ライフサイエンスコーパス: base selection

1 t (i.e., in the absence of space- and object-based selection).

2 even error-prone DNA polymerases function in base selection.

3 ith the replicating base pair, thus relaxing base selection.

4 cile extrusion from the helix in its damaged base selection.

5 cyclic re-entry to ensure efficient affinity-based selection.

6 ndicating that DETC development involves TCR-based selection.

7 This was not due to a TCR-based selection.

8 red from cells that have undergone lethality-based selection.

9 ide library that was formatted for autocrine-based selection.

10 cycles of targeted mutagenesis and affinity-based selection.

11 such selection mechanisms: space- and object-based selection.

12 small molecule were identified by microarray-based selection.

13 ct is not a spatially global form of feature-based selection.

14 zes directed domain shuffling and rapid cell-based selections.

15 eered PKS design by learning from laboratory-based selection; adoption of DNA design software and aut

16 anning and enzyme-linked immunosorbent assay-based selection afforded a panel of nine scFv-phage clon

17 RNA recombination with a powerful host range-based selection allowed by the interspecies chimeric vir

18 were essential in elucidating mechanisms of base selection and exonuclease proofreading.

19 567) is a key determinant of the fidelity of base selection and that the Pol and Exo functions are st

20 provide a conceptual framework for rationale-based selection and combination of anticancer drugs for

21 gut microbiotas include chance events, host-based selection and interactions among microorganisms wi

22 sh N(-) B cells in adult life via repertoire-based selection and suggest the possibility of a TdT-def

23 h were used to examine the effect of feature-based selection and the competitive influence of a secon

24 forming a conceptual framework for rationale-based selection (and combination) of immunosuppressive a

25 at was part of the same object (i.e., object-based selection), and at an uncued location that was par

26 filing, genome-wide knockout studies, stress-based selection, and the use of inhibitors.

27 The results suggest that feature-based selection applies to stimuli at ignored peripheral

28 In this study, we used a novel, cell-based selection approach for isolating 'cell-type specif

29 Thus, this novel fluorescence-based selection approach simplifies the generation of ap

30 scovery typically uses hybridoma- or display-based selection approaches, which lack the advantages of

31 rstanding the direct impacts of ecologically based selection, as well as the indirect effects due to

32 In this study an in vitro PCR-based selection assay was used to identify sequences bou

33 cillatory responses, suggesting that feature-based selection at ignored locations during visual searc

34 et detection at a cued location (i.e., space-based selection), at an uncued location that was part of

35 as length distribution, paired distance, and base selection bias of vsiRNA sequences reflect differen

36 f the same object (i.e., resulting in object-based selection), but little is known about the relation

37 d type and suggest that enhanced fidelity of base selection by a polymerase active site can result in

38 ase is achieved in a multiplicative process: base selection by its polymerase activity and removal of

39 One round of mRNA display-based selection can be accomplished in ~7 d.

40 The results indicate that predation-based selection can increase the influence of distant ne

41 ic flounders is the trait under ecologically based selection causing reproductive isolation, directly

42 g MS-, physical-chemical, and chromatography-based selection criteria including HRMS/MS fragmentation

43 e applied to the models with the GRAPA curve-based selection criteria.

44 The observed distinct mechanisms of base selection demonstrated for members of the uracil gl

45 relates to potential mechanisms for affinity-based selection during the reaction.

46 incorporating this information, the entropy-based selection (EBS) scheme is useful for selecting an

47 ation steps through the use of hybridization-based selection embedded in the assembly process.

48 face of Galphas and argues that mRNA display-based selection/evolution is a powerful route for target

49 demonstrate this notion, we preformed growth-based selection experiments at nonpermissive temperature

50 as identified as an important determinant of base-selection fidelity.

51 50 to 80 years to estimate outcomes of risk-based selection for CT lung screening, assuming screenin

52 ation of new lineages under host- or element-based selection for function, in either case followed by

53 Using a transposon-based selection for increased hemA expression in the abs

54 of infection and suggest that genetic marker-based selection for resistance to bTB has the potential

55 reated by combination of design and reaction-based selection from libraries.

56 binding site previously identified by a PCR-based selection from random oligonucleotides by using re

57 ine-induced cells, and low-dose chemotherapy-based selection further increased engraftment.

58 During base selection, human Pol(iota) preferred T-G base pairi

59 zF72 was generated and subjected to a growth based selection in a chorismate mutase deficient strain.

60 mechanisms appear to operate during feature-based selection in much the same manner as has been show

61 d the effects of reward on space- and object-based selection in the same experimental setting.

62 regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retro

63 We observed that global feature-based selection, indexed by the brain response to unatte

64 , however, whether and how early oscillation-based selection influences speech perception.

65 A crucial factor determining object-based selection is the grouping between visual elements.

66 imary electrophysiological marker of feature-based selection is the N2pc, a lateralized posterior neg

67 to investigate DNA polymerase catalytic and base-selection mechanisms.

