ライフサイエンスコーパス: basicity

1 cidity of 2-Z) and beta (dependence on amine basicity).

2 bI3) crystals as a response to environmental basicity.

3 its energy, which is a measure of the sigma-basicity.

4 bulky base is of sufficiently high Bronsted basicity.

5 shes the rate of hydrolysis by lowering N(7) basicity.

6 push-pull nitrogen bases exhibit a very high basicity.

7 gnificantly changes these groups' acidity or basicity.

8 ion of imidazole to pyrimidine decreases its basicity.

9 and substrate binding to reach the required basicity.

10 idic sites, while simultaneously introducing basicity.

11 rather than inhibited by increasing solvent basicity.

12 which are known to potently affect the TAML basicity.

13 onses for H2Pc correlated with hydrogen-bond basicity.

14 ms were investigated with respect to analyte basicity.

15 ative relationship between proteome size and basicity.

16 he catalytic base is activated for increased basicity.

17 bonds is correlated with increased phenolate basicity.

18 nce of reactivity toward silicon and reduced basicity.

19 ydrophobicity, hydrogen-bonding ability, and basicity.

20 ](2), with phosphines(X) of various size and basicity.

21 is CH or N, display an exceptionally strong basicity.

22 Co(+) has substantially higher stability and basicity.

23 as arginine-mimicking groups with modulated basicity.

24 was improved on decreasing the central amine basicity.

25 lity to hydrolysis was found to correlate to basicity.

26 , we noted a similar light-induced change in basicity.

27 on constants decrease with decrease of anion basicity.

28 high nucleophilicity despite relatively low basicity.

29 a previously undetected isomer with enhanced basicity.

30 r Friedel-Craft reactions, due to their high basicity.

31 d removal of functional groups that mitigate basicity.

32 sts confirm trends consistent with predicted basicities.

33 he presence of two amino groups of different basicities.

34 alkanes could have quite large hydrogen bond basicities.

35 y when the two anions have similar gas-phase basicities.

36 that is supported by experimental gas-phase basicities.

37 obicity and medium hydrogen bond acidity and basicity (a), and the cluster IV micellar systems are ch

38 rt quantitatively correlates to polarity and basicity, a relationship we formalize as the lipid perme

39 s used to link the observed results with the basicity/acidity of the reactants.

40 amate with several amines possessing varying basicities and nucleophilicities: n-butylamine, diethyla

41 tional design, oxazinoindolines with varying basicities and tunable absorption bands that extend to t

42 brings about a decrease in hydrogen-bonding basicity and an increase in dipolarity and cohesive ener

43 rk is subject to changes with changing amine basicity and carbene complex acidity; these changes can

44 l properties such as hydrophobicity, acidity/basicity and conformation of the specific side chains an

45 ction in vivo with low permeability and high basicity and demonstrate that nonspecific binding to lun

46 ttention paid to maintaining the appropriate basicity and limiting the number of H-bonding donors of

47 med lithium alcoholates, which show enhanced basicity and nucleophilicity in the inner phase as compa

48 heir preparation is often complicated by the basicity and nucleophilicity of nitrogen, its susceptibi

49 nyl oxygen, in spite of the reverse order of basicity and nucleophilicity of the carbonyl group and t

50 n low dielectric solvents due to the reduced basicity and nucleophilicity of the negatively charged c

51 y of TBD is a consequence of both its higher basicity and nucleophilicity than TBO as well as the hig

52 of the deprotonation rate constants on amine basicity and on carbene complex acidity (variation of Z)

53 and molecular modeling show that increasing basicity and optimal alkyl chain length enhance use-depe

54 y of the 8-phenoxy substituent to lower N(7) basicity and predict a preference for N(3)-protonation f

55 nships were identified based on the Bronsted basicity and redox potential of the active site, explain

56 using two approaches: increasing the overall basicity and reducing molecular weight of the lead.

57 of compounds was found to be related to the basicity and stereochemical location of the nitrogen.

58 bond geometry is sensitive to both phenolate basicity and structure.

59 es and found a strong correlation between N5 basicity and the conformation of the Met(20) loop.

