ライフサイエンスコーパス: be advanced

1 ance and implications of these insights will be advanced.

2 nished collateral normal tissue toxicity can be advanced.

3 tential explanations for their existence can be advanced.

4 perglycemia, and atherosclerosis appeared to be advanced.

5 and protein functioning in the ToMO system, is advanced.

6 to rationalize the formation of all products is advanced.

7 of exceptionally small quantities of current is advanced.

8 An explanation of this effect is advanced.

9 to rationalize the sense of stereoselection is advanced.

10 maintenance of papillae after morphogenesis is advanced.

11 for which outcomes are poor when the disease is advanced.

12 e basis of its superior profile, compound 12 was advanced.

13 both hyaluronidases and exoglycosidases has been advanced.

14 ernative proposals for this interaction have been advanced.

15 Consistent mechanisms for these results have been advanced.

16 with high-risk myeloma whose outcome has not been advanced.

17 s; 37 adenomas were >/=6 mm, and 20 adenomas were advanced.

18 g colonoscopy; none of these missed adenomas were advanced.

19 We find that TS is advanced (50-90% of overall surface burial) and that

20 At target sites, the needle was advanced 7 to 9 mm into the myocardium, permitting p

21 In this review, two main hypotheses are advanced: (a) Maltreatment in childhood is associate

22 enomas in 15 patients; of those, three (15%) were advanced adenomas.

23 The primary outcome measure was advanced adenomatous polyps (AAPs).

24 The main risk factors are advanced age, hypertension, diabetes, smoking, hyper

25 tor for developing carcinoma of the prostate is advanced age.

26 factors associated with atrial fibrillation were advanced age (odds ratio [OR] for 10-year increase,

27 refusal in patients considered "too ill/old" were advanced age and low functional status.

28 ndent predictors of DNR status at enrollment were advanced age, chronic obstructive pulmonary disease

29 Independent predictors of major bleeding were advanced age, female gender, diabetes, hypertension

30 CU refusal in patients considered "too well" were advanced age, male sex, university hospital admissi

31 Which diagnoses are advanced and by how much depends on the preclinical

32 rowth it is recommended that, even when they are advanced and incurable, unlike in patients with comm

33 During warmer spring and autumn, GSstart is advanced and GSend delayed, respectively.

34 stituting dead myocardium by stem-like cells is advanced and proposed as a major area of future resea

35 A ligand field rationalization is advanced and supported by DFT calculations.

36 The feeding tube was advanced and a final chest roentgenogram verified it

37 Enteral nutrition (EN) was advanced and PN weaned as indicated.

38 A theoretical explanation of this pattern is advanced, and its practical implications are discusse

39 tigations and if successful will potentially be advanced as anti-cancer modalities.

40 the phosphoepitope encompassing Ser2808 has been advanced as a central mechanism in the pathogenesis

41 In a pediatric context, activin A has been advanced as a potential marker for the severity of

42 nosylmethionine decarboxylase (ADOMETDC) has been advanced as a potential target for antiparasitic ch

43 images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR

44 As such, the intestinal microbiota has been advanced as an important contributor in the develop

45 ass is among the foremost herbaceous species being advanced as a source of biomass for biofuel end us

46 y, health workforce shortages like these are being advanced as cause for repealing or "defunding" the

47 erein, the concept of the perinuclear region is advanced as a formal, identifiable structure.

48 ecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largel

49 le preclinical species, compound 5 (AMG 579) was advanced as our PDE10A clinical candidate.

50 le cross-species pharmacokinetic profile and was advanced as the clinical candidate.

51 The majority of esophageal cancers are advanced at presentation, rendering cure unlikely, e

52 est that it is more likely than adult CRC to be advanced at presentation and to have a poor outcome.

