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1 icases in RNA regulation, ATP hydrolysis may be a widely used activity in target RNA discrimination.
2                                     Nicotine is a widely used addictive drug, with an estimated 73 mi
3                      Titanium dioxide (TiO2) is a widely used additive in foods.
4                                        BLAST is a widely used alignment tool for detecting matches be
5                  Acetaminophen (paracetamol) is a widely used analgesic and antipyretic drug with onl
6 medulla.SIGNIFICANCE STATEMENT Acetaminophen is a widely used analgesic drug with multiple but only i
7 ncreasingly popular and has the potential to be a widely used and valuable research tool.
8                    Rush desensitization (DS) is a widely used and effective clinical strategy for the
9                                    Cisplatin is a widely used and effective drug, but its use is asso
10                                      Lithium is a widely used and effective treatment for mood disord
11 ation of protein coding genes in genomic DNA is a widely used and essential tool for analyzing newly
12                                      Lithium is a widely used and highly effective treatment for mood
13 of a Position-Specific Scoring Matrix (PSSM) is a widely used and highly informative representation o
14                     Gene expression analysis is a widely used and powerful method for investigating t
15                           Cyclic voltammetry is a widely used and powerful tool for sensitively and s
16                  Colorectal distension (CRD) is a widely used and reliable method for evaluating colo
17                      Glatiramer acetate (GA) is a widely used and safe formulation for treatment of m
18 k fibroin, derived from Bombyx mori cocoons, is a widely used and studied protein polymer for biomate
19 ymmetric flow field-flow fractionation (AF4) is a widely used and versatile technique in the family o
20                                The mdx mouse is a widely used animal model of DMD.
21 xperimental allergic encephalomyelitis (EAE) is a widely used animal model of the human demyelinating
22                                    Metformin is a widely used anti-diabetic drug with potential anti-
23 e neuraminidase (NA) inhibitor, oseltamivir, is a widely used anti-influenza drug.
24                           Methotrexate (MTX) is a widely used anticancer and antirheumatic drug that
25                                    Etoposide is a widely used anticancer drug successfully used for t
26                                    Cisplatin is a widely used anticancer drug that acts by binding DN
27                        5-fluorouracil (5-FU) is a widely used anticancer drug that disrupts pyrimidin
28                                     Warfarin is a widely used anticoagulant that has a narrow therape
29                 Unfractionated heparin (UFH) is a widely used anticoagulant that has long been known
30                                      Heparin is a widely used anticoagulant.
31                                Valproic acid is a widely used anticonvulsant that has recently been a
32                          Valproic acid (VPA) is a widely used anticonvulsive agent that has profound
33                                    Metformin is a widely used antidiabetic drug that exerts cardiovas
34                                 Troglitazone was a widely used antidiabetic drug that activates PPARg
35                                   Topiramate is a widely used antiepileptic agent whose mechanism of
36                             Chloroquine (CQ) is a widely used antimalarial drug with emerging potenti
37                                   Mefloquine is a widely used antimalarial without a known mode of ac
38 ), which is mostly referred to as cisplatin, is a widely used antineoplastic.
39                                   Adriamycin is a widely used antitumor antibiotic, but its use has b
40                            Doxorubicin (DOX) is a widely used antitumor drug, but its application is
41                                 Fine mapping is a widely used approach for identifying the causal var
42 xternal reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome
43                    Metabolic network mapping is a widely used approach for integration of metabolomic
44    Tandem mass spectrometry (MS/MS or MS(2)) is a widely used approach for structural annotation and
45 ation coupled with mass spectrometry (AP-MS) is a widely used approach for the identification of prot
46 ssing one or more recombinant gene sequences is a widely used approach in biomedical research, biotec
