ライフサイエンスコーパス: basigin

1 nd that binds with its erythrocyte receptor, Basigin.

2 acid (SA), complement receptor 1 (CR1), and basigin.

3 g the interaction of PfRH5 with its receptor basigin.

4 t mouse basigin can functionally replace fly basigin.

5 fects and neuron-glia interaction defects of basigin.

6 o determine the identity of the receptor for basigin.

7 We show that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed spec

8 The specific and limited expression of 5A11/Basigin-2 explicitly within photoreceptor cells implies

9 5A11/Basigin-2 expression was limited to the retina, specific

10 lin gene superfamily and has been named 5A11/Basigin-2.

11 sociates with a novel form of human basigin (basigin-3).

12 in tissue remodeling and angiogenesis makes basigin a potential target for the development of strate

13 ial binding of PfRh5/CyRPA/PfRipr complex to basigin, a step linked to the formation of a pore betwee

14 raction with the erythrocyte surface protein basigin (also known as CD147 and EMMPRIN).

15 CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a

16 recombinant chimeric antibody (Ab-1) against basigin, an erythrocyte receptor necessary for parasite

17 PvTRAg38 binds to two erythrocyte receptors basigin and band 3 through P2 and P4 regions, respective

18 e architecture, presenting binding sites for basigin and inhibitory antibodies at one tip.

19 l molecule that inhibits the binding between Basigin and MCT4.

20 ting that simultaneous blockade of the PfRH5-Basigin and PfRH5/PfRipr/CyRPA interactions produced an

21 functions as a membrane receptor for soluble basigin and this homophilic interaction is not dependent

22 crystal structures of PfRH5 in complex with basigin and two distinct inhibitory antibodies.

23 All variants bound the PfRH5 receptor basigin and were recognized by a panel of monoclonal ant

24 ely blocked using low concentrations of anti-basigin antibodies; importantly, these effects were obse

25 Here, we have identified basigin as the second erythrocyte receptor for PvTRAg38,

26 , rBSG associates with a novel form of human basigin (basigin-3).

27 ng CRISPR/Cas9, we deleted two host factors, basigin (BSG) and CD44, for which no natural nulls exist

28 n mouse chromosome 10, delimited by the gene basigin (Bsg) and marker D10Mit140.

29 ck Swiss mouse strain, delimited by the gene basigin (Bsg) and the marker D10Mit140.

30 atrix metalloproteinase (MMP)-2, MMP-14, and basigin (BSG) are major enzymes involved in the maintena

31 Reticulocyte-binding protein Homolog 5 (RH5)-Basigin (BSG) interaction in host-species selectivity an

32 Basigin (BSG) is a multifunctional glycoprotein that pla

33 mate association with the glycoprotein CD147/BASIGIN (BSG).

34 identified as the transmembrane glycoprotein basigin (BSG, CD147); more particularly, its low glycosy

35 the photoreceptors demonstrating that mouse basigin can functionally replace fly basigin.

36 asma membrane requires association with 5A11/basigin (CD147).

37 ibodies or other therapeutics targeting host basigin could be an effective treatment for patients inf

38 Antibodies targeting PfRH5 or basigin efficiently block parasite invasion in vitro, ma

39 The immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein e

40 results demonstrate that rBSG interacts with basigin expressed on the surface of fibroblasts and is s

41 Localization of 5A11/Basigin expression was evaluated by immunoblot, immunohi

42 rane protein CD147 (also known as EMMPRIN or basigin) forms a specific heterodimeric complex in the m

43 nd the extracellular domains are crucial for basigin function in the visual system while the short in

44 It was concluded that cell surface basigin functions as a membrane receptor for soluble bas

45 t is highly conserved with the mouse EMMPRIN/basigin gene.

46 alternative transcription initiation of BSG (Basigin) gene by differentially influencing RNAPII densi

47 srupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and gliob

48 ultiple highly expressed proteins, including basigin, Glut1, and CD98hc.

