ライフサイエンスコーパス: basic

1 Although much of the basic actin machinery was intact, Cdc42 null cells lacke

2 The basic active site is due to the presence of a remote bas

3 cores were not associated with disability in basic activities of daily living or with cognition.

4 a bimolecular mechanism in which either the basic Al(I) center or the transient Al horizontal lineNT

5 The macaque A2*05 allotype prefers the basic amino acid arginine at the second position of the

6 nism involves protein electrostatics between basic amino acid residues and acidic lipids such as phos

7 ween negatively charged PM phospholipids and basic amino acids found in K-Ras4B (K-Ras) but not in H-

8 gosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress genes.

9 better health and will ultimately serve both basic and applied goals.

10 ll as nonionic surfactants (NIS) are of both basic and applied relevance.

11 is fundamental to many research areas, both basic and applied.

12 It is suitable for both basic and clinical applications.

13 as, themes, trends, and advances relevant to basic and clinical aspects of eosinophil biology, a sear

14 oup of internationally recognized leaders in basic and clinical FBD research.

15 , and analysis of CSR junctions is useful in basic and clinical research studies of B cell functions.

16 TIRAP PBM bound PIs through basic and nonpolar residues with high affinity, favoring

17 The technique is now widely employed in basic and translational research, and increasingly is al

18 es, with strong potential to accelerate both basic and translational research.

19 The basic applicability of this approach was demonstrated by

20 lation pathways, raising questions as to the basic architecture and detailed function of trypanosome

21 del organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomp

22 idence using genetic lineage tracing for two basic assumptions in Schwann cell biology: that myelin a

23 a large, rapid and long-lasting effect on a basic auditory judgement.

24 , increased thigmotaxis, abnormal spectra of basic behavioral activities, impaired muscle grip streng

25 A sequencing takes approximately 7 d and the basic bioinformatic pipeline takes 1 d.

26 Africa is not unique in its need for basic bioinformatics training for individuals from a div

27 tastases is critical for understanding their basic biological principles and has profound clinical im

28 sive despite major efforts to understand its basic biology and clinical pathophysiology.

29 portant challenge with relevance both to the basic biology of animal communication and to biomedicine

30 that are relevant for understanding both the basic biology of bacterial adaptation and its technologi

31 This review covers the basic biology of this class of peptides and discusses th

32 hat we develop a better understanding of the basic biology of this parasite and how it interacts with

33 ecules identified in screens designed with a basic biology perspective.

34 nition in Glomeromycotina and parts of their basic biology that define species.

35 le in several ways that have implications in basic biology.

36 owever, we critically lack quantification of basic biomechanical parameters describing the vocal orga

37 arency, reproducibility, and open science in basic biomedical research.

38 Carbon, the basic building block of our universe, enjoys a vast numb

39 rod-like structures of adjustable length as basic building blocks.

40 isolate infectious virus rely on in vivo or basic cell culture approaches, which prohibit rapid resu

41 t ATP6AP2 is an essential gene implicated in basic cellular mechanisms and necessary for multiple org

42 eover, endogenous metabolites generated from basic cellular processes such as glycolysis and oxidativ

43 m the maternal genome and included genes for basic cellular processes.

44 h of water-soluble indirubins by introducing basic centers.

45 Many basic characteristics of gustatory neurons remain unknow

46 mark approved bioresorbable scaffolds, their basic characteristics, and clinical results.

47 Here, we briefly report on the basic characterization of this mouse line including conf

48 Mer2 has important functions in relation to basic chromosome structure.

49 Our results therefore show that basic circadian clock properties are governed by dynamic

50 ased heparin binding because it disturbs the basic cluster.

51 ions can be seen as an initial sketch of the basic components of the human mind.

52 turated hydrocarbons, aromatic hydrocarbons, basic compounds, naphthenic acids, and other oxygen-cont

53 lator circuits have been analyzed before for basic computing operations, but using complex networks o

54 The basic concept of many of these supramolecular biomateria

55 been confirmed in numerous studies, and its basic concept remains valid.

56 We introduce the basic concepts in coating materials and showcase several

57 Utilizing mild basic conditions and as low as 0.5 mol % catalyst loadin

58 These reactions occur under mildly basic conditions and enable the late-stage hydroxylation

59 with 4-fold excess of ethyl propiolate under basic conditions at ambient temperature, and characteriz

60 ulfinyl aldimines with beta-keto acids under basic conditions at room temperature proceeds with high

61 n reactions of 3-substituted pyrazoles under basic conditions has been undertaken.

