ライフサイエンスコーパス: be able to

1 Selective ER downregulators (SERDs) are able to ablate ER and thus, theoretically, to preven

2 eroxo dicopper(II) complex 2, while 3 itself is able to abstract H-atoms from weaker X-H bonds such a

3 easingly critical for biology researchers to be able to accurately and automatically annotate ISs in

4 ostatic drug effects whereas the MZOnano-QCM was able to accurately detect the drug effects.

5 otype datasets showed that the ELS algorithm was able to accurately estimate frequencies of gametes a

6 We were able to accurately classify missense BRCA1 or BRCA2

7 The smartphone spectrometer is able to achieve a resolution of 5 nm in a wavelength

8 The resulting architecture is able to achieve accurate results with relatively few

9 star (GNS)-mediated photothermal therapy, we were able to achieve complete eradication of primary tre

10 oration, and capping linker installation, we were able to achieve the highest Th wt % in mono- and bi

11 first parvovirus whose NS1 has been shown to be able to activate all three PI3KKs (ATM, ATR, and DNA-

12 ues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome.

13 receptor protein (CAP), a classic activator, is able to activate transcription independently through

14 Both Dlx3 and Osx were able to activate Dspp promoter from nucleotides (nt

15 ty to survive depends on its sensory systems being able to adapt to a wide range of environmental con

16 simulated loss of contractility (2% strain) is able to additionally induce increased CF release of i

17 Both variables were able to affect cell viability, and the release of s

18 The obtained polymers were able to amplify the intensity and the duration of t

19 dard genomic datasets and simulated data, we are able to analyze how accurate the output of the varia

20 network of microtubules in the spindle must be able to apply and sustain large forces to maintain sp

21 type enzyme and two mutagenesis variants, we are able to assign the IR signals of the individual CN(-

22 ibroblasts using whole-exome sequencing, and were able to assign a causal or likely causal germ line

23 formance as grammar + processing will always be able to attribute psycholinguistic data to processing

24 y structure and reactor performance have not been able to be directly established, the increase in se

25 xpression profiles from single stressor data were able to better predict effects on reproduction comp

26 ing units, but the aforementioned substances are able to bind only a few of them.

27 gh cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell

28 8 MAPKs, is unique amongst the MKP family in being able to bind to both ERK3 and ERK4.

29 istidine residues, we demonstrated that MsrQ is able to bind two b-type hemes through the histidine r

30 Here, we were able to biochemically analyze autophagic intermedia

31 induced cross-reactive IgG antibodies, which were able to block the binding of human serum IgE.

32 ize and the particle number distribution, we were able to calculate the ENM mass remaining in suspens

33 rned density functional on malonaldehyde and are able to capture the intramolecular proton transfer p

34 We were able to capture information on 51 variables reflect

35 Notably, 12 was able to cause concentration-dependent inhibition of

36 atoms oriented within the macrocycle cavity are able to chelate copper(I) endotopically.

37 iol- and disulfide-containing compounds, but is able to chemically react with them without addition o

38 resentative of each harvest year, the models were able to classify unknown samples correctly (100% co

39 binations yield semi-immobilized FLPs, which are able to cleave dihydrogen heterolytically at ambient

40 Mtb and related species may be able to combat this harsh acidic environment which co

41 uggesting that spontaneous neurotransmission is able to communicate independently with the postsynapt

42 aortic banding procedure; however the cells are able to compensate Ca(2+) homeostasis in an efficien

43 The hyPAD is able to concentrate a range of analytes, including sm

44 We were able to confirm expression of SMAD3 in intact and d

45 that relate to model interactions, but also be able to contextualize the evidence and provide additi

46 eutron scattering, under conditions where we are able to control the redox state of the enzyme precis

47 melanomas, demonstrating that residual Tregs were able to control CD8(+) T-cell responses against the

48 st molecules, and when bound to plasminogen, was able to convert plasminogen to plasmin in the presen

49 P(res) We show that only GPI-anchored PrP(C) was able to convert to PrP(res) and able to serially pro

50 Therapeutically, GH supplementation was able to correct growth retardation and muscle weakne

51 healthy from adenomatous parathyroid tissue was able to correctly classify all samples in the calibr

