ライフサイエンスコーパス: be administered orally

1 erest in developing small molecules that can be administered orally.

2 t hydrolysed by endogenous proteases and may be administered orally.

3 velop live, attenuated HAV vaccines that can be administered orally.

4 reatment with succimer, a lead chelator that is administered orally.

5 , large volumes of enteric contrast material are administered orally.

6 mg/kg), a glycogen phosphorylase inhibitor, was administered orally.

7 Drugs were administered orally.

8 potecan CNS penetration, 200 mg/kg gefitinib was administered orally 1 hour before 4 mg/kg topotecan

9 rvival occurred when 2 x 10(6) corneal cells were administered orally 10 days before orthotopic corne

10 Two days later, 400 mg of ketoconazole was administered orally 2 hr before to the morning dose.

11 Biotin was administered orally (2.1, 8.2, or 81.9 micromol) or

12 pression of the NGF receptor-IR elements, C3 was administered orally (25 mg/kg, once a day), by gavag

13 or myelodysplastic syndromes (MDS), MGCD0103 was administered orally 3 times weekly without interrupt

14 TMZ was administered orally 30 minutes after completion of e

15 eased in diabetic subjects only when glucose was administered orally (37.8 +/- 14.9 vs 68.3 +/- 22.8

16 Treatment was administered orally 5 d/wk for 3 months.

17 PN401 was administered orally 8 hours after 5-FU administratio

18 Acyclovir or a matched placebo was administered orally, 800 mg five times daily, for 21

19 Treatments were administered orally, 801 mg or 399 mg three times a

20 A-988315 (20 or 60 mg/kg) or water was administered orally 90 min before retention testing,

21 lective high-affinity FXR inhibitor that can be administered orally and prevents, or reverses, high-f

22 principal adverse event observed when 2-CdA was administered orally and IV.

23 Contrast media were administered orally and by means of an enema.

24 Zinc stable isotopes were administered orally and intravenously.

25 d murine lymphoid tumors (even when the drug was administered orally) and against human breast and bl

26 (13)C-glycerol tripalmitin was administered orally as an independent measure of CM

27 VP-16 was administered orally as repeated 21-day courses at 50

28 Immunosuppressants were administered orally as single daily doses.

29 RAD was administered orally at 0.5 mg/kg per day for days 0

30 Everolimus was administered orally at 10 mg daily and letrozole was

31 nistered orally at 10 mg daily and letrozole was administered orally at 2.5 mg daily.

32 Lenalidomide was administered orally at 25 mg on days 1 through 21 of

33 Marimastat was administered orally at 25, 50, or 100 mg twice daily

34 Sorafenib was administered orally at 400 mg twice daily on a conti

35 Alisertib was administered orally at 50 mg twice daily for 7 days

36 Prednisone or a matched placebo was administered orally at 60 mg/d for the first 7 days,

37 Everolimus was administered orally at a daily dose of 2.1, 3, 5, or

38 In nonclinical studies, fidaxomicin was administered orally at approximately 1 g/kg/d to dog

39 ither human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 1

40 Drug was administered orally at escalating doses as a solutio

41 Quizartinib was administered orally at escalating doses of 12 to 450

42 PT2385 was administered orally at twice-per-day doses of 100 to

43 3C, methyl-2H3]methionine and [2H2]cysteine) were administered orally at 30-min intervals for 8 h.

44 rated virulence attenuation when the strains were administered orally but not when they were administ

45 In groups PROB and LIP/PROB, the PROB was administered orally by addition to the drinking wate

46 y, the intravenous formulation of irinotecan was administered orally daily for 5 days for 2 consecuti

47 Temozolomide was administered orally daily for 5 days, with subsequen

48 Vorinostat was administered orally daily starting at 180 mg/m(2)/d

49 Erlotinib was administered orally daily to groups of at least thre

50 mg/kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hyp

51 Thereafter, 80 mg/kg hydroxyurea was administered orally every 3 days.

52 methionine aminopeptidase type 2 inhibitor, was administered orally every other day at 1, 5, or 10 m

53 Pravastatin and nicotinamide were administered orally every day for 14 days, starting

54 Citicoline (500 mg/day) was administered orally for 6 weeks, and patients were f

55 PSC 833 was administered orally for 7 days, beginning 72 hours b

56 AQX-1125 (450 mg daily) or placebo was administered orally for 7 days.

57 In the present phase 1 study, capravirine was administered orally for up to 28 days to 55 HIV-1-in

58 ndothelial cells from relevant donor strains were administered orally from day -14 to day -4 on a dai

59 hat any potential neuroprotective agent must be administered orally, have a safe profile and poses a

60 In addition, we propose that the vaccine be administered orally in a 2-dose schedule, with the fi

61 Alisertib was administered orally in 21-day cycles at the recommen

62 C3 was administered orally in 5, 10, and 25 mg/kg/day conce

63 th conventional antimicrobial therapy, which was administered orally in 96 percent.

64 fashion via subcutaneous implant, whereas P was administered orally in a cyclic fashion.

