ライフサイエンスコーパス: be beginning to

1 ' resources and high-throughput based assays are beginning to accelerate antiviral drug discovery and

2 Whereas nutrigenomics research is beginning to account for resident microbiota, the nee

3 ical communication between Drosophila organs are beginning to address the fundamental problem of how

4 In this review, we discuss how studies are beginning to address the nature of these niches as w

5 Policymakers are beginning to address the risk of ecological impact,

6 Research on the human microbiome is beginning to address factors associated with between-

7 stem cell biology and regenerative medicine are beginning to advance and refine our understanding of

8 archers build on this early foundation, they are beginning to advance the field towards more fine-gra

9 dy of atherosclerosis, and our new knowledge is beginning to affect how we treat this ubiquitous dise

10 cellular mechanisms, novel treatment options are beginning to appear for a number of specific conditi

11 Main group examples are beginning to appear, although here it is mainly by c

12 However, integrative models are beginning to appear.

13 We are beginning to appreciate that the AIS is dynamically

14 for its reinvention has now come, just as we are beginning to appreciate the antibody immune response

15 While we are beginning to appreciate the cellular roles played by

16 As humans, we are beginning to appreciate the diversity and function o

17 proteins subject to cleavage by caspases, we are beginning to appreciate the full functional repertoi

18 Early phase trials are beginning to assess the activity of small-molecule i

19 , the climate science and policy communities are beginning to assess the feasibility and potential be

20 orthologous phenotypes and cell types, which are beginning to be addressed by emerging technologies.

21 eview, we discuss analytical approaches that are beginning to be applied to help synthesize the vast

22 teomic analyses, newer non-gel-based methods are beginning to be applied to overcome throughput and c

23 rited platelet disorders, and these findings are beginning to be applied to the genetic diagnosis of

24 ole in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregul

25 The implications of the 80-h work week are beginning to be appreciated.

26 on and action of these two cytokine families are beginning to be appreciated.

27 ways responsible for alpha-granule formation are beginning to be assembled as a result of the charact

28 ll as of invertebrate tricellular junctions, are beginning to be characterized, many questions remain

29 High zinc homeostasis mechanisms are beginning to be defined in animals, but low zinc hom

30 s (DUBs) that function in the nervous system are beginning to be defined, but the mechanisms that con

31 eptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the m

32 e phenomena such as neutrophil migration and are beginning to be developed for diagnostic application

33 hanisms that govern glia-mediated regulation are beginning to be discovered, but much remains unknown

34 n localized, and some aspects of their roles are beginning to be discovered.

35 of Wnts and Wnt amplifers such as R-spondins are beginning to be elucidated as well as their function

36 via repulsive dendrite-dendrite interactions are beginning to be elucidated, but the control, and imp

37 Cellular events monitored by this checkpoint are beginning to be elucidated, yet signaling pathways u

38 the development of the olfactory sensory map are beginning to be elucidated.

39 ces as global cues that bias PCP orientation are beginning to be elucidated.

40 or interaction and specificity determination are beginning to be elucidated.

41 regulating these two phases of astrogliosis are beginning to be elucidated.

42 nd the functional relationships between them are beginning to be elucidated.

43 rapies based on knowledge of viral functions are beginning to be evaluated, mostly in preclinical mod

44 Metallosupramolecular architectures are beginning to be exploited for a range of application

45 ghly stable, so it is unsurprising that they are beginning to be exploited industrially.

46 Disease-relevant aquaporin polymorphisms are beginning to be explored.

47 pounds, scaffolds, and biological activities are beginning to be globally explored, beyond individual

48 ost receptors for secreted nematode peptides are beginning to be identified and their roles in parasi

49 mponents underlying this rapid communication are beginning to be identified, such as the ROS producin

50 sh and maintain themselves in this ecosystem are beginning to be identified.

51 uences of gonadal hormones on human behavior are beginning to be identified.

52 nse interest, and their complex interactions are beginning to be identified.

53 r mechanisms of external genital development are beginning to be identified; however, the origin of c

54 pathologies, and microbiome-based approaches are beginning to be implemented in the clinic for diagno

55 In this review we outline how cancer genomes are beginning to be investigated from an evolutionary pe

56 create analogous nanoparticle superlattices are beginning to be realized, but the concept of anisotr

57 nsequences of individual m(6)A modifications are beginning to be revealed, but the effects of m(5)C a

58 f primary disorders of erythrocyte hydration are beginning to be revealed.