52 which performs both tasks simultaneously and is able to couple light at normal incidence and near nor

53 io > 10(6)), and the integrated F-P filters, being able to cover whole visible spectrum, successfully

54 ed to be an amphiphilic nanostructure, which is able to cross several biological membranes and accumu

55 dPGS is able to cross the BBB, bind to P/L-selectins and accu

56 Further, the algorithms are able to deal with networks containing different comb

57 based model, and termed as dMAGA-FCMD, which is able to deal with large-scale FCMs with up to 500 nod

58 carbonate is only formed when the electrode is able to decompose/oxidize MeOH to form (adsorbed) met

59 ing a supervised machine learning algorithm, are able to deliver behaviorally triggered stimuli to fl

60 Using the inkjet printing technology, we are able to deliver multiple 100pico-liter (pL) volume d

61 kHz) MAS and high magnetic field (1 GHz), we were able to describe the motions of the residues of the

62 substrate profiling and structural data, we were able to design a selective peptide inhibitor of APN

63 ime that the mitochondria-based piezosensors are able to detect ion fluxes and thus be utilized for d

64 Therefore, it is important to be able to detect CVD biomarkers early so that patients

65 r-infrared fluorescent psiRGDechi derivative is able to detect alphavbeta3 integrin in human melanoma

66 ed as a new electrochemical indicator, which is able to detect hybridization of probe (single strande

67 Importantly, ERI was able to detect many disease relevant proteins before

68 The new assay was able to detect RNA from five currently used vaccine

69 The method was able to detect several species of crab spiked into c

70 population diversity were even closer, as we were able to detect some differences between population

71 lation reaction in the crystalline state, we were able to detect the intermediate radical pairs withi

72 assays with three prenyltransferases, and we were able to detect turnover in >55% of the cases.

73 We were able to detect urinary black carbon in all children

74 In addition, these techniques are able to determine the effect of TFA on the stability

75 iting symmetries of the Fourier transform we are able to determine the phase directly from straightfo

76 Furthermore, the presented chiral assay is able to determine the enantiomeric excess (ee) of D-c

77 Transplanted cells are able to differentiate into mature photoreceptors exp

78 This technique is able to differentiate composition on the nanoscale an

79 These DNAm signatures were able to differentiate pathogenic mutations in these

80 anti-migraine calcium channel (CC) blocker - being able to diminish intracellular Angpt-2 protein in

81 Subjective experience suggests that we are able to direct our auditory attention independent of

82 ry FAs, in particular, saturated FAs (sFAs), are able to directly trigger macrophage cell death.

83 the fluorophore to the dendrimer is 1:1, we were able to directly compare uptake kinetics, the mode

84 The patient was able to discontinue immunosuppression and exogenous

85 model based on the abundance of 12 compounds was able to discriminate amongst all 21 tea cultivars.

86 The signature was able to discriminate between patients with severe sy

87 PLS-DA" and Support Vectors Machines "SVM"), was able to discriminate the wine vinegar category withi

88 AXIN1 and TRAIL were able to discriminate between TBI and HV at <1 hr.

89 , while separate IRMS and RRS investigations were able to discriminate only samples from Sicily and L

90 discuss the need to design experiments that are able to distinguish TGP from selection and TGP from

91 feedback and analysis with an algorithm that is able to distinguish and select the most reactive path

92 CR tests for vlhA3.04a, vlhA3.05, and mg0359 was able to distinguish the M. gallisepticum ts-11 vacci

93 MRI brain lesion distribution criteria were able to distinguish RRMS with a sensitivity of 90.9

94 In addition, highly purified PF were able to dose dependently stimulate cytokine TNF-alp

95 Importantly, HL2-m5 is able to effectively suppress Shh-mediated hedgehog si

96 portant physically motivated constraints, we are able to efficiently reconstruct stress fields with l

97 Nanocarrier and diagnostic ultrasound are able to enhance the drug penetration for achieving i

98 tasks) demonstrate that this PDE4D inhibitor is able to enhance memory in AD transgenic mice and conc

