ライフサイエンスコーパス: basement membrane

1 emidesmosomes (which mediate adhesion to the basement membrane).

2 nt biomimetic substrates (e.g., collagen and basement membrane).

3 e occurred frequently in expanded regions of basement membrane.

4 nor accumulation of C3 along the glomerular basement membrane.

5 deposit different laminin isoforms into the basement membrane.

6 promote folliculogenesis via assembly of the basement membrane.

7 olayer of thyrocytes resting on a continuous basement membrane.

8 d persisting between the endothelium and the basement membrane.

9 the basal keratinocytes lose adhesion to the basement membrane.

10 of cells as well as on the elasticity of the basement membrane.

11 mooth muscle cells, and a collagen-fortified basement membrane.

12 as a pump to counteract the leakiness of its basement membrane.

13 relative positions and association with the basement membrane.

14 elial cells (podocytes) along the glomerular basement membrane.

15 ions used by invasive cells to penetrate the basement membrane.

16 , occasionally, disengaged from the parietal basement membrane.

17 complex, which is believed to stabilize the basement membrane.

18 rate an invasive protrusion that crosses the basement membrane.

19 rom the primary tumor and invade through the basement membrane.

20 IV collagen chains present in the glomerular basement membrane.

21 was, in part, attributable to damage of the basement membrane.

22 ition occurred linearly along the epithelial basement membrane.

23 rved that basal cells flattened to cover the basement membrane.

24 pport and cues to the cells as an engineered basement membrane.

25 ced using an antibody against the glomerular basement membrane.

26 lial cell junction proteins and a continuous basement membrane.

27 ing are modulated by components of the mural basement membrane.

28 in the testis: role of laminin alpha2 in the basement membrane.

29 d collagen IV immunoreactivity at the muscle basement membrane.

30 that stabilizes collagen IV scaffolds in the basement membrane.

31 ized by weak interactions between muscle and basement membranes.

32 ulfilimine bonds to reinforce collagen IV in basement membranes.

33 eavy chains along the glomerular and tubular basement membranes.

34 deposition, and thickness of the glomerular basement membranes.

35 deposits in the glomeruli and along tubular basement membranes.

36 collagen is a major and crucial component of basement membranes.

37 a structural protein of epidermal/epithelial basement membranes.

38 l. (2017) identify a mechanism for breaching basement membranes.

39 etworks that provide mechanical stability to basement membranes, a specialized form of extracellular

40 pillary and vasa recta thrombi and capillary basement membrane alterations primarily involving the re

41 xpression of secreted proteases that degrade basement membrane, an ECM barrier surrounding all epithe

42 ing the sensory nerve fibers in crossing the basement membrane and branching into nerve endings.

43 These analyses revealed the evolution of basement membrane and cellular defects through the progr

44 o disrupt laminin expression in the vascular basement membrane and demonstrate that microglia respond

45 s of kidneys revealed a thickened glomerular basement membrane and effaced podocytes in the diabetic

46 sting of podocyte foot processes, glomerular basement membrane and endothelial cells.

47 ring which they remain associated with their basement membrane and express markers of both epithelial

48 nates in the proliferative cell layer at the basement membrane and extends to the upper epithelial la

49 thelium and is transmitted to the supporting basement membrane and internal elastic lamina macromolec

50 al glomerulonephritis, being anti-glomerular basement membrane and lipopolysaccharide-induced glomeru

51 genes mediating epithelial cell adhesion to basement membrane and mesenchymal-epithelial cross-talk.

52 GF-A165 b rescues the increase in glomerular basement membrane and podocyte slit width, as well as th

53 erve fiber branching points, penetrating the basement membrane and reaching into the stroma.

54 e avoids complete removal of the retinal ILM basement membrane and subjacent tissues and appears to p

55 ibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events

56 he BBB through their proteolytic activity on basement membrane and tight junction proteins.