59 Muller glia-derived progenitor cells (MGPCs) are beginning to be revealed.

60 which can be used to augment rehabilitation, are beginning to be studied in the context of their effe

61 In turn, the results of scientific studies are beginning to be translated back to the bedside to im

62 rdiovascular benefits of nitrite and nitrate are beginning to be translated in humans by the increasi

63 rimary cilium formation and ciliary motility are beginning to be understood, but little is known abou

64 yrus (DG) and CA3 regions of the hippocampus are beginning to be understood, notably the way that gri

65 gh many aspects of optic pathway development are beginning to be understood, the mechanisms promoting

66 s that control formation of such asymmetries are beginning to be understood.

67 Molecular mechanisms underlying T-cell aging are beginning to be understood.

68 epair, but lead to disease when overwhelmed, are beginning to be understood.

69 chanisms underlying aphid-plant interactions are beginning to be understood.

70 Pathogenic pathways of Huntington's disease are beginning to be unravelled, offering targets for tre

71 underpinning vertebrate body plan evolution are beginning to be unravelled.

72 tion of post-transcriptional gene expression are beginning to be unveiled, the precise roles of m(6)A

73 n cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and d

74 rognosing the associated outcomes, its value is beginning to be appreciated, and the genomics revolut

75 ical elements to cell polarity and migration is beginning to be appreciated, underlying mechanisms ar

76 tion capabilities, in therapeutic resistance is beginning to be better understood, the significance o

77 lationship between these two key early steps is beginning to be clarified.

78 nd reconstitution after lymphocyte depletion is beginning to be defined.

79 sease pathogenesis following viral infection is beginning to be elucidated.

80 lar counting is the method of the future and is beginning to be performed today.

81 fect of particulate matter (PM) on the brain is beginning to be recognized.

82 hways, such as Toll-like receptors and NOD2, is beginning to be studied, with dysbiosis following the

83 ugh piRNA biogenesis from cluster precursors is beginning to be understood, little is known about piR

84 ing, although the basis for these challenges is beginning to be understood.

85 urnover through a degradation mechanism that is beginning to be understood.

86 genetic architecture of quantitative traits is beginning to be understood.

87 And its life outside the laboratory is beginning to be unveiled.

88 ed and massively parallel genomic sequencing is beginning to be used in clinical practice to determin

89 r large-scale genome sequencing projects and is beginning to be used in the clinical diagnostic testi

90 System-level modeling is beginning to be used to decipher high throughput data

91 of brain-derived neurotrophic factor (BDNF) is beginning to be well appreciated not only in mice, bu

92 NA-seq) technology is hitting its stride and is beginning to be widely adopted.

93 onists - which drive the intrinsic pathway - are beginning to bear clinical fruit.

94 these pathways function to specify cell fate is beginning to become clear.

95 Some of the developments described herein are beginning to carry over into clinical imaging as wel

96 Sea-level rise is beginning to cause increased inundation of many low-l

97 goal; however, advances in stem cell science are beginning to challenge this assumption.

98 and allele discovery for various conditions, is beginning to challenge classic definitions of genetic

99 on, and tissue-engineering technology, which are beginning to change the way investigators view the s

100 ation and damage limitation during infection is beginning to change perspectives on infectious diseas

101 This is beginning to change.

102 tal one-carbon metabolism, and animal models are beginning to clarify the roles of the cytoplasmic an

103 of mechanotransduction at the cellular level is beginning to clarify the role of mechanics in pattern

104 gineering by endothelializing these networks is beginning to close the gap between in-vitro and in-vi

105 Fortunately, this gap is beginning to close, and these two fields are merging

106 g Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to c

107 ion and metastatic outgrowth of cancer cells are beginning to come into view.

108 ough exome- and genome-sequencing approaches are beginning to compete, disease-targeted testing retai

109 ype (e.g., feeding, pollination), ecologists are beginning to consider networks which combine multipl

110 aging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the n

111 and activity-dependent modes of myelination are beginning to crystallize in a model of myelin plasti

112 ts, studies of guidance receptor proteolysis are beginning to define new relationships between neurod

113 Clinical studies are beginning to define these factors as immune profiles

114 ystem to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of o

115 Recent chemical biology developments are beginning to demonstrate how the incorporation of an

116 Recent efforts are beginning to demonstrate the potential to build on t

117 Metagenomics is beginning to demonstrate the role of the oral resisto

118 role in hair or feather bud development, we are beginning to discover that multiple mechanisms may,

119 Although case-control approaches are beginning to disentangle schizophrenia's complex pol

120 have led to a renaissance in this field and are beginning to dissect circuit mechanisms in the basal

121 ation; hence even the earliest mammaliaforms were beginning to diversify--morphologically, functional

122 d here we detail how the upstream haplotypes are beginning to dominate the system.