60 g occurs via a synergistic action of amines' basicity and the progressively more curved backbone of t

61 The basicity and, to a lesser extent, ionization potential o

62 ic triaminophosphines, even those of similar basicity and/or bulk, were inferior.

63 ged hydrotalcite support provides sufficient basicity (and buffer) for the catalytic reactions; thus,

64 tical evaluation of the electron affinities, basicities, and H-atom transfer kinetics and thermodynam

65 ice responses for CoPc correlated with Lewis basicity, and device responses for H2Pc correlated with

66 cluding the anions' charge, size, hydration, basicity, and hydrogen-bond acceptor abilities.

67 ctrostatic interactions, sequence, gas-phase basicity, and molecular geometry in determining the stru

68 nts with solvent parameters such as acidity, basicity, and polarity/polarizability from Catalan's sca

69 Hydrogen bond basicities are analyzed in order to examine what types o

70 Basicities are enhanced by the lone-pair possessing atom

71 dary beta-deuterium isotope effects on amine basicities are measured using a remarkably precise NMR t

72 rface Bronsted and Lewis acidity and surface basicity are treated in detail.

73 population, as well as the pi-acidity and pi-basicity, are related to the pi-MOs.

74 toluene and in ligating media that differ in basicity, aromaticity, and steric encumbrance.

75 ganolithium reagent possesses relatively low basicity at low temperature, and is compatible with a va

76 reducing agent while moderate Lewis acidity/basicity at the active centers promotes catalysis by rel

77 pyrazolate > triazolate), metal (relative pi-basicity Au > Cu > Ag), and ligand substituents.

78 rocycloalkane has a very small hydrogen bond basicity, B = 0.1 units.

79 t extraordinary except for the hydrogen bond basicity, B, which is indeed very large.

80 sulting in sites with the greatest gas phase basicities being, in large part, unreactive.

81 r b and y ions reveal that the difference in basicity between Arg and Lys results in different dissoc

82 chemistry in the gas phase (i.e., acidities, basicities, bond strengths, binding energies, etc.) has

83 By taking the advantage of difference in basicity, both products can be obtained in good purity.

84 Outside of the range of solvent basicity bounded at the lower end by dichloromethane and

85 not to be correlated by measures of solvent basicity but rather by the negative of measures of solve

86 obicity and medium hydrogen bond acidity and basicity but rather weak dipolarity.

87 on at any position of pyridine increases the basicity, but the IE per deuterium is largest for substi

88 Deuteration definitely increases the basicity, by approximately 0.021 in the Delta pK per D.

89 These changes in acidity or basicity can lead to carboxylate salts forming carboxyli

90 Loss of basicity can result in catalytically impaired enzymes.

91 rge zeolites because of their unusually high basicity combined with their large size and rigidity.

92 macromolecules show superior pi-acidity and -basicity compared to their organic counterparts.

93 by a ca. 10(10)-fold increase in the carbon basicity compared with the proton basicity of X-.

94 n of the equilibrium was sensitive to ligand basicity, conjugate acid strength, solvent polarity, and

95 When the solvents and anions have comparable basicity, contact ion pairs of the type [H(3)O(+).nSolv.

96 cleave alkane C-H bonds is due to its strong basicity coupled with large reduction potentials of near

97 izability descriptor S and the hydrogen bond basicity descriptor B.

98 The paradoxically low basicity (despite high anionicity) of oxygen in the char

99 rg, indicating that differences in intrinsic basicity do not play a role in the relative SB stabiliza

100 ts are used to probe the so-called anomalous basicity effect of ammonia and the methylamines on going

101 The acidity/basicity effects of the electrolytes arise in part from

102 The decrease in basicity enhanced the binding of carbamylated sulfopepti

103 formation, proton affinities, and gas-phase basicities for gaseous lactone enols with four- (C(4)-1)

104 and 2, compounds 6 and 7 display rather high basicity, forming chelated monocations.

105 ase in splitting with the decrease in 4-X-py basicity found is consistent with the theoretically pred

106 to a significant reduction in the gas-phase basicity (GB) of the phosphate group when bound to {LGa2

107 ry and secondary amines of varying gas-phase basicity (GB) were investigated using infrared multiple

108 cid)) and proton affinity (PA, and gas phase basicity (GB)) of adenine, guanine, and O(6)-methylguani

109 sorption of the anions, while solute H-bond basicity has a negative effect.

