ライフサイエンスコーパス: basic science

1 al vs. human, classification of clinical and basic sciences).

2 avigation, communication, remote sensing and basic science.

3 n from those direct clinical translations of basic science.

4 cit is a key challenge for both clinical and basic science.

5 re less likely to be published compared with basic science.

6 n spectroscopy, communication, metrology and basic science.

7 ice-changing clinical trials, and insightful basic science.

8 ignition and producing warm dense matter for basic science.

9 lanar superconducting tunnelling studies for basic science.

10 relevance to biomedicine, biotechnology and basic science.

11 being used by the institutions to teach the basic sciences.

12 ation through its use in the teaching of the basic sciences.

13 experimental approaches in the clinical and basic sciences.

14 n of citation from the applied fields to the basic sciences.

15 o generate a convergence between applied and basic sciences.

16 llaboration patterns between the applied and basic sciences.

17 for improving biostatistics education in the basic sciences.

18 rofessional stakeholder groups, and clinical/basic science academicians, recommendations were made on

19 goals are to build a contiguous bridge from basic science, accelerate the advancement of promising p

20 brosis has generated great interest now that basic science advances are being translated into promisi

21 These basic science advances have taken the field to its first

22 mportant recent clinical, epidemiologic, and basic science advances within this area of rheumatology.

23 y of PBC in the 2000s has been buoyed by two basic science advances: rapid sequencing technologies th

24 Discoveries in the basic sciences allow us to better understand tumor biolo

25 w strategy for plant genetic manipulation in basic science and agricultural applications.

26 road range of applications in biotechnology, basic science and biosensing.

27 olecule level holds great potential for both basic science and biotechnology applications.

28 otein degradation has many potential uses in basic science and biotechnology.

29 holding great potential for applications in basic science and biotechnology.

30 purpose of this study is to review both the basic science and clinical advancements in the last 12 m

31 made for future research priorities for both basic science and clinical application of emerging thera

32 indings, and discuss the challenges for both basic science and clinical applications in the continued

33 Exciting new advances in both the basic science and clinical applications of new therapies

34 tterns in B cell Ig sequences have important basic science and clinical applications, but they are of

35 pathologies would be greatly beneficial for basic science and clinical applications.

36 vestigate luminance vision intended for both basic science and clinical applications.

37 in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the bi

38 Here, we review the basic science and clinical development of these and othe

39 may provide data complementary to that from basic science and clinical intervention studies, all of

40 ing of disease progression and regression in basic science and clinical investigations.

41 This minireview examines both the basic science and clinical observations over the past 20

42 Historically, evidence from both basic science and clinical research has been used to dev

43 the past 3 years, numerous breakthroughs in basic science and clinical research have been made, augm

44 hment of multicentered collaboration in both basic science and clinical research interests has been a

45 respect to their contributory roles in both basic science and clinical research investigations.

46 Ongoing basic science and clinical research is critical to impro

47 ute to the field with their participation in basic science and clinical research.

48 s that have aimed to accomplish this in both basic science and clinical settings and follow the gener

49 Basic science and clinical studies were included; non-En

50 y requiring more careful scrutiny in ongoing basic science and clinical studies.

51 There is ongoing research, both basic science and clinical trials, to establish the caus

52 The basic science and clinical use of morphine and other "op

53 Reviewed reports (both basic science and clinical) included epidemiologic studi

54 eview summarizes the past year's literature, basic science and clinical, regarding the neural, paracr

55 stric exocrine and endocrine secretion, both basic science and clinical.

56 ratory mice are used to address questions in basic science and experimental medicine.

57 review, we discuss the implications both for basic science and for targeting glutamine metabolism in

58 Research in this area has both advanced basic science and generated broader lessons for studying

59 al for developing models that can be used in basic science and medicine, to aid in predicting cells f

60 Results from basic science and narrative reviews suggest a potential

61 statin protection against OAG including both basic science and observational clinical studies, an int

62 Basic science and patients are the immediate beneficiari

63 s from radiology, hepatology, pathology, and basic science and physics to arrive at a consensus regar

64 be used to manipulate cytokine signaling for basic science and possibly for therapeutic applications.

