ライフサイエンスコーパス: basement

1 e within, and assimilation of, local granite basement.

2 e axial rift, within a gabbro and peridotite basement.

3 ea of 700-1600 m(2), the volume of a typical basement.

4 ace heat sources such as buildings and their basements.

5 tions, which are softer than the crystalline basement, are rarely critically stressed; (ii) the least

6 ressure, depth, and proximity to crystalline basement do not strongly correlate with earthquake assoc

7 ies were similar across most room types, but basements exhibited more unique community compositions.

8 from saprolitic remnants constrains original basement exposure in the Late Triassic (221.3+/-7.0-206.

9 We collected passive air samples from basements in 50 homes (36 flood-damaged, 14 non-flooded)

10 Using first-floor and basement indoor radon results reported to the PADEP betw

11 The basement is a calc-silicate rock housing hydrothermal de

12 gical evidence that some of the low-altitude basement landforms on- and offshore southwestern Scandin

13 e into a static structure, mimicking in vivo basement layer assembly during sporulation in Bacillus s

14 Here, we reconstitute the basement layer of the coat atop spherical membranes supp

15 ension of invadopodia and podosomes into the basement layer.

16 We identified basement membrane (BM) and collagen IV in Ctenophora, an

17 r assessment of the mean number of layers of basement membrane (BM) around peritubular capillaries (P

18 Cell invasion through basement membrane (BM) barriers is crucial in developmen

19 obust mechanical anisotropy in the ECM-based basement membrane (BM) but not in the underlying epithel

20 th retention of collagen IV, reiterating the basement membrane (BM) changes observed in vivo.

21 How the basement membrane (BM) contributes to the normal functio

22 is one of the constituent components of the basement membrane (BM) in adult rat testes.

23 The islet basement membrane (BM) influences islet function and sur

24 The basement membrane (BM) is a form of extracellular matrix

25 The basement membrane (BM) is a thin layer of extracellular

26 othelial cells (ECs) enhances subendothelial basement membrane (BM) stiffness, which, in turn, promot

27 loss (PL), vessel tortuosity, and capillary basement membrane (BM) thickness.

28 for its localization to the neuroepithelial basement membrane (BM) to effectively antagonize HH path

29 vasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tiss

30 dings of a local regulatory axis between the basement membrane (BM), the blood-testis barrier (BTB),

31 f fibrotic lung myofibroblasts to invade the basement membrane (BM).

32 ndothelial cells (ECs), pericytes (PCs), and basement membrane (BM).

33 etween the muscle fiber cytoskeleton and the basement membrane (BM).

34 ctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV), were down-regulated upo

35 mediated, cytokine-dependent anti-glomerular basement membrane (GBM) glomerulonephritis (GN), in alph

36 by immigration of cells along the glomerular basement membrane (GBM) is under debate.

37 Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosi

38 eutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogsto

39 in the kidney, commonly along the glomerular basement membrane (GBM).

40 (LAMB2), a major component of the glomerular basement membrane (GBM).

41 l thickening and splitting of the glomerular basement membrane (GBM).

42 rtment: epithelium (basal region), reticular basement membrane (Rbm) and underlying lamina propria (L

43 We assessed airway inflammation, reticular basement membrane (RBM) thickness, airway smooth muscle

44 assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detach

45 pillary and vasa recta thrombi and capillary basement membrane alterations primarily involving the re

46 ing the sensory nerve fibers in crossing the basement membrane and branching into nerve endings.

47 These analyses revealed the evolution of basement membrane and cellular defects through the progr

48 o disrupt laminin expression in the vascular basement membrane and demonstrate that microglia respond

49 s of kidneys revealed a thickened glomerular basement membrane and effaced podocytes in the diabetic

50 sting of podocyte foot processes, glomerular basement membrane and endothelial cells.

51 ring which they remain associated with their basement membrane and express markers of both epithelial

52 nates in the proliferative cell layer at the basement membrane and extends to the upper epithelial la

53 thelium and is transmitted to the supporting basement membrane and internal elastic lamina macromolec

54 al glomerulonephritis, being anti-glomerular basement membrane and lipopolysaccharide-induced glomeru

55 genes mediating epithelial cell adhesion to basement membrane and mesenchymal-epithelial cross-talk.

56 GF-A165 b rescues the increase in glomerular basement membrane and podocyte slit width, as well as th

57 erve fiber branching points, penetrating the basement membrane and reaching into the stroma.

58 e avoids complete removal of the retinal ILM basement membrane and subjacent tissues and appears to p

59 ibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events

60 he BBB through their proteolytic activity on basement membrane and tight junction proteins.