53 Prominent theoretical proposals have been advanced attempting to find common mechanisms acros

54 o the authors, essentially the same idea has been advanced before and studied extensively from a diff

55 RC), and darkfield surface reflection (DFSR) are advanced but expensive light microscopy techniques w

56 Artificial photosystems are advanced by the development of conformal catalytic m

57 We believe that Smaldino's discussion would be advanced by a more thorough analysis of the appropria

58 s in understanding cortical oscillations can be advanced by also considering the olfactory system--wh

59 ns associated with cystic fibrosis (CF) will be advanced by an improved understanding of P. aeruginos

60 gest ways in which auditory neuroscience may be advanced by connecting early sound representation to

61 anding of pathologic perinatal processes may be advanced by considering, in varying ways, the populat

62 ate medical education in critical care would be advanced by consolidation and organization into forma

63 g of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns

64 ment of therapeutic strategies, continues to be advanced by imaging the penumbra in novel ways.

65 ecies distributions across broad scales, can be advanced by incorporating diverse biotic factors.

66 ial activation close to the His bundle could be advanced by late extrastimuli delivered at the anteri

67 novel cytosine methylation inhibitors would be advanced by our structural and thermodynamic characte

68 to protecting privacy as an ethical norm can be advanced by psychiatrists' requesting patients' conse

69 tional studies of these nerve subtypes would be advanced by selective, effective and long-term transd

70 harmacological treatment of strabismus could be advanced by simultaneous injection of agonist-antagon

71 These goals can be advanced by testing hypotheses that emerge from cross

72 tively new field, entitled epigenomics, will be advanced by the recently completed sequence of the Te

73 pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenomics, and bioinfo

74 obabilistic stimulus-reward associations has been advanced by a convergence between reinforcement lea

75 ssection of signal transduction pathways has been advanced by classic genetic approaches including ta

76 f this complex and heterogeneous disease has been advanced by experimental data obtained from animal

77 athways under different metabolic states has been advanced by live cell imaging and organelle specifi

78 he study of genome architecture has recently been advanced by new techniques combining nuclear proxim

79 doped Hubbard Hamiltonian, and has recently been advanced by quantum gas microscopy.

80 associated with monoclonal gammopathies has been advanced by recent clinical studies.

81 ions, in particular plasmid replication, has been advanced by recent studies.

82 Understanding of cell fate has been advanced by studying single-cell RNA-sequencing (RN

83 athophysiology of immunobullous diseases has been advanced by the demonstration that passive transfer

84 of the evolution of microbial pathogens has been advanced by the discovery of "islands" of DNA that

85 microbiota and host physiology in humans has been advanced by the human gut reference catalogue(3,4).

86 In the past two years, the field has been advanced by the regulatory approval of agents with

87 ciceptive processing in the infant brain has been advanced by the use of electrophysiological and hem

88 rescent protein (GFP), and biotechnology has been advanced by the use of FPs.

89 understanding of plant circadian rhythms has been advanced by two papers investigating the roles of t

90 The study of plant biological pathways is advanced by easy access to integrated data sources.

91 RDF is advanced by the World Wide Web Consortium (W3C) to en

92 romocenters, replication of chromocenter DNA was advanced by 10-15% of the length of S phase.

93 ve immunity against recurrent S. aureus SSTI was advanced by antibody and the Th17/IL-17A pathway and

94 treated control brain slices from Y1-/- mice was advanced by approximately 1 h as compared to the Y1+

95 The daily onset of LHY gene expression was advanced by approximately 4 h in det1-1 mutant plant

96 e insights into how the genome editing field was advanced by early access to biological resources and

97 lecular interactions between AKR1B1 and PGA1 was advanced by molecular modeling.

98 herapeutics for chronic lymphocytic leukemia was advanced by the description of a new mouse model of

99 the driver of the synchrony, as gamma phases were advanced by 20 ms in IFJ compared to FFA or PPA.

100 d after the first year of follow-up) and 520 were advanced cases (stage III or IV or a Gleason score

101 ounced and prolonged when the light schedule is advanced compared with light schedule delays.