47                             T cell depletion is a widely used approach in clinical transplantation.
48     Shape-based alignment of small molecules is a widely used approach in computer-aided drug discove
49                               Ligand docking is a widely used approach in virtual screening.
50                    Phage display mutagenesis is a widely used approach to engineering novel protein p
51         The addition of processing additives is a widely used approach to increase power conversion e
52                       Bacillus thuringiensis is a widely used bacterial entomopathogen producing inse
53                                           SG is a widely used bariatric operation leading to weight l
54                       The elevated plus maze is a widely used behavioral assay for rodents and it has
55                                  Free recall is a widely used behavioral paradigm for studying retrie
56                                    BRaliBase is a widely used benchmark for assessing the accuracy of
57                              Clavulanic acid is a widely used beta-lactamase inhibitor whose key beta
58                  Poly(ethylene glycol) (PEG) is a widely used biocompatible polymer.
59 cence-associated beta-galactosidase activity is a widely used biomarker for assessing replicative sen
60                Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication of neurol
61              H3-K4 methylation may therefore be a widely used but not universal means for controlling
62  shoot meristems from cultured root explants is a widely used, but poorly understood, process in whic
63                                    Cisplatin is a widely used cancer therapy drug that unfortunately
64                                       Phenol is a widely used chemical that for several reasons may b
65                            Bisphenol A (BPA) is a widely used chemical that has been shown to adverse
66                                   Paclitaxel is a widely used chemotherapeutic agent and is known to
67                                    Cisplatin is a widely used chemotherapeutic agent for the treatmen
68                        5-fluorouracil (5-FU) is a widely used chemotherapeutic drug for the treatment
69                             Cyclophosphamide is a widely used chemotherapeutic drug that was recently
70                                  Gemcitabine is a widely used chemotherapeutic drug, but limited ther
71      The antimetabolite 5-fluorouracil (5FU) is a widely used chemotherapeutic for the treatment of s
72                                    Cisplatin is a widely used chemotherapy drug, which has a major si
73                      Scutellaria baicalensis is a widely used Chinese herbal medicine that has been u
74 n calcium channel blockers such as verapamil are a widely used class of antihypertensive drugs that b
75 coenzyme A reductase inhibitors, or statins, are a widely used class of drugs for cholesterol reducti
76  brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for the diagnosis, p
77           Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting
78                 Deep brain stimulation (DBS) is a widely used clinical treatment for Parkinson's dise
79                                   Clustering is a widely used collection of unsupervised learning tec
80       Vitek 2 (bioMerieux, Inc., Durham, NC) is a widely used commercial antimicrobial susceptibility
81        Vitek 2 (bioMerieux Inc., Durham, NC) is a widely used commercial antimicrobial susceptibility
82            The African clawed frog, Xenopus, is a widely used comparative model for studying the immu
83 es induced by pentylenetetrazol (PTZ), which is a widely used convulsant agent, on rat brain.
84 on against a stably expressed reference gene is a widely used data analysis method in microarray and
85                          The de Bruijn graph is a widely used data structure in fragment assembly alg
86                                         Pfam is a widely used database of protein families and domain
87 available via servers in the UK and the USA, is a widely used database of protein families, containin
88                                         Pfam is a widely used database of protein families, currently
89                     The van der Waals volume is a widely used descriptor in modeling physicochemical
90                           Tilt-table testing is a widely used diagnostic tool.
91                        Neighbor joining (NJ) is a widely used distance-based phylogenetic tree constr
92                                    The E-Box is a widely used DNA control element.
93         Angiotensin-receptor blockers (ARBs) are a widely used drug class approved for treatment of h
94                                    Metformin is a widely used drug and targets OCT type 2 located in
95                                    Tamoxifen is a widely used drug for chemotherapy and chemopreventi
96                                    Metformin is a widely used drug for treatment of type 2 diabetes w
97                                      Digoxin is a widely used drug for ventricular rate control in pa
98                                    Marijuana is a widely used drug that impairs memory through intera
99 ed partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and me
100                           Directed evolution is a widely-used engineering strategy for improving the
101  (15)N-(1)H vector reorientational dynamics, is a widely used experimental method to assess the motio
102                   The rodent vibrissa system is a widely used experimental model of active sensation
103          2-Aminoethyldiphenyl borate (2-APB) is a widely used experimental tool that activates and th
