ライフサイエンスコーパス: be complicated by

1 er, their applications as optical-gain media are complicated by a non-unity degeneracy of band-edge s

2 cineurin activity in transplant patients has been complicated by a lack of consistent correlation bet

3 Analysis of the developing proteome has been complicated by a lack of tools that can be easily e

4 Attempts to induce antibody persistence have been complicated by a loss of efficacy, presumably by in

5 matopoietic stem cell transplantation (HSCT) is complicated by a high incidence of life-threatening i

6 ry folate recommendations for optimal health is complicated by a lack of data quantifying the biomark

7 alidation of models is still a challenge and is complicated by a lack of field and laboratory data.

8 eded for tool assessment and improvement but is complicated by a lack of gold standards, by extensive

9 l compounds in wine, key oxidation products, is complicated by a multitude of kinetically reversible

10 ran Africa and the development of strategies is complicated by a scarcity of good data from countries

11 -7 Ma, reconstructing hominin gait evolution is complicated by a sparse fossil record and challenges

12 The response to deposition was complicated by a drought in the early 2000s that enh

13 protection against S. epidermidis challenge was complicated by a highly efficacious innate immune re

14 ld have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality.

15 ies during the study period, 76,108 of which were complicated by a hypertensive disorder of pregnancy

16 g 137 surgical procedures analyzed, 9 (6.5%) were complicated by abnormal bleeding.

17 d immunological parameters substantially but were complicated by acute leukemia as a result of insert

18 ling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulati

19 Their use may be complicated by adverse events such as venous thromboe

20 Both anorexia nervosa (AN) and obesity are complicated by affective comorbidities and hypothala

21 Of 1,918,789 pregnancies, 188 were complicated by AKI treated with dialysis (incidence

22 ell types from one CNS region to another and are complicated by alterations in cellular composition d

23 of chronic lung diseases, some of which may be complicated by an infectious process.

24 ommon pathogenic process underlying PMD have been complicated by an incomplete understanding of PLP1

25 and Aedes albopictus remains incomplete and is complicated by an ongoing range expansion fuelled by

26 The postoperative course was complicated by an episode of hemobilia due to the ru

27 Two surgeries were complicated by an intraoperative perforation of Des

28 ar cells to metaplastic ductal cells in vivo is complicated by analysis of the entire organ, an in vi

29 disease of the aorta and its large branches, is complicated by aneurysm formation, dissection, and ar

30 Gonorrhea treatment has been complicated by antimicrobial resistance in Neisseri

31 Treatment for gonorrhea has been complicated by antimicrobial resistance.

32 Staphylococcus aureus bacteremia cases are complicated by bacterial persistence and treatment f

33 piratory and cardiac failure in children but is complicated by bleeding and thrombosis.

34 BACKGROUND & AIMS: Liver cirrhosis is complicated by bleeding from portal hypertension but

35 he submitter, and mining the data in the SRA is complicated by both the amount of data and the detail

36 The patient's posttransplantation course was complicated by bronchiolitis obliterans from chronic

37 ysis of cell division in the mammalian heart is complicated by cardiomyocyte binucleation shortly aft

38 The patient's clinical course was complicated by cardiopulmonary failure and he ultima

39 Data pooling was complicated by center-related differences in subject

40 One hundred thirty-five cases were complicated by CIHB (2.2%; 95% confidence interval,

41 l response in around 50% of individuals, and is complicated by clinically significant adverse events.

42 e of the Y chromosome in the gambiae complex is complicated by complete F1 male hybrid sterility.

43 entration, the most commonly used indicator, is complicated by concomitant inflammation.