110 the first time that such large hydrogen bond basicities have been identified in compounds with no fun

111 capability was found to increase with their basicity (i.e., pKa of their conjugated acids, BH(+)), c

112 ariation of the bridging ligand (relative pi-basicity imidazolate > pyridiniate > carbeniate > pyrazo

113 xperimentally supported very high (pKa > 40) basicities in acetonitrile, which cannot be directly mea

114 A good correlation between basicities in THF and acetonitrile spanning 25 orders of

115 ion center, thereby increasing the intrinsic basicity in the gas phase, while the bulk prevents effic

116 x stability was mainly affected by the anion basicity in the presence of monocarboxylates, whereas th

117 hibition were dependent on lipophilicity and basicity in this series.

118 The photoswitching of Sp induces a large basicity increase in the polymeric phase, which triggers

119 numbers of aminophenyl groups, the relative basicity increased and the hyperporphyrin effect increas

120 by metal ion Lewis acidity and solvent Lewis basicity, indicating that C-H deactivation can be modula

121 e trend in redox potentials, indicating that basicity is a key factor in determining the striking dif

122 fies amines without sacrificing their native basicity is developed.

123 Amine basicity is the primary controller of detection.

124 ates that the dominant term causing the high basicity is the relaxation energy.

125 rd the active site to increase the residue's basicity) is positioned to act as a general base, abstra

126 ide toward VX, in contrast to their relative basicity, is discussed.

127 (LA) of the benzhydrylium ions and the Lewis basicity (LB) of the phosphines, pyridines, etc.

128 nd phosphate salts are milder, but their low basicity limits the scope of their reactions.

129 not meet the stringent requirements of weak basicity, low polarizability of high chemical stability,

130 roperties of a suitable counterion: very low basicity, low polarizability, and high chemical stabilit

131 Solvent basicity measures such as Donor numbers and beta values

132 ion to these structural effects, the anion's basicity modulates the anion exchange rate between its f

133 nts an analysis of the exceptional gas-phase basicity, mostly in terms of experimental data, in relat

134 ed by the ultrasmall PtNCs and Lewis acidity/basicity/nanoconfinement endowed by UiO-66-NH2 , Pt@UiO-

135 cidity (electrophilicity), and hydrogen-bond basicity (nucleophilicity).

136 yridine 14a (pKa = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of

137 Basicities of 47 compounds (around half of which are new

138 values are in good agreement with the sigma basicities of all of the rNHCs.

139 hrough an NMR titration method that compares basicities of alpha and beta anomers in a mixture of the

140 ate for substitution reactions; however, the basicities of bromide and trifluoroacetate are reversed

141 Secondary deuterium isotope effects (IEs) on basicities of isotopologues of trimethylamine have been

142 Experimental basicities of some of the strongest superbases ever meas

143 boranes > oxyanions, reflecting the relative basicities of the anions.

144 The basicities of the compounds were evaluated by potentiome

145 ation experiments reveals that the gas-phase basicities of the deprotonated analyte molecule ([M - H]

146 nature of the guest, shifts in the effective basicities of the encapsulated amines of up to 4.5 pK(a)

147 Basicities of the pyridinols approached physiological pH

148 Basicities of the two amines determine the threshold pH

149 tability increases with the rising gas-phase basicities of the two moieties.

150 Secondary isotope effects (IEs) on basicities of various deuterated pyridine isotopologues

151 are ignored, this result indicates that the basicity of 1 is similar to that of triphenylmethide.

152 The basicity of 1,3-di-tert-butylimidazol-2-ylidene (1) was

153 In addition, the basicity of a 2,3-bis(dialkylamino)cyclopropenimine is m

154 reducibility of H(+), and the high gas-phase basicity of Ac(-) and (ii) a reproducible LC separation

155 (H0) is not realized in practice because the basicity of an added base is suppressed by Lewis acid/ba

156 [reaction: see text] The basicity of an amine has a great impact on physicochemic

157 The strong basicity of biomolecules containing a push-pull nitrogen

158 have been used to bracket the solution-phase basicity of C(60) between that of mesitylene and xylene.

