ライフサイエンスコーパス: base pair substitution

1 ation site in hDGAT1 was mutated by a single base pair substitution.

2 s particularly sensitive to reversion by DNA base-pair substitution.

3 ation of the ssODNs enabled effective single-base-pair substitution.

4 imilar but shows a deletion plus a number of base pair substitutions.

5 DNAs that differed from each other by single base pair substitutions.

6 All six are unique single base pair substitutions.

7 ifically cleaves a site with four contiguous base pair substitutions.

8 ng orientation in response to amino acid and base pair substitutions.

9 nts occur at only 1/10th the genomic rate of base-pair substitutions.

10 onucleotide duplexes containing I.C or other base-pair substitutions.

11 d undetectable with dsOligos carrying single base-pair substitutions.

12 mutations in a chosen gene, typically single base-pair substitutions.

13 mutations in the Mlh1 null cells were due to base-pair substitutions.

14 l as the slow, steady accumulation of single base-pair substitutions.

15 c landscape of these two species than single-base-pair substitution (1.2%).

16 Z.bailii substrate primarily due to a single base-pair substitution (A/T+5 --> T/A+5).

17 he affected patients had an identical single base pair substitution, a G-->A, at the -1 position of t

18 ts, was unexpectedly affected by a 1062/1076 base pair substitution; additional mutations were requir

19 three sister plaques showed only two single-base-pair substitutions after in vitro passage.

20 Base pair substitution analysis suggests that the sequen

21 c changes in this region, including a single base pair substitution and deletions of arginine repeats

22 boxylase activity (encoded by pyrF), whereas base pair substitutions and an 18-bp deletion had no eff

23 low and the products comprised a mixture of base pair substitutions and deletions.

24 All base pair substitutions and mismatches were examined at

25 In addition to base pair substitutions and one- or two-base deletions,

26 tent with E. coli DNA polymerase V-generated base-pair substitutions and that matched that of sequenc

27 Over 22% of all single base-paired substitutions and 30% of all deletions and i

28 intragenic events, which were predominantly base-pairs substitutions, and loss of heterozygosity eve

29 rallels findings of in vivo experiments that base pair substitutions are induced by PdG in the former

30 Recurrent somatic base-pair substitutions are believed to be less contribu

31 These homologs differ by single base pair substitutions as well as indels in regions cod

32 The mutant allele contains a single base pair substitution at amino acid 510.

33 this study, mutant Ter sites carrying single base pair substitutions at 16 different positions were e

34 M1G induced base pair substitutions at comparable frequencies in bot

35 The rank order of effects of canonical base pair substitutions at each position on kcat/Km was

36 n vitro competition assays demonstrated that base pair substitutions at positions 8-19 had significan

37 Base pair substitutions at potential CRP binding sites i

38 tation rates orders of magnitude higher than base pair substitutions at single-copy genes.

39 ion sequences, the consequences of analogous base pair substitutions at the same relative positions o

40 ds to partial intron inclusion, and a single base-pair substitution at an acceptor site, which gives

41 induced mutations were deletions and single-base-pair substitutions at or adjacent to the targeted P

42 ites contained symmetrical single and double base-pair substitutions at positions 4 and/or 5 [sequenc

43 Base-pair substitutions at positions 5 and 6 in U3 mostl

44 f a specific lamivudine-resistant virus with base-pair substitutions at the YMDD locus of the DNA pol

45 ties are not tightly coupled: individual DNA base-pair substitutions at those positions that signific

46 ngineer mouse strains with reciprocal single base pair substitutions (B6-Cdh23(c.753A>G) and 129S1-Cd

47 The mutations include base pair substitutions (BPSs) and additions and deletio

48 ts of this reaction, frameshifts outnumbered base pair substitutions by greater than 70-fold.

