or DNA glycosylase-initiated base excision repair.

6 lase plays a key role in DNA maintenance via base excision repair.

7 ), and restoration of cytosine via follow-on base excision repair.

8 n and thymine DNA glycosylase (TDG)-mediated base excision repair.

9 ted intermediates and ensuring completion of base excision repair.

10 eparation of these critical functions during base excision repair.

11 and exhibit a gap-filling deficiency during base excision repair.

12 d to gastric carcinoma via interference with base excision repair.

13 emonstrated transcription-coupled nucleotide/base excision repair.

14 ), an enzyme normally involved in error-free base excision repair.

15 suggests that the G231D variant has impaired base excision repair.

16 amily involved in abasic site removal during base excision repair.

17 in DNA repair beyond the established role in base excision repair.

18 protein with well documented involvement in base excision repair.

19 iple steps of DNA single-strand breakage and base excision repair.

20 involves Tet3-mediated oxidation followed by base excision repair.

21 newly discovered fidelity checkpoint during base excision repair.

22 n or thymine DNA glycosylase (TDG)-dependent base excision repair.

23 oxidative products 5fC and 5caC, initiating base excision repair.

24 erated by DNA glycosylases that initiate DNA base excision repair.

25 9, a cytidine deaminase, and an inhibitor of base excision repair.

26 more than two nucleotides during long-patch base excision repair.

27 nscription factor and an accessory factor in base excision repair.

28 inic/apyrimidinic lyase activity to initiate base excision repair.

29 erase beta (Pol beta), an integral enzyme in base-excision repair.

30 XRCC1 operates as a scaffold protein in base excision repair, a pathway that copes with base and

31 idative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA

32 However, ATMIN also has a role in base excision repair, a process that has been demonstrat

33 In DNA base excision repair, a tight heterodimer complex formed

34 We reported here a new assay to detect base excision repair activities from purified enzymes, a

35 lycosylase (TDG) plays critical roles in DNA base excision repair and DNA demethylation.

36 s suggest that XRCC1 is a component of plant base excision repair and functions at several stages dur

37 x that may be capable of replication-coupled base excision repair and further highlight the role of D

38 on, we show that Acr treatment also inhibits base excision repair and mismatch repair.

39 This severe phenotype involved defective base excision repair and non-homologous end-joining, pat

40 with their proposed biological functions in base excision repair and nonhomologous end joining.

41 cellular DNA damage response by controlling base excision repair and p53 protein levels.

42 that Pol epsilon participates in short-patch base excision repair and ribonucleotide excision repair.

43 eracts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSB

44 This review focuses on the classical base excision repair and strand incision pathways in euk

45 sed by uracil DNA glycosylase (UNG)-mediated base-excision repair and MSH2-mediated mismatch repair (

46 ation of DNA single-strand break repair, DNA base excision repair, and cell survival.

47 tions of the latter noncanonical proteins in base excision repair are unclear.

48 Mismatch and base-excision repair are important in the somatic expans

49 Lig3 is considered a key ligase during base excision repair because its stability depends upon

50 utant lacking the H2A and H3 N-tails rescues base excision repair (BER) activity but not MMS sensitiv

51 ation, and high-fat feeding from weaning, on base excision repair (BER) and DNA methylation and expre

52 PARP-1 DPCs during alkylating agent-induced base excision repair (BER) and formation of DPCs is enha

53 Base excision repair (BER) and mismatch repair (MMR) pat

54 nduced cytidine deaminase (AID) and requires base excision repair (BER) and mismatch repair (MMR).

55 repeated DNA sequences and the efficiency of base excision repair (BER) and RER enzymes (OGG1, MUTYH,

56 d to a linkage between oxidative DNA damage, base excision repair (BER) and TNR expansion, which is d

57 NA bases and their inefficient processing by base excision repair (BER) are among the factors suggest

58 (PQS) in promoter-coding strands, initiating base excision repair (BER) by 8-oxoguanine DNA glycosyla

59 lymerase beta (Pol beta) plays a key role in base excision repair (BER) by filling in small gaps that

60 uding NEIL1 DNA glycosylase, which initiates base excision repair (BER) by removing damaged DNA bases

61 Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and

62 cell lines, we show that cells defective in base excision repair (BER) display a cisplatin-specific

63 Base Excision Repair (BER) efficiently corrects the most

64 Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1

65 earby lesions in opposing DNA strands by the base excision repair (BER) enzymes can produce double-st

66 The base excision repair (BER) enzymes that repair these les

67 ized DNA, by stimulating the activity of key base excision repair (BER) enzymes, including 8-oxoguani

68 eracts with a key mitochondrial-specific DNA base excision repair (BER) enzymes, namely EXOG and DNA

69 iminary results on recognition of 5'-AODN by base excision repair (BER) enzymes.

