ライフサイエンスコーパス: basophilic

1 nclusions, which ranged from eosinophilic to basophilic.

2 dergoes 3 mitosis to generate sequentially 2 basophilic, 4 polychromatic, and 8 orthochromatic erythr

3 3+)-IMAC (72%), while Pro-directed (85%) and basophilic (79%) phosphorylation sites were enriched in

4 In contrast, basophilic and clear-cell foci, as well as pseudo-glandu

5 94/NKG2A molecules in the HLA-E negative rat basophilic cell line RBL-2H3, we demonstrate that CD94/N

6 it allergen binding to specific IgE on a rat basophilic cell line stably expressing human FcepsilonRI

7 IgEs from those hybridomas could activate a basophilic cell line to undergo degranulation upon the s

8 2+ current, in a model system, the RBL-1 rat basophilic cell line.

9 Similar to the human C3aR, RBL-2H3 rat basophilic cells stably expressing this receptor respond

10 lls (MZL), ii) distinct enlargement of MZ by basophilic centroblast-like cells (MZL+), and iii) exten

11 population of large immunoblastic cells with basophilic cytoplasm, centrally placed nuclei, and disti

12 2(int) large mononuclear cells with abundant basophilic cytoplasm.

13 ononuclear infiltrate, with eosinophilic and basophilic degranulation.

14 mitogenesis, enhanced survival, and enhanced basophilic differentiation.

15 the cells in the midgut, do not stain with a basophilic dye (toluidine blue) and are less osmiophilic

16 cy with inhibition of differentiation at the basophilic erythroblast stage.

17 late burst forming unit-erythroid (BFU-E) to basophilic erythroblast stages.

18 st at the transition from proerythroblast to basophilic erythroblast.

19 ciated glycoprotein (RhAG) were found in the basophilic erythroblast.

20 late terminal erythroid maturation with the basophilic erythroblasts expressing predominantly Hb Gow

21 In later (basophilic) erythroblasts, Epo stimulation triggers a lo

22 strate that the development of dysplasia and basophilic foci in the liver is correlated with aneuploi

23 t Mgat3-/- livers had significant numbers of basophilic foci, and by 10-12 months after diethylnitros

24 ells (e.g., oval cells, early hepatocytes in basophilic foci, and intestinal type of cells) are most

25 The lesions were putatively preneoplastic basophilic foci, hepatocellular karyomegaly, megalocytic

26 c/TGF-alpha liver is dysplastic and contains basophilic foci.

27 eosinophilic myelocytes that showed abnormal basophilic granulation.

28 The cytokine was localized to basophilic granules by electron microscopic examination

29 The dose-dependent presence of basophilic granules in multiple tissues in ISIS 416858-t

30 Basophilic granules reflect cellular drug uptake and sub

31 dies revealed that IgE specifically bound to basophilic granulocytes and mast cells through the Fc po

32 Mediator release from basophilic granulocytes correlated better with allergen

33 titial collections of collagenous tissue and basophilic ground substance.

34 approximately twice as many focal lesions of basophilic hepatocytes as treated wild-type littermates.

35 ogen that infects platelets of dogs, forming basophilic intracellular morulae.

36 site at serine 14 of TRPC6 is embedded in a basophilic kinase motif that is highly conserved across

37 lated phosphopeptides was highly enriched in basophilic kinase substrate motifs (AGC or calmodulin-se

38 ecificity for moesin compared to traditional basophilic kinase substrates.

39 e specificity analyses characterize LOK as a basophilic kinase whose optimal substrate sequence resem

40 trategy that assures distinct substrates for basophilic kinases (PKA, PKG and PKC (AGC) and calmoduli

41 this by designing families of kinase such as basophilic kinases and proline-directed kinase with dist

42 Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 1

43 h forms a consensus phosphorylation site for basophilic kinases, markedly reduced the endocytosis, wh

44 alysis of reported substrates of two typical basophilic kinases, protein kinase C and protein kinase

45 of which many represent putative targets of basophilic kinases.

46 matches the consensus for the AGC family of basophilic kinases.

47 terized both in ELISA and in a humanized rat basophilic leukaemia (RBL) cell model.

48 human T cells, DT40 chicken B cells and rat basophilic leukaemia (RBL) cells were examined.

49 elease-activated Ca2+ current (ICRAC) in rat basophilic leukaemia (RBL) cells.