44 er, understanding the compensatory mechanism is complicated by concomitant upregulation of alpha7beta

45 mists acquired photosynthetic organelles has been complicated by conflicting phylogenetic results, al

46 tential and tests of these models have often been complicated by conformational changes and multisite

47 ion spectroscopy and magnetic susceptibility are complicated by contributions from inactive 'spectato

48 ostic methods rely on serologic testing that are complicated by cross reactivity and therefore unable

49 His clinical course was complicated by debilitating neurological symptoms an

50 Management was complicated by delays in diagnosis, uncertainties ab

51 f ecological contributions to this variation is complicated by differences among populations in other

52 The study of semantic representations is complicated by difficulty in disentangling perceptual

53 en worldwide, but establishing the cause can be complicated by diverse diagnostic approaches and vary

54 However, CMV antiviral therapy can be complicated by drug resistance associated with mutati

55 el and symptom improvement in 1 patient, but was complicated by duodenal bleeding in both patients.

56 While pancreas transplant can be complicated by early graft loss, our results suggest

57 -of-function studies of PRC2 components have been complicated by early embryonic dependence on PRC2 a

58 Acute decompensated heart failure (ADHF) can be complicated by electrolyte abnormalities, but the maj

59 Moreover, stable detection may be complicated by environmental uncertainty; stimulus pr

60 Consequently, SSc patients may be complicated by erosive esophagitis and eventually by

61 However, long-term L-DOPA treatment is complicated by eventual debilitating abnormal involun

62 of alternative isoforms of the same gene may be complicated by experimental protocols that favour one

63 mental and computational substituent effects is complicated by formation of Au-complexes with the Lew

64 eceived the fourth dose of ipilimumab, which was complicated by grade 3 transaminitis and hypophysiti

65 g adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disea

66 This is complicated by HA and NA residing in lipid raft-like

67 -aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose

68 Pregnancy was complicated by heart failure in 6.7% of asymptomatic

69 The procedure was complicated by hemoperitoneum in four patients (10%)

70 sion, although such observational data might be complicated by hidden confounders.

71 y methylated species using mass spectrometry are complicated by high sample diversity, competition fo

72 ned by permethylation analysis, but this can be complicated by high viscosity or poor solubility, res

73 However, the analysis of such measurements is complicated by high levels of technical noise and int

74 ook reveals that EPR-dependent drug delivery is complicated by high tumor interstitial fluid pressure

75 n of Opa proteins to gonococcal pathogenesis is complicated by high-frequency phase variation of the

76 Measurement of such generalization is complicated by how generalization doesn't always mani

77 sis (1,089 patients), 178 (14.4%) admissions were complicated by ICU-acquired infections (at Day 10 [

78 ver, eliciting such responses by vaccination is complicated by immunodominance, the preferential targ

79 Cardiac device implantation can be complicated by inability to adequately place leads be

80 g results obtained with different approaches are complicated by incongruence of experimental and comp

81 carotid-cavernous sinus fistula (CCF), which was complicated by increased intra-ocular pressure (IOP)

82 of fusion dates is common and interpretation is complicated by increasingly precise data obtained via

83 tic ecological responses to climatic warming are complicated by interactions between thermal effects

84 tential for coral adaptation to warming seas is complicated by interactions between symbiotic partner

85 erpretation of these optogenetic experiments is complicated by interactions that may occur within the

86 fficials, but estimation of the distribution is complicated by interval censoring of exposures.

87 en mortality, particularly when the syndrome is complicated by intracranial haemorrhage or brain infa

88 profound gastrointestinal manifestations and is complicated by intravascular volume depletion, shock,

89 This pathway is complicated by involvement of the orphan receptor Tie

90 s, women whose pregnancies with a male fetus were complicated by isolated LUTO were randomly assigned

91 rs prior to prediction is necessary, but may be complicated by issues such as noisy data and uncertai

92 ever, applying this to free-ranging settings is complicated by issues involving sample collection, pr

93 However, this task is complicated by issues of undersampling of the phospho

94 he diagnosis of von Willebrand disease (VWD) is complicated by issues with current laboratory testing

95 cancer stem cell phenotype, direct targeting is complicated by its expression in neurons.

96 g this domain with small-molecule inhibitors is complicated by its intrinsic disorder.

97 nt Staphylococcus aureus (MRSA) epidemiology is complicated by its transmissibility.

98 se (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID).

99 , it has been observed that ulcerated CH may be complicated by life-threatening bleeding episodes.

100 commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia.