62 istant and stable under acidic, neutral, and basic conditions, are more suitable for photoanode appli

63 Under basic conditions, the neutral network assumes radical ca

64 hyl acetate, and subsequently oxidized under basic conditions.

65 erstood and applied by understanding several basic considerations.

66 ds to a complex aggregation mechanism with a basic core that resembles that found for the aggregation

67 ities) and increasingly reported problems in basic daily activities.

68 eloped a human organoid-based approach using basic developmental principles to generate large numbers

69 ribe the challenges involved and discuss how basic developmental studies have contributed to and are

70 imics DNA and can overcome repulsion between basic DNA binding regions of three bZIP proteins.

71 enous transgene expression; and we provide a basic driver and effector toolkit.

72 These findings suggest that the basic E/I imbalance model should be updated to higher di

73 r and sanitation, maternal and child health, basic education and literacy, economic and community dev

74 e arrays (MEAs) were characterized for their basic electrochemical characteristics and used for in vi

75 urons, their mRNA translational profile, and basic electrophysiological characteristics in a common s

76 These differences extend to basic electrophysiological properties.

77 t" has features that are inconsistent with a basic emotion, especially its protracted duration and fr

78 to contempt, may be mapped onto a network of basic emotions moderated by attitudinal representations

79 ation of approximately 0.007 mm could supply basic energy needs in non-beating cardiomyocytes, sugges

80 tions to low oxygen conditions, which ensure basic energy supply, have been well characterized, adapt

81 In basic environment (e.g. at physiological pH) SPLET is th

82 The BN conduits can operate in acidic and basic environments and do not degrade after immersing in

83 espite this extensive body of research, many basic epidemiologic questions remain unsolved.

84 rceived.SIGNIFICANCE STATEMENT We examined a basic feature of sensory processing in the olfactory bul

85 udinal liquid-filled channels that mimic the basic features of natural stems and branches.

86 In a design using basic features of revealed preference theory, we measure

87 d to generate mMSCs by utilizing hypoxia and basic fibroblast growth factor supplementation.

88 evascularization of the graft bed by agarose-basic fibroblast growth factor.

89 Clofazimine is a weakly basic, Food and Drug Administration-approved antibiotic

90 A Visual Basic for Applications (VBA) data processing was develop

91 sults are complemented by showing that under basic forms of active quality control, discrepancies bet

92 rmulations were developed, starting with the basic formulation (Jam 1) containing sucrose and without

93 indications, implant-related complications, basic function/programming, common pacemaker-related iss

94 esponse behaviors, is necessary for the most basic functions of life, and over the past half-century,

95 hough acute manipulations more likely reveal basic gene functions, developmental plasticity can be a

96 Specifically, we linked basic groups to insulin via a light cleaved linker.

97 Also, it provides infrastructure and basic guidelines to create, manage and distribute bioinf

98 Our results provide detailed insights into basic HCV T cell immunology and have clinical relevance

99 ve interventions delivered through even very basic health facilities.

100 lth insurance claims data of two large Swiss basic health insurance plans including 28% of the Swiss

101 We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scal

102 tor 4 (TCF4 also known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH) protein associated with Pi

103 Ms23), encoding an anther-specific predicted basic helix-loop-helix (bHLH) transcription factor requi

104 show that mutations in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, incr

105 This includes the basic helix-loop-helix (bHLH) transcription factors SPEE

106 vealed the differential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with

107 The insect juvenile hormone receptor is a basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain

108 rophthalmia transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-bin

109 The basic helix-loop-helix PAS domain (bHLH-PAS) transcripti

110 g ROOT HAIR DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future

111 ays, and 5' RACE identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IR

112 Homeodomain and basic helix-loop-helix transcription factors are require

113 MPK3 and MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulat

114 The transcription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant gro

115 rones are responsible for binding the highly basic histone proteins, shielding them from non-specific

116 s historic opportunity for medicine and also basic human biology.

117 on in old age was part of human nature and a basic human right to others that proposed that with the

118 e thermally and under both strong acidic and basic hydrolytic conditions.

119 The basic idea of tES is that the application of weak curren

120 We demonstrate the basic ideas on a toy example, and the power of the param

121 and the ability to perform a task requiring basic image recognition were restored up to 13 mo follow

122 In addition, basic imaging guidelines for appropriate extent of area

123 compared with demographics, liver function, basic immune markers, treatment dose, and tumor morpholo

124 by parallel HONO collection with a standard, basic impinger (BI) method.