57 ollagen IV scaffold, a function critical for basement membrane and tissue integrity.

58 fter posterior vitreous detachment is a true basement membrane and to postulate its origin.

59 itis elegans striated muscle cells attach to basement membrane and transmit the force of muscle contr

60 thelial cells attached to denuded glomerular basement membrane and, occasionally, disengaged from the

61 cretion, approximately 3x thicker glomerular basement membranes and severe podocyte effacement, match

62 myocardial integrity, improper deposition of basement membrane, and a resultant failure of hearts to

63 in which surgical removal of the epithelium, basement membrane, and anterior stroma was performed.

64 r, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the

65 IgG-positive immune deposits in the tubular basement membrane, and circulating antibodies reactive w

66 ment, irregular thickening of the glomerular basement membrane, and dilated capillary loops, with a s

67 epithelial injury, accumulate in the tubular basement membrane, and elicit an interstitial inflammato

68 animals featured endothelial gaps, thickened basement membrane, and fibrin-like intraluminal deposits

69 ess effacement, thickening of the glomerular basement membrane, and FSGS-like lesions.

70 athway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these ch

71 rastructure of collagen fibers in the vessel basement membrane, and the kinetics of regression were d

72 ed of the endothelial lining, the glomerular basement membrane, and the podocyte intercellular juncti

73 d to podocyte detachment from the glomerular basement membrane, and we detected detached podocytes cr

74 d complement deposition along the glomerular basement membranes, and a nephrotic syndrome, two additi

75 tissue extracts had significantly more anti-basement membrane antibodies than sera from patients wit

76 In GEC(HO-1) rats with anti-glomerular basement membrane antibody mediated, complement-dependen

77 njury induced by injection of antiglomerular basement membrane antibody, deletion of Vangl2 resulted

78 Ts via DNase I did not alter anti-glomerular basement membrane antibody-induced glomerular injury, as

79 e with MPO and a low dose of anti-glomerular basement membrane antibody.

80 bundles in the epithelium and fibrils in the basement membrane are all aligned perpendicular to the e

81 e in glomerular podocytes and the underlying basement membrane are frequently observed in disease, ir

82 a propria and the epithelium, separated by a basement membrane, are linked.

83 arkers for cell junction (ZO1, Desmoplakin), basement membrane assembly (Collagen 7, Laminin 5), diff

84 em cell differentiation that goes far beyond basement membrane assembly and a mechanism by which an M

85 cell polarity, as well as in laminin-511 and basement membrane assembly at the tip of the hair bud.

86 hibitory role, suggesting that regulation of basement membrane assembly requires a complex interplay

87 and Smad1/5(dKO) thyroids displayed impaired basement membrane assembly.

88 ve role, alpha9beta1 has an opposing role in basement membrane assembly/maturation through reduced la

89 Furthermore, the basement membrane-associated type IV collagens regulate

90 Cell invasion across basement membrane barriers is important in both normal d

91 ent serum, and control serum and assayed for basement membrane binding by means of ELISA.

92 ypic cell-cell adhesion and heterotypic cell-basement membrane (BM) adhesion with the latter being im

93 We identified basement membrane (BM) and collagen IV in Ctenophora, an

94 r assessment of the mean number of layers of basement membrane (BM) around peritubular capillaries (P

95 Cell invasion through basement membrane (BM) barriers is crucial in developmen

96 obust mechanical anisotropy in the ECM-based basement membrane (BM) but not in the underlying epithel

97 th retention of collagen IV, reiterating the basement membrane (BM) changes observed in vivo.

98 How the basement membrane (BM) contributes to the normal functio

99 ies the mutation, revealed that both display basement membrane (BM) defects.

100 is one of the constituent components of the basement membrane (BM) in adult rat testes.