70 basis of the role of PARP in recruitment of base excision repair (BER) factors to sites of DNA damag

71 Gh and Sp are known to be substrates for base excision repair (BER) glycosylases; however, large

72 DNA base excision repair (BER) has a critical role in genome

73 enome that are supposed to be substrates for base excision repair (BER) in the framework of active de

74 ion oligonucleotide fragments in addition to base excision repair (BER) incision products.

75 In the absence of APTX activity, blocked base excision repair (BER) intermediates containing the

76 occurring, spontaneous damages that are also base excision repair (BER) intermediates.

77 Base excision repair (BER) is a frontline repair system

78 Base excision repair (BER) is a highly conserved DNA rep

79 DNA base excision repair (BER) is an essential cellular proc

80 Base excision repair (BER) is an essential DNA repair pa

81 Base excision repair (BER) is initiated by DNA glycosyla

82 Base excision repair (BER) is one of several DNA repair

83 Base excision repair (BER) is one of the most frequently

84 Furthermore, base excision repair (BER) is responsible for causing CA

85 Base excision repair (BER) is the main repair pathway to

86 Base excision repair (BER) is the major cellular pathway

87 Base excision repair (BER) is the predominant pathway fo

88 Abortive ligation during base excision repair (BER) leads to blocked repair inter

89 Analysis of these maps revealed that base excision repair (BER) of alkylation damage is signi

90 Base excision repair (BER) of an oxidized base within a

91 from G.T mispairs and is thought to initiate base excision repair (BER) of deaminated 5-methylcytosin

92 During mammalian base excision repair (BER) of lesion-containing DNA, it

93 ntly demonstrated to initiate prereplicative base excision repair (BER) of oxidized bases in the repl

94 breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce s

95 is an essential protein that operates in the base excision repair (BER) pathway and is responsible fo

96 repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing qu

97 The base excision repair (BER) pathway is mainly responsible

98 Additionally, we find that the base excision repair (BER) pathway is required to mainta

99 The DNA base excision repair (BER) pathway is the frontline mech

100 Repair of these lesions via base excision repair (BER) pathway maintains genomic fid

101 APE1) is the main abasic endonuclease in the base excision repair (BER) pathway of DNA lesions caused

102 and inflammation-induced DNA lesions by the base excision repair (BER) pathway prevents mutation, a

103 The base excision repair (BER) pathway repairs a wide variet

104 The base excision repair (BER) pathway repairs oxidized lesi

105 tosines by thymine-DNA glycosylase (TDG) and base excision repair (BER) pathway, but it is unclear to

106 sites are efficiently dealt with through the base excision repair (BER) pathway, genetic studies sugg

107 ease 1 (APE1/Ref-1), a key enzyme in the DNA base excision repair (BER) pathway, is often associated

108 ase beta (Pol beta), a key enzyme in the DNA base excision repair (BER) pathway, is pivotal in mainta

109 Within the base excision repair (BER) pathway, the DNA N-glycosylas

110 glycosylases catalyze the first step of the base excision repair (BER) pathway.

111 roxymethylcytosine, including members of the base excision repair (BER) pathway.

112 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.

113 al of uracil in DNA as the first step in the base excision repair (BER) pathway.

114 A is mutagenic, if it is not repaired by the base excision repair (BER) pathway.

115 endent checkpoint signaling pathways and the base excision repair (BER) pathway.

116 ctures, oxidative damage to DNA requires the base excision repair (BER) pathway.

117 nuclease (APE1), which functions through the base excision repair (BER) pathway.

118 ylase (hUNG) perform the initial step in the base excision repair (BER) pathway.

119 and cytotoxic abasic lesions as part of the base excision repair (BER) pathway.

120 oth the nonhomologous end-joining (NHEJ) and base excision repair (BER) pathways.

