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1 to 20 mg/kg); however, tobramycin doses must be changed to 1.5 mg/kg intraperitoneally on day 1, then
3 r first online publication: '10-20 days' has been changed to '20-30 days.'] Offspring from each of th
7 the energy content of the isoenergetic diet was changed to 50% fat, 14% protein, and 36% carbohydrat
8 (alpha(i+3))<7 A criteria for defining turns be changed to 6.5 A, identification of beta-strand and t
9 annel activity remained elevated when the pH was changed to 7.5, a reflection of CGB binding to the I
12 alpha-position to the CO(2)(-) group, might be changed to a larger group and lead to better binding
16 Once the MTD was identified, the schedule was changed to a 24-hour continuous infusion once weekly
19 the IL-18 precursor caspase-1 cleavage site was changed to a factor Xa site, and, after expression i
20 PA701-168, where the basic cleft residue R41 was changed to a glutamic acid (R41E), demonstrating tha
23 of the 104 patients (27%); the surgical plan was changed to a nerve-sparing technique in 17 of the 28
26 which normally ends on the sequence ATC-5', was changed to a random position within the AATCCC repea
27 s included a mutant in which Env residue 767 was changed to a stop codon, a double mutant in which po
29 When the animals weighed 20 g, their diets were changed to a high-fat (HF) diet (58% kcal), and a c
30 or up to 7 years, compared with patients who were changed to a placebo after about 5 years, experienc
31 C48 tertiary "Levitt base-pair" in tRNA(Ser) was changed to A15-U48; the number of nucleotides in the
36 in the alpha and beta regions of the D-loop was changed to achieve the positioning of G18 and G19 th
38 In addition, mutant ribosomes in which G1575 was changed to adenosine supported growth comparable to
39 me miscalibrated, Purkinje cell output would be changed to adjust the motor command and restore good
47 hich individual cleavage site P1 amino acids were changed to Ala was performed to delineate their imp
48 hains in the active site, Lys111 and Arg120, were changed to Ala, causing an increased partitioning o
49 hosphorylation sites in the cytoplasmic tail were changed to Ala, did not internalize in response to
50 s of the catalytic triad, Asp107 and His207, were changed to Ala, with the resulting mutants lacking
52 bacteriorhodopsin transmembrane helices can be changed to alanine with little structural consequence
53 artate residue at amino acid position 54 has been changed to alanine (D54A), consistent with this bei
54 ate and aspartate residues have individually been changed to alanine, all retain the ability to hydro
58 as reinhardtii and a mutant in which ThrA739 is changed to alanine [TA(A739) mutant] were studied.
61 which the phosphorylation site at serine 133 was changed to alanine (CREB-S133A) upregulated cyclin A
62 n which the catalytic nucleophilic aspartate was changed to alanine (D204A) allowed visualization of
63 V(2) proteins in which this conserved serine was changed to alanine could activate the yeast two-hybr
64 ions in which the central tryptophan residue was changed to alanine did not have a significant impact
66 important, an IRS-1 mutant in which Ser(312) was changed to alanine was found to be resistant to insu
68 yr-12, Tyr-76, or Tyr-104 of the VPg protein was changed to alanine, but virus was not recovered when
69 the activase/Rubisco interaction, proline 89 was changed to alanine, which is not present in either n
73 tant xPlkk1 in which these three amino acids were changed to alanine (xPlkk1(SA3)) was unable to be p
74 ylation sites, threonine 14 and tyrosine 15, were changed to alanine and phenylalanine, respectively
75 harged residues located within the C2-domain were changed to alanine in clusters of 1-3 mutations per
76 in which glycine residues in two RGD motifs were changed to alanine residues showed the greatest red
77 ion sites, in which the Thr and Ser residues were changed to alanine residues, reduced the apoptotic
78 form a casein kinase II phosphorylation site were changed to alanine residues, reducing phosphorylati
81 Residues D58, K121, C123, and H125 of PrpB were changed to alanine, and residue R122 was changed to