159 ation of the cation scales linearly with the basicity of carborane anions on the nuNH scale.

160 ry, yet little has been done to modulate the basicity of compounds.

161 K(a), was analyzed by comparing the relative basicity of DABCO and 3-acetoxyquinuclidine in DMSO.

162 Last, the gas-phase basicity of deprotonated alpha-D-glucose (i.e., the gas-

163 s a host to dramatically shift the effective basicity of encapsulated protonated amine guests.

164 Predictions are made for hydrogen bond basicity of fluorine in situations where relevant experi

165 roxyethyl flip results in both the decreased basicity of Glu166 and a significant increase in the dis

166 ygen-reduction turnover number and the Lewis basicity of graphitic carbon support (accessed via C 1s

167 kely facilitates catalysis by increasing the basicity of H154.

168 4 and 9.3, respectively, indicating that the basicity of His-464' in TrxR in complex with its substra

169 enhance the substrate binding, increase the basicity of His143, strengthen the catalytic role of zin

170 her Nudix enzymes, is not due to the greater basicity of histidine, since the pK(a) of E124 in the ac

171 Under pyrolytic conditions the acidity/basicity of Maillard reaction mixtures can be controlled

172 as been used to assess the pi-acidity and pi-basicity of metal-organic trimetallic macromolecular com

173 Deuteration is found to increase the basicity of methylamine, dimethylamine, benzylamine, and

174 Deuteration is found to increase the basicity of methylamine, dimethylamine, benzylamine, N,N

175 To attenuate the basicity of morpholine, a bicyclic amine was designed an

176 th the Lewis acidity of the aluminum and the basicity of nearby oxygens, hence the high reactivity of

177 licate its chemical synthesis because of the basicity of nitrogen atoms and their susceptibility to o

178 ks our study with Laurence's scale of H-bond basicity of organic molecules.

179 o lower C-H activation barriers, because the basicity of oxygen adatoms increases with coverage and t

180 face is most likely due to the high Bronsted basicity of oxygen, our model could be a more general pi

181 e important factor than the higher gas-phase basicity of PABAOMeH(+) in stabilizing protonation at th

182 aldol reaction does not exhibit the ordinary basicity of tertiary amines; 3 can be extracted from aci

183 However, owing to the basicity of the -amino group in lysine, this strategy ge

184 e catalyst resting state(s) depending on the basicity of the alkyl ether.

185 that K218A activity rescue depended upon the basicity of the amine.

186 etonitrile and decreased with the decreasing basicity of the anion (CH(3)COO(-) > C(6)H(5)COO(-) > H(

187 luene coordination increases with decreasing basicity of the anion (i.e., decreasing pK(a) of the cor

188 luorogenic substituent, the solvent, and the basicity of the anion.

189 strate coordination step correlates with the basicity of the anionic ligands coordinated to Pd(II), a

190 uents in the aromatic ring that increase the basicity of the aromatic amine.

191 his activity was shown to correlate with the basicity of the aromatic group, with activity decreasing

192 is observed and taken as evidence for a high basicity of the aryl anion.

193 fine tune this reactivity by considering the basicity of the attached functionality.

194 ive charge in the transition state, and with basicity of the attacking nucleophile as a strong predic

195 nd a straightforward correlation between the basicity of the base and reactivity has been established

196 CO2 hydrogenations: the steric bulk and the basicity of the base.

197 dence of the C-H stretching frequency on the basicity of the carborane anion.

198 at pH < 6 and an ~2 pK unit decrease in the basicity of the carboxylate side chain of Glu-167 at the

199 pieces are consistent with a decrease in the basicity of the carboxylate side chain of Glu-167 for th

200 there is a large ~6 pK unit increase in the basicity of the carboxylate side chain of Glu-167 upon b

201 This reflects the large increase in the basicity of the carboxylate side chain of Glu-167 upon b

202 role in effecting the large increase in the basicity of the catalytic base upon the binding of subst

203 esence of Glu(78) and Glu(122) modulates the basicity of the catalytic groups.