123 Genome-wide association studies are beginning to elucidate how our genetic differences c

124 Systems-level, integrative pathway analyses are beginning to elucidate the additive, polygenic contr

125 We discuss recent advances that are beginning to elucidate the complex relations between

126 composition of dorsal-horn networks, studies are beginning to elucidate the intricate computational l

127 of miRNA biogenesis and modes of action, and are beginning to elucidate the mechanisms of miRNA degra

128 The underlying genetic determinants are beginning to emerge and are interpreted in the conte

129 nce, it is not surprising that disease links are beginning to emerge and that interference with sumoy

130 in particular, the areas of convergence that are beginning to emerge from multiple study designs.

131 nd NF2 genes, molecularly targeted therapies are beginning to emerge, as a result of a deeper underst

132 indings from genome-wide association studies are beginning to emerge, as are discoveries of large-eff

133 ssically cytoplasmic proteins in the nucleus are beginning to emerge, in particular, as participants

134 differentiation in normal tissue homeostasis are beginning to emerge, it is still unclear whether can

135 h intriguing roles for plant linker histones are beginning to emerge, much of our current understandi

136 Massive behavioral datasets are beginning to emerge, particularly from zebrafish lab

137 ation is still lacking, but important themes are beginning to emerge, primarily in budding yeast.

138 anisms of unconventional secretory processes are beginning to emerge.

139 acids under transition-metal-free conditions are beginning to emerge.

140 consequences of such changes for ecosystems are beginning to emerge.

141 s of both convergent and divergent evolution are beginning to emerge.

142 its of low calorie and low cholesterol diets are beginning to emerge.

143 bules control FA turnover in migrating cells are beginning to emerge.

144 GTP, key cellular functions for Galphai-GDP are beginning to emerge.

145 both high permeability and high selectivity are beginning to emerge.

146 new research areas and treatment strategies are beginning to emerge.

147 unravel mechanisms of symmetry establishment are beginning to emerge.

148 mporal dementia improves, rational therapies are beginning to emerge.

149 exists to date, intermediate-term follow-up is beginning to emerge and appears similar to open-radic

150 A picture is beginning to emerge of chromatin loops representing a

151 A cross-species consensus is beginning to emerge suggesting that subtle synaptic a

152 erlying ligand-dependent receptor activation is beginning to emerge with the recent expansion in GPCR

153 ment is ivermectin, however, drug resistance is beginning to emerge, thus, new therapeutic targets an

154 Although the role of 5-LO in tumor cells is beginning to emerge, with the notion that tumor-promo

155 tophagy in bone remodelling and bone disease is beginning to emerge.

156 impact on their cardioprotective properties is beginning to emerge.

157 neurogenesis and neurotransmitter signaling is beginning to emerge.

158 sfunction and atherosclerosis susceptibility is beginning to emerge.

159 ectly and indirectly affects drug metabolism is beginning to emerge.

160 ruses transform cells into a malignant state was beginning to emerge as the first viral genomic seque

161 sms underlying nonclear cell variants of RCC are beginning to engender novel therapeutic strategies d

162 ating regenerative strategies in RPE disease are beginning to enroll subjects, and initial results su

163 for infectious diseases at the point of care is beginning to enter clinical practice in developed and

164 as well as novel experimental manipulations, are beginning to erode many of these established concept

165 articles from the peer-reviewed literature, is beginning to erode the trust of both the scientific c

166 the cells and their biological consequences are beginning to evolve.

167 ohormonal, vascular, and coagulation systems are beginning to explain how this haemostatic impairment

168 in hematological and solid malignancies that are beginning to exploit these approaches.

169 oss the globe have large shale resources and are beginning to explore extraction of these resources.

170 asingly becoming more networked, researchers are beginning to explore how social media can be used to

171 omic gas Bose-Einstein condensates, research is beginning to focus on the roles of vortices in quantu

172 inclusions had 2 to 5 reticulate bodies and were beginning to fuse.

173 harmacological and interventional techniques are beginning to gain momentum once again.