50 In rat basophilic leukaemia (RBL-1) cells dialysed with high in

51 elease-activated Ca2+ current (ICRAC) in rat basophilic leukaemia (RBL-1) cells under conditions of w

52 release-activated Ca2+ current ICRAC in rat basophilic leukaemia (RBL-1) cells.

53 l Mast Cells (PMCs) from BALB/c mice and Rat Basophilic Leukaemia (RBL-2H3) MCs led to significant ki

54 f store-operated Ca2+ entry in the RBL-1 rat basophilic leukaemia cell-line.

55 Rat basophilic leukaemia cells (RBL-2H3-M1) were used to stu

56 asuring beta-hexosaminidase release from rat basophilic leukaemia cells passively sensitized and stim

57 Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 int

58 pressed CD94/NKG2A-EGFP receptors in the rat basophilic leukemia (RBL) cell line.

59 In studies using transfected rat basophilic leukemia (RBL) cell lines expressing either f

60 itro with human and mouse mast cells and rat basophilic leukemia (RBL) cells and in vivo in mice.

61 ocessed appropriately, and functional in rat basophilic leukemia (RBL) cells following retroviral tra

62 Cross-linking of FcepsilonRI on rat basophilic leukemia (RBL) cells initiates a signaling ca

63 parallel studies of FcepsilonRI-bearing rat basophilic leukemia (RBL) cells transfected with constru

64 ion channel, in human and rat platelets, rat basophilic leukemia (RBL) cells, and phorbol myristate a

65 and capacitative Ca(2+) influx, we used rat basophilic leukemia (RBL) cells, vascular smooth muscle

66 gE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.

67 ysteinyl leukotriene type I receptors in rat basophilic leukemia (RBL)-1 cells, large amplitude Ca(2+

68 to analyze published experiments on the rat basophilic leukemia (RBL)-2H3 cell line that seem to con

69 d, disassembled, and soluble vimentin in rat basophilic leukemia (RBL)-2H3 cells expressing human CCR

70 ist of (125)I-C3a radioligand binding to rat basophilic leukemia (RBL)-2H3 cells expressing the human

71 Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degran

72 Here we show that stimulation of rat basophilic leukemia (RBL)-2H3 mast-like cells with the A

73 Rat basophilic leukemia (RBL)-SX38 cells that express human

74 and intracellular Ca2+ concentrations in rat basophilic leukemia (RBL-2H3 m1) cells.

75 lation of the CCR1 chemokine receptor, a rat basophilic leukemia (RBL-2H3) cell line was modified to

76 n-8 (CXCR1) were stably coexpressed in a rat basophilic leukemia (RBL-2H3) cell line.

77 IV-1 infection, monocytes and MAGIC5 and rat basophilic leukemia (RBL-2H3) cell lines co-expressing t

78 Rat basophilic leukemia (RBL-2H3) cells predominantly expres

79 hannels and store-operated Ca2+ entry in rat basophilic leukemia (RBL-2H3) cells.

80 of 60 phosphate units was identified in rat basophilic leukemia (RBL-2H3) mast cells using specific

81 are expressed either in the cytoplasm of rat basophilic leukemia (RBL-2H3) mucosal mast cells or anch

82 e phosphatase-inactive forms of SHP-1 in rat basophilic leukemia 2H3 (RBL-2H3) mast cell line.

83 Overexpression of Gab2 in rat basophilic leukemia 2H3 cell line cells inhibited the Fc

84 investigated the role of Gab2 using the rat basophilic leukemia 2H3 cell line mast cells.

85 The receptors were stably expressed in rat basophilic leukemia 2H3 cells and characterized for rece

86 lize the level of LAT phosphorylation in rat basophilic leukemia 2H3 cells show that Erk2 phosphoryla

87 duces an increase in 5-HT uptake Vmax in rat basophilic leukemia 2H3 cells that is enhanced by pretre

88 A were then cotransfected with CD94 into rat basophilic leukemia 2H3 cells.

89 ing events that lead to degranulation in rat basophilic leukemia 2H3 cells.

90 ctions enriched in plasma membranes from rat basophilic leukemia 2H3 mast cells.

91 n a Syk-negative variant of the RBL-2H3 (rat basophilic leukemia 2H3) mast cell line.