49 5A11/Basigin has recently been identified as a critical glyco

50 Our previous work on Drosophila basigin has shown that it is required for normal photore

51 However, the biological function of 5A11/Basigin has yet to be determined.

52 In contrast, overexpression of basigin in SH-5YSY cells, which poorly express BSG, rest

53 used to evaluate the number of forms of 5A11/Basigin in the mouse retina.

54 r transgenic fly basigin or transgenic mouse basigin in the photoreceptors demonstrating that mouse b

55 the neural retina supporting a role for 5A11/basigin in the targeting of these transporters to the pl

56 hermal-shift-assays confirmed ACF binding to basigin in vitro and in live glioblastoma cells, respect

57 Ab-1 inhibited the PfRH5-basigin interaction and potently blocked erythrocyte inv

58 following: 1) the ability to block the PfRH5-basigin interaction in vitro is predictive of functional

59 sought to determine if disruption of the MCT-Basigin interaction may be achieved with a small molecul

60 Drosophila basigin is a cell-surface glycoprotein of the Ig superfa

61 he interaction with its erythrocyte receptor basigin is essential for invasion.

62 Basigin is involved in many physiological functions duri

63 Interaction between P2 and basigin is stabilized through multiple amino acid residu

64 In summary, our results demonstrate that basigin is very likely the apoD receptor and provide add

65 Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglo

66 Emmprin (CD147; basigin) is a plasma membrane glycoprotein, enriched on

67 lin superfamily glycoprotein CD147 (emmprin; basigin) is associated with an invasive phenotype in var

68 oproteinase inducer) also known as CD147 and basigin, is a member of the immunoglobulin family that i

69 longer form, a splice variant of mouse 5A11/Basigin, is a member of the immunoglobulin gene superfam

70 have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that

71 corresponding to the extracellular domain of basigin, it was demonstrated that the native, nonglycosy

72 potently inhibited by soluble basigin or by basigin knockdown, and invasion could be completely bloc

73 Furthermore, expression of the basigin ligand PfRh5 was the best predictor of donor par

74 The EBA-175/glycophorin A (GPA) and Rh5/basigin ligand-receptor interactions, referred to as inv

75 n is not dependent upon glycosylation of the basigin ligand.

76 disruption of MCT binding to their chaperon, Basigin, may be an effective approach to target GSC and

77 family that includes mammalian EMMPRIN/CD147/basigin, neuroplastin, and embigin.

78 itudes in the electroretinograms in the 5A11/basigin null mouse (Bsg(-/-)) may be linked to altered e

79 e invasion was potently inhibited by soluble basigin or by basigin knockdown, and invasion could be c

80 oproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on

81 scued by expression of either transgenic fly basigin or transgenic mouse basigin in the photoreceptor

82 15 monoclonal antibodies recognizing EMMPRIN/basigin/OX-47/M6, a 45-55-kDa transmembrane protein with

83 fluenced by endemicity levels, and the PfRh5-basigin pathway is a potential vaccine target.

84 ports indicate the presence of multiple 5A11/Basigin polypeptides within the retina.

85 Using a novel recombinant basigin protein (rBSG) corresponding to the extracellula

86 To determine what regions of the basigin protein are required for each of these functions

87 he identity of the cell surface receptor for basigin remains controversial.

88 osaic animals that are mutant in the eye for basigin show altered cell structure with nuclei, mitocho

89 an effort to determine the function of 5A11/Basigin, the molecular diversity of its expression was e

90 er and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization.

91 The ability of basigin to stimulate expression of molecules involved in

92 Two 5A11/Basigin transcripts of approximately 1.5 kb and approxim

93 performed to determine the sequence of 5A11/Basigin transcripts.

94 h of these functions, we have created mutant basigin transgenes coding for proteins that are altered

95 ermore, Ok(a-) erythrocytes, which express a basigin variant that has a weaker binding affinity for P

96 cificity of interaction between PvTRAg38 and basigin was confirmed by direct interaction where basigi

97 r mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-indep

98 in was confirmed by direct interaction where basigin was specifically recognized by P2 and not by the

99 In addition, antibodies against CR1 and basigin were used to determine the contributions of thes