82 ids between residues 331 and 462 of sigma 54 were changed to alanine, and the mutant proteins were st
83 ers of 1-5 putative solvent-exposed residues were changed to alanine, ultimately changing 65 residues
84 aced by a positively charged residue or both were changed to alanine, viruses were recovered that con
89 udy we used receptors in which these serines were changed to alanines (SA3) or to aspartic acids (SD3
90 ne residues at positions 12, 24, 76, and 104 were changed to alanines by mutagenesis of an infectious
92 amino acids from various extracellular loops were changed to alanines, and we examined their ability
93 These MutH histidines (His-112 and His-115) were changed to alanines, but the mutant proteins had wi
96 omain protein 1CSQ, with six of its residues being changed to all possible (20) amino acids, were scr
98 patients for whom an off-pump strategy must be changed to an on-pump procedure during surgery have n
99 roles in catalytic function, each lysine has been changed to an uncharged methionine or alanine, and
100 deficient mutant of eNOS in which serine 116 is changed to an alanine residue (S116A) shows significa
102 ls adjust rapidly, but when a figure display is changed to an ambiguous edge display, the signals dec
103 residue 48 in the periplasmic sensor domain is changed to an isoleucine, was shown previously to res
104 the 5'-end nucleotide G of the replicon RNA was changed to an A upon multiple rounds of replication.
105 safe and effective, the irinotecan schedule was changed to an accepted brain tumor regimen of four d
106 A mutant in which the catalytic glutamate was changed to an alanine crystallized in a closed compl
111 c residues in the third extracellular domain were changed to an acidic residue and initially examined
114 NA in which the conserved lysine at codon 71 was changed to arginine, thus impairing the catalytic ef
116 cifically, when at least two lysine residues were changed to arginine in the histone H3 tail, a hat1D
117 reaction such that the RGD in the pro-toxin was changed to arginyl-alanyl-aspartic or to arginyl-gly
118 secutive Asp residues of the "Ca-bowl" motif are changed to Asn, reduces (45)Ca(2+)-binding activity
119 compared with wild-type CthPnkp when His-189 is changed to Asp, Arg-237 is replaced by Ala or Gln, an
123 one of the three active site aspartates has been changed to asparagine (D211N), is still capable of
126 coli ribosomal protein S5, in which glycine is changed to aspartate at position 28 [S5(G28D)], resul
127 -mimetic" eNOS mutant in which threonine 497 is changed to aspartate shows attenuated phosphorylation
128 ants, in which threonine 33 and/or serine 35 were changed to aspartic acid to mimic the phosphorylati
133 n of opsin genes in the inner PRCs R7 and R8 are changed to become identical to those of outer R1-R6
135 ases of nafcillin discontinuation, treatment was changed to cefazolin; all 9 completed treatment with
140 xed amplitude: far and near target positions were changed to create an accommodative demand of 1.5 D
142 steady-state kinetic assays show that it can be changed to Cys (A62C) and labeled with the fluorescen
143 ructure, the active-site nucleophile, Ser80, was changed to Cys, and the other members of the catalyt
145 peptide substrate in which the target serine is changed to cysteine also gives rise to turnover, supp
146 possible perturbations of H by D as H-C-C-H is changed to D-C-C-H have been determined experimentall
148 en the base pairing partner for hypoxanthine is changed to difluorotoluene, which cannot hydrogen bon
149 eks in culture, the astrocyte culture medium was changed to DMEM containing various concentrations of
150 the [DAsp(1)(betaAla), DOrn(3)] cycle of 21 was changed to [DOrn(1)(betaAla), DAsp(3)] of cyclo(1,1'
152 e their roles in lambda DNA packaging, Y(46) was changed to E, A, and F, and K(84) was changed to E a
153 aged 2-17 years when antiretroviral therapy was changed to either a dual nucleoside analogue regimen
154 r derivatives in which the regulatory serine was changed to either alanine or aspartate were construc
155 All six native cysteine residues of GLUT1 were changed to either glycine or serine residues by sit
156 h had begun in 79 (69%), including those who were changed to either itraconazole or posaconazole.