99 In all its diversity, this discipline is able to enrich the debate on medical issues, thanks t

100 Circadian clocks must be able to entrain to time-varying signals to keep their

101 Finally, we are able to establish for the first time that the curren

102 Using this system, we have been able to establish which decorations underpin the fo

103 My group was able to establish, contrary to common assumption (de

104 Using the DFT calculations, we have been able to estimate in the photoinduced isomer the dis

105 Our fitted model was able to explain most of the variability in GEP at ho

106 We conclude that plant breeders may be able to exploit the thermal limits of G. pallida by d

107 g4-deficient mouse model, we show that Abcg4 was able to export Abeta and desmosterol at the BBB leve

108 ty and genome completeness as long fragments are able to extend paths into problematic or repetitive

109 The N-terminus of MerA is able to extract the bound Pb(VI) but not the bound Sn

110 xperimental indicates the novel microreactor was able to extract 93% phenol and 82% Cu(2+) from exter

111 at, compared to existing methods, our method is able to find significant covariances and also to cont

112 ign of an interlocked DNA nanostructure that is able to fine-tune the oxidative catalytic activity of

113 mplex visual environment, it is essential to be able to flexibly allocate attention to parts of the v

114 Being able to focus on a complex task and inhibit unwant

115 her with molecular biology experience should be able to follow this protocol, processing up to 400 sa

116 previous study of bee spatial navigation has been able to follow animals' movement during learning; w

117 By controlling the PSC growth, we were able to, for the first time, precisely tune both th

118 Thus, SmI2(H2O)n should be able to form very weak C-H bonds.

119 t as an ideal semiconductor interface, which is able to form a homogenous layer on the electrode surf

120 showed the better antihypersensitive profile being able to fully counteract the oxaliplatin-induced n

121 cific lineages indicates that exogenous gdf3 is able to fully rescue mutants only when co-expressed w

122 Static spatial and spectrotemporal processes were able to fully explain motion-induced activation in

123 Two-dimensional (2D) separations are able to generate significantly higher peak capacitie

124 Thus, we are able to generate testable mechanistic hypotheses of

125 ing various PTC-inducing non-sense mutations is able to generate and present epitopes downstream of t

126 The algorithm is able to generate approximate oligomer solutions quick

127 Our evaluation shows that Seqping was able to generate better gene predictions compared to

128 Importantly, MAJIQ-SPEL is able to handle both classical (binary) and complex, n

129 ce (TMRMR) feature selection approach, which is able to handle multivariate temporal data without pre

130 such an expert system of mitotic progression is able to highlight the complexity of the mechanisms re

131 ntifying shared motifs in core sequences, we were able to highlight key conserved residues driving es

132 Thus, we were able to highlight the complementarity of top-down a

133 tingly, through this computational model, we are able to identify a critical stiffness that is requir

134 t we lack single-cell epigenomic assays that are able to identify and characterize them.

135 eftAlignAndTrimVariants shows that UPS-indel is able to identify 456,352 more redundant indels in dbS

136 A spectroscopic technique is presented that is able to identify rapid changes in the bending modulus

137 sample sizes, the proposed testing framework is able to identify study subjects that are genetically

138 t with haRPA, the so-called viability haRPA, is able to identify viable Legionella on DNA microarrays

139 extraction followed by HPLC-MS analysis, and was able to identify 14 fungus secondary metabolites, na

140 t at low population frequencies, the T2D-PLN was able to identify a convergent set of biological path

141 ion and subsequent functional validation, we were able to identify a MHCII-restricted CD4 T cell epit

142 In addition, we were able to identify effects on gene expression of rare

143 Additionally, we were able to identify putative molybdopterin synthase as

144 Using cytometry by time-of-flight, we were able to identify several major time-dependent pheno

145 cin, a pharmacologic inhibitor of mTORC1, we were able to identify six T-bet phosphorylation sites.

146 Using this approach we were able to identify two novel cis-regulatory regions,

147 Oral administration of resveratrol is able to improve glucose homeostasis in obese individu

148 fection model, CTLA-4 blockade in particular was able to improve control of viral replication.

149 Baseline slow walkers who were able to improve the 6MWT distance presented with si

150 presents a clinically feasible approach that is able to increase the safety and efficacy of cancer ad

151 er, Morris water maze-trained wild-type mice were able to increase astrocyte-produced glial fibrillar

152 The IO-LAHP NPs are able to induce efficient apoptotic cancer cell death

153 l and C1-epimeric monomeric nuphar analogous are able to induce rapid apoptosis.

