ライフサイエンスコーパス: bay region

1 c blocking of the most reactive sites at the bay region.

2 The structure of the bay region (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4

3 nzymatic activation to enantiomeric pairs of bay-region 7,8-diol 9, 10-epoxides (the benzylic 7-hydro

4 The structure of the non-bay region (8S,9R,10S,11R)-N(6)-[11-(8,9,10, 11-tetrahyd

5 on adducts are readily bypassed in vivo, the bay region adducts are both blocking to approximately th

6 While both non-bay region adducts are readily bypassed in vivo, the bay

7 s been linked to repair efficiency such that bay region adducts can be readily repaired while their f

8 nt intrinsic topologies of the rigid, planar bay region adducts versus the twisted, sterically hinder

9 ed from shorebirds and gulls in the Delaware Bay region and from ducks in Alberta, Canada, during >18

10 xy-derivatives of three important classes of bay-region and fjord-region PAHs whose diol-epoxides ext

11 benzylic carbocations formed by 1,2-epoxide (bay-region) and 5,6-epoxide (K-region) ring opening.

12 -K-region o-quinones (bay region, methylated bay region, and fjord region o-quinones) produced by AKR

13 lication system, we have shown that both non-bay region anti-trans-benz[a]anthracene adducts are esse

14 In contrast, the bay region anti-trans-benz[a]anthracene lesions do induc

15 is most efficient in the GSH conjugation of bay-region anti-diol epoxide of benzo(a)pyrene (anti-BPD

16 group) at the imide sites as well as at the bay regions are described in this study.

17 This differed from the bay region BA RSRS (61,2) adduct, in which the lesion wa

18 orotation at A6 appears to be common to both bay region BA RSRS (61,3) and BP SRSR (61,3) adducts.

19 on BcPh amino tribenzoate as compared to the bay-region BaP amino tribenzoate.

20 In contrast, the non-bay region benz[a]anthracene adduct was easily bypassed

21 The bay region benzo[a]pyrene and bay region benz[a]anthracene adducts were poorly replica

22 rison with the bay region benzo[a]pyrene and bay region benz[a]anthracene adducts with the correspond

23 try and at the same site shows that this non-bay region benz[a]anthracene lesion assumes different ba

24 This was the bay region benz[a]anthracene RSRS (61,3) adduct.

25 Comparison with the bay region benzo[a]pyrene and bay region benz[a]anthrace

26 The bay region benzo[a]pyrene and bay region benz[a]anthrace

27 analogous stereoisomeric DNA adducts of the bay region benzo[a]pyrene diol epoxide (B[a]PDE), 10S (+

28 s-anti-[BP]dA.dT 11-mer duplex, containing a bay region benzo[a]pyrenyl [BP]dA adduct, is compared wi

29 striking contrast to earlier research with "bay" region benzo[a]pyrene-N2-guanine (designated (BP)G)

30 r their fjord-region benzo[c]phenanthrene or bay-region benzo[a]pyrene analogues.

31 By contrast, the bay region BP-N2-G adducts are susceptible to repair, si

32 (HFP) mediated substitution reaction of the bay-region C10 acetoxy group in four stereoisomeric 7,8,

33 (5-MeC-1,2-diol), as well as 5-MeC-7,8-diol, bay region dihydrodiols, and phenols.

34 or metabolites of 6-MeC were 6-MeC-1,2-diol, bay region dihydrodiols, phenols, and 6-(hydroxymethyl)c

35 that DNA adducts formed from benzo[a]pyrene bay-region diol epoxides can markedly affect top1 activi

36 ate that the adenine adducts induced by both bay-region diol epoxides of DMBA lead to the mutation at

37 d anti-DMBADE), the two metabolically formed bay-region diol epoxides of DMBA, and we have also analy

38 tralis (diatom) was observed in the Monterey Bay region during the same period.

39 of adducts derived from the highly reactive bay region enantiomeric (+)- and (-)-anti-7,8-diol-9,10-

40 e short 2.055 A interatomic distance between bay-region F-9 and H-8, downfield shift of H-8, and a 26

41 e carboxylic acid group is introduced to the bay region for the purpose of further bioconjugation.

42 ivative (10), relief of steric strain in the bay-region greatly favors ipso-protonation (10aH+).

43 ry, the Hampton Roads area of the Chesapeake Bay region has experienced one of the highest rates of r

44 ion of zethrene core and substitution at the bay region in one single step.

45 ructural differences between the non-bay and bay region lesions are correlated with site-specific mut

46 The mutagenic frequency of these bay region lesions is dependent on the stereochemistry a

47 Classes of PAH non-K-region o-quinones (bay region, methylated bay region, and fjord region o-qu

48 ester and carboxylate functionalities at the bay region of the acenaphthene motif increases each liga

49 ergies for Diels-Alder cycloadditions in the bay regions of periacenes should diminish monotonically

50 erred binding sites for the diol epoxides of bay region polycyclic aromatic hydrocarbons (PAH).

51 igenic potential of fjord region compared to bay region polycyclic aromatic hydrocarbons.

52 The results suggest the bay region ring contributes to base stacking interaction

53 ifferences are attributed to the loss of the bay region ring.

54 n, new catalysts were prepared in which the "bay region" tert-butyl groups were replaced by trimethyl

55 of the two aryl substituents within the same bay region, the chiral peropyrene adopts a twisted backb