104                        Trinitrotoluene (TNT) is a widely used explosive in landmines and military ope
105                                          ATP is a widely used extracellular signaling molecule.
106                                  Fluorescein is a widely used fluorescent probe in DNA analysis.
107                                   Allura red is a widely used food colorant, but there is debate on i
108 s well as by PCR measurements of pmoA, which is a widely used functional gene biomarker for methanotr
109                                     Acivicin is a widely used gamma-glutamyltranspeptidase inhibitor
110  from the jellyfish Aequorea victoria, which is a widely used gene expression marker owing to its eff
111                                          TCS is a widely used haplotype network reconstruction softwa
112    The Dermatology Life Quality Index (DLQI) is a widely used health-related quality of life measure.
113                                    Echinacea is a widely used herbal remedy for treatment of upper re
114                                       Diuron is a widely used herbicide detected in freshwater ecosys
115                                   Glyphosate is a widely used herbicide that inhibits the synthesis o
116 Dicamba (3,6-dichloro-2-methoxybenzoic acid) is a widely used herbicide that is efficiently degraded
117                         Terbuthylazine (TBA) is a widely used herbicide, and its heterogeneous reacti
118                                    MapReduce is a widely used high performance parallel framework tha
119 o-1H-3-benzaze pine hydrochloride (SCH23390) is a widely used, highly selective antagonist of D1 dopa
120                                  Gemfibrozil is a widely used hypolipidemic and triglyceride lowering
121 alcium dynamics using fluorescent indicators is a widely used imaging method for large-scale recordin
122 escence recovery after photobleaching (FRAP) is a widely used imaging technique for measuring the mob
123                              As pimonidazole is a widely used immunohistochemical marker of tissue hy
124                         Cyclosporine A (CsA) is a widely used immunosuppressant, with clinical applic
125                                   Tacrolimus is a widely used immunosuppressive drug that inhibits th
126 CsA), an inhibitory ligand of cyclophilin A, is a widely used immunosuppressive drug, it causes arter
127                 Bioluminescent imaging (BLI) is a widely used in vivo method to determine the locatio
128               Alanine aminotransferase (ALT) is a widely used index of liver integrity or hepatocellu
129 bit polyclonal antithymocyte globulin (ATG), is a widely used induction therapy in clinical organ tra
130                                 Tracheostomy is a widely used intervention in adult critical care uni
131                                     Propofol is a widely used intravenous anesthetic agent with antio
132                  Ferric pyrophosphate (FePP) is a widely used iron source in food fortification and i
133              Prostate specific antigen (PSA) is a widely used marker for prostate cancer, which is se
134                           Tyrosine nitration is a widely used marker of peroxynitrite (ONOO(-)) produ
135                         Ferric pyrophosphate is a widely used material in the area of mineral fortifi
136                    Type-II glass-like carbon is a widely used material with a unique combination of p
137 MENT The central alpha mu rhythm oscillation is a widely used measure of the human mirror neuron syst
138                              Co-localisation is a widely used measurement in immunohistochemical anal
139 CD, suggesting that complex coacervation may be a widely used mechanism to promote intracellular phas
140 induced transactivation of frameshifting may be a widely used mechanism, potentially including previo
141 eins through the ubiquitin-proteasome system is a widely used mechanism for controlling signalling pa
142 recent results showing that ribosome pausing is a widely used mechanism for controlling translation a
143 nd the release of RNA polymerase II (Pol II) is a widely used mechanism for regulating gene expressio
144 this Cindr/CD2AP-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
145               Promoter chromatin disassembly is a widely used mechanism to regulate eukaryotic transc
146                          Computed tomography is a widely used medical imaging technique that has high
147      The film bulk acoustic resonator (FBAR) is a widely-used MEMS device which can be used as a filt
148                                           Ti is a widely used metal in colorants, foods, and implants
149                                   Bacitracin is a widely used metal-dependent peptide antibiotic prod
150               Analytical ultracentrifugation is a widely used method for characterizing the solution
151                      Hierarchical clustering is a widely used method for detecting clusters in genomi
152         Circular dichroism (CD) spectroscopy is a widely used method for examining the structure, fol
153 rature conversion/elemental analysis, TC/EA) is a widely used method for hydrogen isotopic analysis o
154 o their respective 3D macromolecular targets is a widely used method for lead optimization.