102 table definitions of nonbeneficial treatment were "advanced curative/life-prolonging treatments that

103 The greatest risk factor for late relapse was advanced disease at transplantation.

104 A pressure transducer was advanced down the airways during chest compressions

105 ing targeted drug delivery system, which can be advanced for the treatment of atherosclerosis and oth

106 eloped to deliver HIV genes, only a few have been advanced for clinical trials.

107 Although several designs have been advanced for coupling sample enrichment devices to

108 urized microfluidic biosensors have recently been advanced for portable point-of-care diagnostics by

109 Two hypotheses have been advanced for the mechanism of homophilic binding.

110 ence was first reported, various models have been advanced for the structure of apolipoprotein A-I, t

111 The explanations that have been advanced for these effects are that there is either

112 Mechanisms have been advanced for these mitomycins that differ from 1.

113 everal digital data sources and systems have been advanced for use in augmenting traditional influenz

114 A robust strategy is advanced for the discovery of interacting proteins as

115 (LY317615.HCl), suppresses angiogenesis and was advanced for clinical development based upon this an

116 duced lung inflammation in a mouse model and was advanced for further development for the treatment o

117 Four compounds were advanced for further evaluation in a preclinical mo

118 rable pharmacologic properties, eight agents were advanced for secondary screening.

119 actors significantly correlated with relapse were advanced French-American-British classification (P

120 Three arguments are advanced from human and nonhuman primate infancy res

121 Since much of this knowledge has been advanced from murine studies, we focus our review o

122 understanding of motor cortex plasticity has been advanced greatly using rodents as experimental anim

123 maintained even as the onset of the first AP was advanced >5 ms by increasing stimulus intensity and

124 tly associated with recurrence and mortality were advanced heart failure, VT cycle length, and a left

125 tocytosis (ASM) and mast cell leukemia (MCL) are advanced hematopoietic neoplasms with poor prognosis

126 Two main conjectures are advanced: (i) the appearance of grain boundary like

127 ists of the glucagon-like-peptide-1 receptor are advanced in development, and they improve prandial i

128 the highest degree of protection and should be advanced in clinical development.

129 ese data suggest that this rhIL-7 dose could be advanced in future rhIL-7 clinical studies.

130 s other than hydrogen bonding AuH-X can also be advanced in most cases.

131 Such inhibitors should be advanced in SHH-MB studies; however, molecular and ge

132 of psychosocial epidemiology and how it can be advanced in the future.

133 Therapy for WT has been advanced in part by an increasingly complex risk-st

134 imensional infrared spectroscopy (2D IR) has been advanced in recent years toward measuring signals f

135 arge number of experiments and theories have been advanced in the attempt to characterize the transfe

136 the basis of these findings, a new mechanism is advanced in which the protonated amine not only acts

137 d flowering phenology of the plant community is advanced in years with warmer temperatures (higher cu

138 ed by CYC-B(S) expression and, reciprocally, was advanced in a CycB mutant.

139 With IGF-1 administration, puberty was advanced in control females, but not in females with

140 ncy analysis demonstrated that this activity was advanced in phase relative to post-block responses o

141 In boys, midadolescent height growth was advanced in the calcium group, which resulted in gre

142 cap, which suggests that plaque progression was advanced in these mice.

143 In addition, melatonin timing measures were advanced in pregnant women with a personal or famil

144 ponses were achieved when stronger responses were advanced in time relative to weaker responses.

145 Although many theories have been advanced, in the current issue of the JCI, Gonzalez

146 cerns to be overcome as tankyrase inhibitors are advanced into the clinic.

147 ment of novel combination therapies that can be advanced into the clinic, we have evaluated the combi

148 atoscopy whereby a 2.1-mm diameter scope can be advanced into the pancreatic duct through a duodenosc

149 nd explored how the most promising areas may be advanced into translational research.