65 cant to the generation of gametes for future basic science and potential clinical applications.

66 ertook a detailed review of data from recent basic science and preclinical studies to investigate the

67 too difficult to tackle have benefited from basic science and technological advances over the past d

68 This review highlights developing basic science and technologies for potential application

69 ries, the wisdom of the West of investing in basic science and technology led to its dominance in wor

70 easons: first, the intellectual curiosity of basic science and the desire to understand fundamental p

71 me suggest significant implications for both basic science and the development of novel biomarkers/di

72 active motifs because of their importance in basic science and their broad utility in medicine and bi

73 by oxygen are of considerable interest from basic science and therapeutic perspectives.

74 a powerful tool in developing antibodies for basic science and therapy.

75 iated virus (rAAV) is an attractive tool for basic science and translational medicine including gene

76 oding DNA can have enormous benefit for both basic science and translational research because over 98

77 Here, we review the most current basic science and translational research findings on sev

78 g is an independent review that analyzes the basic science and translational strategies supporting th

79 d have wide applications to glycoproteins in basic sciences and industry because no apparent bias for

80 itis classification, differential diagnosis, basic science, and clinical trial design.

81 atology practice, enriched multiple areas of basic science, and had pervasive ripple effects in law,

82 clinical findings, pathology, epidemiology, basic science, and risk-management issues associated wit

83 argets developed on the basis of advances in basic science; and (4) to understand current critical is

84 A variety of basic science, animal, and human data suggests that cont

85 review outlines the lessons learned from the basic science, animal, observational, and randomized tri

86 apacity in living cells is valuable for both basic science applications and epidemiological studies,

87 king functional predictions for clinical and basic science applications.

88 and pathways for therapeutic, diagnostic and basic science applications.

89 roteases and should have clinical as well as basic science applications.

90 early apoptotic events for both clinical and basic science applications.

91 There is an urgent need to expand basic science approaches for neglected diseases, especia

92 e disorders in recent years, and advances in basic science are being translated into increasing numbe

93 ponential increase was seen in the number of basic science articles (P < .001), review articles (P <

94 computer science, new imaging technique, and basic science articles were considered "preclinical." Us

95 Thus, HistoMosaic has wide applicability in basic science as a tool to map genetic heterogeneity.

96 oung researchers are crucially important for basic science as they make unexpected, fundamental disco

97 We cover epidemiology and basic science as well as the treatment of depression in

98 Psychiatry has similarly emphasized the basic sciences as the starting point of translational re

99 Basic science aside, clinical ophthalmology has benefite

100 ples of a synergism between the clinical and basic science aspects of a modern biological topic is cy

101 Here, we will review the basic science aspects of chromatin modifications and the

102 anticipate that these results, besides most basic science aspects, hold the potential for numerous a

103 Despite a need for basic science backgrounds within these fields, finding e

104 hat the interaction between investigators of basic science, basic and applied pharmacology, and clini

105 The basic science behind cognition, emotion, behavior, and s

106 of research has been primarily practiced in basic science but has recently been extended to clinical

107 omposed of researchers with expertise in the basic science, clinical science, and epidemiological asp

108 tutes, the workshop addressed epidemiologic, basic science, clinical, and translational issues in can

109 l sciences, which are largely unknown to the basic sciences community.

110 There has been development of new basic science concepts, especially with regard to endoth

111 n is thought to improve the understanding of basic science conceptual knowledge and to better prepare

112 Basic sciences constitute the most abundant sources of c

113 Both the basic science data and the clinical experience with PPAR

114 Recent basic science data indicate that in healthy individuals,

115 Clinical and basic science data suggest a role for reduced gamma-amin

116 Clinical and basic science data support an integral role of calcitoni

117 clinical trials, translational research, and basic science demands that investigators in the field us

118 ed as assistant professors in medical school basic science departments was not related to the number

119 epartments now exceeds the number working in basic science departments.

120 s low relative to that of faculty members in basic science departments.