158 ch meningococcal disease is diagnosed should be changed to emphasise identification of these early sy
159 multiway analyses, four model variables must be changed to extreme values for the cost-utility of ann
160 tinuous collapse when the solvent conditions are changed to favor the fully folded native conformatio
161 al gastrointestinal disorders" (AP-FGID) has been changed to functional abdominal pain disorders (FAP
164 therefore recommend that the jal designation be changed to Gata3jal, and suggest that this mouse vari
165 observed regardless of whether the contacts were changed to give devices with or without significant
167 re, the conserved active site residue His200 is changed to Gln, Glu, Ala, Asn, and Phe, and the react
168 d mutagenesis experiments, in which each Asn was changed to Gln independently, revealed that only asp
170 ch the active site ligand, aspartate (D) 84, is changed to glutamate (E) are capable of accumulating
172 , Tat, and TAR, these serines and threonines were changed to glutamate in a kinase-inactive Cdk9 prot
174 6, a potential catalytic residue in VPH, has been changed to glutamine, and the resulting E106QVPH mu
175 n which an invariant transmembrane glutamate was changed to glutamine integrated into the membrane bu
177 , in which a single or double lysine residue was changed to glutamine within the in vivo N-terminal t
178 nsfer deficiency in a mutant in which Trp 80 was changed to Gly, we determined the X-ray structures o
179 idue in the ATP binding site (glutamine 103) is changed to glycine, allowing this mutant to utilize a
180 S and 4028T.V, in which residue threonine-28 was changed to glycine, serine, and valine, respectively
184 ase intein improved when its penultimate Phe was changed to His, but splicing of the RNA polymerase s
186 e show that mutant CPRs in which Trp-676 has been changed to histidine (W676H) and alanine (W676A) ca
187 constructed in which this glutamine, Gln937, was changed to histidine, glutamic acid, aspartic acid,
189 ic medium in which the normal 5.6 mm glucose is changed to hyperglycemic 25.6 mm glucose greatly incr
190 national strategy for biosurveillance should be changed to incorporate data from the whole health rec
193 ting, in which genomically encoded adenosine is changed to inosine in RNA, is catalyzed by adenosine
196 ithin the P4-P2' region; the sequence ITLLSA was changed to ITLSSA to relocate the reactive site to P
200 Kinetic analysis of mutants in which Arg237 was changed to Leu, Lys, His, and Gln revealed that Arg2
201 in the hydrophobic core, valine-14 and -16, are changed to leucine and to the extensively fluorinate
202 ide in which two of the three phenylalanines are changed to leucine is considerably less structured,
204 inst voltage-gated potassium channels should be changed to limbic encephalitis associated with LGI1 a
205 1.5 +/- 2.5 cm, and 22 mastectomy candidates were changed to lumpectomy, with tumor size decreasing f
207 ariant in which five acidic amino acids have been changed to lysine (5K) (pI=10.2) was measured and c
209 IS (structurally homologous to K274 in ADCS) was changed to lysine in an attempt to convert IS to an
213 by histologic findings, and his medications were changed to methotrexate and hydroxychloroquine.
218 the mutant in which the five basic residues were changed to neutral glutamine (bvPLA(2)-Q5) with pho
220 yptophan residues present in the enzyme have been changed to nonfluorescent ones in various combinati
221 tants in which the Akt phosphorylation sites are changed to nonphosphorylatable or phospho-mimicking
222 n which the phosphorylation sites of cMyBP-C were changed to nonphosphorylatable alanines (MyBP-C(All
224 It is shown how these conditions have to be changed to obtain correct quantifications of the weig
226 ed model is then described in which the drug is changed to one in which both strains are susceptible,
227 structures must be left intact and which can be changed to optimize biochemical and immunologic perfo
229 c, as no effect is observed when the uridine is changed to other naturally occurring nucleotides.
232 ced with alanine, and/or the activation site was changed to permit activation by bovine factor Xa.