150 Special emphasis is given to those that have been advanced into clinical trials.

151 fully obtained and seven such compounds have been advanced into early phase clinical trials for the t

152 etic and preclinical safety profiles, 10 has been advanced into phase I clinical trials.

153 interaction, SAR405838 (MI-77301), that has been advanced into phase I clinical trials.

154 Compound (S)-33a was advanced into a pharmacodynamic model in cynomolgus

155 Compound R,R-19a was advanced into a phase 1 clinical trial and produced

156 led the identification of compound 20, which was advanced into a target engagement pharmacodynamic mo

157 harmacology of VX-809, a CFTR corrector that was advanced into clinical development for the treatment

158 generate an excellent therapeutic window, 1b was advanced into clinical development.

159 The compound was advanced into clinical development.

160 ent pan-JAK inhibitor 2 (PF-06263276), which was advanced into clinical studies.

161 ability and safety profile, 14f (BMS-986142) was advanced into clinical studies.

162 ), a potent inverse-agonist of 5-HT(2A) that was advanced into clinical trials for the treatment of i

163 ology and other favorable characteristics, 4 was advanced into human clinical studies.

164 basis of its noteworthy preclinical data, 8 was advanced into human clinical trials and successfully

165 A 0.030-inch-diameter IVMRI detector coil was advanced into isolated human aortoiliac arteries and

166 Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.

167 s a result of its promising activity, R,S-7c was advanced into phase I clinical studies.

168 itumor activity in numerous tumor models and was advanced into phase I clinical trials as the water-s

169 sis of its preclinical profile, compound 10g was advanced into preclinical safety studies.

170 This compound was advanced into rat pharmacokinetic and pharmacodynami

171 transesophageal echocardiography transducer was advanced into the esophagus.

172 hrough a standard 17-gauge introducer needle was advanced into the liver, and real-time measurements

173 At selected sites, the needle was advanced into the myocardium.

174 A latex balloon was advanced into the right atrium.

175 nhibition, and CYP3A4 TDI, several compounds were advanced into in vivo target engagement and efficac

176 Several compounds were advanced into pharmacodynamic studies and demonstra

177 The arterial guide wire and catheter were advanced into the heart with x-ray fluoroscopic gui

178 Indications for prenatal diagnosis were advanced maternal age (46.6%), abnormal result on D

179 omaly and in 1.7% of those whose indications were advanced maternal age or positive screening results

180 parahisian ventricular electrogram (SVE) has been advanced, may help in this diagnosis.

181 date of the solitary bee Andrena nigroaenea is advanced more by higher temperatures than is flowerin

182 polyps detected at CT colonography proved to be advanced neoplasia and did not differ significantly a

183 possible explanations for this mismatch have been advanced, none has addressed the laboratory chamber

184 A new mechanistic proposal for O2 reduction is advanced on the basis of thermodynamic considerations

185 rged heart was gently tented, and the needle was advanced on delivery of radiofrequency.

186 scillator can recover although its phase may be advanced or delayed relative to the original cycle.

187 Likewise, the timing of expression could be advanced or delayed.

188 uiescence even when the timing of quiescence is advanced or delayed by changing temporal identity fac

189 pressure-monitoring microcatheter, which can be advanced over a traditional coronary guidewire, facil

190 rmined that a T7 elongation complex (EC) may be advanced past a halted T3 EC, and that after the coll

191 ter with a 27-gauge needle at its distal tip was advanced percutaneously to the endocardial surface o

192 8F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myoc

193 There are advanced plans to implement these and other quantum

194 s into early anaphase A, furrowing could not be advanced prior to the metaphase-anaphase transition.

195 A model was advanced proposing that the tolerance phenotype resu

196 ostate cancer were ascertained, 448 of which were advanced prostate cancer.