92 or genetically encoded Ca(2+) sensors in rat basophilic leukemia and bone marrow-derived rat mast cel

93 release-activated Ca2+ (CRAC) channel in rat basophilic leukemia and other hematopoietic cells to rel

94 Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the pa

95 Rat basophilic leukemia cell line (RBL-2H3) stably expressin

96 In mast cells of the rat basophilic leukemia cell line (RBL-2H3), cholera toxin (

97 in a similar manner, we studied a stable rat basophilic leukemia cell line (RBL-CR1) transfected with

98 ere therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed

99 blasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cel

100 In fact, CaG chemoattracts rat basophilic leukemia cells (RBL cells) expressing the hig

101 ctive channels in the plasma membrane of rat basophilic leukemia cells (RBL-2H3 m1), an immortalized

102 donoyl ethanolamide (anandamide, AEA) in rat basophilic leukemia cells (RBL-2H3) has been proposed to

103 investigated the regulation of CXCR4 in rat basophilic leukemia cells (RBL-2H3) stably transfected w

104 alcium mobilization and degranulation in rat basophilic leukemia cells and cytokine production (IL-6

105 gated through patch-clamp experiments on rat basophilic leukemia cells and fluorometric imaging plate

106 , 5-LO is localized to the cytoplasm; in rat basophilic leukemia cells and human alveolar macrophages

107 o image Annexin 2-GFP in live, secreting rat basophilic leukemia cells and in cells performing pinocy

108 s across intact cell-attached patches in rat basophilic leukemia cells and rat megakaryocytes reveale

109 on-dependently inhibited CRAC current in rat basophilic leukemia cells and thapsigargin-induced Ca(2+

110 cts more effectively with FcepsilonRI(+)-rat basophilic leukemia cells at 37 degrees C compared with

111 Examination of rat basophilic leukemia cells by both immunocytochemistry an

112 that the mitotic clock of unsynchronized rat basophilic leukemia cells has a marked precision with 80

113 inity receptor for IgE (Fc epsilonRI) on rat basophilic leukemia cells is regulated by its initiating

114 sured the extent and rate of adhesion of rat basophilic leukemia cells preincubated with anti-dinitro

115 Recent studies in Jurkat T cells and in rat basophilic leukemia cells revealed an Mg(2+)-inhibited c

116 ster ovary cells and alpha4 integrins on rat basophilic leukemia cells showed little or no associatio

117 iating Ca(2+) waves are observed in most rat basophilic leukemia cells stimulated with soluble Ag and

118 Using rat basophilic leukemia cells transfected with the human hig

119 gh affinity receptors (Fc epsilon RI) on rat basophilic leukemia cells using both single particle tra

120 we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled c

121 cepsilonRI-mediated calcium signaling in rat basophilic leukemia cells, a property dependent on the S

122 rent (I(crac)) in lacrimal acinar cells, rat basophilic leukemia cells, and DT40 B-lymphocytes.

123 In rat basophilic leukemia cells, emptying of the stores activa

124 ar characteristics to that recorded from rat basophilic leukemia cells, namely a similar time course

125 Here we show, in intact rat basophilic leukemia cells, that calcium responses induce

126 degranulation assay in C3aR-transfected rat basophilic leukemia cells, two were prominent agonists (

127 Using mFPR-transfected rat basophilic leukemia cells, we found that a recently iden

128 om HeLa cells expressing SERT and intact rat basophilic leukemia cells, we show that agents such as N

129 ays and degranulation tests of humanized rat basophilic leukemia cells.

130 activation of whole-cell CRAC current in rat basophilic leukemia cells.

131 usly measured in thousands of individual rat basophilic leukemia cells.

132 itutions on FPR functions in transfected rat basophilic leukemia cells.

133 um compounds in Jurkat T lymphocytes and rat basophilic leukemia cells.

134 e-labeled anti-DNP IgE on the surface of rat basophilic leukemia cells.

135 ase-activated calcium current (Icrac) in rat basophilic leukemia cells.

136 roliferation in human Jurkat T-cells and rat basophilic leukemia cells.

137 sequent release of chemical mediators on rat basophilic leukemia cells.

138 I(CRAC) to a size comparable to that in rat basophilic leukemia cells.

139 se-activated Ca(2+) current (I(CRAC)) in rat basophilic leukemia cells.

140 a large gain in CRAC channel function in rat basophilic leukemia cells.

141 lently cross-linked IgE dimers stimulate rat basophilic leukemia cells.