49 specificity switches for multiple concerted base pair substitutions can be computationally designed,

50 ex (IDI), to more accurately determine which base pair substitutions can potentially occur in conserv

51 We describe how a small number of single-base-pair substitutions can generate hotspots de novo an

52 uch of its target site, such that few single base pair substitutions cause a significant decrease in

53 The possibility that rRNA base pair substitutions compensate for variants in L11 a

54 Cloning of BRAF double base-pair substitutions confirmed that both base changes

55 (and both parents heterozygous) for a single base pair substitution converting the codon for Arg-282

56 Tandem base-pair substitutions encoding V599R and V599K amino a

57 deficient cells exhibited two well-separated base-pair substitution events.

58 Single amino acid and base-pair substitutions had parallel effects on DNA bend

59 ntaining either 5' deletions or continuous 6-base pair substitutions identified a hyperosmotic stress

60 revealed a missense mutation due to a single base pair substitution in exon 6 in cpfl3.

61 Here, we report that a homozygous single base pair substitution in POLE1 (polymerase epsilon 1),

62 ects on protein levels of an adaptive single-base pair substitution in the coding sequence of a signa

63 inding to the AREs is diminished by a single base pair substitution in the core sequence.

64 likely to be caused by the same mutation, a base pair substitution in the G protein-coupled inwardly

65 The mutant results from a single base pair substitution in the rpoD gene that causes a Gl

66 t of Bxb1 prophage orientation, and a single base pair substitution in the two sites is sufficient to

67 s-linked, consistent with the observation of base pair substitutions in 5'-d(CG) sites in the MDA-ind

68 Among the six possible base pair substitutions in a lacZ reversion system, the

69 sequence-dependent frameshift mutations and base pair substitutions in bacteria and in mammalian cel

70 moter P1 of the C. crescentus dnaK gene, and base pair substitutions in either the -10 or -35 region

71 patients with a nearly identical cluster of base pair substitutions in exon 23.

72 ot present; instead, we found several single base pair substitutions in exons 2 and 6.

73 ividuals were discovered to have clusters of base pair substitutions in exons 23 and 25.

74 ot detect associations between the number of base pair substitutions in genes and their orientation o

75 binants, rOKAgI-Sp1 and rOKAgI-USF, with two base pair substitutions in Sp1 or USF sites, replicated

76 We found that single base pair substitutions in the consensus sequence result

77 We examined the effects of single base pair substitutions in the high-affinity GerE bindin

78 Single base pair substitutions in this IRE decreased transcript

79 melanoma include a cell line possessing a 2 base-pair substitution in BRAF exon 11 and a case harbor

80 l to SL3 except for the presence of a single-base-pair substitution in each of the two core elements.

81 In a second family, there was a homozygous base-pair substitution in the alternative splice site of

82 A single base-pair substitution in the DNA binding sequence reduc

83 A single base-pair substitution in the first intron of Btk was id

84 A single base-pair substitution in the nieuwkoid/dharma gene resu

85 The single-base-pair substitution in the seed region of miR-184 is

86 ion mutation spanning the site of the single-base-pair substitution in trans.

87 gnition, we systematically introduced single base-pair substitutions in an a1-alpha2 DNA-binding site

88 site found at silencers, which contains four base-pair substitutions in comparison to the telomeric b

89 TA step was further tested by making single base-pair substitutions in Fragment 67 and the results r

90 cted novel dinB alleles, generated by single-base-pair substitutions in the dnaE915 strain, indicated

91 Mutant virus LST-4BS contains four single-base-pair substitutions in the ICP4 binding site in the

92 Compensatory base pair substitutions incorporated into the helical st

93 analysis of stem 1 hairpins and compensatory base-pair substitutions incorporated into helical stem 2

94 Compensatory base-pair substitutions incorporated into helical stems

95 tant alleles with two and occasionally three base-pair substitutions increased when the Pms2 and Mlh1

96 us to detect a variety of spontaneous single-base pair substitutions, insertions, and deletions, and

97 two regions of the TolC protein and included base-pair substitutions, insertions, and deletions.