68 Dendritic cell maturation and TCR affinity-based selection mechanisms control the recruitment and e

69 attention and rivalry rely on shared object-based selection mechanisms.

70 We have developed an activity-based selection method to evolve DNA polymerases with RN

71 such enzymes, we have developed an activity-based selection method which isolates polymerase mutants

72 site, identified by a combinatorial activity-based selection method, within genomic and subgenomic RN

73 In summary, we describe a novel cell-based selection methodology that enables the identificat

74 elements of both modular design and activity-based selection methods typically used for generation of

75 t and validate a scoring system for evidence-based selection of bariatric and metabolic surgery proce

76 ation and updates previous models of spindle-based selection of cell fate during mitosis.

77 However, epitope density-based selection of cells with different avidities was ev

78 is paper are the starting point for pedigree based selection of cultivars with high levels of resista

79 d CD8alphabeta(+) T cells, mediated affinity-based selection of memory precursor cells.

80 r cells, demonstrate preferential repertoire-based selection of N(-) B cells into the MZ.

81 pportunity for genomics- and transcriptomics-based selection of patients for rationally designed ther

82 ful procedure that permits an unbiased trait-based selection of plant samples based on such phenotypi

83 In this study, structure- and computation-based selection of the predicated VDAC1 dimerization sit

84 The reports further suggest that the marker-based selection of the tumor cell population will facili

85 ll model of how the GC reaction and affinity-based selection operate.

86 We posit that feature-based selection operates by implementing multiple mechan

87 ese spike mimics no longer required antibody-based selection, positive or negative.

88 a were resistant, indicating strong antibody-based selection pressure.

89 this problem, we have developed a population-based selection procedure to increase aggression in Dros

90 d WIN protein in a polymerase chain reaction-based selection procedure.

91 The cell-based selection process is simple, fast, straightforward

92 We find that the time-course of the object-based selection process is well explained by a 'growth-c

93 minate the use of helper phage from phagemid-based selection protocols; reducing the amount of techni

94 population-level signature of global feature-based selection reflects a sequence of hierarchically or

95 Proximity based selections resulted in a population of antibodies

96 These findings indicate that object-based selection results from an object-sensitive reorien

97 lter intein specificity, we developed a cell-based selection scheme to evolve split inteins that spli

98 Using a yeast-based selection scheme, we isolated derriere, a novel TG

99 In contrast, risk-based selection screening of the same number of ever-smo

100 nT(reg) TCR repertoire is shaped by affinity-based selection, similar to conventional T cells.

101 oral data to determine how space- and object-based selection simultaneously evolve under conditions t

102 ng resulting from a spatial cue (i.e., space-based selection) spreads to uncued locations if those lo

103 Targeted therapy arms that used a biomarker-based selection strategy (n = 57 trials) were associated

104 We used a high throughput, cell-based selection strategy to screen a BSB library for seq

105 ifunctional gp17, we developed an expression-based selection strategy to select for mutants that are

106 s of targeted agents did not use a biomarker-based selection strategy.

107 arental rodent antibody into a phage display-based selection strategy.

108 mutagenesis and a green fluorescent protein-based selection strategy.

109 Importantly, this nonantibiotic-based selection system allows the use of cheap and widel

110 Given the large library sizes our bacterial-based selection system can handle, this method should pr

111 t the development and application of a yeast-based selection system designed to functionally interrog

112 By combining a previously developed FACS-based selection system for functional expression with ul

113 he efficacy of the non-invasive fluorescence-based selection system is promising for its application

114 thod that makes use of a powerful host range-based selection system.

115 ss, making it more general than biologically based selection systems because it is not limited to rea

116 cally not amenable to traditional antibiotic-based selection systems, and may be used in combination

117 ific tools, including promoters for reporter-based selection systems, that we employed to improve lov

118 An entropy-based selection test is presented that explicitly takes

119 lygenic resistance and field- vs. laboratory-based selection, the application of molecular cloning to

120 pansion, somatic hypermutation, and affinity-based selection, the combination of which results in the

121 ate progressive but discontinuous repertoire-based selection throughout B cell development supporting

122 he G185V substitution was used in a function-based selection to identify mutations that would further

123 impede anaerobic growth, followed by growth-based selection to isolate suppressor mutants that resto

124 Here, we adapted a phage display library-based selection to screen and identify binding peptides

125 rgo somatic hypermutation (SHM) and affinity-based selection toward antigen in activated germinal cen

126 ralleled advantage over traditional pedigree-based selection (TS) methods by reducing the time commit

127 ing bacteria and methanogens indicate energy-based selection typical of anoxic marine sediments, 5-15

128 dinated network of water molecules acting in base selection upstream of the GGAA core and the structu

129 Imaging-based selection, used in some of the recent trials to ex

130 or the isolation of bona fide hiPSCs in FACS-based selection using an optimized combination of cell s

131 Reaction-based selection with 1,3-diketones was performed to trap

132 MS analysis of the suspension after density-based selection yielded a sensitivity of 72.1% and a spe

133 FLoSS-based selection yields families with exceptional longevi