101 nvoluting congenital hemangiomas (RICH) that were complicated by life-threatening bleeding episodes i

102 vant matrices is a formidable challenge that is complicated by limitations imposed by the Langmuir bi

103 t incidental intracranial saccular aneurysms is complicated by limitations in current knowledge of th

104 f the absolute brightness of this background is complicated by local foregrounds like the Earth's atm

105 Adult vulvar lichen sclerosis (VLS) may be complicated by loss of vulvar structure and vulvar ca

106 uitous physiological states, but their study is complicated by low levels of metabolic activity.

107 tive description of the interparticle forces is complicated by many obstacles that are not present, o

108 Exploiting lactobacilli has been complicated by metabolic diversity, unclear species

109 tion, dissociations obtained in many studies are complicated by methodological difficulties in obtain

110 ental measurement of this important property is complicated by micron-scale beam sizes, and the prese

111 Interpreting these data is complicated by multiclonal infections in humans, espe

112 unctional interactions between these regions are complicated by multiple direct and indirect hippocam

113 apour deposition (CVD) of graphene on copper are complicated by multiple processing steps and by high

114 and delirium in critically ill patients can be complicated by multiple factors.

115 correlates of protection for viral vaccines is complicated by multiple factors, but there is general

116 nant patient with inflammatory bowel disease is complicated by multiple providers, misinformation, an

117 cumenting the costs of medication behaviours is complicated by natural variation in the medicinal com

118 nditions are prevalent, iron supplementation is complicated by observations that iron deficiency anae

119 dentification of blasting-related NO3(-) can be complicated by other NO3(-) sources, including agricu

120 d actin assembly promoting host cell binding is complicated by other, potentially redundant EHEC-enco

121 Achieving this goal is complicated by our incomplete understanding of the me

122 However, the correct assignment of signals is complicated by overlapping and shifting signals in di

123 ation of serologic, urine and biopsy studies is complicated by oxalate accumulation in chronic renal

124 lammation using traditional immunostimulants is complicated by paracrine and autocrine signaling, whi

125 Longitudinal studies are complicated by participant dropout, which could be r

126 vaccination against chronic viral infections is complicated by pathogen genetic variations.

127 cation of robust PD susceptibility genes has been complicated by phenotypic diversity, underpowered a

128 in complex matrices by fluorescence methods is complicated by photodegradation, blinking, and the pr

129 y 90% of cases) and intramural hematoma, may be complicated by poor perfusion, aneurysm, or uncontrol

130 ructure of samples after deformation, and so are complicated by post-shock annealing and reverberatio

131 V) reactivation results in zoster, which may be complicated by postherpetic neuralgia, myelitis, meni

132 from latency causes herpes zoster, which may be complicated by postherpetic neuralgia.

133 95% confidence interval, 11%-59%) in 3 women were complicated by preeclampsia, a frequency greater th

134 Seven pregnancies (26%) were complicated by pregnancy-associated aHUS (p-aHUS),

135 Such inferences are complicated by presence of both fast and slow gates

136 may benefit appetite control but its utility is complicated by psychological influences on eating.

137 py for malignant and nonmalignant conditions is complicated by pulmonary infections.

138 His condition was complicated by pulmonary emboli and lobar infarction

139 This concern was complicated by questions about vaccine safety in pre

140 ) acute myeloid leukemia; however, their use is complicated by rapid development of resistance, which

141 ogically induced remission of this condition is complicated by relapses.

142 osis and C. difficile infections may however be complicated by relapsing courses.

143 Cryptosporidiosis was complicated by renal failure in 15 patients.

144 ective markers of disease; however, this has been complicated by reports of similar abnormalities in

145 g those undergoing vitrectomy after 3 months were complicated by retinal detachment, none of which re

146 Since somatic phylogenetics is complicated by sample heterogeneity, novel specialize

147 Fifty-six cases of PPV were complicated by SCH (1.03%).

148 RATIONALE: Sepsis can be complicated by secondary infections.

149 f the basin, and because interpretations can be complicated by sediment preservation, uncertainties i

150 of results using this pharmacological agent are complicated by several factors: poor SK1/2 selectivi

151 But interpreting fcMRI is complicated by several factors.

152 egnant donors with a previous pregnancy that was complicated by severe PE (sPE).