98 sertion of linear plasmids containing either base-pair substitutions, insertions, or deletions in the

99 o, we have introduced an extensive series of base pair substitutions into an Mcm1 operator site and e

100 Base-pair substitutions introduced at these positions in

101 This clustering of base pair substitutions is unusual and suggests that mut

102 s (LD50 < 900 PFU), although the four single-base-pair substitutions lie outside the coding region fo

103 The spectrum of single-base-pair substitutions logged in The Human Gene Mutatio

104 cherichia coli and mammalian cells, inducing base-pair substitutions (M(1)dG --> A and M(1)dG --> T)

105 enced by DNA breathing dynamics, we designed base-pair substitutions, mismatch, and methylation modif

106 Two base or base pair substitution mutant RNAs which destabilize the

107 and was a compound heterozygote for a single-base-pair-substitution mutation and a novel, approximate

108 Analysis of the base-pair-substitution mutations induced by recA730 in a

109 Mutations were represented mainly by single base pair substitutions (n = 63) with rare deletions/ins

110 The mutation consists of a single base pair substitution of the gene encoding the G-protei

111 ents of the effects of every possible single base-pair substitution of a consensus sequence, we defin

112 The effects of individual amino acid and base pair substitutions on heterodimer binding orientati

113 promoter by measuring the effects of single base pair substitutions on in vitro promoter activity.

114 nine base are explained by the impact of the base pair substitutions on the delocalized conduction ch

115 t cases the distance separating the multiple base-pair substitutions on a given allele was in excess

116 omain were influenced by the identity of the base pair substitution or mismatch as well as by the sit

117 I-CreI homing site mutants contained base pair substitutions or single base deletions that al

118 nB intragenic mutations examined were either base pair substitutions or those that we inferred to be

119 A single base pair substitution outside the sequences contacted i

120 ng an in silico screen, we identified single base-pair substitutions predicted to disrupt binding by

121 are evenly distributed and show a variety of base pair substitutions, predominantly transitions.

122 Base-pair substitution rates for the mitochondrial cytoc

123 surrounding DNA sequence on relative single-base-pair substitution rates was observed, which extende

124 ure-sensitive dnaE allele indicated a single base pair substitution resulting in a change from valine

125 In this report we identify a novel, single base pair substitution resulting in an amino acid exchan

126 esions delineated thus far consist of single-base-pair substitutions resulting in nonsense, missense,

127 e specificity of I-MsoI for three contiguous base pair substitutions, resulting in an endonuclease wh

128 Analysis of a series of 7- to 13-base-pair substitutions revealed two regions crucial for

129 The base pair substitution specificity and high fidelity for

130 Y955C derivative is 2-fold less accurate for base pair substitutions than wild-type pol gamma despite

131 however, stable alleles contain one to three base pair substitutions that interrupt the TNR tract.

132 Most were single-base-pair substitutions that identified separate DNA- an

133 For RNA pairs distinguished by a base pair substitution, the deltaDeltaG values were clos

134 l but 6 of the 33 independent mutations were base pair substitutions, the majority of which (17/33; 5

135 Although single base-pair substitutions throughout the entire DNA target

136 system that allows the rates of all possible base pair substitutions to be measured when the TRP5 loc

137 system could transfer each of 23 nonselected base pair substitutions to the recipient chromosome alon

138 Also, over 59% of single base-paired substitutions versus 20% of deletions and in

139 In addition, 3.7% of single base-paired substitutions versus 30% of deletions and in

140 ons were large insertions and deletions, but base pair substitutions were also detected.

141 nt and repair-deficient E. coli strains, and base pair substitutions were quantitated by hybridizatio

142 At each of the specified base pairs, substitutions were found which reduced promo

143 ne pyrimidine dimer, and predominantly makes base pair substitutions when replicating undamaged DNA.

144 icating undamaged DNA, Dpo4 is prone to make base pair substitutions, whereas Dbh predominantly makes

145 dsRBD] is sensitive to specific Watson-Crick base-pair substitutions which also inhibit RNase III.

146 ed DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high p