121 Base excision repair (BER) processes non-helix distortin

122 erase beta (Polbeta), known as a key nuclear base excision repair (BER) protein, in mitochondrial pro

123 Recent evidence suggests a role for base excision repair (BER) proteins in the response to D

124 Base excision repair (BER) recognizes and repairs minima

125 SB plays a significant role in mitochondrial base excision repair (BER) regulation.

126 Base excision repair (BER) removes at least 20,000 DNA l

127 nduced mutation, it is unknown if subsequent base excision repair (BER) steps function on replication

128 (N7-methylguanine and N3-methyladenine) are base excision repair (BER) substrates, these DNA lesions

129 induced cytidine deaminase (AID) followed by base excision repair (BER) was found not to be involved.

130 Oxidative DNA damage is mainly repaired by base excision repair (BER), a process initiated by DNA g

131 hway for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polym

132 f the major abasic endonuclease in mammalian base excision repair (BER), apurinic/apyrimidinic endonu

133 maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-D

134 Endogenous DNA damage is removed mainly via base excision repair (BER), however, whether there is pr

135 ine deacetylases contribute to DNA repair by base excision repair (BER), nucleotide excision repair (

136 y oxidative DNA base damage and fulfilled by base excision repair (BER), suggesting active roles for

137 ole in single strand break repair (SSBR) and base excision repair (BER), the p1p2 and p1p2k80 mutants

138 B formation when replication interferes with base excision repair (BER), the predominant pathway for

139 ary to complete an alternate repair pathway, base excision repair (BER), they lack a DNA glycosylase

140 pol beta) is the main polymerase involved in base excision repair (BER), which is a pathway responsib

141 of a reactive DNA repair intermediate during base excision repair (BER).

142 d by thymine DNA glycosylase (TDG) initiated base excision repair (BER).

143 racil, causes DNA damage that is repaired by base excision repair (BER).

144 ast majority of these lesions are subject to base excision repair (BER).

145 (CHB) patients is influenced by IFN-induced base excision repair (BER).

146 l DNA glycosylase (UDG) in the first step of base excision repair (BER).

147 ioned whether Rev1 could also be involved in base excision repair (BER).

148 ambda (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).

149 nondamaged DNA bases is vitally important in base excision repair (BER).

150 homozygous germline nonsense mutation in the base-excision repair (BER) gene NTHL1.

151 Indeed, nutrient deprivation led to impaired base-excision repair (BER) in cardiomyocytes in vitro, a

152 nitiate active DNA demethylation through the base-excision repair (BER) pathway.

153 These lesions cannot be repaired by base excision repair, but they are substrates for nucleo

154 ate the pathway taken by 8-oxoguanine during base excision repair by Fpg, we calculated free energy s

155 This process may involve base excision repair, C-C bond cleaving reactions or dea

156 dings demonstrate that a modest decrement in base excision repair capacity can render the brain more

157 arise during Okazaki fragment processing and base excision repair, cleaves model flap substrates asse

158 base lesions in the human genome to initiate base excision repair, contains an intrinsically disorder

159 ides into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent com

160 lomere regions would block completion of the base excision repair cycle potentially causing telomere

161 We also show that mitochondrial base excision repair depends on TDP1 activity and provid

162 harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which

163 ere, we investigated our hypothesis that the base excision repair enzyme alkylpurine-DNA-N-glycosylas

164 The DNA base excision repair enzyme DNA polymerase (pol) beta is

165 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair an

166 s missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3

167 removal of methylated cytosines requires the base excision repair enzyme TDG, but the mechanism by wh

168 uanine DNA glycosylase) is one such silenced base excision repair enzyme that can restore DNA integri

169 om previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2

170 However, mice deficient for the base excision repair enzyme, apurinic/apyrimidinic endon

171 that DinG and Endonuclease III (EndoIII), a base excision repair enzyme, cooperate at long-range usi

172 se that is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase beta.

173 ription-associated demethylation promoted by Base Excision Repair enzymes further modifies methylatio

174 We have characterized meningococcal base excision repair enzymes involved in the recognition

175 ow that RNF4 interacts with and requires the base excision repair enzymes TDG and APE1 for active dem

176 own did not change the levels or activity of base excision repair enzymes, but significantly reduced

177 nactivation is required for stabilization of base excision repair enzymes, the failure of cells to do

178 ress, compared to strains deficient in other base excision repair enzymes.