121 pace in clinical departments but declines in basic science departments; and research is judged more o

122 Basic science derived data seem to only add to the confu

123 Subsequently, my desire to do research in basic science developed.

124 Basic science developments have focused on defects in mo

125 In addition, basic science discoveries about neuroinflammation are no

126 chromosome now serves as a paradigm for how basic science discoveries can lead to effective new appr

127 the demand for more effective translation of basic science discoveries into new clinical applications

128 However, even as basic science discoveries remain promising, clinical uti

129 ering the field, and a growing bottleneck of basic science discoveries waiting to be "translated" int

130 functional specialization; integrating these basic science discoveries with clinical efforts will sup

131 connect in the translational process between basic science discovery, early drug development, and def

132 Controversies from basic science, discrepancies from clinical trials, and d

133 ate that simulation is an effective tool for basic science education and garners high learner satisfa

134 then, continued cross-fertilization between basic science efforts and clinical endeavors has highlig

135 e view from different disciplines, including basic science, epidemiology, bioinformatics, and network

136 microscopy is an essential technique for the basic sciences, especially biomedical research.

137 There is also new basic science evidence for stress as a contributing fact

138 Accumulating basic science evidence has identified chloride as a crit

139 This article reviews the basic science evidence, animal experiments, and human cl

140 Like other basic sciences, evolutionary biology needs to be taught

141 A basic sciences examination has been added to the process

142 d an explosion in studies--both clinical and basic science--examining the relationship between the mi

143 ns have been described and modeled both as a basic science exercise and for a range of applied goals

144 steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] yo

145 value to researchers working in clinical and basic science fields.

146 In this review, I discuss the basic science findings that position the TSC1 and TSC2 g

147 Translation of these basic science findings to clinical applications represen

148 on is that evolutionary biology is a crucial basic science for medicine.

149 ing needs, in turn, require mission-oriented basic science, for example about potential signposts and

150 ovation and the high-profile achievements of basic science generated in academic and biomedical labs.

151 y of the epidermis and, in turn, progress in basic science has informed our understanding of disease.

152 Basic science has provided a better understanding of the

153 assessments of disease for both clinical and basic science imaging research studies.

154 Our finding has basic science implications for understanding network fun

155 We believe basic science in communication and decision making, impl

156 s, and pathology), clinical research, and/or basic science in the areas of PH identified important qu

157 The role of basic science in the development of health care has rece

158 Basic science indicates a complex interplay of genetic,

159 for very diverse analytical applications in basic science, industry, and medicine.

160 The new basic science information gathered during the past year

161 The new basic science information gathered during the past year

162 of an unprecedented opportunity to translate basic science into clinical advances.

163 late the biologic-mechanistic knowledge from basic science into efficacious treatments able to improv

164 ponsible for SCD has emerged from decades of basic science investigation into the normal electrophysi

165 Basic science investigations elucidating the mechanisms

166 Basic science investigations have consistently shown tha

167 r many applications, whether the focus is on basic science investigations or therapeutic efficacy, ac

168 models will continue to be of great value in basic science investigations, they can also be used to i

169 reviews, prospective randomized trials, and basic science investigations, were identified in a PubMe

170 presented here is instructive to clinicians, basic science investigators, and policy makers who deter

171 ed in moving from being Editor-in-Chief of a basic science journal to the same position at Annals of

172 l biomedical engineering journals, and the 5 basic science journals with the highest impact factor, w

173 To translate our growing basic science knowledge into better treatments for patie

174 d tissue, preoperative neuroimaging, and the basic science laboratory suggest that the syndrome is no

175 molecular basis of lymphoid neoplasms in the basic science laboratory.

176 and later life outcomes at a mechanistic and basic science level, it is important to understand the p

177 We review the current clinical and basic science literature related to postinjury inflammat

178 cripts (0.94 vs. 1.67, p < 0.05), as well as basic science manuscripts (0.21 vs. 0.54, p < 0.05) and

179 sed materials, with numerous applications in basic science, materials engineering, and biotechnology.

180 ic research and a perception that success in basic science may no longer be achievable.

181 choice of anti-inflammatory agent given the basic science mechanisms and epidemiologic results that

182 te to human adulthood, with consequences for basic science, medicine, and public policy.

183 ansplantation creates the ideal medium where basic science meets clinical science.