155 transform infrared microspectroscopy (FTIRM) is a widely used method for mapping the material propert
156                     Deep mutational scanning is a widely used method for multiplex measurement of fun
157                       Non-linear calibration is a widely used method for quantifying biomarkers where
158             Phylogenetic tree reconciliation is a widely used method for reconstructing the evolution
159 nsform infrared (FTIR) spectroscopic imaging is a widely used method for studying the chemistry of pr
160 nal stereotactic surface projection (3D-SSP) is a widely used method for the analysis of clinical (18
161          The northern blot, or RNA gel blot, is a widely used method for the discovery, validation an
162      Catalytic ring-closing metathesis (RCM) is a widely used method for the synthesis of large unsat
163 r relative and absolute quantitation (iTRAQ) is a widely used method in quantitative proteomics.
164           Multi-locus sequence typing (MLST) is a widely used method of characterization of bacterial
165 scriptase polymerase chain reaction (RT-PCR) is a widely used method that enables transcriptional pro
166  mediated by short interfering RNAs (siRNAs) is a widely used method to analyze gene function.
167         Chromatin immunoprecipitation (ChIP) is a widely used method to explore in vivo interactions
168                                      Epitaxy is a widely used method to grow high-quality crystals.
169 transepithelial electrical resistance (TEER) is a widely used method to monitor cellular barrier tigh
170                                Phage display is a widely used method to optimize the binding characte
171 ls reacted with fluorescently labeled probes is a widely-used method for assessing cell biology.
172 ased on microfluidic affinity chromatography is a widely used methodology in cell analysis research w
173 th the popular term carbon footprints (CFP), are a widely used metric of climate change impacts and t
174                Biological process enrichment is a widely used metric for evaluating the quality of mu
175 of arginine residues to narrow minor grooves is a widely used mode for protein-DNA recognition.
176       In vitro cultures of endothelial cells are a widely used model system of the collective behavio
177 ps and oligo(ethylene glycol) (OEG) moieties are a widely used model system.
178                      Although RCS/N-rdy rats are a widely used model to investigate mechanisms of pho
179        The fruit fly Drosophila melanogaster is a widely used model for cell biology, development, di
180                         The Arabidopsis root is a widely used model for developmental, physiological
181 ate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse f
182          The nematode Caenorhabditis elegans is a widely used model for genetic dissection of animal
183                      Zebrafish (Danio rerio) is a widely used model for toxicological studies, in par
184                                      The rat is a widely used model in biomedical research and is oft
185  17beta-Estradiol stimulation of MCF-7 cells is a widely used model in the growth of breast cancer.
186 ent of extinguished cocaine-seeking behavior is a widely used model of cue-elicited craving in abstin
187 odium berghei ANKA infection of C57BL/6 mice is a widely used model of experimental cerebral malaria
188 tid artery occlusion in the Mongolian gerbil is a widely used model of forebrain ischemia due to spec
189 stemic injection of lipopolysaccharide (LPS) is a widely used model of immune/inflammatory challenge,
190 erimental autoimmune encephalomyelitis (EAE) is a widely used model of multiple sclerosis.
191                      Drosophila melanogaster is a widely used model organism for genetic dissection o
192 ellular green alga Chlamydomonas reinhardtii is a widely used model organism for studies of oxygenic
193   The social amoeba Dictyostelium discoideum is a widely used model organism for studying basic funct
194 The invertebrate chordate Ciona intestinalis is a widely used model organism in biological research.
195                 The salamander retina, which is a widely used model system for analyzing retinal func
196 l artery (MCA) with an endovascular filament is a widely used model to induce focal cerebral ischemia
197 r-induced choroidal neovascularization (CNV) is a widely used model to mimic many features of CNV res