174 Thus, we are beginning to get a clearer picture of how this paras

175 Three-dimensional (3D) imaging technologies are beginning to have significant impact in the field of

176 s is becoming more critical as microfluidics is beginning to have novel applications at larger millif

177 R and highlight the way in which AHR testing is beginning to highlight distinct abnormalities associa

178 Studies in model organisms are beginning to identify the genes and pathways importa

179 rieties of maize, teosinte and other grasses are beginning to identify the genes responsible for the

180 in regions and neuronal subsets, researchers are beginning to identify the neuroanatomical substrates

181 Two recent advances are beginning to illuminate such mechanisms: realization

182 in part by an interest in tumor metabolism, are beginning to illuminate the mechanisms through which

183 These techniques are beginning to impact our understanding of thermodynam

184 cians, as well as public and private payers, are beginning to implement alternative delivery and paym

185 As a small number of dietary guidelines are beginning to incorporate more general environmental

186 l treatment, genetic and genomic information is beginning to influence pregnancy management.

187 p and laptop usage, scientists and educators are beginning to integrate mobile devices into their res

188 neering liver-experimental and computational-are beginning to interplay toward greater illumination o

189 amsters to study acute social stress, and we are beginning to investigate the genetic mechanisms subs

190 tion of the effect of frailty and disability is beginning to lead to new management approaches.

191 We are beginning to learn about the mechanisms of progressi

192 space and time, but new multiscale knowledge is beginning to link these relationships.

193 r own unconventional petroleum resources and are beginning to move forward with development, thus cal

194 RECENT FINDINGS: The field is beginning to move beyond a cartilage focus to include

195 equivalents that mimic mechanical signaling are beginning to offer exciting new methods for improvin

196 These alternative control measures are beginning to penetrate the market, although many rem

197 Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynami

198 perturbation and systems-biology approaches are beginning to provide a glimpse of how natural popula

199 Findings emerging from these studies are beginning to provide a picture of how signal-depende

200 Mathematical models are beginning to provide a quantitative framework for in

201 Studies reviewed herein are beginning to provide an explanation for chiasma loca

202 large-scale studies and converging findings are beginning to provide an understanding of mechanisms

203 However, larger prospective studies are beginning to provide evidence regarding the potentia

204 Recent studies are beginning to provide evidence that many plant-associ

205 Sensors are beginning to provide individuals and communities the

206 Other studies are beginning to provide insight into how neuronal diver

207 Although genome-wide studies are beginning to provide insight into the molecular mech

208 communities across all aquatic environments are beginning to provide insights into the ecology of mi

209 Such 'systems vaccinology' studies are beginning to provide mechanistic insights about inna

210 These systems-level approaches are beginning to provide novel avenues for drug targetin

211 otyping, cytogenetic, and molecular analysis are beginning to provide some understanding.

212 of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster p

213 sible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insight

214 of SELEX with novel sequencing technologies is beginning to provide the data that will allow the exa

215 in chemistry, radiology, and systems biology is beginning to provide useful biomarkers, and the emerg

216 ., folkphysics, folkpsychology, folkbiology) are beginning to query the domains themselves and offer

217 e of research on membrane protein structures is beginning to quicken thanks to various improvements i

218 astatic or locally advanced solid tumors who were beginning to receive a course of chemotherapy were

219 We are beginning to recognize the brain's susceptibility to

220 or the direct functionalization of C-H bonds are beginning to reshape the field of retrosynthetic ana

221 strate the ways in which simulation modeling is beginning to reshape our understanding of the domesti

222 Studies with these and other vaccines are beginning to reunite the estranged fields of immunol

223 Recent structural and biophysical studies are beginning to reveal a fascinating multistep mechanis

224 Together, these insights are beginning to reveal answers to century-old mysteries

225 anding hormone signalling networks in plants are beginning to reveal how co-ordination of activity ac

226 These findings are beginning to reveal how individual components of cir

227 ide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each s

228 dies on the molecular-structural association are beginning to reveal how the spatiotemporal gene expr

229 teractions with their host; new technologies are beginning to reveal important aspects of host-microb

230 Recent data are beginning to reveal the biological significance and

231 deling of upconverting nanoparticles (UCNPs) are beginning to reveal the complex details of their ene

232 Studies are beginning to reveal the function of reconsolidation,

233 of DNA methylation and histone modifications are beginning to reveal the landscape of cancer-specific

234 of high fidelity structural information and are beginning to reveal the macromolecular organization

235 tional, and electrophysiological experiments are beginning to reveal the mechanism of action of parti

236 Although cancer genome sequencing studies are beginning to reveal the mutational patterns of genes

237 in cellular organisation, and recent studies are beginning to reveal the relationship between virus f

238 Recent research is beginning to reveal how the connectivity of individua

239 A synthesis of opto- and pharmacogenetics is beginning to reveal how various interneuron types dir

240 ingly computational nature of social science is beginning to reverse this traditional bias against pr

241 We are beginning to see that pathogenic microbes are capabl

242 ancestor was the stem cnidarian, researchers are beginning to see the genomic underpinnings of cnidar

243 he recreational use of Ketamine increases we are beginning to see the signs of major renal and bladde

244 reatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advan

245 This work is beginning to shed light on how this complex regulator

246 However, recent work is beginning to shed light on key aspects of chaperonin

247 c range of prosocial sentiments and behavior is beginning to shed some light on this issue.