61 ollagen IV scaffold, a function critical for basement membrane and tissue integrity.

62 fter posterior vitreous detachment is a true basement membrane and to postulate its origin.

63 thelial cells attached to denuded glomerular basement membrane and, occasionally, disengaged from the

64 tissue extracts had significantly more anti-basement membrane antibodies than sera from patients wit

65 In GEC(HO-1) rats with anti-glomerular basement membrane antibody mediated, complement-dependen

66 njury induced by injection of antiglomerular basement membrane antibody, deletion of Vangl2 resulted

67 Ts via DNase I did not alter anti-glomerular basement membrane antibody-induced glomerular injury, as

68 e with MPO and a low dose of anti-glomerular basement membrane antibody.

69 e in glomerular podocytes and the underlying basement membrane are frequently observed in disease, ir

70 arkers for cell junction (ZO1, Desmoplakin), basement membrane assembly (Collagen 7, Laminin 5), diff

71 hibitory role, suggesting that regulation of basement membrane assembly requires a complex interplay

72 and Smad1/5(dKO) thyroids displayed impaired basement membrane assembly.

73 ve role, alpha9beta1 has an opposing role in basement membrane assembly/maturation through reduced la

74 Cell invasion across basement membrane barriers is important in both normal d

75 ent serum, and control serum and assayed for basement membrane binding by means of ELISA.

76 tein netrin 1 (Ntn1), which is necessary for basement membrane breakdown, although the underlying mol

77 lls lose their epithelial morphology and the basement membrane breaks down.

78 rhans, and the constitution of the beta cell basement membrane can both be affected by proteolytic en

79 on in response to recognition of the exposed basement membrane collagen by the GPVI receptor, which i

80 t that allows LOXL2-mediated crosslinking of basement membrane collagen IV.

81 ependent on the expression of muscle-derived basement membrane collagens and motor neuron-derived eph

82 albuminuria and thickening of the glomerular basement membrane compared with nondiabetic FHL2(+/+) mi

83 d cancer cell invasion through reconstituted basement membrane compared with serum from saline contro

84 Perivascular access to smooth muscle basement membrane compartments also exhibited size-depen

85 er and putative smooth muscle and astroglial basement membrane compartments.

86 Collagen XV is a basement membrane component mainly expressed in skeletal

87 Moreover, the expressions of basement membrane components and other vascular proteins

88 ment therapy, and they also suggest that the basement membrane components at the dermal-epidermal jun

89 The lower amounts of basement membrane components in metformin-treated indivi

90 The amounts of the basement membrane components, alpha1-type IV collagen an

91 defects or with mutations in genes encoding basement membrane components, which are known to interac

92 hat Rab10 directs site-specific secretion of basement membrane components, which assemble into fibril

93 editary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juven

94 ontribute to P. aeruginosa keratitis through basement membrane degradation, and its inhibition could

95 were characterized by amnion cell puckering, basement membrane degradation, and tunnels that extended

96 Capillarization was characterized by ectopic basement membrane deposition, formation of a continuous

97 l Akt deletion induces retinal VSMC loss and basement membrane deterioration resulting in vascular re

98 lonephritis, a model of human antiglomerular basement membrane disease, depends on both Ab and T cell

99 oimmune GN, a rodent model of antiglomerular basement membrane disease.

100 invasive phenotype such as lumen-filling and basement membrane disruption.

101 MMP to promote invasive behaviour leading to basement membrane disruption.

102 nce of an irregular and thickened epithelial basement membrane duplicating or insinuating into the co

103 l architecture, remodeling of the epithelial basement membrane during branching morphogenesis is also

104 re observed in 86 of 87 eyes with epithelial basement membrane dystrophy (45 patients) on SD OCT scan

105 OCT findings in the diagnosis of epithelial basement membrane dystrophy (kappa = 0.98).

106 Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched

107 al changes occurring in eyes with epithelial basement membrane dystrophy based on SD OCT findings wer

108 al changes occurring in eyes with epithelial basement membrane dystrophy.

109 firm or rule out the diagnosis of epithelial basement membrane dystrophy.

110 hat the posterior hyaloid membrane is a true basement membrane enveloping the posterior hyaloid surfa

111 ctin signalling depends on a cross-talk with basement membrane extracellular matrix (ECM) via beta1 i

112 es to flow through microchannels coated with basement membrane extract.

113 utrophils need to penetrate the perivascular basement membrane for successful extravasation into infl

114 hown to cooperate to promote proper vascular basement membrane formation and contribute to endothelia

115 Anti-glomerular basement membrane GN involved NET formation and vascular

116 -complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulo

117 ore blisters at two or more sites and linear basement membrane IgG or C3).

