ライフサイエンスコーパス: basic domain

1 membrane targeting through an effect on the basic domain.

2 activity has been ascribed to the conserved basic domain.

3 locked by a mutant c-Jun protein lacking the basic domain.

4 binding and conformation of the C-terminal, basic domain.

5 like its human counterpart, also contains a basic domain.

6 supporting specific DNA binding by the CREB basic domain.

7 ore they can bind to DNA through an upstream basic domain.

8 at K-cyclin interacted with Cdk9 through its basic domain.

9 confer noncanonical E box binding to the E12 basic domain.

10 required to alleviate the inhibition by the basic domain.

11 minal activation domain 1 and the C-terminal basic domain.

12 recognized a clade B-specific epitope in the basic domain.

13 AGATCT arises from the C-terminal non-finger basic domain.

14 ombinations of fatty acids, isoprenoids, and basic domains.

15 and contains two extensively hydrophilic and basic domains.

16 hich one is bipartite, and two widely spaced basic domains.

17 action between the phosphorylated acidic and basic domains.

18 h the tail enables the close approach of the basic domains.

19 this hypothesis, mutations in the N-terminal basic domain (29/31KE) or deletion of the membrane-targe

20 The MB2 protein has an amino-terminal basic domain, a central acidic domain, and a carboxyl-te

21 The 50-kDa tail consists of a basic domain, a glycine/proline/alanine-rich (GPA) domai

22 Tat carrying alanine substitutions in the basic domain (AKKAAQAAA) remained localized in the cytos

23 Expression of the basic domain alone revealed a non-specific microtubule l

24 A synthetic peptide encompassing the TRF2 basic domain also binds to DNA four-way junctions, where

25 now demonstrate that mutations in the highly basic domain also retarget virus particle formation to t

26 This catalogue of point mutants reveals that basic domain amino acids play distinct functions in bind

27 This association is specific, requiring the basic domain (amino acids 122 to 189) of K-bZIP and a sp

28 ty has been mapped to two amino acids in the basic domain, an alanine and threonine, referred to as t

29 the C terminus, and these are followed by a basic domain and a C-terminal domain that is highly simi

30 lmodulin, CaM53, with an extended C-terminal basic domain and a CTIL CaaX-box motif which are require

31 ininamide, a linear peptide mimic of the Tat basic domain and a cyclic peptide that potently inhibits

32 ide, a proline-rich domain, a histidine-rich basic domain and a cysteine-containing 'PAC' domain that

33 y small proteins consisting of essentially a basic domain and a long leucine zipper.

34 carboxyl-proximal amino acid position of the basic domain and a position within the amino-proximal se

35 nd with IkappaB-alpha through its 15-aa bZIP basic domain and adjacent sequences, respectively, and t

36 a HIF-1alpha construct with deletions of the basic domain and carboxy terminus blocked reporter gene

37 rodimerization with E proteins and an intact basic domain and carboxyl-terminus.

38 shortest isoform, VEGF120, lacks this highly basic domain and is freely diffusible upon secretion.

39 the C-terminus of ATF-4, which contains the basic domain and leucine zipper.

40 A spacer between this basic domain and NLS I is necessary for the entrance of

41 trating peptide constructs such as HIV-1 TAT basic domain and related peptides have been developed to

42 Thus, the inhibitory basic domain and the common property for p53 mutants can

43 inding of the Sema III immunoglobulin- (Ig-) basic domain and the unrelated ligand, vascular endothel

44 It contains an N-terminal basic domain and two GTP-binding motifs.

45 These include the CXXC/Basic domain and two novel domains of unknown function.

46 oduct from Xenopus laevis containing several basic domains and a weak coiled-coil.