153 The patient's condition was complicated by severe sepsis with positive blood cul

154 regnancies with male offspring in one family were complicated by severe polyhydramnios and prematurit

155 led in antiretroviral therapy (ART) programs is complicated by short observation periods and loss to

156 promising approach, but in situ measurements are complicated by slow mass transfer of strongly hydrop

157 s sharing the same pathway with disease risk is complicated by small individual effects and intercorr

158 However, the energetics of cooperativity are complicated by solvent effects and the dynamics of i

159 However, this proposition is complicated by spatial and temporal heterogeneity.

160 Severe disease is complicated by spontaneous preterm delivery and still

161 I) quantum yields in optically dense systems are complicated by steep tissue light gradients due to s

162 tree mortality in the global carbon balance is complicated by strong spatial and temporal heterogene

163 hoA in promoting directed cell migration has been complicated by studies showing that it is activated

164 re for individuals with these conditions but is complicated by substantial clinical overlap in sympto

165 mples with pronounced topographical features is complicated by systematic and measureable shifts in t

166 letion with antithymocyte globulin (ATG) can be complicated by systemic coagulation activation.

167 e Chesapeake Bay because the bay restoration is complicated by temporally and seasonally variable nut

168 Solutions are complicated by tensions between private property and

169 Many homogeneous assays are complicated by the adsorption of probe molecules by

170 g the catalytic mechanism of decarboxylation are complicated by the difficulty of assigning the signa

171 gnitive dysfunction; however, these findings are complicated by the fact that ApoE knock-out mice hav

172 ine-elicited neutralizing antibody responses are complicated by the genetic and antigenic variability

173 Many surgeries are complicated by the need to anastomose, or reconnect,

174 in the human leukocyte antigen (HLA) region are complicated by the strong linkage disequilibrium in

175 is a common cause of hospitalization and can be complicated by the development of acute kidney injury

176 However, transplantation may be complicated by the development of mixed chimerism and

177 aluation of fitness consequences can notably be complicated by the existence of trade-offs among diff

178 h proliferation or ADC with cell death might be complicated by the interplay of multiple processes at

179 a more native environment, data analysis may be complicated by the normally found statistical orienta

180 lar biology research is non-trivial, and can be complicated by the presence of a diverse bacterial fl

181 etection and analysis of these molecules can be complicated by the presence of background matrix or c

182 ssociated congenital myasthenic syndrome may be complicated by the presence of myopathic features, bu

183 orces between such colloidal particles would be complicated by the presence of other effects, such as

184 cies without a reference genome sequence can be complicated by the presence of sequencing errors, par

185 Recently, this paradigm has been complicated by the demonstration that alterations i

186 ver, development of an effective vaccine has been complicated by the diversity of HCV genotypes, and

187 Prevention and treatment of SSIs have been complicated by the emergence of multidrug-resistant

188 However, development of CB1/2 agonists has been complicated by the need to avoid cardiovascular and

189 ibosome footprints is still unknown, and has been complicated by the recent observation of footprints

190 ctional characterization of Tet proteins has been complicated by the redundancy between the three fam

191 their identification in mammalian cells has been complicated by the size of these genomes.

192 ifferentiation using Bcl6-deficient mice has been complicated by the strong proinflammatory phenotype

193 l analyses of these distinct MP subsets have been complicated by the substantial overlap in their sur

194 secretion functions of these AT regions has been complicated by the use of multiple overlapping and

195 use interpretation of single absolute values is complicated by the abnormal cardiovascular hemodynami

196 s of childhood pulmonary tuberculosis (CPTB) is complicated by the absence of an accurate reference t

197 This task is complicated by the apparently low metabolism of these

198 ease, long-term dopamine replacement therapy is complicated by the appearance of L-DOPA-induced dyski

199 live oils cultivar and origin authentication is complicated by the broad range of variables (e.g., mu

200 rgeting this disordered release of cytokines is complicated by the changing cytokine milieu that driv

201 Gene therapy for patients with this disorder is complicated by the complex cellular abnormalities and

202 the in vivo potency of vitamin K antagonists is complicated by the complex multicomponent nature of t

203 Characterizing these interactions is complicated by the complexity of these communities an

204 tigation of the mechanism of protein folding is complicated by the context dependence of the rates of

205 als, their use in immunocompromised patients is complicated by the development of resistance.