154 sUA is released in a hypoxic environment and is able to induce IL-1beta release.

155 to control mutant MEK expression in vivo, we were able to induce tumor regression and significantly i

156 ndicate that LP avian H7 influenza A viruses are able to infect and cause disease in mammals without

157 ement of drug interventions for a virus that is able to infect a wide range of tissues and cell types

158 esults suggest that individual granule cells are able to influence relatively large groups of MCs and

159 gations could prove that l-pyroglutamic acid was able to influence non-enzymatic browning reactions.

160 These compounds are able to inhibit GSK3beta and induce the Nrf2 phase I

161 Inh2-B1 nor Ceftriaxone or Cefotaxime alone was able to inhibit the growth of bacteria or protect th

162 On the other hand, polyphenols from guarana were able to inhibit alpha-glucosidase and alpha-amylase

163 ical neuron primary culture, both Nanobodies were able to inhibit endogenous EphA4-mediated growth-co

164 tY (MUTYH in humans) adenine DNA glycosylase is able to initiate the repair of A:oxoG by selectively

165 on of multiple megaspore mother cells, which were able to initiate gametogenesis.

166 To perform this task effectively they must be able to integrate multiple stimuli and distinguish pe

167 M.AluI, M.CviPI, M.HhaI, and M.EcoGII were able to introduce (5m)C or (N6m)A into 9 g DNA as c

168 mogenous at the nanoscale, but specific ions are able to locally alter molecular organization and mob

169 ty in sub-Saharan Africa, yet few facilities are able to maintain long-term surveillance.

170 ate dehydrogenase 1(Gpd1p)-dependent shuttle are able to maintain the intraperoxisomal redox balance.

171 Nongeneticist providers may be able to manage WGS results appropriately, but WGS may

172 permeabilization and immune cell activation is able to markedly increase therapy response in silico

173 c transcript abundance in the F1 hybrids, we were able to measure the abundance of cis- and trans-reg

174 onsive host molecule has been described that is able to mechanically twist a bound molecular guest, a

175 didates in many cell signaling pathways that were able to mediate significant decreases in aggregate

176 CHO cell fibronectins were able to mediate the binding of a diverse panel of g

177 sing a single guide RNA, dCas9-SunTag-DNMT3A is able to methylate a 4.5-kb genomic region and repress

178 achines, which convert energy into movement, are able to mimic the function of these amazing natural

179 ort an additional mechanism by which GABABRs are able to modulate fast synaptic inhibition.

180 unt of dimethyl sulfoxide (DMSO), the adduct is able to move to a solvent-exposed conformation, which

181 These different isoforms are able to nucleate or frustrate the assembly of each o

182 Using F-PTS1 we are able to observe the pH conditions inside glycosomes

183 y following the loss of GFP fluorescence, we were able to observe the cells that had undergone target

184 Seqping generates species-specific HMMs that are able to offer unbiased gene predictions.

185 Thus prepared BioCapacitor based circuit was able to operate an ultra-low-power microcontroller c

186 ighly efficacious vaccine candidate; when we are able to optimize the immunization regimen (dose, int

187 em of neural systems identification, AMA may be able to overcome a fundamental limitation of standard

188 t a large cross-section of (3)CDOM* moieties are able to oxidize TMPD and that the complex mixture of

189 Using building blocks, which are able to pack with icosahedral symmetry, we examine h

190 and the cowpea chlorotic mottle virus (CCMV) are able to perform catalysis after introduction of the

191 l evidence shows that some plant virus RdRPs are able to perform replication in trans of genomic or D

192 l cycles of rest-activity and food intake or are able to persist in vitro in a cell-autonomous manner

193 However, the question of how barites were able to precipitate from a contemporary ocean that

194 The Sino-Nasal Outcome Test score might be able to predict more severe reactions and merits furt

195 contrast to the direct use of FBA, SteadyCom is able to predict the change in species abundance in re

196 Our framework is able to predict the correlations between functional o

197 variable model using routine laboratory data was able to predict advanced chronic kidney disease foll

198 A miR628-5p value above 1.336 was able to predict CAV with a sensitivity of 72% and a

199 The model was able to predict participant performance in motor lea

200 s to the measured capacitance signal, and we were able to predict the contribution of endocytosis to

201 We were able to predict the proportion of cardiomyocytes ma

202 omegalovirus pp65 or influenza hemagglutinin were able to present the antigens to autologous antigen-

203 In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations fr

204 lation of a water softener in early life may be able to prevent AD development.