198 ANCE STATEMENT The whisker system of rodents is a widely used model to study tactile processing.
199 he Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating the patho
200                         Intracellular Ca(2+) is a widely used neuronal activity indicator.
201                 Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating trem
202   While saturation transfer difference (STD) is a widely used NMR method for ligand screening, the se
203      Transcranial magnetic stimulation (TMS) is a widely used non-invasive tool to study and modulate
204      Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating ner
205                            Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NS
206                                   Diclofenac is a widely used nonsteroidal anti-inflammatory drug and
207  combination of fenfluramine and phentermine was a widely used obesity treatment before the withdrawa
208                                  Bimatoprost is a widely used ocular hypotensive agent to treat glauc
209                                      PANTHER is a widely used online resource for comprehensive prote
210                                         Jmol is a widely used, open-source Java viewer for 3D structu
211                          Anaerobic digestion is a widely used organic waste treatment process.
212                                 Chlorpyrifos is a widely used organophosphate insecticide that is a s
213                                   Gentamicin is a widely used ototoxic agent.
214  amplification of cDNA ends (RACE) procedure is a widely used PCR-based method to clone the cDNA ends
215   Significance analysis of microarrays (SAM) is a widely used permutation-based approach to identifyi
216                                          TFM is a widely used pesticide for the population control of
217         Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac
218 ring in noble metal nanoparticles (e.g., Au) is a widely used phenomenon to report molecular interact
219         We combined DMN with mimMiner, which was a widely used phenotype database in disease gene pre
220                               Anatase TiO(2) is a widely used photocatalytic material, and catechol (
221                           Polypropylene (PP) is a widely used plastic with consumer applications rang
222                                     Propofol is a widely used, potent intravenous anesthetic for ambu
223                   Organic matter application is a widely used practice to increase soil carbon conten
224                     Osmotic dehydration (OD) is a widely used preservation technique that consists in
225               Guided bone regeneration (GBR) is a widely used procedure for augmenting alveolar ridge
226                                       CD-HIT is a widely used program for clustering and comparing la
227                                       CD-HIT is a widely used program for clustering biological seque
228                                  SweepFinder is a widely used program that implements a powerful like
229 orporation of 3H-thymidine into cellular DNA is a widely used protocol to monitor rates of DNA synthe
230 etreatment of MDMs with the Vpx+ VLPs, which is a widely used protocol, displayed identical proviral
231                           Hand grip strength is a widely used proxy of muscular fitness, a marker of
232 oembolism prevention during critical illness is a widely used quality metric.
233                           Oxolinic acid (OA) is a widely used quinolone antibiotic in aquaculture.
234            Purified protein derivative (PPD) is a widely used reagent for the diagnosis of Mycobacter
235                                        Yeast is a widely used recombinant protein expression system.
236                                    Marijuana is a widely used recreational agent, and Delta(9)-tetrah
237                    Chlamydomonas reinhardtii is a widely used reference organism in studies of photos
238                            Pre-mRNA splicing is a widely used regulatory mechanism for controlling ge
239                    Fluorescence spectroscopy is a widely used research tool in biochemistry and molec
240                           Gene ontology (GO) is a widely used resource to describe the attributes for
241                      Dental (silver) amalgam is a widely used restorative material containing 50% ele
242  in particular virus-induced gene silencing, is a widely used reverse- and forward-genetics tool in p
243              Prostate-specific antigen (PSA) is a widely used serum marker for prostate cancer (PCa)
244              Prostate-specific antigen (PSA) is a widely used serum marker for prostate cancer (PCa),
245              Prostate specific antigen (PSA) is a widely used serum marker for prostate cancer (PCa),
246                               BRB-ArrayTools is a widely used software system for the analysis of gen
247 cates with feature selection by thresholding is a widely used solution for learning features with hig
248                                    The EQ-5D is a widely-used, standardised, quality of life measure
249                                      q-value is a widely used statistical method for estimating false
250 function of cellular PDZ proteins appears to be a widely used strategy for viruses to enhance their r