125 fferent social-ecological contexts, but some basic information can guide optimal investments to count

126 They are enabling new basic insights into DNA and RNA, and are facilitating a

127 The basic instrument setup and operation are discussed and i

128 ing factors as major impediments to pursuing basic investigation: pressure to be clinically productiv

129 in the ion mobility spectrum agree with the basic ion mobility equation when using nitrogen as drift

130 The basic knowledge of these characteristics is important to

131 Basic knowledge, in close and fertile contact with medic

132 searchers are never taught the equivalent of basic lab skills for research computing.

133 Fear conditioning and other elements of basic learning theory offer a framework for understandin

134 The basic leucine zipper transcription factor nuclear factor

135 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory.

136 Heart Association recommendations for adult basic life support incorporate the most recently publish

137 ical semilocal density functionals, from the basic local density approximation (LDA) to our most adva

138 HDX analysis demonstrates that two basic loops in the mVP40 C-terminal domain make importan

139 Although the basic mechanism of its degenerative pathogenesis remains

140 rexcitability of the nociceptive system is a basic mechanism of neuropathic pain.

141 A basic mechanism to implement this process is the tempora

142 Basic mechanisms for this association are poorly underst

143 be aligned to form a visuotopic map, but the basic mechanisms mediating this alignment remain elusive

144 An improved understanding of the basic mechanisms of auditory perception will aid us in t

145 ast genomes have been very informative about basic mechanisms of evolution, speciation, hybridization

146 Here, we review the basic mechanisms of excision repair in Escherichia coli

147 Its development involves conserved basic mechanisms of induction and patterning, combined w

148 will review the most recent understanding of basic mechanisms underlying IgE-mediated food allergies

149 in their composition and architecture, many basic mechanisms underlying target recognition and cleav

150 to engage in autophagosome formation, review basic mechanisms used to sense this curvature, and then

151 m(-2) at a low voltage of 1.44 V for 48 h in basic media for overall water splitting.

152 rithm, the selection and distribution of the basic meta-atoms are optimized simultaneously to obtain

153 al mechanism based on size adjustment of the basic meta-atoms is proposed for ultra-wideband manipula

154 Her complete blood count and basic metabolic profile were unremarkable.

155 le, and further probing will answer exciting basic microbiological and clinically relevant questions.

156 aches rooted in computer science to minimize basic models of computation through iterative partition

157 This S1 photoinhibition did not impair basic motor patterns, post-perturbation completion of th

158 hesizes immunological knowledge derived from basic mouse studies and from human cohorts and provides

159 erformance in a changing world or to recover basic movement after neural injuries.

160 ll lipid transporters that are important for basic mycobacterial physiology and Mycobacterium tubercu

161 Improved understanding of basic mycological, pharmacological, and immunological pr

162 vers and aquifers that is sufficient for the basic needs of 136 million people, or most of the annual

163 portantly, the utility of SELDOM goes beyond basic network inference (i.e. uncovering static interact

164 but little is known about its importance in basic neuronal processes in vivo Here, we show that OGT

165 our system revealed remarkable stability in basic neuronal properties, such as firing rates and inte

166 rcome some of the obstacles on the road from basic neuroscience to better health and will ultimately

167 Drawing on computational models from basic neuroscience, Vaghi and colleagues (2017) suggest

168 rging clinical studies and insights from the basic neurosciences have shed important new light on how

169 ns were identified in several topics in four basic nursing care activities: comprehensive assessment,

170 of Things technology can be used to promote basic nursing care in the hospital environment by improv

171 tories, the importance of radioactivity, the basics of Np decay and its ramifications (including the

172 eve a stable PEC reaction in either strongly basic or acidic electrolytes without degradation of the

173 ly captured and stabilized, identifying five basic organic and inorganic floc components and quantify

174 However, the basic organization of this auditory thalamotectal pathwa

175 The Basic Package of Health Services (BPHS) program has incr

176 Electrophoretic mobility is a basic parameter that describes the electromigration of a

177 Basic partitioning theory comparisons indicate that over

178 he BRDs associate with DNA through a surface basic patch and that the BRD and an adjacent AT-hook mak

179 e to the mammalian IP5 2-K, as an unexpected basic patch on the protein surface.

180 bsorption spectroscopy and was used to probe basic photophysical properties of (3)CDOM*.