118 onstrate that microglia respond to the mural basement membrane in an isoform-specific manner.

119 Recent work on the basement membrane in developmental systems is transformi

120 yte protrusions invading into the glomerular basement membrane in disease and these occurred frequent

121 s displayed defects in BCT cell polarity and basement membrane integrity at the chorioallantoic inter

122 st proteins central to blood coagulation and basement membrane integrity, suggesting a role for these

123 e collagen IV network, an event essential to basement membrane integrity.

124 The basement membrane is a dense, highly cross-linked, sheet

125 Here we show that assembly of the epithelial basement membrane is crucial for folliculogenesis and is

126 Contact with the basement membrane is lost in differentiating daughter ce

127 Because podocyte adhesion to the glomerular basement membrane is mediated by integrins, the relevanc

128 gnment, but it becomes dispensable after the basement membrane is polarized.

129 This basement membrane is rich in laminin-III (L1), which pla

130 astructural studies show that the glomerular basement membrane is thickened, podocyte slit width is i

131 are grown in substrata that have elements of basement membrane leading to the formation of tissue-lik

132 Furthermore, reconstitution of the basement membrane leads to characteristic cortical tissu

133 munohistochemically staining for collagen IV basement membrane markers, in addition to extracellular

134 f the native structure by locally depositing basement membrane materials onto type 1 collagen nanofib

135 NIH (Bethesda, MD), where the reconstituted basement membrane Matrigel was discovered, I had the int

136 ciated from whole fundic tissue and grown in basement membrane matrix (Matrigel) and organoid growth

137 Basement membrane matrix proteins, such as matrigel, are

138 oplasticity, in collagen gels, reconstituted basement membrane matrix, agarose gels, alginate gels, a

139 of the laminin-gamma2 chain is a hallmark of basement membrane maturation in the skin.

140 uitment of ECs in vivo in a murine synthetic basement membrane model.

141 Severe peritubular capillary basement membrane multilayering (PTCBML) is part of the

142 Moreover, after induction of anti-glomerular basement membrane nephritis in young mice, iPLA2gamma KO

143 fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is als

144 stribution was observed (i) in the thickened basement membrane of asthmatic lower airways, (ii) aroun

145 tes are vascular mural cells embedded in the basement membrane of blood microvessels.

146 biopsies of patients with SS reveal that the basement membrane of dermal postcapillary venules underg

147 ost universally deposited linearly along the basement membrane of NP tissue.

148 C3 deposits were conspicuous in the tubular basement membrane of proximal tubules, corresponding to

149 vasive cellular protrusions that expand tiny basement membrane openings.

150 esion to laminin-332, is critical for proper basement membrane organization during skin development a

151 ect on the ability of alpha3beta1 to promote basement membrane organization.

152 iltration, and collagen disorganization; and basement membrane preservation.

153 acterized by autoantibodies directed against basement membrane protein BP180.

154 The basement membrane protein netrin-4 was found to be local

155 The distinct accumulation of arterial basement membrane proteins in type 2 diabetes mellitus d

156 By day 28, basement membrane proteins were reduced in drug-eluting

157 sion of genes encoding extracellular matrix, basement membrane proteins, and members of ERK, FGF and

158 vitro and in vivo wound healing by enhancing basement membrane proteins, granulation tissue component

159 er to new collagen I surfaces, and away from basement membrane proteins.

160 ion in a macrophage-mediated anti-glomerular basement membrane reactive serum-induced immune nephriti

161 ration of neurovascular structures including basement membrane reduction, pericyte loss, and astrocyt

162 that generally remain confined to the basal/basement membrane region.

163 ntact pObs only where an otherwise occluding basement membrane remains incompletely assembled.

164 F-alpha and IL-17A were conducted to dissect basement membrane remodeling.

165 Both local and global dynamics of the basement membrane require protease and myosin II activit

166 AAVs is the inner limiting membrane (ILM), a basement membrane rich in heparan sulfate (HS) proteogly

167 llular polymerization of laminin trimers and basement membrane scaffolding.

168 Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations

169 rular hypertrophy, podocyte loss, glomerular basement membrane splitting, and secondary focal and seg

170 A2) form heterotrimers critical for vascular basement membrane stability and function.

171 networks, which are essential for glomerular basement membrane stability and molecular ultrafiltratio

172 g tolerant mice with anti-ER-TR7 altered HEV basement membrane structure and the distribution of CCL2

173 Basement membrane structures on the serous side stimulat

174 nctions, adherens junctions, and stabilizing basement membrane structures.