184 Basic sciences, microbiology, infectious diseases, and p

185 r the MA are taking up new challenges in the basic science needed to assess, project, and manage flow

186 The way forward is to invest more in basic science, not less.

187 avenues to advance OPV technologies and the basic science of charge transfer in organic semiconducto

188 review we update recent data concerning the basic science of cryobiology, technical trends, oncologi

189 r materials could contribute not only to the basic science of fullerene chemistry but would also be u

190 has two major objectives: first, to sketch a basic science of intentional change centered on evolutio

191 "translational nanotechnology" as it bridges basic science of nanomaterials with practical applicatio

192 To begin organizing the basic science of psychiatry in a comprehensive manner, w

193 how that this issue is deeply related to the basic science of soft matter, especially to the viscosit

194 ropathies has in turn driven progress in the basic science of telomere biology.

195 Further research into the basic science of the condition is required to identify t

196 recent advances in our understanding of the basic science of the overactive bladder it is becoming c

197 What began as three questions of basic science one half-century ago has now grown into th

198 r increasing funding and the subspecialty of basic science or clinical research funded.

199 not as well understood or established as is basic science or clinical research.

200 PubMed databases from inception to 2013 for basic science or clinical studies relating to genetic as

201 ommon reasons for such manipulations involve basic science or therapeutic quests.

202 f the BPH literature with a special focus on basic science or translational studies concerned with th

203 ed by article type (clinical, population, or basic science; P=0.19), whether an article had an editor

204 Jak/STAT research has not only impacted basic science, particularly in the context of intercellu

205 elucidate these complex circuits both from a basic science perspective and in the context of psychiat

206 hese rich phenomena are fascinating from the basic science perspective and offer possibilities for te

207 Moreover, from a basic science perspective, CRAC channels exhibit a uniqu

208 y relevant and of particular interest from a basic sciences perspective due to the complex nature of

209 aused the steady drop in the number of young basic-science PIs and could reduce future US discoveries

210 this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for youn

211 Basic sciences play the role of stem cells, providing ma

212 article explores the latest developments in basic science presented at the Congress which may offer

213 hlights how translation of these advances in basic science promises to change clinical practice.

214 at recent young surgeons published 59% fewer basic science publications (IRR 0.41, 95% CI 0.29-0.57,

215 rating that statistical errors are common in basic science publications have led to calls to improve

216 ng tunnel junctions from these materials for basic science purposes and applications.

217 summarizing progress in clinical trials and basic science redefining the diagnosis and treatment of

218 prospective randomized clinical trials, and basic science reports, were identified in a PubMed searc

219 e the potential to advance both clinical and basic science research and practice.

220 Basic science research articles, review articles, case r

221 esearch faculty, 33.6% exclusively conducted basic science research as principal investigators compar

222 This review will focus on clinical and basic science research efforts related to the diagnosis,

223 As both clinical and basic science research expands our understanding of TIC,

224 For the greater part of the last century, basic science research has been limited to in vitro stud

225 Basic science research has demonstrated a protective eff

226 However, funding for basic science research has not kept up, such that we are

227 Insights from basic science research have helped elucidate the mechani

228 e challenges confronting surgeons performing basic science research in today's academic surgery envir

229 on (MI) are important for the translation of basic science research into bedside medicine.

230 hey had a good understanding for translating basic science research into clinical practice, and 77.2%

231 Despite recent progress, further basic science research into the autoimmune process is ne

232 rgeted agents for therapeutic use, much more basic science research is required before we fully under

233 University basic science research laboratory.

234 The past decade has seen advances in basic science research of neural repair in stroke.

235 Owing to relatively rapid translation of basic science research on a novel regulatory pathway of

236 urope, and Australia engaged in clinical and basic science research on ALPS and related disorders.