47 ins numerous alanine-rich, proline-rich, and basic domains and has limited homology to an expressed s

48 association reaction suggested that the two basic domains and the linker region between the subunits

49 band shift assays has demonstrated that both basic domains and the three leucine zipper motifs are ne

50 ed glycosylation site, a central lysine-rich basic domain, and a C-terminal tail containing 10 cystei

51 ch (C/H) domain found just N-terminal to the basic domain, and a carboxy-terminal amphipathic alpha-h

52 ptad repeat of five leucines (L(1)--L(5)), a basic domain, and a conserved alanine characterize the d

53 inger motif, a serine/proline-rich domain, a basic domain, and a leucine-zipper-like domain and is ex

54 s two tandem RNA recognition motifs (RRM), a basic domain, and a third RRM.

55 erminal acidic domain and a carboxy-terminal basic domain, and displaying partial homology to the HMG

56 both activation domain 2 and the C-terminal basic domain, and p53-(DeltaPRDDeltaBD), which lacks bot

57 hypothesis that the functions of this highly basic domain are mediated by neutralization of linker DN

58 evealed that the PHD, CXXC, coiled-coil, and basic domains are identical between mouse and human, whi

59 h the proline-rich domain and the C-terminal basic domain, are also inert in inducing apoptosis.

60 the proline-rich domain, and the C-terminal basic domain, are only required for inducing apoptosis.

61 ce the electrostatic fields produced by this basic domain at the membrane interface and may play a ro

62 Despite the near identity in their basic domains, AtDPBFs are distinct in their DNA-binding

63 We demonstrate that the basic domain (B-domain) of the N-terminal tail of SEPT9

64 Deletion of the p53 basic domain (BD) abrogated GSK3beta binding, and a ten

65 depended on a positively charged N-terminal basic domain (BD).

66 proline-rich domain (PRD), and a C-terminal basic domain (BD).

67 rodimers with other bHLH proteins, and their basic domain binds to a DNA sequence element, the E-box,

68 The RPGR(ORF15) C-terminal basic domain binds to the noncatalytic cofactor interact

69 Mutations in either the VP5 hydrophobic or basic domain blocked VP5-directed permeability of cells.

70 l APC sequences lacking or including the APC basic domain but encompassing the EB1 binding region in

71 s, and includes the two adjacent zinc-finger/basic domains characteristic of the GATA factor family.

72 tributions of the amino acid residues in the basic domain combine to determine DNA-binding specificit

73 o interact with M-Twist, suggesting that the basic domain contacts M-Twist.

74 The basic domain-containing RASSF1C isoform also interacts w

75 Removal of the carboxyl-terminal basic domain decreased transferase, but enhanced NAD gly

76 Surprisingly, basic-domain-dependent DNA binding of Mad3 is not requir

77 that the in vivo inhibitory activity of the basic domain depends upon activation domain 1, such that

78 o interaction studies confirmed that the APC basic domain did not contribute to EB1 binding.

79 it was shown that vertebrate APC through its Basic domain directly collaborates with the formin mDia1

80 served alanine and threonine residues in the basic domain, do not interact with MEF2.

81 gy between the vertebrate and Drosophila APC Basic domains, Drosophila APC1 collaborates with Dia to

82 llectively, our data indicate that the small basic domain encompassing residues R(537) and R(538) con

83 Furthermore, we showed that deletion of the basic domain enhances, whereas a mutation in activation

84 mutations within either the cysteine-rich or basic domains exerted minimal effects on the endothelial

85 While the MyoD HLH domain without the basic domain failed to interact with M-Twist, a MyoD pep

86 alleviates the requirement of the C-terminal basic domain for apoptotic activity.

87 Although the basic domain has been implicated in Gag membrane binding

88 Membrane permeation peptides, such as Tat basic domain, have emerged as useful membrane transducti

89 SCL is a basic domain helix-loop-helix (bHLH) oncoprotein that is

90 nslational products of this gene contain the basic domain helix-loop-helix motif characteristic of a

91 he scl (also called tal-1 or TCL5) gene is a basic domain, helix-loop-helix (bHLH) transcription fact

92 nreported transcript, designated BHLHB1 (for basic domain, helix-loop-helix protein, class B, 1) that

93 The TAL-1 gene specifies for a basic domain-helix-loop-helix protein, which is involved

94 argeted mutagenesis of basic residues within basic domain I caused loss of hr-dependent transactivati

95 We concluded that basic domain I is the enhancer-binding domain for IE1.

96 DNA binding mediated by basic domain I was also required for IE1 transactivation

97 sisting of mostly positive-charged residues (basic domain I) abolished hr-dependent transactivation.