204 By reducing the basicity of the core heterocycle in a series of HCV NS5B

205 The basicity of the CPO-II ferryl [pKa > 8.2 (where Ka is th

206 ddition of cerium(III) chloride mediated the basicity of the dianion and suppressed enolate formation

207 of proton transfer mechanisms shows that the basicity of the dioxo dianion and the hydroperoxo-iron (

208 nes are then used to calculate the effective basicity of the encapsulated amines.

209 xidation potential has a compensating higher basicity of the ferryl oxygen.

210 correlate with the size rather than with the basicity of the guests.

211 iacetal and His 57 are explained by the high basicity of the hemiacetal oxygen (pK(a) > 13.5) relativ

212 he adjacent carbonyl group and decreased the basicity of the hydroxyl group of the CF3 amino alcohol

213 The strong Bronsted basicity of the iminophosphorane moiety of the catalyst

214 The basicity of the ipso-carbon atom of the pincer ligand wa

215 ous adducts are discussed in relation to the basicity of the Me(n)H(3-n)N fragment.

216 Control of the basicity of the media allows further discrimination of t

217 becomes more stable with an increase in the basicity of the medium.

218 enerally increases with increasing gas-phase basicity of the N-terminal amino acid, but only ArgArg x

219 the side chain of N-terminal Asp reduces the basicity of the N-terminal amino group and, as hence, it

220 Calculated basicity of the N-terminus of tubulysins was shown to be

221 th a concomitant substantial decrease in the basicity of the N1H sites (pKa approximately 7.0 in CD3C

222 e extra carbonyl group, which diminishes the basicity of the nitrogen atom, thereby retarding the rin

223 ivity of these amides; it also increases the basicity of the nitrogen so that it often behaves more l

224 t the process, it appeared that the moderate basicity of the nitroso compound plays a crucial role to

225 The basicity of the nucleophile as well as solvent effects c

226 involved in reactivity when compared to the basicity of the nucleophiles.

227 x potiental of the complexes, suggesting the basicity of the oxo ligand is a major contributor to the

228 avior can be explained in the context of the basicity of the oxo ligands that leads to different mech

229 ination of the aminoisoquinoline reduced the basicity of the P1 group and significantly improved perm

230 BH(3).THF, or Br(2) further demonstrated the basicity of the P6-phosphorus yielding the new arachno-s

231 Despite the basicity of the parent amido ligand and the typically fa

232 Further SAR on reducing the basicity of the piperidine and introducing polarity led

233 the pushing amino-group(s) and increases the basicity of the pulling cyano, imino, or phosphoimino gr

234 nd pulling groups in such systems lowers the basicity of the pushing amino-group(s) and increases the

235 harge-transfer states leading to an enhanced basicity of the pyridine (pKa* approximately 12) and enh

236 oblematic C(2)(3) epimerization provided the basicity of the reaction is minimized.

237 ions also changed according to the intrinsic basicity of the rescuing nucleobase, providing further e

238 Systematic variation of the branching and basicity of the side chain of chloroquine yielded a seri

239 extreme to the other by increasing the Lewis basicity of the solvent, and the equilibrium E/Z ratio g

240 complexes is basic with a pK(a) of 28.3; the basicity of the terminal oxo ligand in the Mn(IV)(O) com

241 f the open-shell radical is derived from the basicity of the tert-butylimino group and the intramolec

242 e carried on the carboxyl group, whereas the basicity of the tropylium ion facilitates cation export.

243 as the hydrogen bond partners to adjust the basicity of the water molecule.

244 The solution basicity of the well-known t-Bu-N horizontal lineP4(dma)

245 relief on protonation largely determines the basicity of these compounds, and the key to the design o

246 ed)piperidin-4-yl ring to exploit the higher basicity of this nucleus and for the the possibility to

247 pose that there is a similar increase in the basicity of this side chain when the physiological subst

248 hould provide reliable information about the basicity of valine and other aliphatic amino acids.

249 the carbon basicity compared with the proton basicity of X-.

250 ng on the electron-donating abilities (Lewis basicity) of anions and electron-accepting abilities (pi

251 The donor capacity (basicity) of the anionic subunit in these zwitterions is

252 ed have been explained in terms of substrate basicity, of the distance between the two basic centers

253 or enthalpic and entropic stability (and low basicity) on permethylated Si-O-Si linkages.