197 Each of these topics has been advanced recently, strengthening models for how com

198 A number of conflicting claims have been advanced regarding the role of the left inferior fr

199 ML29 as a Lassa virus vaccine candidate have been advanced, showing high levels of protection in nonh

200 n LPHL patients, negative prognostic factors were advanced stage (P = .0092), Hb less than 10.5 g/dL

201 , factors associated with decreased survival were advanced stage, presence of LR, and absence of horm

202 classic 'bottom-up' formation mechanism have been advanced, starting with C2 units that build up to f

203 Nevertheless, arguments can be advanced suggesting that a physically consistent desc

204 The most common method employed is advanced surface ablation using the excimer laser, su

205 onance (MR) imaging and perfusion MR imaging are advanced techniques that provide information not ava

206 A mechanistic framework has been advanced that involves one Mg(2+)-independent and t

207 Several hypotheses have been advanced that link physical forces to intracellular

208 A hypothesis has been advanced that the incursion of woody plants into wo

209 A mechanistic model is advanced that accounts for the basis of selectivity o

210 An explanation is advanced that is based on changes in outer-sphere reo

211 A stereochemical model for this reaction is advanced that is in line both with these features and

212 A hypothesis is advanced that SUT4-mediated tonoplast sucrose fluxes

213 The proposal is advanced that the first steps deal with forests becau

214 er, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs

215 apidly growing field of nanoscale lasers can be advanced through the discovery of new, tunable light

216 anguage and related aspects of cognition has been advanced through detailed studies of patients with

217 standing in the field of transplantation has been advanced through genetic and genomic studies.

218 Our understanding of the disease has been advanced through its molecular characterization.

219 Treatment of dyslexia has been advanced through neuroscience, yet further study is

220 thogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive co

221 ES) technologies have arrived, they too have been advanced through the study of animal models.These m

222 nding cellular repair mechanisms in vivo has been advanced through the use of well-defined injury and

223 This intermediate is advanced through six additional steps to the target a

224 The catheter, which was advanced through an 18-gauge sheath, showed resoluti

225 idine-alpha-sulfone hydroxamate 35f (SC-276) was advanced through antitumor and antiangiogenesis assa

226 Compound R,R-19a (MK-1903) was advanced through preclinical studies, was well toler

227 A microinfusion (IntraLume) catheter was advanced through the needle, deep into remote myocar

228 The fiberoptic scope was advanced through the rostral trachea into the pharyn

229 Two alternative hypotheses are advanced to explain both the diminution in rates wit

230 Flexible synthesized MoS2 transistors are advanced to perform at GHz speeds.

231 ers inserted at the sacral hiatus can easily be advanced to a lumbar or thoracic level.

232 Moreover, this approach could be advanced to an unprecedented stereodivergent resoluti

233 rocess and the products of the arylation can be advanced to complex polycyclic molecules by sequentia

234 We show that fragment hits can be advanced to furnish selective ligands that affect the

235 se novel chemical entities could potentially be advanced to the clinic as new drug candidates for tre

236 carboxylate links into extended networks has been advanced to a point that allowed the design of poro

237 umber of functional hypotheses have recently been advanced to account for how the cerebellum may cont

238 Although underfunded, it has been advanced to be competitive with corn ethanol; howev

239 bioavailable NS3 protease inhibitor that has been advanced to clinical trials in human beings for the

240 Analogue 13-15 has been advanced to clinical trials.

241 Analogue 12-3 has been advanced to clinical trials.

242 ptual model of movement ecology has recently been advanced to explain all movement by considering the

243 neural computation, and multiple models have been advanced to explain behavioral and neural responses

244 ytoplasmic face, and mechanistic models have been advanced to explain how ESCRT-III filaments and the

245 ecretion remain unknown, several models have been advanced to explain if they involve generation of m

246 social networks, and theoretical models have been advanced to explain it.

247 However, various models have been advanced to explain temperature regulation.

248 Hypotheses have been advanced to explain the different inhibition kineti

249 Several models have been advanced to explain the flexible binding of protein

250 Several theories have been advanced to explain the nature of enzymatic control

251 mer's disease (AD) and several theories have been advanced to explain the relationship.