98 ly through a conformational change involving basic domain I.

99 sidues 180-207, and that a 40 residue highly basic domain, immediately preceding the zipper, is respo

100 show that despite the crucial role for Zta's basic domain in eliciting cell growth arrest, its amino

101 ic residues that are organized into a single basic domain in the folded MIP-1 beta monomer, three (R1

102 ocalize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyri

103 s implicate a functional role for the agouti basic domain in vivo, possibly influencing the biogenesi

104 xamine vectorial transport properties of Tat basic domain in well-differentiated epithelial cells pos

105 Z(S186A), a point mutant in ZEBRA's basic domain in which serine 186 is changed to alanine,

106 interactions being required to bring the two basic domains in close register with the mTERF target DN

107 In addition to a leucine zipper, two basic domains in TB-RBP are essential for RNA binding, b

108 We found that the basic domain increased dynein processivity fourfold wher

109 nding protein 3 (IGFBP3) by p53 and that the basic domain inhibits induction of this gene by p53.

110 Although the myristate plus basic domain is also present in the p17MA proteolytic pr

111 while at least a portion of the lysine-rich basic domain is dispensable for normal function.

112 fically between telomeric substrates; TRF2's basic domain is particularly important for this stimulat

113 The C-terminal basic domain is required for maintaining this activation

114 ed polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction.

115 minal activation domain 1 and the C-terminal basic domain, is paralleled in nature.

116 nding domain in the middle of the protein, a basic domain just upstream of this domain, and several s

117 Thus, the basic domain (-KHIAKRF-) and the cysteine cluster (-CKCC

118 A barley basic domain/Leu zipper (bZIP) transcription factor, HvA

119 onsive element (ABRE), which is regulated by basic domain/Leu zipper transcription factors.

120 an eif3h mutant, including the mRNA for the basic domain leucine zipper (bZip) transcription factor

121 ntagonizing the enhancer action of NF-IL6, a basic domain leucine zipper transcription factor belongi

122 o the production of K-bZIP, a protein of the basic domain-leucine zipper (bZIP) family.

123 The TGA genes encode a family of basic domain-leucine zipper (bZIP) transcription factors

124 Rather, it interacts with basic domain-leucine zipper transcription factors CREB a

125 lear factor-IL6 (NF-IL6) expression, a human basic domain-leucine zipper-containing transcription fac

126 We have identified three membrane-associated basic domain/leucine zipper (bZIP) factors in Arabidopsi

127 ELONGATED HYPOCOTYL5 (HY5) is a basic domain/leucine zipper (bZIP) transcription factor,

128 f genes dependent on the membrane-associated basic domain/leucine zipper (bZIP) transcription factor,

129 lly Interesting New Gene finger proteins and basic domain/leucine zipper and basic helix-loop-helix t

130 Maf is a basic domain/leucine zipper domain protein originally id

131 nce supporting VIP2 interaction with VIP1, a basic domain/leucine zipper motif-containing protein req

132 re mediated in large part by the ABA-induced basic domain/leucine zipper transcription factor ABA INS

133 ivator, Tax, interacts specifically with the basic-domain/leucine-zipper (bZip) protein, cAMP respons

134 A basic domain, Lys(305)-Arg(306), is required for p53 nuc

135 PI(4,5)P(2) on the membrane and that the MA basic domain mediates this interaction.

136 henotypes correlating with signal peptide or basic domain mutations, and more devastating phenotypes

137 different from that associated with the five basic domain mutations.