254 ons observed for analytes of lower gas-phase basicity or higher electron affinity than O2.

255 located nearer to the AP site, that reduced basicity or hydrogen bonding potential, increased Km 2-

256 sult most likely attributed to the different basicities (or nucleophilicities) and steric effects of

257 ities of anions generally follow their Lewis basicity order, whereas pi-acidity of NDIs can be fine-t

258 It is found that the decrease in basicity, per deuterium, increases with the number of de

259 In contrast, when the low Lewis basicity phosphane containing alkyne (C6F5)2P-C identica

260 ng equilibrium constants (log K) or Bronsted basicities (pK(aH)) do not show enhanced nucleophiliciti

261 nalyte adsorption is largely affected by the basicity (pKb) of surface groups.

262 o be an effective predictor of hydrogen bond basicity (pKBHX), and predictive models are presented fo

263 London dispersion, hydrogen-bond acidity and basicity, polarizability and lone-pair electrons.

264 estimated gas-phase enthalpies of formation, basicities, proton and electron affinities, and adiabati

265 (3 to 106) x 10(-5) s(-1), while the amidine basicity ranged over 5 pK(a) units.

266 ngement of the polycationic amines and their basicity requirements to fulfill outer membrane destabil

267 s molar refraction, and hydrogen acidity and basicity, respectively; and ai is the sorbate's aqueous

268 f one of these inhibitors, which reduced its basicity, resulting in compounds with monocationic chara

269 e2 group, contrary to the "aniline-pyridine" basicity rule.

270 een the solvent donor number (DN) or solvent basicity (SB) parameters and the change in the Cotton ef

271 observed is used to provide a relative Lewis basicity scale of nine ionic liquids commonly used as so

272 compounds, the experimental self-consistent basicity scale of superbases in THF, reaching a pKalpha

273 l(-1)) and bridges the gas-phase acidity and basicity scales for the first time.

274 ease in the negative D with increasing Lewis basicity (shortening of the Co-N bond distances) of the

275 Rate constants corrected for amidine basicity showed the pyrrolidine derived amidines to be m

276 lity at the phosphorus atom, hydrophobicity, basicity, size, and charge all influence the ability of

277 factors, including molecular hydrophobicity, basicity, solution composition, and instrumental paramet

278 presence of not just N2 but also much higher-basicity solvents.

279 compiled scale is a useful tool for further basicity studies in THF as well as in other solvents, in

280 y occurring amino acids have lower gas phase basicities than the side chains of the basic amino acids

281 trimers are found to exhibit pi-acidity and -basicity that can be systematically tuned both coarsely

282 in elucidating factors, such as terminal oxo basicity, that may control ferryl reactivity.

283 rogen bond acidity, the solute hydrogen bond basicity, the solute dipolarity/polarizability, the inte

284 clization rates by nucleophile proximity and basicity, through detailed analyses of starting material

285 ionic liquid (IL) electrolytes with tailored basicities to solvate SO2 by reversible chemical absorpt

286 anesulfonamide was found to be of sufficient basicity to cause enolate formation with sensitive subst

287 rograms it is relatively common to attenuate basicity to circumvent undesired effects such as lack of

288 ted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance.

289 Analysis of structure-basicity trends is presented.

290 However, functional-group Lewis basicity typically depresses catalytic activity and co-m

291 The remeasured basicity values are in close agreement with the values r

292 Previously established gas-phase basicity values were remeasured for LIAD-evaporated orga

293 Linear correlations of ten superbase basicities vs that of their substituents demonstrated th

294 Apparent basicity was verified to be an effective indicator for t

295 eakly basic structural isomers with variable basicity, we illustrate that the magnitude of the pKa va

296 ucturally modified forms of DNR with reduced basicity were synthesized, and their intracellular distr

297 Physicochemical properties (polarity and basicity) were considered to guide the design process.

298 ity) and beta(B) values (dependence on amine basicity) were determined.

299 hrinkage of CO2 bubbles occurred with higher basicity, while an increased expansion of CO2 bubbles wa

300 ders of magnitude in CH2Cl2 as well as Lewis basicities (with respect to C-centered Lewis acids) for