205 With nearly complete success, we are able to produce a strain between any two target node

206 ed that the updated jump-walking simulations are able to produce equilibrium isotherms which are typi

207 t the activated UCNP@mSiO2-Dopa nanoplatform is able to produce a pronounced photothermal effect, tha

208 experiments demonstrate that the CFF process is able to produce SRMs with uniform size distribution,

209 Furthermore, this approach was able to produce a targeted autosome loss in aneuploi

210 3 Fab' fragments in the lungs but PEGylation was able to prolong their presence in both the healthy a

211 lia linked with allergic respiratory disease is able to promote antiviral host defenses against the i

212 ce VSMCs proliferation and migration, and it is able to promote the expression of selective VSMCs mar

213 ations of reduced glutathione (1.0 and 2.0%) were able to promote a whiter color and a low free 5-hyd

214 On this basis, we are able to provide a better understanding of the comple

215 iency virus (HIV) drug resistance tests that are able to provide timely actionable HIV resistance dat

216 By combining these strategies, we were able to provide a causal link between DEE and the f

217 Most centres were able to provide diagnostic challenges to antibiotic

218 demonstrate that the sensor is selective and is able to quantify diclofenac in tap water.

219 Furthermore, we were able to quantify a biological characteristic of mac

220 FASTmiR122 was able to quantitatively detect the differences in miR

221 Many laboratories reported being able to quickly correct the minor deficiencies ide

222 These analyses suggest that CSmetaPred_poc is able to rank putative catalytic residues at lower (be

223 pared from TBA(+) modified Aquivion ionomers were able to reach maximum power densities (Pmax) up to

224 erits, the textile sensor is demonstrated to be able to recognize finger movement, hand gestures, aco

225 E MAb which was immobilized on the test line was able to recognize both organophosphorus BChE adducts

226 position to modern atmospheric GEM levels we are able to reconstruct the first millennial-scale atmos

227 es, applied to routine duodenum biopsies, we were able to record neuronal Ca(2+) responses and mitoch

228 We conclude that trained individuals are able to redistribute the pre-existing pool of PLIN p

229 negatively impact virulence, and that aphids are able to reduce VPS52 levels during infestation, indi

230 s to examine whether molecular hydrogen (H2) is able to reduce oxidative stress after corneal damage

231 g murine macrophages showed that FPW extract is able to reduce the LPS-induced expression of pro-infl

232 LyeTxI was able to reduce multispecies 2-day metabolic activity

233 The compounds were able to reduce QS-regulated virulence factors (elas

234 with the wound healing process and may also be able to regulate the responsiveness of these cells to

235 cterized Legionella effectors that appear to be able to regulate yeast vacuolar fusion.

236 ct theory model to participants' choices, we were able to reliably estimate risk and loss aversion an

237 The resulting POP is able to remove aqueous and airborne mercury with upta

238 This HSV-1 mutant was able to replicate in noncomplementing cells, even at

239 ent, highly proliferative Lgr5(-) cells that are able to repopulate entire glands, including the base

240 omposed by renal stem/progenitor-like cells, were able to repopulate different nephron portions of re

241 tococcus cristatus arginine deiminase (ArcA) was able to repress the expression and production of sev

242 With this model, we were able to reproduce measured PNS thresholds of two le

243 HBEGF-transformed cells; however, only EGFR was able to rescue the phenotype in cells lacking both R

244 conventional transmission based THz-TDS and are able to resolve conductivity changes in response to

245 rgeting a majority of inhibitory neurons may be able to resolve this question.