179 ammalian cells, but recent studies implicate base excision repair for genome-wide DNA demethylation i

180 reduced enzyme activity may have compromised base excision repair function, as evidenced by our methy

181 Additionally, mutations in a base-excision-repair gene (SMUG1) correlate with a C-to-

182 etween XPD and Endonuclease III (EndoIII), a base excision repair glycosylase that also contains a [4

183 Endonuclease III (EndoIII) is a base excision repair glycosylase that targets damaged py

184 r mechanism may also be operative in related base excision repair glycosylases and provides a critica

185 age (homologs of HUS1, CHK2), nucleotide and base excision repair (homologs of XPF, XPC and AP-endonu

186 In the absence of additional factors, base excision repair in NCPs will stall at the gap-filli

187 ble to oxidation, few biochemical studies of base excision repair in telomeric DNA and quadruplex str

188 inant-negative manner and impairs long-patch base excision repair in vitro and in vivo.

189 eta carries out two of the four steps during base excision repair, including a lyase reaction that re

190 ier in mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned wheth

191 ) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common t

192 ests that, for poxviruses, DNA synthesis and base excision repair is coupled.

193 DNA base excision repair is essential for maintaining genomi

194 Base excision repair is hindered by nucleosomes.

195 Base excision repair is initiated by DNA glycosylases th

196 Base excision repair is responsible for correcting nucle

197 Base excision repair is the major pathway in mammalian c

198 ne DNA glycosylase, and subsequent action of base-excision repair machinery restores unmethylated cyt

199 ing that in humans gBGC is not caused by the base-excision repair machinery.

200 zyme component suggests that replication and base excision repair may be coupled.

201 The role of polymerase beta and base excision repair may be of particular importance due

202 Such compromised base excision repair may drive tumorigenesis by leading

203 r of which takes place by a highly efficient base excision repair mechanism.

204 perhelicity of the DNA indirectly facilitate base excision repair mediated by repair endonucleases of

205 nucleotide excision repair, mismatch repair, base excision repair, nonhomologous end joining, homolog

206 n for non-homologous end-joining (cku-80) or base excision repair (nth-1, exo-3), the Fanconi-related

207 rved NEIL2-initiated transcription-dependent base excision repair of 5-hydroxyuracil in the transcrib

208 romoter sequences, and transiently inhibited base excision repair of 8-oxoG.

209 In humans, short-patch base excision repair of 8-oxoG:dA base pairs requires hu

210 ethylpurine DNA glycosylase (hMPG) initiates base excision repair of a number of structurally diverse

211 glycosylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out

212 DNA polymerase beta (Pol beta) is central to base excision repair of damaged DNA.

213 s not known if histone acetylation modulates base excision repair of DNA lesions in chromatin.

214 L5 modulates and/or directly participates in base excision repair of endogenous DNA damage, thereby p

215 ed in active DNA demethylation by initiating base excision repair of G.T mispairs generated by a deam

216 Base excision repair of genotoxic nucleobase lesions in

217 a basis for understanding the mechanisms of base excision repair of ICLs.

218 lated chromatin remodelling is important for base excision repair of oxidative lesions.

219 he repair of double-strand DNA breaks and in base excision repair of oxidized guanine residues (8-oxo

220 lack a DNA glycosylase required to initiate base excision repair of pyrimidine-pyrimidine photoprodu

221 ese enzymes have been known only to initiate base excision repair of small adducts by extrusion from

222 During base excision repair of this mispair, DNA polymerase (po

223 vity in mammalian cells, and a key factor in base-excision repair of DNA.

224 Ape1 is one of the major proteins in the base excision repair pathway (BER), and deletions in any

225 ,8-dihydro-8-oxoguanine (8-oxoG) via the DNA base excision repair pathway (OGG1-BER).

226 Conversely, inhibiting the base excision repair pathway accentuated NAD decline in

227 Our results indicate a synergism between the base excision repair pathway and direct alkylation repai

228 ated by DNA glycosylases, which initiate the base excision repair pathway by locating and excising ab

229 glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine ba

230 Deletion of TPA1 along with the base excision repair pathway DNA glycosylase MAG1 render

231 integrity and define the specificity of the base excision repair pathway for discreet, detrimental m

232 Analysis of the contribution of the base excision repair pathway in lymphocyte development h

233 n cells, NMPs are repaired by the multi-step base excision repair pathway initiated by human alkylade

234 The base excision repair pathway is largely responsible for

235 The DNA base excision repair pathway is the main system involved

236 beta) is the main polymerase involved in the base excision repair pathway responsible for repairing d

237 damage; their rates were limited by upstream base excision repair pathway steps.

238 ckbone at the abasic site, thus initiating a base excision repair pathway that finally inserts an unm

239 reactive oxygen species, is repaired via the base excision repair pathway that is initiated with the

240 that utilizes DNA glycosylases found in the base excision repair pathway to excise the modification.