65 ronic disease, a range of doses (0.4-100 mg) was administered orally in a single dose before challeng

66 MA 800 mg/d was administered orally in divided doses.

67 WAY-202196 or control (vehicle) was administered orally in doses ranging from 1.5 to 50

68 SM16 was administered orally in formulated chow.

69 Dasatinib (15 to 240 mg per day) was administered orally in four-week treatment cycles, o

70 ated escalations in the dose of PLX3397 that was administered orally in patients with solid tumors (d

71 Nicotine was administered orally in the drinking water to achieve

72 Both treatments were administered orally in 10 ml (increasing to 20 ml,

73 When suboptimal doses were administered orally in combination to wild-type mic

74 Arimoclomol was administered orally, in drinking water, from symptom

75 Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a pote

76 ve a favorable risk-to-benefit ratio when it is administered orally long-term to patients with the pr

77 dehydrogenase, allows fluorouracil (5-FU) to be administered orally on a schedule that simulates cont

78 Dexamethasone 40 mg daily was administered orally on days 1, 8, 15, and 22 of each

79 Therapy was administered orally on the first 5 days of a 28-day

80 Melphalan and prednisone were administered orally on days 1 to 4; carfilzomib was

81 Temodar was administered orally once a day for five consecutive

82 COL-3 was administered orally once daily at one of two doses (

83 Darapladib 160 mg or placebo monotherapy was administered orally once daily for 3 months, and pat

84 Sunitinib (25, 37.5, or 50 mg) was administered orally once daily on three dosing sched

85 Erlotinib was administered orally once daily to cohorts of three t

86 COL-3 was administered orally once daily, and doses were escal

87 Pazopanib 800 mg was administered orally once daily.

88 LCL161 was administered orally, once weekly, on a 21-day cycle

89 uires weeks of antibiotic therapy, which can be administered orally or intravenously via a peripheral

90 solution of diatrizoate meglumine and sodium was administered orally or by means of a nasogastric tub

91 shown that this novel formulation of AmB can be administered orally, resulting in 99% inhibition of p

92 ificant number (N = 34) of these macrocycles are administered orally, revealing that oral bioavailabi

93 Dipyridamole 75 mg was administered orally three times daily during the FU

94 dose-escalation phase (n = 47), panobinostat was administered orally thrice weekly every week in comb

95 STI571 was administered orally to 83 patients with CML in the c

96 9-cis-Retinal was administered orally to a subset of Rpe65(-/-) mice,

97 Gefitinib (150, 300, 400, or 500 mg/m2) was administered orally to cohorts of three to six patie

98 mg/kg), a glycogen phosphorylase inhibitor, was administered orally to decrease glucose output in ea

99 eptide synthesized from D-amino acids (D-4F) was administered orally to LDL receptor-null mice on a W

100 Then, to assess its efficacy in vivo, BTKB66 was administered orally to mice for 7 days before subjec

101 ARRY-063 was administered orally to ovalbumin (OVA) sensitized an

102 Lorlatinib was administered orally to patients at doses ranging fro

103 lective P2X3 and P2X2/3 receptor antagonist, was administered orally to rats and found to produce hig

104 lead that also contained two chlorine atoms was administered orally to rats, and samples of bile, ur

105 lbladder filling, 30 mL of corn oil emulsion were administered orally to all patients followed by dyn

106 Vector strains were administered orally to germfree mice that were subs

107 ailability was established whereby compounds were administered orally to mice and plasma levels were

108 The compounds were administered orally to mice with acute T. cruzi inf

109 Antigens were administered orally to mice, and antigen-specific g

110 asing doses of egg white or ovomucoid as OIT were administered orally to sensitized mice.

111 Elacridar and cold erlotinib were administered orally to wild-type (WT) and Abcb1a/b;

112 d once a day on days 1 to 28 and abexinostat was administered orally twice a day on days 1 to 5, 8 to

113 Patients and Methods MK-8242 was administered orally twice a day on days 1 to 7 in 21

114 Lonafarnib was administered orally twice daily at dose levels of 70

115 Lapatinib was administered orally twice daily at escalating doses

116 Capecitabine (825, 1,000, or 1,250 mg/m(2)) was administered orally twice daily on days 1 to 14 ever

117 s phase 2 open-label study, 400 mg nilotinib was administered orally twice daily to 280 patients with

118 ML120B was administered orally twice daily, either prophylactic

119 AZD1775 was administered orally twice per day over 2.5 days per

120 ct (active) and appropriate placebo solution were administered orally twice daily for 12 months, and

121 (acetylcysteine 1200 mg or matching placebo) were administered orally twice daily for 2 doses before

122 Ibrutinib at a daily dose of 420 mg was administered orally until disease progression or the

123 Allogeneic dendritic cells (DC) were administered orally using a protocol that is known

124 A taste-masked preparation of SNAC 2.25 g was administered orally with heparin 30000 to 150000 IU.

125 70Zn and dysprosium were administered orally with all meals for 5 consecutiv

126 Axitinib or placebo were administered orally with food at a starting dose of

127 Temozolomide was administered orally within 60 minutes of the end of