175 ic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes.

176 etachment and disruption of the perivascular basement membrane surrounding the VECs.

177 nges in the ultrastructure of the glomerular basement membrane that increase in severity in parallel

178 Cs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types.

179 QR], 3.5% to 10.1%, P < .001), subepithelial basement membrane thickening (4.4 mum [25th-75th IQR, 4.

180 anges was associated with a higher degree of basement membrane thickening and edematous changes withi

181 y, mesangial matrix accumulation, glomerular basement membrane thickening, albuminuria, and podocyte

182 ponse to bleomycin administration, including basement membrane thickening, interstitial fibrin deposi

183 pithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, ai

184 ard to pulmonary function indices, bronchial basement membrane thickness, and BAL fluid neutrophil an

185 sing image analysis, together with reticular basement membrane thickness, mucus gland area, collagen

186 rway smooth muscle (ASM) area, subepithelial basement membrane thickness, nerve fibers, and epithelia

187 cellular matrix, collagen markers, reticular basement membrane thickness, or glandular percentage are

188 th severe asthma were analyzed for ASM area, basement membrane thickness, vessels, eosinophils, neutr

189 h production and maintenance of the vascular basement membrane to prevent abnormal aortic expansion a

190 ells proliferate and spread onto the denuded basement membrane to reseal the barrier.

191 Globally, the basement membrane translocates rearward as a whole, accu

192 brane structures that are thought to mediate basement membrane transmigration during development and

193 pithelial cells covered the denuded visceral basement membrane via formation of proliferative pseudoc

194 esangial expansion, and increased glomerular basement membrane width in diabetic mice.

195 we identified sub-podocyte expansions of the basement membrane with both cellular and matrix gene def

196 en, an extracellular matrix component of the basement membrane zone forming the anchoring fibrils.

197 n-serrated IgG deposition pattern along the basement membrane zone in 9 of 11 patients.

198 oantibodies against a 200-kDa protein in the basement membrane zone.

199 of human type VII collagen restricted to the basement membrane zone.

200 These findings establish the basement membrane's active role in tissue sculpting.

201 Invasive and metastatic cells must cross the basement membrane's extracellular matrix to disseminate

202 emidesmosomes (which mediate adhesion to the basement membrane).

203 nt biomimetic substrates (e.g., collagen and basement membrane).

204 xpression of secreted proteases that degrade basement membrane, an ECM barrier surrounding all epithe

205 in which surgical removal of the epithelium, basement membrane, and anterior stroma was performed.

206 r, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the

207 IgG-positive immune deposits in the tubular basement membrane, and circulating antibodies reactive w

208 ment, irregular thickening of the glomerular basement membrane, and dilated capillary loops, with a s

209 epithelial injury, accumulate in the tubular basement membrane, and elicit an interstitial inflammato

210 animals featured endothelial gaps, thickened basement membrane, and fibrin-like intraluminal deposits

211 ess effacement, thickening of the glomerular basement membrane, and FSGS-like lesions.

212 athway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these ch

213 rastructure of collagen fibers in the vessel basement membrane, and the kinetics of regression were d

214 ed of the endothelial lining, the glomerular basement membrane, and the podocyte intercellular juncti

215 d to podocyte detachment from the glomerular basement membrane, and we detected detached podocytes cr

216 a propria and the epithelium, separated by a basement membrane, are linked.

217 y contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth

218 porting cells, which retain contact with the basement membrane, exhibit biased protrusive activity an

219 ies with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules

220 by preserved epithelium integrity and intact basement membrane, leading to reduced bacterial dissemin

221 heir microenvironment and alterations of the basement membrane, led to ESC mislocalization and exhaus

222 ucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, ch

223 Laminin, a major component of the basement membrane, plays an important role in blood brai

224 By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth

225 t of Bergmann glia, and the integrity of the basement membrane, primarily in the anterior lobules.

226 roxidasin, a heme peroxidase embedded in the basement membrane, produces hypohalous acid intermediate

227 e breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis.

228 thelial-cadherin (VE-cadherin) junctions and basement membrane, similar to collecting lymphatics.

229 tus et al. (2015) reveal that to invade past basement membrane, the C. elegans anchor cell must cease

230 was required to invade past the endothelial basement membrane, whereas its attenuation in a syngenei

231 tight junctions and focal disruptions of the basement membrane, which eventually lead to a breakdown

232 pdgfr signaling leads to a reduced vascular basement membrane, which in turn results in enhanced dor

233 at the endothelium in developing bones lacks basement membrane, which normally isolates the blood ves

234 a1, -gamma2 and -gamma3 chains in the limbal basement membrane, with LN-alpha5 representing a signatu

235 l functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptid

236 l accumulation and damage in anti-glomerular basement membrane-induced (anti-GBM-induced) glomerulone

237 Similarly, both anti-glomerular basement membrane-induced glomerulonephritis and experim

238 glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis.