237 search relevant to the proposal to integrate basic science research on the five-factor model of gener

238 tiary PAH centers often support clinical and basic science research programs to gain novel insights i

239 Today, more than ever, basic science research provides significant opportunitie

240 RECENT FINDINGS: Basic science research shows us that varicoceles exert d

241 ove their communication skills by explaining basic science research to a general audience, and studen

242 Research overseen by RDRCs is considered basic science research when its purpose is to advance sc

243 reatment will require a rapid translation of basic science research, and the simultaneous development

244 eated; opportunities for proteomics to drive basic science research, facilitate clinical translation,

245 espread use in both clinical diagnostics and basic science research, nearly all methods require direc

246 d 9 technology, the impact on cardiovascular basic science research, possible therapeutic application

247 present a review of the literature including basic science research, prevalence, clinical presentatio

248 ng to encourage participation of surgeons in basic science research, translational research, clinical

249 aving a substantial effect on cardiovascular basic science research.

250 mainly for vaccines and microbicides), or to basic science research.

251 or clinical diagnostics, drug discovery, and basic science research.

252 s 1.7 years, with 72% of trainees performing basic science research.

253 food safety, and public security as well as basic science research.

254 cation of knowledge generated by advances in basic sciences research translated into new approaches f

255 earchers were significantly more likely than basic science researchers (41.9%) to report a relationsh

256 red, a proportion that ranged from 11.5% for basic science researchers to 46.8% for health services r

257 the field, and propose ways to translate the basic science results as well as the mechanistic underst

258 ory of T1 translational research-translating basic science results into new interventions-and T2 tran

259 ith those suggested by the epidemiologic and basic science results.

260 Basic science studies demonstrating disparate regulation

261 Many clinical and basic science studies have provided important insights i

262 Translation of these basic science studies into clinically valuable biomarker

263 le to translate the discoveries derived from basic science studies into the clinical care of the pati

264 Basic science studies investigating nutritional modulati

265 ight glycemic control in ICU patients and on basic science studies investigating the pathophysiology

266 Our findings, in conjunction with basic science studies on erythropoietin and erythropoiet

267 While basic science studies show repeated and chronic stress e

268 Meanwhile, a variety of basic science studies testing different exercise protoco

269 his timely review will focus on clinical and basic science studies that have greatly advanced our kno

270 We present findings from clinical and basic science studies to help gastroenterologists naviga

271 translational and treatment-focused studies, basic science studies with the greatest impact on the fi

272 Clinical trials and basic science studies without statistically significant

273 e evidence from a wide range of clinical and basic science studies, especially genetic, reveals multi

274 vides a realistic human cell based model for basic science studies, identification of new treatment t

275 e bulk of research is limited to preclinical basic science studies.

276 putational reinforcement-learning models and basic-science studies of the dopamine system, we show th

277 ging evidence from epidemiologic studies and basic science suggests an inverse association between me

278 diagnosis of prostate cancer, highlight the basic science supporting this role, and analyze the phas

279 eering and opened countless possibilities to basic science, synthetic biology and gene therapy.

280 in vivo may ultimately have applications in basic science, technology and therapeutics.

281 nd cellular specificity has been greater for basic science than clinical research, it is natural to a

282 S: This review will focus on two advances in basic science that are now translating into clinical tri

283 In basic science, the conditions of an experiment can be se

284 arly-stage translation of the discoveries in basic science, the National Institutes of Health and the

285 Just as in basic science, this approach to research can facilitate

286 Cancer models relating basic science to clinical care in oncology may fail to a

287 therapies are rapidly transitioning from the basic science to clinical care.

288 hly desired for applications that range from basic science to healthcare.

289 pplication including hypothesis testing from basic science to precision medicine.

290 ut the translational research continuum from basic science to public health.

291 All aspects of the field of itch, from basic science to quality of life to therapeutics, are mo

292 Promising advances are being translated from basic science to the clinic, including approaches to dis

293 suggest potential applications ranging from basic science to the clinic.

294 education, specifically, the teaching of the basic sciences to accomplish the goal of improved integr

295 The importance of continued basic science, translational, and animal studies for pro

296 ely new discipline; and finally to share our basic science, translational, and clinical research inte

297 Further delineation of the basic science underlying BRCA network function holds pro

298 e discoveries emphasize the critical role of basic science, which often evolves in unpredictable and

299 The exciting discoveries in basic science will require rigorous testing in animal mo

300 Ongoing basic science work has provided considerable new insight