233 drogen bond to the 9-keto C=O group of P(A), is changed to Phe, a differential signal at 1653(+)/1638
234 tructure, we determined that Tyr286 in AeKAT is changed to Phe278 in human KAT I, which may explain w
235 eins in which either Y801 or Y854 of DOS has been changed to phenylalanine are unable to function dur
236 ivo expression of a Grb2 mutant where Tyr209 was changed to phenylalanine enhanced BCR/ABL-induced ER
237 Mutant proteins in which these tyrosines were changed to phenylalanine had reduced phosphorylatio
239 It follows that "potential compression" is changed to "potential expansion" (i.e., a further sep
240 to answers to certain questions...." It has been changed to read, "As with any other product that cl
241 o searched for meditation adherence." It has been changed to read, "Because medication may be a compo
242 tional Research Council, Naples, Italy," has been changed to read, "Institute of Genetics and Biomedi
243 lvira Donnarumma, PhD, "SDN Foundation," has been changed to read, "IRCCS SDN, Naples, Italy." The in
245 n services, especially fee-for-service, must be changed to recognize the value of services performed
246 ure or content of the atherosclerotic plaque is changed to reduce the risk of subsequent rupture and
248 bitor of matrix metalloproteinase-1 (TIMP-1) is changed to regulate the activities of MMPs after part
249 The processing of mfVEP signals needs to be changed to remove the relationship between the number
250 Accordingly, the symbol for this allele has been changed to restorer-of-fertility lethal 1 (rfl1).
251 ntive system for university researchers must be changed to reward research on problems of practice.
255 nhibition in mutant yeast, each p53 cysteine was changed to serine, and the effect of the substitutio
259 ansforming activity if Cys(181) and Cys(184) are changed to serines, implying that palmitates make im
260 Mutant alpha(13), in which both cysteines were changed to serines, failed to localize to plasma me
262 ich progerin's carboxyl-terminal -CSIM motif was changed to -SSIM) also develop severe progeria, rais
263 e., single-step two-electron transfer; 8-10) is changed to stepwise ETs of the Weitz type for two-pyr
264 double mutant in which positions 738 and 739 were changed to stop codons, another mutant in which a p
265 diated through the nigrostriatal system must be changed to take into account extrastriatal dopaminerg
266 ndicate that the HSV-1 latency phenotype can be changed to that of HSV-2 by substitution of a 2.8-kb
267 pecimens in seven, a diagnosis of malignancy was changed to that of another malignancy in four, and t
268 ein in which a 17-amino-acid segment of UpaY was changed to that of UpeY altered UpaY's specificity,
269 at on shorter substrates the cutting pattern was changed to that predicted for the activity of a 3'-5
270 ants in which each residue facing the pocket was changed to that present in CCK2R had no negative imp
271 in which amino acid residues M205-M210 have been changed to the corresponding L subunit amino acids.
272 eto and 10a-carbomethoxy groups of P(A) have been changed to the symmetry-related side chains present
274 bjects to reach and grasp an object whose CM was changed to the left, center, or right of the object
278 assignment of 16,19-cis-murisolin as RRRSSS was changed to the RSSRRS diastereomer and murisolin A i
279 gnition sequence for carbohydrate attachment was changed to the structurally similar glutamine such t
280 ly, nine individual 2B1 active-site residues were changed to the corresponding 2C5 residues, and the
281 ctivities of mutants in which these residues were changed to the corresponding IGFBP-1 sequence were
282 brane spanning segments of the alpha subunit were changed to the corresponding residues common to gas
283 h the C2 domain hydrophobic amino acid pairs were changed to the homologous residues of the other pro
286 P-4) is achieved if the residues A, S, and R are changed to those in 8-Cys3(LTBP1) (D, D, and E) and
289 within three previously implicated segments were changed to those in the alpha(L)I-domain, which is
293 e; the point mutation results in cysteine-66 being changed to tryptophan-66 in the conserved 'twin CX
297 ns, UA(1831)GUA(1834)G, in its kinase domain were changed to UG(1831)GUG(1834)G by RNA editing in per
300 nature, essentially a catalogue of loci that were changed to varying degrees in different tumor types
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