181 we adopt a tutorial approach to present the basic physical mechanisms at stake in phoretic motion, a

182 As the basic physicochemical principles of matrix crosslinking

183 well characterized as an anesthetic, but the basic physiological effects of fentanyl in the brain whe

184 mulates the distributions of biomes based on basic plant functional types with projections from empir

185 ia N-acetylation, have been globally used in basic plant research and genetically engineered crops (1

186 tions of polycrystalline films, where excess basic precursors are found between grains.

187 alysis of different phenomena that violate a basic principle, Kasha's rule, when applied to photochem

188 Altogether, our study reveals the basic principles and a circuit diagram enabling speed mo

189 This review introduces readers to the basic principles and fundamentals of flow chemistry and

190 W) and their nanocomposites with emphasis on basic principles and literature reported during the last

191 dealing with prognostic imbalance and to the basic principles and relative trustworthiness of various

192 In this review, we present some of the basic principles behind 2D IR and show how they have, an

193 Each of these discoveries not only revealed basic principles governing the operation of light-gated

194 This is essential for studying the basic principles in order to develop a full understandin

195 important insights into the understanding of basic principles of reductive graphene functionalization

196 This Feature overviews the basic principles of using stable organic radicals involv

197 Here, the basic principles of various heterojunction photocatalyst

198 This basic processing unit is embedded into a scalable phase-

199 Many factors influence the basic properties of honey including the nectar-providing

200 In summary, our study shows that some of the basic properties of recombination differ considerably be

201 aries considerably in nature, due largely to basic properties of the sexual network (size and density

202 n detail biochemically and functionally, the basic properties of TMPRSS13 remain unclear.

203 otein 1 [M1], nucleoprotein [NP], polymerase basic protein 1 [PB1]).

204 nally, the eosinophil granule proteins major basic protein and eosinophil peroxidase were more freque

205 receptor cells (TRCs), representing all five basic qualities: sweet, sour, bitter, salty and umami.

206 elopment has long been appreciated, but many basic questions remain, such as what initiates or termin

207 e propose that boron-imidates form under the basic reaction conditions that aid coordination of nitro

208 e double stranded RNA binding domain and the basic region underlie the ability of RNAs containing lim

209 ansmission potential and by estimates of the basic reproduction number of the virus.

210 The basic reproduction number R 0 is calculated, and its num

211 Basic reproductive number was smaller (2.1 vs 4.0) and h

212 BaSiC requires no manual parameter setting and is availa

213 ers that confront academic surgeons pursuing basic research and a perception that success in basic sc

214 ctor proteins have become powerful tools for basic research and biotechnology.

215 o guide future utilization of 2A peptides in basic research and clinical applications.

216 d quantification play critical roles in both basic research and clinical practice.

217 advance applications of cell mechanotype in basic research and clinical settings.

218 , has attracted attention for its promise in basic research and gene editing-based therapeutics.

219 he activity of this enzyme is useful both in basic research and in clinical applications involving th

220 activity in vivo could have a high impact in basic research as well as in clinical applications.

221 garettes is needed in order to better inform basic research as well as the general public, regulators

222 n of intra-host diversity, enabling not just basic research in personalized medicine but also accurat

223 chnology as well as to those applications in basic research, biotechnology and synthetic biology that

224 light some of the remarkable advancements in basic research, biotechnology, and therapeutics science

225 Protein affinity reagents are widely used in basic research, diagnostics and separations and for clin

226 and analysis of pathway knowledge to support basic research, genome analysis, modelling, systems biol

227 ditions, limiting the translational value of basic research.

228 179)) located in the ECL2 of hNTS2 or with a basic residue (Arg(212)) at the same position in hNTS1.

229 oI-CTD, a 27-amino-acid tail that is rich in basic residues at the C-terminal end is responsible for

230 at KKRSHLKR(199) downward arrow (underlined basic residues critical for the recognition by PCs), but

231 Mutation of basic residues decreased heparin binding and activation

232 his model explains diverse effects of the TL basic residues on catalysis through their effects on pos

233 We found that substituting all five basic residues, and seven UM-associated substitutions, i

234 urther medicinal chemistry on the compounds' basic scaffold could enhance the potency and selectivity

235 A basic scheme of neuronal organization in the mammalian r

236 ommon infections does not affect the child's basic school performance.

237 vestigate luminance vision intended for both basic science and clinical applications.

238 Here, we review the most current basic science and translational research findings on sev

239 king functional predictions for clinical and basic science applications.