206 development of inhibitors for these enzymes is complicated by the diversity and flexibility of their

207 Understanding CaM binding is complicated by the diversity of target proteins seque

208 Characterization of NifB-co in NifB is complicated by the dynamic nature of the assembly pro

209 rpretation of such decision-related activity is complicated by the effects of interneuronal "noise" c

210 However, detection of V. cholerae in water is complicated by the existence of a dormant state in wh

211 ed by the gamma-glutamylation pathway, which is complicated by the existence of multiple homologous e

212 Estimation of this potential hazard is complicated by the fact that chemical composition, wh

213 the brain's structural variance in the deaf is complicated by the fact that deaf individuals also di

214 e for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary cont

215 nithine at high concentrations by this assay is complicated by the fact that it also acts as a substr

216 n humans but understanding the role it plays is complicated by the fact that little is known about th

217 stical analysis of X-chromosomal information is complicated by the fact that males only have one copy

218 ollateral damage to healthy or to host cells is complicated by the fact that many proteins are very s

219 This issue is complicated by the fact that OTRs in finches and vole

220 However, its inhibition is complicated by the fact that PAK4 has both kinase-dep

221 The issue is complicated by the fact that prokaryotes may develop

222 Data interpretation is complicated by the fact that short sequencing reads c

223 unction in metastasis remains incomplete and is complicated by the fact that the four RSK isoforms pe

224 vital for human functioning, but the process is complicated by the fact that the incoming signal is o

225 This situation is complicated by the fact that the lung has two separat

226 The task is complicated by the fact that while sequence-based fea

227 This situation is complicated by the fact that, unlike in adults, the t

228 struts of a foam is not well understood and is complicated by the foam microstructure.

229 However, oral DNA delivery is complicated by the harsh and variable conditions enco

230 r years, the standardization of immunoassays is complicated by the heterogeneity of antibodies used a

231 Assessment and management of asthma is complicated by the heterogeneous pathophysiological m

232 losis in patients with HIV in eastern Europe is complicated by the high prevalence of multidrug-resis

233 However, dopamine analysis is complicated by the interference from other electroche

234 but in this case, the pretargeting approach is complicated by the internalization of 5B1 by CA19.9-e

235 ch as single-stranded nucleic acids (ssNAs), is complicated by the interplay of chain backbone entrop

236 single-cell level with current technologies is complicated by the lack of reliable methods to stably

237 Following the fate of SMCs is complicated by the lack of specific markers for the m

238 theses and quantifying the Moon's topography is complicated by the large basins that have formed sinc

239 However, finding relevant microarray data is complicated by the large number of available studies.

240 Microbial ecosystem modeling is complicated by the large number of unknown parameters

241 ge genes, PKD1 and PKD2, but genetic testing is complicated by the large transcript sizes and the dup

242 non-intensive care unit (ICU) hospital wards is complicated by the limited availability of evidence.

243 However, analysis of 4C-Seq data is complicated by the many biases inherent to the techni

244 erstanding how climate influences ecosystems is complicated by the many correlated and interrelated i

245 nfection of the central nervous system (CNS) is complicated by the mostly irreplaceable nature of neu

246 However, developing this technology is complicated by the multi-valley nature of silicon.

247 tion severity is less well understood, as it is complicated by the multifaceted nature of bacterial v

248 Restoration of the Bay is complicated by the multitude of nutrient sources, the

249 Predicting nonlinear partition coefficients is complicated by the number of model parameters to fit

250 However, the interpretation of RNAi screens is complicated by the observation that RNAi reagents des

251 following burn injury, and sepsis diagnosis is complicated by the ongoing inflammatory response.