138 A mutation in the basic domain of ADD1/SREBP1 that allows E-box binding bu

139 Alanine scanning mutagenesis of the basic domain of AHR and substitution with conservative a

140 first time that the Ala/Thr dipeptide of the basic domain of an invertebrate MRF behaves as a myogeni

141 Mutagenesis studies indicated that the basic domain of C/EBPdelta was necessary for nuclear loc

142 An N-terminal basic domain of Dia is crucial for apical localization,

143 icrotubule-binding assays, we found that the basic domain of dynactin moves progressively along micro

144 Our data show that the ability of the basic domain of dynactin to skate along microtubules is

145 through the second zinc finger and adjacent basic domain of GATA-4 and the N-terminal domain of Smad

146 that the C-terminal zinc finger and adjacent basic domain of GATA-4 is bifunctional, modulating both

147 NA and that the protein residues outside the basic domain of Hexim1 are involved in specific RNA inte

148 A deletion involving the basic domain of HIF-1alpha eliminated DNA binding withou

149 cally interacted with GATA proteins, and the basic domain of HRT was critical for physical associatio

150 Here we show that purified carboxyl-terminal basic domain of human APC protein (APC-basic) bound dire

151 p on Kar9p maps to a short region within the basic domain of Kar9p that contains a conserved phosphor

152 a functional relationship between the highly basic domain of MA (amino acids 17 to 31) and residues 8

153 We propose that the highly basic domain of MA contains a major determinant of HIV-1

154 AML2 protein chimera in which the N-terminal basic domain of MAML2 is replaced by the N-terminal doma

155 tion is promoted by dephosphorylation of the basic domain of p150 dynactin.

156 the first time we provide evidence that the basic domain of p53 is inhibitory in vivo as has been de

157 Therefore, the basic domain of pUS9 contributes to anterograde axonal t

158 diated E-selectin up-regulation required the basic domain of Tat and was inhibited by a Tat antibody.

159 of the protein, and peptides containing this basic domain of Tat protein can bind TAR RNA with high a

160 to bind specifically to the highly conserved basic domain of Tat, which also mediates binding to the

161 d domain located immediately adjacent to the basic domain of the bHLHZip region is required for SREBP

162 he LR domain of HIV-1 Vpr, when fused to the basic domain of the cellular transcription factor CREB,

163 r DNA binding specificity by mutation of the basic domain of the G-box-binding protein EmBP-1.

164 An 11-residue basic domain of the HIV-1 tat protein, termed the tat tr

165 This compound was designed to mimic the basic domain of the HIV-1 transactivation protein, Tat,

166 phosphorylation/dephosphorylation within the basic domain of the linker region is not directly involv

167 The reduction of positive charge in the NC basic domain of the M1-2/BR virus adversely affects both

168 e charges of the amino acids adjacent to the basic domain of the protein.

169 RAP1 cooperates with the basic domain of TRF2 (TRF2(B)) to repress PARP1 and SLX4

170 e U937 cells stably transfected with deleted basic domain of TRF2 is partially sensitive to Pu-27 but

171 onsensus acceptor site in the amino-terminal basic domain of TRF2.

172 All identified mutations fell in the basic domain of TWIST2 and altered the DNA-binding patte

173 iple Glu-Gly tandem repeats and a C-terminal basic domain of unknown function, localizes to the conne

174 ar transcription factor CREB, by binding the basic domains of an intact bZIP dimer.

175 th HIV-1 and HIV-2 Tat demonstrated that the basic domains of both the HIV-1 and HIV-2 Tat proteins w

176 embly, but low sequence homology between the Basic domains of Drosophila and vertebrate APC has left

177 novel cellular protein interacting with the basic domains of EB1 and c-Jun, and competing of their b

178 ng to mitotic chromosomes, we identified the basic domains of EBNA-1 within amino acids 1-89 and 323-

179 erated by combinations of amino acids in the basic domains of EmBP-1 and TGA1a.

180 Mutations within the basic domains of Fos and Jun abrogated binding to Tat in

181 tive method to prevent errors of omission in basic domains of intensive care unit management that mig

182 terminal cysteine-rich and carboxyl-terminal basic domains of ORF31 mediate the ORF31-ORF34 interacti

183 ulin dimers; both the N-terminal CAP-Gly and basic domains of p150(Glued) are required in tandem for

184 st, tat mutants in the activation, core, and basic domains of Tat did not stimulate HIV-1 gene expres

185 onal antibodies directed against the RGD and basic domains of Tat, but not against the proline-rich d

186 Making use of various combinations of three basic domains of the receptors (i.e., exofacial, transme

187 mer, this novel type of interaction uses the basic domains of the two proteins.