252 No general linguistic mechanism has been advanced to explain this striking variation in rate

253 Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, th

254 and pharmacokinetic profile, PF-06282999 has been advanced to first-in-human pharmacokinetic and safe

255 ve been developed, and several have recently been advanced to genome-wide scale using arrays and next

256 A repurposed compound has been advanced to human clinical studies.

257 Additionally, one compound has been advanced to human clinical studies.

258 led to the identification of 19d, which has been advanced to human clinical trials for weight manage

259 t time, the state-of-the-art methodology has been advanced to include triplet states.

260 Various algorithms have been advanced to operate on such contact data to produce

261 ly developed KOR antagonist tracer has since been advanced to PET imaging of KOR in humans and consti

262 ived 20S human proteasome inhibitor that has been advanced to preclinical development, [(1R)-1-[[(2 S

263 rations of intravenous cyclophosphamide have been advanced to reduce toxicity without sacrificing eff

264 c cancer and therapeutic treatments that are being advanced to target the stroma as a critical part o

265 In four additional steps, this intermediate is advanced to (+/-)-actinophyllic acid.

266 A conformational model is advanced to account for these observations.

267 treating older adults, and a research agenda is advanced to facilitate the development of rationally

268 lecule, selective for the identified target, is advanced to the clinic where it can be shown to be ef

269 The Mucus Shaver is advanced to the distal endotracheal tube tip, inflate

270 a a daily subcutaneous injection; study drug was advanced to a dosage of 1.8 mg/d during the first 30

271 tion in an in vivo pharmacodynamic assay and was advanced to a long-term efficacy study.

272 As a result of these findings, 3S,3aR-27d was advanced to clinical studies.

273 the balloon-based endoscopic ablation system was advanced to each PV ostium, and arcs of laser energy

274 Compound 15d was advanced to efficacy studies in a model of neuropath

275 Compound 7 was advanced to first-in-human trials for the treatment

276 Compound 25 was advanced to first-in-man trials for the treatment of

277 Compound 1 was advanced to human clinical trials, and it exhibited

278 An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated e

279 iazole fragment 3, and the resulting product was advanced to intermediate 11 possessing the thiazolin

280 Compound 2 was advanced to phase II depression trials to test the h

281 ubstituents led to quinoline amide 21, which was advanced to preclinical development.

282 Two decades later, RECIST was advanced to streamline WHO and improve its reproduci

283 Compound 3a was advanced to the clinic.

284 e for cases and their corresponding controls was advanced to the date of first recorded prescription

285 lindenes to prepare a [6-7-6] framework that was advanced to the hetidine skeleton.

286 op SNPs (or their surrogates) from discovery were advanced to a stage-2 evaluation in additional Hena

287 in the identification of two compounds that were advanced to clinical studies: (R)-1-(4-benzoyl-2-me

288 Throughout the 1900s, a number of theories were advanced to explain the numerous growths that cover

289 Elite transgenic lines were advanced to multiyear field trials, which demonstra

290 The gingival flaps were advanced to submerge the membranes and teeth and su

291 der EUS guidance, a 19-gauge EUS fine needle was advanced transhepatically into the portal vein and a

292 The needle system was advanced under real-time MR imaging to puncture the

293 The RF electrode was advanced up the midline between lingual arteries and

294 d of macromolecular signal amplification has been advanced using conjugated polymers, chirality in po

295 model systems: first, the types of questions being advanced using these new models; and second, the e

296 rapeutic antibody with the immune system has been advanced, using both manipulation of the immunoglob

297 embly of a masked N-aryl tetramic acid which is advanced via a highly selective conjugate addition/in

298 ism of integrin signaling and activation has been advanced with truncated ectodomain preparations; ho

299 Many explanations for TLD have been advanced, with recent efforts focused on recombinat

300 posals for this unconventional behavior have been advanced, yet a consensus remains elusive.