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1 epitope, our results suggest that Ig-2D1 may be active against 06HA only in the absence of glycosylat
2 dene]carbonimidic dihydrazide hydrochloride) were active against 24 clinical MRSA and MSSA isolates.
4 famethoxazole (TMP-SMX) and fluoroquinolones were active against 94% and 88% of isolates, respectivel
5 ecies, compounds that bind to the new target are active against a broad spectrum of bacterial species
6 c acid carbamoyl methyl amides (PACMAs) that are active against a panel of human ovarian cancer cell
9 y active neutralizing antibodies (NAbs) that are active against a wide variety of circulating strains
12 te broadly neutralizing antibody (bnAb) that is active against a broad range of HIV-1 primary isolate
13 can generate a potent triamino scaffold that is active against a panel of hard-to-kill epithelial can
14 actericidal lipoglycopeptide antibiotic that is active against a range of clinically relevant gram-po
24 acetylated substrates in vitro, only CjCE2C was active against acetylated mannan in Physcomitrella.
29 tool for risk assessment showed coumarin to be active against Aliivibrio fischeri bacteria down to 1
30 embers of the miR-34 family of miRNAs, which are active against all three viruses as well as the clos
32 st activity against xanthine than uracil and is active against all xanthine-containing DNA (C/X, T/X,
37 producers, and (iii). in vitro, carbapenems are active against AmpC-producing strains of K. pneumoni
39 terminal, glycine-rich attacin-analog region was active against any of the bacterial strains studied,
40 aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant ca
43 pecific chimeric antigen receptor (CD19.CAR) are active against B-cell malignancies, but it is unknow
45 , anhydrodinemasone BC, and nor-dinemasone B are active against bacteria, including Legionella pneumo
46 idinone antibiotics, linezolid, was found to be active against bacteria and against the halophilic ar
48 -blocking activity in rodent malaria models, are active against blood-stage field isolates of the maj
49 reased efficacy compared with bortezomib and was active against bortezomib-resistant MM cell lines an
50 ide chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -res
51 (F98Y) S. aureus DHFR and found that several are active against both enzymes and specifically that th
52 s with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative
56 tdins, the mouse intestinal defensins, rHD-5 is active against both mouse-virulent wild-type Salmonel
57 l candidate 35b (vaniprevir, MK-7009), which is active against both the genotype 1 and genotype 2 NS3
61 te specificity studies suggested that AGPAT6 was active against both saturated and unsaturated long-c
62 virus type 1 revealed that the heterocycle 3 was active against both viruses but also was cytotoxic.
64 lysis showed that the recombinant leukotoxin was active against bovine polymorphonuclear leukocytes a
65 roduced for treatment of metastatic melanoma are active against brain metastases and offer new opport
66 e-Poulenc Rorer, Antony, France) appeared to be active against breast cancer in phase I trials, we pe
68 he antiproliferative activity, all compounds were active against Caco-2 cell line, being the ones wit
69 conventional peptidic inhibitors of hTS that are active against cancer cells and do not result in the
73 e VLY and ILY, which are human specific, INY is active against cells from a broad range of species.
74 veral human cancer cell lines, cyclostreptin was active against cells resistant to paclitaxel and epo
78 le of eliciting neutralizing antibodies that are active against clinically relevant HIV-1 strains.
81 discovered, and the most promising compounds were active against COX-1 in intact ovarian carcinoma ce
82 ilability of powerful antifungal agents that are active against Cryptococcus neoformans, these drugs
83 enic acid and ergosterol endoperoxide, which were active against Cryptococcus neoformans and methicil
84 Thus, cotreatment with LBH589 and AMN107 is active against cultured or primary IM-resistant CML c
89 the parasite's replicative blood stages and is active against developing gametocytes, the forms resp
91 z-423 is a novel immunomodulatory agent that is active against disease even in the context of defecti
92 ly-induced antiviral gene expression program is active against disparate human arthropod-borne viruse
93 antibiotic produced by Bacillus cereus that is active against diverse bacteria and lower eukaryotes.
94 velopment of new antituberculosis drugs that are active against dormant or persister populations of M
95 ng the first 28 days of therapy and rifampin was active against dormant bacilli after the establishme
99 xhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb.