240 There is an urgent need to expand basic science approaches for neglected diseases, especia

241 oung researchers are crucially important for basic science as they make unexpected, fundamental disco

242 assessments of disease for both clinical and basic science imaging research studies.

243 ic research and a perception that success in basic science may no longer be achievable.

244 e challenges confronting surgeons performing basic science research in today's academic surgery envir

245 hey had a good understanding for translating basic science research into clinical practice, and 77.2%

246 University basic science research laboratory.

247 We present findings from clinical and basic science studies to help gastroenterologists naviga

248 ing needs, in turn, require mission-oriented basic science, for example about potential signposts and

249 n spectroscopy, communication, metrology and basic science.

250 n from those direct clinical translations of basic science.

251 steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] yo

252 this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for youn

253 Basic sciences constitute the most abundant sources of c

254 Collectively, the basic scientific discussions herein should provide a fra

255 th a hope to facilitate the research of both basic scientists and clinicians to better understand ADP

256 ) did not believe surgeons can be successful basic scientists in today's environment, including depar

257 ntegrative approach to data science, whereby basic scientists, clinicians, data analysts, and epidemi

258 ion and communication between clinicians and basic scientists, which resulted in the elucidation and

259 ard, enabling adaptive responding under this basic selection pressure.SIGNIFICANCE STATEMENT Among th

260 The method employs a chiral, Lewis basic selenophosphoramide catalyst and a Bronsted acid c

261 ividual animal influences the development of basic sensory detectors in primary visual cortex.

262 tive site is due to the presence of a remote basic site in the anion namely, OH of bicarbonate, NH of

263 Protonation of all basic sites of the hybrid material nearly doubles its co

264 early: Infants and toddlers already possess basic skills to help others and share resources.

265 of the E. coli Hfq CTD transiently binds the basic Sm core residues necessary for RNA annealing.

266 s in many vertebrates, family represents the basic social unit during development.

267 terminal and internal alkynes using a super basic solution of KOH/DMSO has been described.

268 imes higher mass activity in both acidic and basic solution toward the methanol oxidation reaction (M

269 nalysis methods starting from an overview of basic statistical techniques underlying the analysis of

270 This basic structural information could be relevant for provi

271 Such self-assemblies describe not only the basic structural motif of G-quadruplexes formed by, e.g.

272 In brief, consistent with the results of basic studies, PDE4 was decreased in unmedicated MDD pat

273 Docking studies revealed binding to the basic surface pocket and interactions between the allyli

274 ric peripheral protein with a broad and flat basic surface that can associate with anionic phospholip

275 As of yet, a clear consensus on the basic surface/interfacial properties of the sulfur elect

276 essure.SIGNIFICANCE STATEMENT Among the most basic survival problems faced by animals is balancing th

277 A basic tenet of the energy landscape model is that protei

278 PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process.

279 lain phytoplankton blooms, but over time the basic tenets of these hypotheses have become unclear.

280 tutorial review presents an overview of the basic theoretical aspects of two-dimensional (2D) crysta

281 Us and GPUs, to accelerate BLASTX and BLASTP-basic tools of NCBI-BLAST.

282 The database is also equipped with basic tools which allow users to analyze the topology of

283 , and diagnostic accuracy by physicians with basic training in focused cardiac ultrasonography was mo

284 hibitors, unlinking activated chromatin from basic transcription, counteract the effects of ATF3 or C

285 Part One includes the sections: Basic & Translational Research, Cardiac Failure, Cardiom

286 m North America and Europe with expertise in basic, translational, and clinical sciences in the field

287 The basic two-step terminal differentiation model of the med

288 ely applied and even commercialised, greater basic understanding is needed if the field is to progres

289 This basic understanding is refined in the course of developm

290 In addition to extending our basic understanding of DATs and their role in cocaine re

291 biased behavior and pathology, but we lack a basic understanding of how sex differences in the human

292 In this way, we further our basic understanding of the functioning of tropical rainf

293 These results advance our basic understanding of the henipavirus assembly process

294 es to maintain cardiovascular homeostasis, a basic understanding of the regulation and activity of EN

295 ase pathogenesis will depend on an increased basic understanding of these viruses and, in particular,

296 Cells are deemed the basic unit of life.

297 Conformational studies of the basic units of these foldamers can be of invaluable assi

298 We assume the basic updating rule of the Bounded Confidence Model (BCM

299 The server provides a simple home page for basic use, requiring only two files in Protein Data Bank

300 or the assembly/disassembly processes of the basic YES-gate structure that consists of a polymer core