248 lly high consumption rates, although impacts are beginning to shift to smaller mobile devices.

249 arostat, despite their technical challenges, are beginning to show promise in clinical practice.

250 Cancer vaccines are beginning to show signs of clinical activity, but ma

251 the brain, and how some recent human trials are beginning to show some promise as to the effectivene

252 arch in animal models of Parkinson's disease is beginning to show exercise-induced neuroplastic effec

253 ffective treatment of multiple diseases, and is beginning to show promise for stroke.

254 Evidence is beginning to show that screening first-degree relativ

255 Progress in understanding sterolin function is beginning to show that xenosterols can be toxic and a

256 y to molecular markers to targeted therapies are beginning to solidify the identification of select m

257 ental requirements and function of MPS cells are beginning to solve this problem in an objective mann

258 Related arenaviruses are beginning to spread in human populations in South Am

259 microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures a

260 Although some vendors are beginning to supply multi-kilobase sequence-verified

261 ns of these different chemical modifications is beginning to take shape, but it's clear that in both

262 New tools, practices, and partnerships are beginning to transform local fisheries, biodiversity

263 logists in providing high-resolution insight is beginning to transform drug discovery efforts, and th

264 ective therapies for mitochondrial disorders are beginning to translate from bench to bedside along t

265 mediate TLS and describe how this knowledge is beginning to translate into the development of small

266 However, inspired by Nature, chemists are beginning to turn their attention to the development

267 l groups and genome-wide association studies are beginning to uncover the complex genetic architectur

268 etic tools and other strategies, researchers are beginning to uncover their biological and genetic ch

269 Using animal models, preliminary work is beginning to uncover differences between young and ag

270 cell types and genetically tractable species is beginning to uncover the cellular logic of touch rece

271 We are beginning to understand better the role of JAK2(V617

272 Based on this information, we are beginning to understand how alterations in autophagy

273 ion and super-resolution imaging studies, we are beginning to understand how the ULK1 and PI3KC3-C1 c

274 005, but after 10 years of investigation, we are beginning to understand how they are organized in th

275 We are beginning to understand the connections between QS a

276 We are beginning to understand the function of 3D genome ar

277 Although we are beginning to understand the late stage of neurodegen

278 We are beginning to understand the pathophysiology of compl

279 BACKGROUND & AIMS: Although we are beginning to understand where, when, and how intesti

280 vel investigation of the neonatal microbiome is beginning to unearth substantial information, with a

281 nous viral counterparts, their early history is beginning to unfold.

282 invertebrate and vertebrate model organisms are beginning to unravel a regulatory role for serotonin

283 s for measuring and modeling these exposures are beginning to unravel complex associations with asthm

284 Biologists are beginning to unravel the complexities of gene expres

285 ughs in structural and computational biology are beginning to unravel the mechanistic basis of GPCR a

286 pression are largely unknown, recent studies are beginning to unravel their importance in human healt

287 Research is beginning to unravel the mechanism by which TNF depre

288 Recent discoveries, however, are beginning to unveil new components of the inflammaso

289 ecent genomic and in-vivo biological studies are beginning to unveil the molecular drivers of follicu

290 However, large-scale sequencing is beginning to unveil other unique mutational spectra i

291 microbiology and public health laboratories are beginning to utilize next-generation sequencing (NGS

292 approaches examining regional neurochemistry are beginning to yield additional insights with regard t

293 velopment and summarize recent findings that are beginning to yield important insights into deuterost

294 nstitution and their homeostatic maintenance are beginning to yield improved mouse strains to create

295 to a renaissance in the study of the BF and are beginning to yield new insights about cell-type-spec

296 ompounds against drug-resistant tuberculosis are beginning to yield novel inhibitors.

297 cular networks driving vaccine immunity, and are beginning to yield novel insights about the immune s

298 cardiac stem cell and regenerative biology, are beginning to yield potential new targets and strateg

299 genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.

300 Tandem catalysis is a growing field that is beginning to yield important scientific and technolog