101 The islet basement membrane (BM) influences islet function and sur

102 The basement membrane (BM) is a form of extracellular matrix

103 The basement membrane (BM) is a thin layer of extracellular

104 laminin-332 (LN-332), has critical roles in basement membrane (BM) organization during skin developm

105 othelial cells (ECs) enhances subendothelial basement membrane (BM) stiffness, which, in turn, promot

106 loss (PL), vessel tortuosity, and capillary basement membrane (BM) thickness.

107 for its localization to the neuroepithelial basement membrane (BM) to effectively antagonize HH path

108 vasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tiss

109 dings of a local regulatory axis between the basement membrane (BM), the blood-testis barrier (BTB),

110 f fibrotic lung myofibroblasts to invade the basement membrane (BM).

111 ndothelial cells (ECs), pericytes (PCs), and basement membrane (BM).

112 etween the muscle fiber cytoskeleton and the basement membrane (BM).

113 Basement membranes (BMs) are planar protein networks tha

114 Basement membranes (BMs) are thin, dense sheets of speci

115 that netrin-4 disrupts laminin networks and basement membranes (BMs) through high-affinity binding t

116 ure found within the collagen IV scaffold of basement membranes (BMs).

117 tein netrin 1 (Ntn1), which is necessary for basement membrane breakdown, although the underlying mol

118 lls lose their epithelial morphology and the basement membrane breaks down.

119 y contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth

120 rhans, and the constitution of the beta cell basement membrane can both be affected by proteolytic en

121 To transmigrate basement membrane, cells must coordinate distinct signal

122 on in response to recognition of the exposed basement membrane collagen by the GPVI receptor, which i

123 t that allows LOXL2-mediated crosslinking of basement membrane collagen IV.

124 ctions (VE-cadherin, alpha-Actinin), and the basement membrane (Collagen IV), were down-regulated upo

125 ependent on the expression of muscle-derived basement membrane collagens and motor neuron-derived eph

126 albuminuria and thickening of the glomerular basement membrane compared with nondiabetic FHL2(+/+) mi

127 d cancer cell invasion through reconstituted basement membrane compared with serum from saline contro

128 racellular matrix; and reduced thickening of basement membranes compared with controls.

129 Perivascular access to smooth muscle basement membrane compartments also exhibited size-depen

130 er and putative smooth muscle and astroglial basement membrane compartments.

131 Collagen XV is a basement membrane component mainly expressed in skeletal

132 Moreover, the expressions of basement membrane components and other vascular proteins

133 ment therapy, and they also suggest that the basement membrane components at the dermal-epidermal jun

134 The lower amounts of basement membrane components in metformin-treated indivi

135 The amounts of the basement membrane components, alpha1-type IV collagen an

136 defects or with mutations in genes encoding basement membrane components, which are known to interac

137 hat Rab10 directs site-specific secretion of basement membrane components, which assemble into fibril

138 editary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juven

139 ontribute to P. aeruginosa keratitis through basement membrane degradation, and its inhibition could

140 were characterized by amnion cell puckering, basement membrane degradation, and tunnels that extended

141 d by distinctly circumscribed 3D growth with basement membrane deposition and decreased invasion.

142 Capillarization was characterized by ectopic basement membrane deposition, formation of a continuous

143 l functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptid

144 l Akt deletion induces retinal VSMC loss and basement membrane deterioration resulting in vascular re

145 lonephritis, a model of human antiglomerular basement membrane disease, depends on both Ab and T cell

146 oimmune GN, a rodent model of antiglomerular basement membrane disease.

147 MMP to promote invasive behaviour leading to basement membrane disruption.

148 invasive phenotype such as lumen-filling and basement membrane disruption.

149 nce of an irregular and thickened epithelial basement membrane duplicating or insinuating into the co

150 l architecture, remodeling of the epithelial basement membrane during branching morphogenesis is also

151 re observed in 86 of 87 eyes with epithelial basement membrane dystrophy (45 patients) on SD OCT scan

152 OCT findings in the diagnosis of epithelial basement membrane dystrophy (kappa = 0.98).

153 Forty-five individuals with epithelial basement membrane dystrophy and 45 age- and sex-matched

154 al changes occurring in eyes with epithelial basement membrane dystrophy based on SD OCT findings wer

155 al changes occurring in eyes with epithelial basement membrane dystrophy.