246 anisms wishing to survive and reproduce must be able to respond adaptively to a complex, changing wor

247 the fire salamander (Salamandra salamandra), was able to retain learned spatial information after a p

248 data, which rely on a market counterfactual, are able to reveal effects of the ecological disturbance

249 many examples of bioinspired materials that are able to reversibly alter their stiffness, shape, por

250 ozoites of the rodent parasite P. berghei we are able to robustly quantify parasite infection of hepa

251 -d-Arap from exogenous d-Arap, both proteins were able to salvage l-fucose to GDP-fucose.

252 articularly in the ferric form, such that it is able to sample a broad conformational space.

253 All extracts were able to scavenge reactive oxygen and nitrogen speci

254 show the RSI correlates with reactivity and is able to search chemical space using the most reactive

255 king from background noise, female treefrogs are able to select among individual males advertising fo

256 genetic control suggests that breeders will be able to select semi-independently for mean phenotype

257 n to target the surface of LDs, but how they are able to selectively target this organelle remains la

258 to inhibit the right frontopolar cortex, we were able to selectively inhibit directed exploration wh

259 They were able to self-assemble into lamellar nanostructures

260 Nevertheless, NK cells were able to sense alterations of HLA-C expression demon

261 In the majority of cases, we were able to sequence the ITS region from powdered mycel

262 nthesis of a novel M187 spastin isoform that is able to sever microtubules.

263 To be able to sexually transmit for months after the cleara

264 Based on the MCD structure, we were able to shift substrate specificity of MCD toward s

265 Therefore, we were able to show that oil-in-water emulsions stabilized

266 l interruptions of preoperative posturing we were able to show, in a prospective and ethically accept

267 We were able to show, that whey protein encapsulation modul

268 fatty acids and main energy-redox processes is able to simulate the relationship between VO2 and H2O

269 Furthermore, we are able to simultaneously detect glucose and fatty acid

270 s positive effects on neuronal pathways that are able to slow down the progression of Alzheimer's dis

271 features, this electrochemical immunosensor is able to specifically recognize and detect the PspA pe

272 well as purified recombinant apo(a) variants were able to specifically inhibit HCV by interacting wit

273 rphans and children of disabled soldiers, we were able to study the adult mortality of individuals bo

274 Furthermore, LESA-MS was able to successfully differentiate between simple st

275 Moreover, recombinant galectin-10 by itself was able to suppress T cell proliferation.

276 enetically corrected HSC-derived macrophages were able to suppress T-cell activation and showed resto

277 ated in response to FVIII and ANS8 CAR Tregs were able to suppress the proliferation of FVIII-specifi

278 Moreover, while DeltacheY2 spirochetes are able to survive normally in the Ixodes ticks, mice f

279 ty has prompted suggestions that species may be able to survive future climate change in pockets of s

280 h a mechanism suggests that stony corals may be able to sustain calcification even under lower pH con

281 Importantly, this mutation was able to sustain 15% of wild-type transport activity,

282 7-expressing recombinant virus (rLBNSE-IL-7) were able to sustain VNA levels much longer than those e

283 gs support the idea that bipolar cells might be able to synapse with reintroduced photoreceptors, the

284 lizing factor tristetraprolin, which we show is able to target the IFN-beta mRNA.

285 his Nobel Lecture, J. Stoddart describes how being able to template the formation of mechanically int

286 Our findings show that human NK cells are able to terminate their functional activity without

287 's fate may depend on the degree to which it is able to track a change in the optimum timing either v

288 We were able to track the community diversity at high tempo

289 Finally, SERCA2a 971-990-sensitized T cells were able to transfer disease to naive recipients.

290 s and on a wiping paper towel in a trash can was able to transform ammonium sulfate and ammonium nitr

291 Consequently, gut dysbiosis was able to trigger the development of encephalitogenic

292 udy, we show that a typical globular protein is able to undergo significant changes in volume under n

293 it is still unclear whether this resolution is able to unveil an accurate spatial organization of th

294 r Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-assoc

295 We are able to use these linear correlations to improve rea

296 the use of biomarkers and how clinicians may be able to use them in the future to predict the course

297 s that placed a burden upon staff, but staff were able to use their contextual knowledge to help to c

298 Very few proteases are able to withstand such harsh conditions, with pepsin

299 tructures was fabricated and demonstrated to be able to work up to 200( ) degrees C.

300 f 18 months after transplantation surgery he is able to write and feed, toilet, and dress himself mor