102 ous indirect photoinactivation mechanism may be active against Ent. faecalis, it is not for the sewag
104 Antibacterial assays confirmed that gallin was active against Escherichia coli, but no additional a
106 sults also demonstrate that these mechanisms are active against established tumor as well as developi
110 ovel TKI, demonstrates type I properties and is active against FLT3 containing ITD and/or D835- or F6
112 C(27) 3beta-HSD cDNA encodes an enzyme that is active against four 7alpha-hydroxylated sterols, indi
115 a series of N-lipidated peptide dimers that are active against Gram-negative bacteria, including car
116 t(M)) tetracycline-resistance mechanisms and are active against Gram-positive and Gram-negative organ
123 in, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long pl
125 ial activities showed that the date extracts were active against Gram (+) and Gram (-) bacteria, show
128 cin, linezolid, tigecycline, and minocycline were active against >90% of VISA isolates, while >90% of
130 Furthermore, several antiretroviral agents are active against HBV infection, including lamivudine,
132 log (TCRB), the 5,6-dibromo ribonucleoside 3 was active against HCMV (IC50 approximately 4 microM) bu
133 ast, the 2-aza analogue of sangivamycin (30) was active against HCMV and HSV-1 but this apparent acti
134 ogues with hydrogen-bond-accepting character were active against HCMV (e.g., 3-formyl-2,5,6-trichloro
135 -dichloro series (20a,b, 7a,b, respectively) were active against HCMV (IC50's = 1-10 microM) and nonc
136 he 2-chloro but not the 2-amino heterocycles were active against HCMV (IC50's = 5-8 microM) but not H
138 Preoperative trastuzumab and paclitaxel is active against HER2 overexpressing early-stage breast
140 CN) and triciribine-5'-monophosphate (TCN-P) are active against HIV-1 at submicromolar concentrations
146 that the cationic polypeptide fraction of SP is active against HIV-1, and that semenogelin-derived pe
152 ty testing then resulted in three leads that were active against HsFPPS with IC50 values in the range
155 family of antiviral cytidine deaminases that are active against human immunodeficiency virus, simian
156 esence of the active-site residue Ser-529 to be active against human PGHS-1; the S529A mutant is resi
158 's cytotoxicity screen, compounds 11a and 12 were active against human cancer cell lines derived from
159 e heterocycles, but not the difluoro analog, were active against human cytomegalovirus (HCMV) (IC50's
163 e-daily adefovir therapy reduces HIV RNA and is active against isolates resistant to lamivudine or la
170 sensitive cells, compounds 1-6 were found to be active against leukemia K562 cells with IC50 in the n
171 tomegalovirus and along with the Z-isomer 5a was active against leukemia L1210 and solid tumors in vi
172 Notably, the dasatinib/PD184352 regimen was active against leukemic cells exhibiting various for
173 ty, we identified purine-type compounds that were active against lung small cell lung cancer (NSCLC).
175 inhibitor of LepB (MD3; a beta-aminoketone) was active against M. tuberculosis, exhibiting growth in
177 some strain-specific anti-HIV cytokines, CAF is active against many different virus isolates, includi
178 re potent against BCR-ABL than imatinib, and is active against many imatinib-resistant BCR-ABL mutant
181 beta-ketoiminato complexes has been shown to be active against MCF-7 (human breast carcinoma), HT-29
182 ne repertoire of T cells and antibodies that are active against melanoma, with recent glimpses of the
184 tance with marketed antibacterial agents and is active against methicillin-resistant staphylococcus a
185 hat spirohexenolide A, a spirotetronate that is active against methicillin-resistant Staphylococcus a
188 to inhibit IspC in a number of organisms and is active against most gram-negative bacteria but not gr
190 ophenyl)methylene]carbonimidic dihydrazide), was active against MRSA and VRE with MIC's of 8.1 and 4.
191 losis, are nontoxic to human cell lines, and are active against multidrug-resistant M. tuberculosis s
193 strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and
194 e/tazobactam, a novel antimicrobial therapy, is active against multidrug-resistant Pseudomonas aerugi
195 ries of c-Met small molecule inhibitors that are active against multiple mutants previously identifie
196 onstrate that four of these crystal proteins are active against multiple nematode species and that ea
198 ce from disseminated candidiasis and that it is active against multiple virulent strains of C. albica
200 ntify and design inhibitors that will likely be active against mutants found in different cancers.