156 firm or rule out the diagnosis of epithelial basement membrane dystrophy.

157 hat the posterior hyaloid membrane is a true basement membrane enveloping the posterior hyaloid surfa

158 porting cells, which retain contact with the basement membrane, exhibit biased protrusive activity an

159 ctin signalling depends on a cross-talk with basement membrane extracellular matrix (ECM) via beta1 i

160 es to flow through microchannels coated with basement membrane extract.

161 ies with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules

162 utrophils need to penetrate the perivascular basement membrane for successful extravasation into infl

163 hown to cooperate to promote proper vascular basement membrane formation and contribute to endothelia

164 mediated, cytokine-dependent anti-glomerular basement membrane (GBM) glomerulonephritis (GN), in alph

165 The glomerular basement membrane (GBM) is a specialized extracellular m

166 by immigration of cells along the glomerular basement membrane (GBM) is under debate.

167 Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosi

168 eutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogsto

169 in the kidney, commonly along the glomerular basement membrane (GBM).

170 (LAMB2), a major component of the glomerular basement membrane (GBM).

171 l thickening and splitting of the glomerular basement membrane (GBM).

172 n severe or manifest by multilayering of the basement membranes (glomerular and/or peritubular capill

173 eristics during experimental anti-glomerular basement membrane glomerulonephritis (anti-GBM-GN), usin

174 Anti-glomerular basement membrane GN involved NET formation and vascular

175 -complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulo

176 ore blisters at two or more sites and linear basement membrane IgG or C3).

177 onstrate that microglia respond to the mural basement membrane in an isoform-specific manner.

178 Recent work on the basement membrane in developmental systems is transformi

179 yte protrusions invading into the glomerular basement membrane in disease and these occurred frequent

180 riking ultrastructural changes in glomerular basement membranes in FVB mice.

181 l accumulation and damage in anti-glomerular basement membrane-induced (anti-GBM-induced) glomerulone

182 Similarly, both anti-glomerular basement membrane-induced glomerulonephritis and experim

183 glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis.

184 s displayed defects in BCT cell polarity and basement membrane integrity at the chorioallantoic inter

185 st proteins central to blood coagulation and basement membrane integrity, suggesting a role for these

186 e collagen IV network, an event essential to basement membrane integrity.

187 on by localizing these molecules to the cell-basement membrane interface.

188 The basement membrane is a dense, highly cross-linked, sheet

189 Remodeling of the basement membrane is assumed to occur during branching m

190 Here we show that assembly of the epithelial basement membrane is crucial for folliculogenesis and is

191 Contact with the basement membrane is lost in differentiating daughter ce

192 Because podocyte adhesion to the glomerular basement membrane is mediated by integrins, the relevanc

193 gnment, but it becomes dispensable after the basement membrane is polarized.

194 This basement membrane is rich in laminin-III (L1), which pla

195 astructural studies show that the glomerular basement membrane is thickened, podocyte slit width is i

196 are grown in substrata that have elements of basement membrane leading to the formation of tissue-lik

197 by preserved epithelium integrity and intact basement membrane, leading to reduced bacterial dissemin

198 Furthermore, reconstitution of the basement membrane leads to characteristic cortical tissu

199 heir microenvironment and alterations of the basement membrane, led to ESC mislocalization and exhaus

200 abrogated when accompanied by an increase in basement-membrane ligands.

