ライフサイエンスコーパス: base excision repair pathway

1 iently repaired by the mammalian short patch base excision repair pathway.

2 ase, a component of the highly conserved DNA base excision repair pathway.

3 xoguanine glycosylase 1 (OGG1)-initiated DNA base excision repair pathway.

4 hought to be conducted primarily through the base excision repair pathway.

5 initiate repair of most abasic sites in the base excision repair pathway.

6 sulting from processing abasic sites via the base excision repair pathway.

7 ], and it is the primary activity in the DNA base excision repair pathway.

8 different steps and adducts repaired via the base excision repair pathway.

9 (Pol beta) is one of the key enzymes in the base excision repair pathway.

10 stability via repair of DNA lesions via the base excision repair pathway.

11 ove 3MeAs from alkylated DNA to initiate the base excision repair pathway.

12 tagenic and cytotoxic but are removed by the base excision repair pathway.

13 A by specific uracil-DNA glycosylases in the base excision repair pathway.

14 during repair of damaged DNA as part of the base excision repair pathway.

15 ial removal of abasic lesions as part of the base excision repair pathway.

16 involved in active DNA demethylation via the base excision repair pathway.

17 plicated in active DNA demethylation via the base excision repair pathway.

18 an cells through a process that requires the base excision repair pathway.

19 sis of the N-glycosidic bond to initiate the base excision repair pathway.

20 n processing and enzyme communication in the base excision repair pathway.

21 porated opposite 8-oxoguanine as part of the base excision repair pathway.

22 ognize the damaged bases and to initiate the Base Excision Repair pathway.

23 reby coordinating the first two steps of the base excision repair pathway.

24 to release the lesion base and initiate the base excision repair pathway.

25 ntral role in the repair of AP sites via the base excision repair pathway.

26 5-methylcytosine DNA glycosylases through a base excision repair pathway.

27 purines, and initiating their repair via the base excision repair pathway.

28 ondria in the recently discovered long-patch base excision repair pathway.

29 sed by ionizing radiation, is removed by the base excision repair pathway.

30 polymerases, is the major polymerase in the base excision repair pathway.

31 l)ation and functions as a key enzyme in the base excision repair pathway.

32 e necessary for efficient functioning of the base excision repair pathway.

33 e and deoxyribose to initiate the uracil-DNA base excision repair pathway.

34 coli endonuclease III and processed via the base excision repair pathway.

35 by acting as a dual-function nuclease in the base excision repair pathway.

36 contributing to two consecutive steps of the base excision repair pathway.

37 (ROS)-induced DNA damage is repaired by the base excision repair pathway.

38 APE1, and possibly other enzymes, in the DNA base excision repair pathway.

39 lts suggest that hMYH repair is a long patch base excision repair pathway.

40 r the repair of UV-induced DNA damage is the base excision repair pathway.

41 ction to promote DNA demethylation through a base excision-repair pathway.

42 herichia coli is an initiating enzyme in the base-excision repair pathway.

43 Mug interacts with downstream enzymes in the base-excision repair pathway.

44 to defects in nucleotide excision repair or base excision repair pathways.

45 ted either by oxidative stress or during the base excision repair pathways.

46 We now report that BRCA1 stimulates the base excision repair pathway, a major mechanism for the

47 Conversely, inhibiting the base excision repair pathway accentuated NAD decline in

48 Our results indicate a synergism between the base excision repair pathway and direct alkylation repai

49 nd NTG2, whose gene products function in the base excision repair pathway and initiate removal of a v

50 tion of DNA glycosylases, which initiate the base excision repair pathway and protect the sequence in

51 from these mismatches through a short-patch base excision repair pathway and thus prevents G:C-to-T:

52 ambda likely fills short-patched DNA gaps in base excision repair pathways and participates in mammal

53 rase beta is known to be a key player in the base excision repair pathway, and mice devoid of DNA pol

54 are repaired primarily by the Mag1-initiated base excision repair pathway, and nucleotide excision re

55 Thus, the two central players of the base excision repair pathway are coordinated in sequenti

56 The base excision repair pathway (BER) is believed to mainta

57 Ape1 is one of the major proteins in the base excision repair pathway (BER), and deletions in any

58 nuclease 1 (APE1, REF1) functions within the base excision repair pathway by catalyzing the hydrolysi

59 CC1) protein plays a central role in the DNA base excision repair pathway by interacting with DNA lig

60 ated by DNA glycosylases, which initiate the base excision repair pathway by locating and excising ab

61 e the enzymes responsible for initiating the base excision repair pathway by recognizing the damaged

62 glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine ba

63 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil

64 ggest that the DNA polymerase beta-dependent base excision repair pathway can be up-regulated by oxid

65 investigate whether impairment of the uracil base excision repair pathway can enhance its effects.