142 ibitor of mast cell degranulation in the rat basophilic leukemia mast cell model, in the passive cuta

143 ng enlargement of these vesicles in both rat basophilic leukemia mast cells and Jurkat T leukemia cel

144 find that SNAP-23 is phosphorylated when rat basophilic leukemia mast cells are triggered to degranul

145 Rat basophilic leukemia mast cells primed with fluorescent a

146 lation mutants inhibited exocytosis from rat basophilic leukemia mast cells, demonstrating that phosp

147 ) responses to antigen in IgE-sensitized rat basophilic leukemia mast cells.

148 C3a stimulated degranulation in a basophilic leukemia RBL-2H3 cell expressing wild-type C3

149 Using a basophilic leukemia RBL-2H3 cell line expressing wild-ty

150 These mutants expressed in rat basophilic leukemia RBL-2H3 cells bound LTB4 with simila

151 ion of the IgE high affinity receptor on rat basophilic leukemia RBL-2H3 cells results in activation

152 a monoclonal antibody raised against the rat basophilic leukemia RBL-2H3 cells, we identified that pl

153 man chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-re

154 (CD31), after FcepsilonRI stimulation in rat basophilic leukemia RBL-2H3 cells.

155 gE receptor (FcepsilonRI) aggregation in rat basophilic leukemia RBL-2H3 cells.

156 d phospholipase C-gamma1 from lysates of rat basophilic leukemia RBL-2H3 cells.

157 een identified in T-lymphocytes and RBL (rat basophilic leukemia) cells and named MagNuM (for Mg(2+)-

158 STZ mitigated degranulation of RBL-2H3 (rat basophilic leukemia) mast cells induced by compound 48/8

159 retion from transiently transfected RBL (rat basophilic leukemia)-2H3 mast cells (a tumor analog of m

160 d receptor, Mas-related gene X2 (MrgX2), rat basophilic leukemia, RBL-2H3 cells, and murine BMMCs do

161 IgE-dependent stimulation of either rat basophilic leukemia-2H3 cells (RBL-2H3 cells) or mouse b

162 In rat basophilic leukemia-2H3 cells expressing formyl peptide

163 In rat basophilic leukemia-2H3 cells expressing transfected mou

164 In rat basophilic leukemia-2H3 cells, Lyn thus plays a dual rol

165 ransfected the unique domain of Lyn into rat basophilic leukemia-2H3 mast cells and examined the cons

166 E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells in contact with fluid

167 rgent sensitivity of this association on rat basophilic leukemia-2H3 mast cells, and we compare the c

168 The rat basophilic leukemic (RBL-2H3) cell line was stably trans

169 o demonstrate the utility of the system, rat basophilic leukemic cells loaded with Oregon green and f

170 bilizing activity previously reported in rat basophilic leukemic cells.

171 up were irregular and presented an amorphous basophilic line and bone necrosis that was slowly resorb

172 mbra(-/-) mice develop massive splenomegaly, basophilic macrocytic red blood cells, and anemia as the

173 Some had a clearly defined basophilic margin, while others were granular with a hya

174 by dDAVP showed a predominance of so-called "basophilic" motifs consistent with activation of kinases

175 The transition from proerythroblast to basophilic normoblast occurred later, from days 7 to 9,

176 apex in cell cycling and the proerythroblast-basophilic normoblast transition.

177 utant embryos contain few pronormoblasts and basophilic normoblasts and have drastically reduced numb

178 mplete the transition from pronormoblasts to basophilic normoblasts.

179 of papillary renal cell carcinoma had small basophilic nuclei, and clear cell areas lacked a fine va

180 illary in architecture and showed chromophil basophilic, papillary renal cell carcinoma type 1 histol

181 in vitro cell system that progressed through basophilic, polychromatic, orthochromatic, and reticuloc

182 revealed that the ratio of proerythroblasts:basophilic:polychromatic:orthromatic erythroblasts follo

183 sequential formation of proerythroblasts and basophilic, polychromatophilic and orthochromatic erythr

184 emia-associated peptides containing the KXXS basophilic protein kinase consensus motif.

185 rates that we previously defined for related basophilic protein kinases such as protein kinase A, Ser

186 sion system and Syk-negative variants of rat basophilic (RBL-2H3) cells.

187 , eosinophilic inclusions, and vacuoles with basophilic rims were seen in moderately affected muscles

188 Most basophilic serine/threonine kinases preferentially phosp

189 d associated at the plasma membrane from the basophilic stage of erythropoiesis.

190 coagulative necrosis associated with intense basophilic staining of extracellular matrix, including c

191 Unlike tolerant challenged controls, basophilic upregulation of CD203c in response to moxiflo