251         Tris(2-carboxyethyl)phosphine (TCEP) is a widely used substitute for dithiothreitol (DTT) in
252                     The embryonic mouse lung is a widely used substitute for human lung development.
253                     Fasting hyperinsulinemia is a widely used surrogate measure of insulin resistance
254                        The Morris Water Maze is a widely used task in studies of spatial learning wit
255                               Flow cytometry is a widely used technique among biologists to study the
256          Mapping genes by chromosome walking is a widely used technique applicable to cloning virtual
257                Bisulphite genomic sequencing is a widely used technique for detailed analysis of the
258 by next-generation DNA sequencing (ChIP-seq) is a widely used technique for identifying transcription
259    Serial analysis of gene expression (SAGE) is a widely used technique for large-scale transcriptome
260 uclear magnetic resonance (NMR) spectroscopy is a widely used technique for mixture analysis, but it
261  Reversed-phase liquid chromatography (RPLC) is a widely used technique for molecular separations.
262 olyacrylamide gel electrophoresis (SDS-PAGE) is a widely used technique for protein separation, and i
263         Chromatin immunoprecipitation (ChIP) is a widely used technique for quantifying protein-DNA i
264         Solid-phase peptide synthesis (SPPS) is a widely used technique in biology and chemistry.
265                              Electroporation is a widely used technique to permeabilize cell membrane
266 ement (TGR) using fragments generated by PCR is a widely-used technique for deleting genes in Sacchar
267                         Bisulfite sequencing is a widely-used technique for examining cytosine DNA me
268                         Ultrafiltration (UF) is a widely used technology for inpatient management of
269                            Endemic stability is a widely used term in the epidemiology of ticks and t
270                  The Trail Making Test (TMT) is a widely used test of executive function and has been
271                                   Omalizumab is a widely used therapeutic anti-IgE antibody.
272         High-dose intravenous immunoglobulin is a widely used therapeutic preparation of highly purif
273                            Enteral nutrition is a widely used therapy for nutritional treatment of pa
274              Transarterial chemoembolization is a widely used therapy for the treatment of hepatocell
275 ve enzyme-linked immunosorbent assay (ELISA) is a widely used tool for analyzing biopharmaceutical an
276 sion profiling (GEP) via microarray analysis is a widely used tool for assessing risk and other patie
277                         In vitro translation is a widely used tool for both analytical and preparativ
278  by Forster resonance energy transfer (FRET) is a widely used tool for detecting protein-protein inte
279         Fragment based drug discovery (FBDD) is a widely used tool for discovering novel therapeutics
280 ndard L(2)-norm support vector machine (SVM) is a widely used tool for microarray classification.
281                           The ClusPro server is a widely used tool for protein-protein docking.
282 pray ionization (ESI) mass spectrometry (MS) is a widely used tool for the characterization of organo
283  receptor (alpha(2)-AR) antagonist yohimbine is a widely used tool for the study of anxiogenesis and
284    The antipsychotic compound chlorpromazine is a widely used tool to probe the ion channel pore of t
285 uct enantiometric excess (ee) on catalyst ee is a widely used tool to probe the mechanism of an enant
286                Atomic Force Microscopy (AFM) is a widely used tool to study cell mechanics.
287             Fluorescence tagging of proteins is a widely used tool to study protein function and dyna
288 ssion quantitative trait loci (eQTL) mapping is a widely used tool to study the genetics of gene expr
289 se proteome coverage, dynamic exclusion (DE) is a widely used tool.
290                                    Anthralin is a widely used, topical therapy for psoriasis.
291                                Daphnia pulex is a widely used toxicological model and is known for it
292 ogrammed -1 ribosomal frameshifting (-1 PRF) is a widely used translational mechanism facilitating th
293 c stem and progenitor cell (HSPC) transplant is a widely used treatment for life-threatening conditio
294                                VEGF blockade is a widely used treatment for neovascular diseases such
295                Although lung transplantation is a widely used treatment modality for patients with en
296                     Dental implant placement is a widely used treatment that provides functional and
297 ing clonidine or buprenorphine hydrochloride is a widely used treatment.
298                                          Ad5 is a widely used viral vector for gene therapy that bind
299                        Given that isoflurane is a widely used volatile anesthetic, and is used for in
300                                 IslandViewer is a widely-used webserver for the prediction and intera

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