201 lture ECMs, and electron microscopy revealed basement membrane-like ECM deposition between cocultured

202 munohistochemically staining for collagen IV basement membrane markers, in addition to extracellular

203 f the native structure by locally depositing basement membrane materials onto type 1 collagen nanofib

204 NIH (Bethesda, MD), where the reconstituted basement membrane Matrigel was discovered, I had the int

205 ciated from whole fundic tissue and grown in basement membrane matrix (Matrigel) and organoid growth

206 t interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to mod

207 Basement membrane matrix proteins, such as matrigel, are

208 oplasticity, in collagen gels, reconstituted basement membrane matrix, agarose gels, alginate gels, a

209 of the laminin-gamma2 chain is a hallmark of basement membrane maturation in the skin.

210 uitment of ECs in vivo in a murine synthetic basement membrane model.

211 Severe peritubular capillary basement membrane multilayering (PTCBML) is part of the

212 Moreover, after induction of anti-glomerular basement membrane nephritis in young mice, iPLA2gamma KO

213 Thin-basement-membrane nephropathy (TBMN) and Alport syndrome

214 fenestration, and formation of an organized basement membrane not only precedes fibrosis, but is als

215 stribution was observed (i) in the thickened basement membrane of asthmatic lower airways, (ii) aroun

216 tes are vascular mural cells embedded in the basement membrane of blood microvessels.

217 biopsies of patients with SS reveal that the basement membrane of dermal postcapillary venules underg

218 ost universally deposited linearly along the basement membrane of NP tissue.

219 C3 deposits were conspicuous in the tubular basement membrane of proximal tubules, corresponding to

220 to the perivascular spaces and tunica media basement membranes of leptomeningeal arteries.

221 vasive cellular protrusions that expand tiny basement membrane openings.

222 ucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, ch

223 esion to laminin-332, is critical for proper basement membrane organization during skin development a

224 ect on the ability of alpha3beta1 to promote basement membrane organization.

225 Laminin, a major component of the basement membrane, plays an important role in blood brai

226 By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth

227 iltration, and collagen disorganization; and basement membrane preservation.

228 t of Bergmann glia, and the integrity of the basement membrane, primarily in the anterior lobules.

229 roxidasin, a heme peroxidase embedded in the basement membrane, produces hypohalous acid intermediate

230 e breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis.

231 acterized by autoantibodies directed against basement membrane protein BP180.

232 The basement membrane protein netrin-4 was found to be local

233 . (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell

234 The distinct accumulation of arterial basement membrane proteins in type 2 diabetes mellitus d

235 By day 28, basement membrane proteins were reduced in drug-eluting

236 sion of genes encoding extracellular matrix, basement membrane proteins, and members of ERK, FGF and

237 vitro and in vivo wound healing by enhancing basement membrane proteins, granulation tissue component

238 er to new collagen I surfaces, and away from basement membrane proteins.

239 volutionary conserved ubiquitously expressed basement membrane proteoglycan produced in three isoform

240 rtment: epithelium (basal region), reticular basement membrane (Rbm) and underlying lamina propria (L

241 We assessed airway inflammation, reticular basement membrane (RBM) thickness, airway smooth muscle

242 assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detach

243 ion in a macrophage-mediated anti-glomerular basement membrane reactive serum-induced immune nephriti

244 Sub-threshold doses of glomerular basement membrane-reactive serum induced more severe and

245 ration of neurovascular structures including basement membrane reduction, pericyte loss, and astrocyt

246 that generally remain confined to the basal/basement membrane region.

247 ntact pObs only where an otherwise occluding basement membrane remains incompletely assembled.

248 F-alpha and IL-17A were conducted to dissect basement membrane remodeling.

249 Both local and global dynamics of the basement membrane require protease and myosin II activit

250 AAVs is the inner limiting membrane (ILM), a basement membrane rich in heparan sulfate (HS) proteogly

251 h acute edema due to spontaneous Descemet s (basement) membrane rupture in keratoconus, mimicking thi

252 These findings establish the basement membrane's active role in tissue sculpting.

253 Invasive and metastatic cells must cross the basement membrane's extracellular matrix to disseminate

254 llular polymerization of laminin trimers and basement membrane scaffolding.