66 lase) constitutes a key component of the DNA base excision repair pathway, catalysing the removal of

67 Deletion of TPA1 along with the base excision repair pathway DNA glycosylase MAG1 render

68 Initiating the DNA base excision repair pathway, DNA glycosylases find and

69 d and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and

70 ase 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease

71 integrity and define the specificity of the base excision repair pathway for discreet, detrimental m

72 r enzymes, it may act as a regulator for the base excision repair pathway for efficient and balanced

73 OGG1 functions in the base excision repair pathway, for which a molecular hand

74 sed by either of two DNA glycosylases of the base excision repair pathway: formamidopyrimidine-DNA gl

75 whether Dug could initiate a uracil-mediated base excision repair pathway in E. coli NR8052 cell extr

76 ein may function in several steps of the DNA base excision repair pathway in eukaryotes and may repre

77 e beta (polbeta)-dependent single nucleotide base excision repair pathway in extracts prepared from p

78 Analysis of the contribution of the base excision repair pathway in lymphocyte development h

79 e-specific U:A base pairs to investigate the base excision repair pathway in reconstituted nucleosome

80 the rat Pol beta mutants interfere with the base excision repair pathway in S. cerevisiae.

81 se)polymerase-1 (PARP-1), a component of the base excision repair pathway, in mouse bone marrow HSCs

82 butane pyrimidine dimers can proceed via the base excision repair pathway, in which the initial step

83 n cells, NMPs are repaired by the multi-step base excision repair pathway initiated by human alkylade

84 ain pathway for the repair of 8-oxodG is the base excision repair pathway initiated by oxoguanine DNA

85 es in mammalian genomes are repaired via the base excision repair pathway, initiated with one of four

86 n all organisms occurs primarily via the DNA base excision repair pathway, initiated with their excis

87 The base excision repair pathway is an organism's primary de

88 S patient samples provided evidence that the base excision repair pathway is compromised in DS tissue

89 These results show that an intact base excision repair pathway is essential for normal ear

90 datively damaged bases in the genome via the base excision repair pathway is initiated with excision

91 saturated, and ring-fragmented bases via the base excision repair pathway is known to be critical for

92 The base excision repair pathway is largely responsible for

93 The DNA base excision repair pathway is responsible for removal

94 The DNA base excision repair pathway is the main system involved

95 Inducible DNA repair via the base-excision repair pathway is an important prosurvival

96 datively damaged bases in the genome via the base excision repair pathway, is activated by reactive o

97 endogenous DNA base damage by the ubiquitous base-excision repair pathway largely accounts for the si

98 did not inhibit the subsequent steps of the base excision repair pathway, namely the DNA synthesis a

99 nucleotide (nt) gaps in DNA produced by the base excision repair pathway of mammalian cells.

100 ,8-dihydro-8-oxoguanine (8-oxoG) via the DNA base excision repair pathway (OGG1-BER).

101 ecific mutator and also that elements of the base-excision repair pathway play a central role in clas

102 e damage specificity while aiding subsequent base excision repair pathway progression.

103 n use poly (ADP) ribose inhibitor to inhibit base excision repair pathway rather than mismatch repair

104 f the mechanism by which glycosylases of the base excision repair pathway recognize the presence of 8

105 beta) is the main polymerase involved in the base excision repair pathway responsible for repairing d

106 y of repair occurred by the uracil-initiated base excision repair pathway, since the addition of the

107 EN-1 nucleases have been associated with the base excision repair pathway, specifically processing cl

108 damage; their rates were limited by upstream base excision repair pathway steps.

109 nce of this enzyme, which is part of the DNA base excision repair pathway, suggests that thermophiles

110 clease Ape1 is a key enzyme in the mammalian base excision repair pathway that corrects AP sites in t

111 ckbone at the abasic site, thus initiating a base excision repair pathway that finally inserts an unm

112 g organisms is accomplished primarily by the base excision repair pathway that initiates repair throu

113 reactive oxygen species, is repaired via the base excision repair pathway that is initiated with the

114 lease VIII (Nei) is a DNA glycosylase of the base excision repair pathway that recognizes and excises

115 Unlike other null mutants of the base excision repair pathway, the APNG ko mice exhibit a

116 ylase catalyzes the first step in the uracil base excision repair pathway, the hydrolytic cleavage of

117 Specifically, we show that the base excision repair pathway, the main pathway utilized

118 a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechani

119 cells also has an adverse effect on the DNA base excision repair pathway, the major DNA repair syste

120 In the mammalian nucleotide and base excision repair pathways, the ligation step is carr

121 Although these lesions are repaired by the base excision repair pathway, they have been shown also

122 The XRCC1 protein is involved in the base excision repair pathway through interactions with o

123 that utilizes DNA glycosylases found in the base excision repair pathway to excise the modification.

124 ts use 5-methylcytosine glycosylases and the base excision repair pathway to remove excess cytosine m

125 and repair of DNA damage include a complete base excision repair pathway (uracil DNA glycosylase, AP

126 nitiated by DNA glycosylases, occurs via the base excision repair pathway using conserved repair and

127 of the post-incision steps of the bacterial base excision repair pathway was examined using a DNA pl

128 effort to map the energetic landscape of the base excision repair pathway, we report the first thermo

129 cells is also mediated at least in part by a base excision repair pathway where the AID/Apobec family

130 Such oxidative lesions are removed by the base excision repair pathway, which is initiated by DNA

131 In the base excision repair pathway, wild-type DNA polymerase b