201 it primary FLT3-mutant AML blast growth, and is active against mutations that confer resistance to cl
203 (e.g., thalidomide and lenalidomide), which are active against myeloma, also block the activity of b
204 h are structurally distinct from crizotinib, are active against NB cells expressing ALK(F1174L).
206 after cyclophosphamide is a combination that is active against newly diagnosed RMS, with an acceptabl
207 bitory concentrations (MIC) against R-TB and were active against NRP-TB in the low micromolar range,
208 ot an acid sphingomyelinase but unexpectedly is active against nucleotide diphosphate and triphosphat
211 ic cyanobacterium Hassallia sp. and found to be active against opportunistic human pathogenic fungi.
214 everal previously identified RGS4 inhibitors were active against other RGS members, such as RGS14, wi
215 ive against C. neoformans, and the triazoles were active against other yeasts (MIC90, 2 mug/ml).
216 Levofloxacin, gentamicin, and tetracycline were active against oxacillin-susceptible staphylococci
217 ary results indicated that compounds 3 and 6 are active against P. berghei, prolonged the life span o
218 r, our findings indicate that 4 human sPLA2s are active against P. falciparum in vitro and pave the w
220 teryl linoleate and cholesteryl arachidonate were active against P. aeruginosa at physiological conce
221 zylamine 12a and alpha-methylbenzylamine 12g were active against P. falciparum with IC50 values in th
225 epper line over-expressing functional CaCel1 was active against pepper matrix glycans in vitro, and s
229 enzene-1,3-diamine) (dihydrochloride), which is active against Plasmodium berghei in vivo (oral ID(50
231 ibitors (PIs) recently have been reported to be active against Pneumocystis carinii in cell culture.
232 ithromycin in combination with sulphonamides is active against Pneumocystis carinii pneumonia (PCP) i
234 Finally, we demonstrated that the prodrugs are active against primary chronic lymphocytic leukemia
235 ere we show that the PI3K inhibitor GDC-0941 is active against primary T-ALLs from wild-type and Kras
237 Many inhibitors have been identified that are active against purified viral-encoded integrase prot
242 e-3-carboxamide derivatives, which proved to be active against replicating Mycobacterium tuberculosis
245 py, and the development of novel agents that are active against resistant forms of target proteins cr
246 es with modified side chains, such as AQ-13, are active against resistant parasites, we compared AQ-1
249 novel propargyl-linked DHFR inhibitors that are active against several trimethoprim-resistant enzyme
252 72) inhibits 1,3-beta-d-glucan synthesis and is active against several medically important fungi but
257 atives showed rapid bactericidal killing and were active against several multidrug-resistant (MDR) Gr
261 oreover, both phenanthrene-based derivatives were active against stage IV/V gametocytes of P. falcipa
265 orary naturally infected cattle in Botswana) were active against strain M375 in an in vitro growth in
268 receptors on the surface of mammalian cells, is active against T. gondii tachyzoites (50% effective c
269 otency of PC-1505 was sustained, and PC-1505 was active against T-20-resistant ("DIV") virus with a G
272 ine/adenosine analogues to remain intact and be active against the parasite, they need to either be r
274 Since the prompt institution of therapy that is active against the causative pathogen is one of the m
275 eftaroline is a new antibacterial agent that is active against the major bacterial pathogens found in
277 e specific helicase inhibitors (compound 17) was active against the replicon and inhibited the helica
280 Tetrahydro-beta-carboline-3-carboxylic acids were active against the hydroxylation of 2'-deoxyguanosi
283 nstructural protein 5A (NS5A) inhibitor that is active against these genotypes, improves efficacy and
288 acid, in addition to inhibiting osteoclasts, is active against tumor cells and suggest that zoledroni
291 was observed for compounds 2 and 5-9, but 4 was active against two herpes viruses and cytotoxic in t
292 , and when expressed in Escherichia coli, it is active against tyrosine and to a lesser extent agains
293 d glycopeptides with hydrophobic side chains are active against vancomycin-resistant enterococci and
294 ne derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S
297 Cytosine and thymine Z-isomers 11c and 11d were active against varicella zoster virus (VZV) with EC
300 nt screens, the most potent compound 9 (1C8) was active against wild-type HIV-1IIIB (subtype B, X4-tr
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