255 resulted in renal clear cells, multi-layered basement membranes, severe cystic pathology, and ultimat

256 Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations

257 thelial-cadherin (VE-cadherin) junctions and basement membrane, similar to collecting lymphatics.

258 Agrin is a basement membrane-specific proteoglycan that can regulat

259 rular hypertrophy, podocyte loss, glomerular basement membrane splitting, and secondary focal and seg

260 A2) form heterotrimers critical for vascular basement membrane stability and function.

261 networks, which are essential for glomerular basement membrane stability and molecular ultrafiltratio

262 g tolerant mice with anti-ER-TR7 altered HEV basement membrane structure and the distribution of CCL2

263 Basement membrane structures on the serous side stimulat

264 nctions, adherens junctions, and stabilizing basement membrane structures.

265 ic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes.

266 etachment and disruption of the perivascular basement membrane surrounding the VECs.

267 nges in the ultrastructure of the glomerular basement membrane that increase in severity in parallel

268 Cs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types.

269 ic proteins that are major components of the basement membranes that separate endothelia and epitheli

270 tus et al. (2015) reveal that to invade past basement membrane, the C. elegans anchor cell must cease

271 s with endothelial cells, their adherence to basement membranes, the internal elastica lamina, and ne

272 QR], 3.5% to 10.1%, P < .001), subepithelial basement membrane thickening (4.4 mum [25th-75th IQR, 4.

273 anges was associated with a higher degree of basement membrane thickening and edematous changes withi

274 sion electron microscopy revealed glomerular basement membrane thickening and podocyte effacement in

275 Notably, tubular basement membrane thickening reminiscent of that observe

276 y, mesangial matrix accumulation, glomerular basement membrane thickening, albuminuria, and podocyte

277 uria, mesangial matrix expansion, glomerular basement membrane thickening, and podocyte loss, whereas

278 ponse to bleomycin administration, including basement membrane thickening, interstitial fibrin deposi

279 pithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, ai

280 ard to pulmonary function indices, bronchial basement membrane thickness, and BAL fluid neutrophil an

281 sing image analysis, together with reticular basement membrane thickness, mucus gland area, collagen

282 rway smooth muscle (ASM) area, subepithelial basement membrane thickness, nerve fibers, and epithelia

283 cellular matrix, collagen markers, reticular basement membrane thickness, or glandular percentage are

284 th severe asthma were analyzed for ASM area, basement membrane thickness, vessels, eosinophils, neutr

285 h production and maintenance of the vascular basement membrane to prevent abnormal aortic expansion a

286 ells proliferate and spread onto the denuded basement membrane to reseal the barrier.

287 Globally, the basement membrane translocates rearward as a whole, accu

288 brane structures that are thought to mediate basement membrane transmigration during development and

289 pithelial cells covered the denuded visceral basement membrane via formation of proliferative pseudoc

290 was required to invade past the endothelial basement membrane, whereas its attenuation in a syngenei

291 tight junctions and focal disruptions of the basement membrane, which eventually lead to a breakdown

292 pdgfr signaling leads to a reduced vascular basement membrane, which in turn results in enhanced dor

293 at the endothelium in developing bones lacks basement membrane, which normally isolates the blood ves

294 esangial expansion, and increased glomerular basement membrane width in diabetic mice.

295 we identified sub-podocyte expansions of the basement membrane with both cellular and matrix gene def

296 a1, -gamma2 and -gamma3 chains in the limbal basement membrane, with LN-alpha5 representing a signatu

297 en, an extracellular matrix component of the basement membrane zone forming the anchoring fibrils.

298 n-serrated IgG deposition pattern along the basement membrane zone in 9 of 11 patients.

299 oantibodies against a 200-kDa protein in the basement membrane zone.

300 of human type VII collagen restricted to the basement membrane zone.