241 nitiated by DNA glycosylases, occurs via the base excision repair pathway using conserved repair and

242 We now report that BRCA1 stimulates the base excision repair pathway, a major mechanism for the

243 rase beta is known to be a key player in the base excision repair pathway, and mice devoid of DNA pol

244 d and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and

245 ase 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease

246 se)polymerase-1 (PARP-1), a component of the base excision repair pathway, in mouse bone marrow HSCs

247 es in mammalian genomes are repaired via the base excision repair pathway, initiated with one of four

248 Specifically, we show that the base excision repair pathway, the main pathway utilized

249 a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechani

250 cells also has an adverse effect on the DNA base excision repair pathway, the major DNA repair syste

251 (ROS)-induced DNA damage is repaired by the base excision repair pathway.

252 xoguanine glycosylase 1 (OGG1)-initiated DNA base excision repair pathway.

253 stability via repair of DNA lesions via the base excision repair pathway.

254 tagenic and cytotoxic but are removed by the base excision repair pathway.

255 A by specific uracil-DNA glycosylases in the base excision repair pathway.

256 during repair of damaged DNA as part of the base excision repair pathway.

257 ial removal of abasic lesions as part of the base excision repair pathway.

258 involved in active DNA demethylation via the base excision repair pathway.

259 plicated in active DNA demethylation via the base excision repair pathway.

260 an cells through a process that requires the base excision repair pathway.

261 sis of the N-glycosidic bond to initiate the base excision repair pathway.

262 n processing and enzyme communication in the base excision repair pathway.

263 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil

264 Inducible DNA repair via the base-excision repair pathway is an important prosurvival

265 herichia coli is an initiating enzyme in the base-excision repair pathway.

266 In the mammalian nucleotide and base excision repair pathways, the ligation step is carr

267 hieved by modulating the initial step of the base excision repair process.

268 at the lesion site after processing via the base excision repair process.

269 of restriction enzymes activities as well as base excision repair processes.

270 A base excision repair protein, Apurinic/apyrimidinic (AP)

271 The essential base excision repair protein, apurinic/apyrimidinic endo

272 r predisposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational foot

273 A feature of many base excision repair proteins is that they contain [4Fe4

274 ion of 5-methylcytosine (mC), and downstream base excision repair proteins restore a G.C pair.

275 e appropriate DNA lesions also interact with base excision repair proteins, we investigated whether C

276 DNA-mediated redox signal resembles that of base excision repair proteins, with a DNA-bound redox po

277 for many of NEIL1's interactions with other base excision repair proteins.

278 nd an indication of the versatility of these base excision repair proteins.

279 s p53, DNA mismatch repair proteins, and DNA base excision-repair proteins), transcription factors (s

280 CA1/BRCA2, transcription-coupled repair, and base excision repair seemed to be important for MLN4924

281 XRCC1 is a key component of DNA base excision repair, single strand break repair, and ba

282 Two glycosylases involved in base excision repair, SMUG1 and MUTYH, were characterize

283 in binary complex with template 8-oxoG in a base excision repair substrate.

284 Initiating base excision repair, TDG removes thymine from mutagenic

285 s of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance, and stalled

286 the mispaired A giving way to the canonical base excision repair that ultimately restores undamaged

287 re enzymes that perform the initial steps of base excision repair, the principal repair mechanism tha

288 veal that beyond the known pathways, such as base excision repair, the process of transcription-coupl

289 cision repair may act as a backup pathway to base excision repair to remove uracils arising from cyto

290 deaminating 5-methylcytosine in concert with base-excision repair to exchange cytosine.

291 n essential enzyme playing multiple roles in base excision repair, transcription regulation, and DNA

292 trary to current ideas, that cellular uracil base excision repair (UBER) enzymes target and cleave A3

293 iral DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1%

294 DNA polymerase X family that is involved in base excision repair, uses a processive hopping search m

295 ause detectable nuclear DNA damage even when base excision repair was blocked by an inhibitor of poly

296 beta to extend from 8-oxoG during long-patch base excision repair was unknown.

297 ts to all DNA-templated processes, including base excision repair where Pol beta catalyzes two key en

298 /U-containing CRE by UNG2 and, therefore, to base excision repair, whereas UNG2 exposure prevented CR

299 ce XPB-R(-/-) cells were not impaired in DNA base excision repair, XPB-R appears to function specific

300 hree genes essential to NER (ERCC1, XPD) and base excision repair (XRCC1).