188 acid residues, alanine and threonine, in the basic domains of these factors.

189 Here, we show that the C-terminal "basic" domain of APC (APC-B) potently nucleates the form

190 of Gag proteins with mutations in either the basic domain or between residues 84 and 88 was rescued b

191 These results indicate that a basic domain other than the well defined NLS is required

192 activation domain 2 and lacks the C-terminal basic domain, p53-(DeltaAD2DeltaBD), which lacks both ac

193 runcation mutant (TRF2(DeltaB)) and a mutant basic domain peptide do not.

194 To define the basic domain residues essential for activity, a series o

195 Furthermore, we identified arginines in the basic domain (RKKRRQRRR) of Tat as essential for (1) tar

196 ma domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D) was sig

197 ainly with clade B and with only one clade B basic domain sequence, which included the rare amino aci

198 RGD sequence but contains cysteine-rich and basic domains similar to HIV-1 Tat, induced aggregation

199 The N-terminal basic domain specifies nucleolar localization, the p53 i

200 n modeling of a missense mutation within the basic domain suggests DLF1 protein functions through DNA

201 specific case of HIV-1, this subunit is the basic domain Tat(49-57) (RKKRRQRRR).

202 A Tat protein containing a deletion of the basic domain (Tat(delta)49-57) localized exclusively to

203 ve identified the RASSF1A region harboring a basic domain that appears to mediate the interactions be

204 eted to the plasma membrane by an N-terminal basic domain that binds phosphatidylinositol-4,5-bisphos

205 the presence of domain II plus an additional basic domain that can be represented by an NLS or a basi

206 Four subregions of the EmBP-1 basic domain that differ from the C-box-binding protein

207 ers from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chrom

208 alanine-threonine (Ala-Thr) dipeptide of the basic domain that is known in vertebrates as the myogeni

209 * required for pore formation: an N-terminal basic domain that permits VP5* to peripherally associate

210 arginine residues within the conserved pUS9 basic domain that were essential for binding the molecul

211 synaptic targeting requires three N-terminal basic domains that bind F-actin and acidic phospholipids

212 In the absence of the basic domain, the ability of TRF2 to localize to model t

213 Unlike that of the basic domain, the activity of NpLS is dynamically contro

214 ne the functional significance of the agouti basic domain, the entire 29-aa region was deleted from t

215 s domain involved in lipin activation is its basic domain, the interaction domain is mapped to the N-

216 that M-Twist interacts with MyoD through the basic domains, thereby inhibiting MyoD.

217 ebrate APC collaborates with Dia through its Basic domain to assemble actin filaments.

218 d alpha-helix in CREB that spans most of its basic domain to include amino acid residues localized to

219 ibutions of NC's zinc fingers and N-terminal basic domain to the two major components of chaperone ac

220 By virtue of its basic domain TRF2 performs an extensive 1D search on non

221 TRF2 but not TRF2 lacking its amino-terminal basic domain (TRF2DeltaB).

222 ined deletion of activation domain 1 and the basic domain was required to alleviate the inhibition by

223 arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding

224 HIV-1 Tat contains a basic domain which can interact with growth factor tyros

225 Interestingly, we showed that the C-terminal basic domain, which is required for wild-type p53 activi

226 tions were identified, three residing in the basic domain, which is responsible for DNA binding, and

227 hat only the C-terminal zinc finger (Cf) and basic domain, which together constitute the GATA-binding

228 Here, we show that substitution of the MyoD basic domain with that of E12 does not prevent interacti

229 CSF receptor promoter but associates via its basic domain with the ETS domain of PU.1.

230 The C-terminal basic domain within residues 364-393 and the proline-ric