252 mpact of these mutations on network activity is complicated by the plasticity of these networks, maki

253 The prediction of precipitation reactions is complicated by the porous nature of rocks and soils a

254 The decision to pursue an invasive strategy is complicated by the potential for procedural risks.

255 is of glycan microheterogeneity at this site is complicated by the presence of 72 additional potentia

256 ased topological insulators, their behaviour is complicated by the presence of a considerable residua

257 at sequence (GGGGCC); however, this approach is complicated by the presence of antisense strand trans

258 ass spectrometry (LC-MS) proteomics analyses is complicated by the presence of isobaric coeluting pep

259 rpes simplex virus 1 (HSV-1) entry mechanism is complicated by the presence of more than a dozen prot

260 Deployment of the resistance is complicated by the presence of multiple copies of the

261 andidate symptoms in retired athletes to CTE is complicated by the presence of multiple premorbid and

262 But the annotation of these tails is complicated by the presence of sequencing errors and

263 netic analysis of BMP signaling requirements is complicated by the presence of three partially redund

264 deling and simulation of biochemical systems is complicated by the problem of combinatorial complexit

265 Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at

266 standard of care" approach to its management is complicated by the recognition that long-term overall

267 enetic risk associations for prostate cancer is complicated by the relatively large number of risk va

268 Pharmacologic management is complicated by the risk of immunosuppressive therapy

269 Computational modeling of the HDDA reaction is complicated by the significant diradical character th

270 me rainfall events before the historical era is complicated by the sparsity of long-term "direct" sto

271 Defining this interface on a regional scale is complicated by the spatial variability of reaction ra

272 eatability, although a comparison of reports is complicated by the use of different methodologies and

273 s in the impaired processes in iput1 mutants is complicated by the vast compensatory changes in the s

274 holinergic modulation on particular circuits is complicated by the widespread projections of choliner

275 This exercise was complicated by the absence of a broadly accepted, sy

276 uation of the phenoxide activation mechanism was complicated by the concurrent activation of persulfa

277 experienced clinical benefit, and her course was complicated by the development of graft-related dysk

278 The reaction was complicated by the fact that the substrates containe

279 f ecologically relevant traits, however, can be complicated by their complex genetic, physiological,

280 e biological roles of their glycodomains has been complicated by their massive size, domain polymorph

281 Molecular diagnosis of skeletal dysplasias is complicated by their extreme clinical and genetic het

282 al loci from which Alu transcripts originate is complicated by their highly repetitive nature.

283 Measuring infant pain is complicated by their inability to describe the experi

284 tural analysis of proteins and nucleic acids is complicated by their inherent flexibility, conferred,

285 using depth-dependent quenching methodology is complicated by thermal motion in the lipid bilayer.

286 The situation is complicated by tight genetic associations across the

287 Although generally safe, thoracentesis may be complicated by transient hypoxemia, bleeding, patient

288 umor necrosis factor-alpha inhibitor therapy is complicated by tuberculosis reactivation and fungal i

289 The roles of autophagy in cancer treatment are complicated by two important discoveries over the pa

290 Teaching bioinformatics at universities is complicated by typical computer classroom settings.

291 Accurate CNA determination is complicated by uneven genomic distribution and non-un

292 oral information to modulate gene expression is complicated by unknowns regarding the number, structu

293 Long-term vitamin K antagonist therapy can be complicated by unstable international normalized rati

294 ress hyperexcitability; however, these drugs are complicated by unwanted effects on motor, central ne

295 Variant matching is complicated by variants that have multiple equivalent

296 irus type 1 (HIV-1) vaccine development that is complicated by variations in envelope (Env) subtype a

297 Interpretation of the data is complicated by variations in STH infection intensity

298 of molecular crystallization processes that are complicated by various molecular interactions and so

299 ndolent myeloproliferative neoplasm that may be complicated by vascular events, including both thromb

300 His stay in the intensive care unit was complicated by ventilator-associated pneumonia.