239 Sub-threshold doses of glomerular basement membrane-reactive serum induced more severe and

240 Agrin is a basement membrane-specific proteoglycan that can regulat

241 e occurred frequently in expanded regions of basement membrane.

242 nor accumulation of C3 along the glomerular basement membrane.

243 deposit different laminin isoforms into the basement membrane.

244 promote folliculogenesis via assembly of the basement membrane.

245 olayer of thyrocytes resting on a continuous basement membrane.

246 d persisting between the endothelium and the basement membrane.

247 the basal keratinocytes lose adhesion to the basement membrane.

248 of cells as well as on the elasticity of the basement membrane.

249 mooth muscle cells, and a collagen-fortified basement membrane.

250 as a pump to counteract the leakiness of its basement membrane.

251 relative positions and association with the basement membrane.

252 elial cells (podocytes) along the glomerular basement membrane.

253 ions used by invasive cells to penetrate the basement membrane.

254 , occasionally, disengaged from the parietal basement membrane.

255 complex, which is believed to stabilize the basement membrane.

256 rate an invasive protrusion that crosses the basement membrane.

257 rom the primary tumor and invade through the basement membrane.

258 was, in part, attributable to damage of the basement membrane.

259 ition occurred linearly along the epithelial basement membrane.

260 rved that basal cells flattened to cover the basement membrane.

261 pport and cues to the cells as an engineered basement membrane.

262 ced using an antibody against the glomerular basement membrane.

263 lial cell junction proteins and a continuous basement membrane.

264 ing are modulated by components of the mural basement membrane.

265 in the testis: role of laminin alpha2 in the basement membrane.

266 d collagen IV immunoreactivity at the muscle basement membrane.

267 that stabilizes collagen IV scaffolds in the basement membrane.

268 h acute edema due to spontaneous Descemet s (basement) membrane rupture in keratoconus, mimicking thi

269 Thin-basement-membrane nephropathy (TBMN) and Alport syndrome

270 Basement membranes (BMs) are planar protein networks tha

271 Basement membranes (BMs) are thin, dense sheets of speci

272 that netrin-4 disrupts laminin networks and basement membranes (BMs) through high-affinity binding t

273 ure found within the collagen IV scaffold of basement membranes (BMs).

274 n severe or manifest by multilayering of the basement membranes (glomerular and/or peritubular capill

275 cretion, approximately 3x thicker glomerular basement membranes and severe podocyte effacement, match

276 riking ultrastructural changes in glomerular basement membranes in FVB mice.

277 to the perivascular spaces and tunica media basement membranes of leptomeningeal arteries.

278 ic proteins that are major components of the basement membranes that separate endothelia and epitheli

279 etworks that provide mechanical stability to basement membranes, a specialized form of extracellular

280 d complement deposition along the glomerular basement membranes, and a nephrotic syndrome, two additi

281 resulted in renal clear cells, multi-layered basement membranes, severe cystic pathology, and ultimat

282 s with endothelial cells, their adherence to basement membranes, the internal elastica lamina, and ne

283 ized by weak interactions between muscle and basement membranes.

284 ulfilimine bonds to reinforce collagen IV in basement membranes.

285 eavy chains along the glomerular and tubular basement membranes.

286 deposition, and thickness of the glomerular basement membranes.

287 deposits in the glomeruli and along tubular basement membranes.

288 collagen is a major and crucial component of basement membranes.

289 a structural protein of epidermal/epithelial basement membranes.

290 l. (2017) identify a mechanism for breaching basement membranes.

291 Basement radon concentrations fluctuated between 1987 an

292 ical development of west Scandinavia coastal basement rocks during the Mesozoic and later, long-lasti

293 that deep ice-sheet erosion-enough to expose basement rocks-has occurred in two regions: the head of

294 ed from uplifted, fractured, shocked, felsic basement rocks.

295 e pressure from propagating into crystalline basement rocks.

296 temperatures, building density, and elevated basement temperatures.

297 arshore biofacies (<20 m water depth) to the basement topography undoubtedly shaped by subaerial weat

298 The image clearly shows that the crystalline basement was uplifted within the LMS orogenic belt, and

299 tion of seawater with a mafic and ultramafic basement which precipitates talc on mixing with seawater

300 in dark glass bottles (headspace 0.5%) in a basement without central heating for 24 months.