ライフサイエンスコーパス: base step

1 y significant contacts to an adenine-thymine base step.

2 ues ranged from 20 degrees to 50 degrees per base step.

3 lue comparable to the stacking energy of one base step.

4 ues for helical rise and twist at individual base steps.

5 t deprotonation of the carboxylic acid under base (Step 4), while in the absence of base a stable car

6 f carboxylic acid to carboxylate anion under base (Step 4).

7 om a single guanine base to a double guanine base step across a single adenine.

8 ior determination of the pronounced 5'-TA/TA base-step affinity of the drug have prompted us to inves

9 This results in a centrally underwound base step and a number of subsequent overwinding steps l

10 ugh its dual functionality, with microtubule-based stepping and regulation of microtubule dynamics.

11 intercalated into the 5'-CG/CG and 5'-GA/TC base steps, and penetration of the duplexes occurred fro

12 sence of a severely underwound central py.pu base step (average = 24.1 degrees), which lies on a crys

13 The base step between T4*A17 and FAPYG5*C16 was increased fr

14 ist decrease to approximately 30 degrees per base step, but every base step was approximately 30 degr

15 developed by exploiting the emulsion-droplet-based step-by-step growth featuring shape control.

16 antihypertensive therapy with chlorthalidone-based stepped-care therapy resulted in a lower rate of c

17 (2) maintaining DNA structures dependent on base-step conformational tendencies consistent with the

18 es a detailed description of the dynamics of base-step conformational transitions and of the first st

19 icroscopy and developed a set of information-based step detection procedures to estimate the number o

20 twisting without an increase in intrastrand base-step distance.

21 We provide resampling-based step-down adjustments to correct the observed sign

22 oit et al. have advocated use of permutation-based step-down P-value adjustments to correct the obser

23 rimental data, including local deviations in base step helicoidal parameters in the region of the GU

24 ccessible roll values were obtained for each base step in the relevant octanucleotide context to acco

25 is associated with unstacking of individual base steps in the target site.

26 ty of applying the experimental and software-based steps in multiple-complete-digest mapping to a tar

27 ude the sequence-dependent differences among base steps, in which values ranged from 20 degrees to 50

28 npeptidic, single-digit micromolar mechanism-based STEP inhibitors with greater than 20-fold selectiv

29 The base-step intercalation seen here is reminiscent of doma

30 and tilt were also more variable in certain base steps involving mismatched bases.

31 relationship between local structure at the base-step level and the global superhelical conformation

32 tecture in which segments as small as single base steps may be considered as modular recognition unit

33 useful stereochemical measures of the local base step movements operative in sequence-specific recog

34 photoadduct formation to the intended 5'-TpA base step next to the PNA-binding site, and the photoadd

35 The curvature is due almost entirely to the base-step parameter roll.

36 ystal structures used for compiling the mean base step parameters of DNA is available by anonymous ft

37 The base step parameters which are most strongly coupled to

38 in groove narrowing through: (i) changes in base step parameters, including increased helical twist

39 Although variations in the other base-step parameters perturb the local path of the DNA,

40 performed using octamers containing various base steps present in the 'NMR sequences'.

41 The distribution of base-step roll values and corresponding strain energy re

42 eters in protein-DNA crystal structures, GpG base steps show A-like properties, reflecting their inna

43 he larger 3' bend, 10 degrees, occurs in two base steps: the first composed of tilt, -4.1 degrees, an

44 litated by a highly deformable local -C3-A4- base step, this amino group allows the B[a]P ring system

45 ads, zipper-like interdigitation and sheared base steps, together with base-base and base-sugar stack

46 degrees to 50 degrees kink at a central CpG base step towards the major groove, as dyad-related leuc

47 ximately 30 degrees per base step, but every base step was approximately 30 degrees, suggesting that

48 x 2 covalently modifies adenine at GA and TA base steps, which are high-affinity intercalation sites

49 h a structural distortion localized to an AT base step within the -10 element.