ライフサイエンスコーパス: be compromised

1 cGAMP, suggesting that the STING pathway may be compromised.

2 re, even data from these models is likely to be compromised.

3 ns that the polymeric scaffold integrity may be compromised.

4 cells in which tumor suppressor function may be compromised.

5 s, survival following cardiac remodeling may be compromised.

6 mph drainage into mesenteric lymph nodes may be compromised.

7 sible and clinical efficacy does not seem to be compromised.

8 e homeostasis if one neurotransmitter system is compromised.

9 orf6 and the major late capsid protein hexon is compromised.

10 erved in cells in which Rps6 kinase activity is compromised.

11 epair when resection is misregulated or NHEJ is compromised.

12 e where vasculature is deficient and healing is compromised.

13 sts with GBA1 mutations, suggesting that ALR is compromised.

14 s of the muscle in which the stem cell niche is compromised.

15 acinar differentiation in the adult pancreas is compromised.

16 hyperplasia is abrogated and worm expulsion is compromised.

17 iseases in which brain endothelial integrity is compromised.

18 is if the activity of the protease caspase-8 is compromised.

19 icases under conditions where their activity is compromised.

20 ch other in planta when the function of BIR1 is compromised.

21 ficiency might arise when the intake of milk is compromised.

22 and in disease states when barrier integrity is compromised.

23 cancer cell survival when the autophagy flux is compromised.

24 wth of fruit is blocked when miR172 activity is compromised.

25 when retinoic acid (RA) signaling in the eye is compromised.

26 orce-independent FAs, although cell polarity is compromised.

27 either the durability or the oil-repellency is compromised.

28 ensatory plasticity when one brain structure is compromised.

29 ork where either durability or functionality is compromised.

30 ve supplement when cellular energy provision is compromised.

31 R defects, where ATM/p53-dependent apoptosis is compromised.

32 erythematosus, can arise when TREX1 function is compromised.

33 e function of caveolae as membrane reservoir is compromised.

34 n the activity of regulatory T cells (Tregs) is compromised.

35 ution to many vascular complications when it is compromised.

36 rative diseases where the cholinergic system is compromised.

37 or the cell to divide when ring constriction is compromised.

38 l as for organismal survival when DNA repair is compromised.

39 ntial for DNA repair when the Mre11 nuclease is compromised.

40 y, when connectivity and associated behavior are compromised.

41 l disease only in hosts whose immune systems are compromised.

42 , chondrocyte proliferation and hypertrophy, are compromised.

43 pe of childhood seizures, cognitive outcomes are compromised.

44 limited, biotroph growth and/or development are compromised.

45 ile microglial-mediated clearance mechanisms are compromised.

46 DSB) repair by homologous recombination (HR) was compromised.

47 gyrus at time points where sparse activation was compromised.

48 were also up-regulated when the Rho function was compromised.

49 e endosomes, and as a consequence, signaling was compromised.

50 re lost from the CMs, and membrane integrity was compromised.

51 cinergic inhibition onto the same population was compromised.

52 ssion of structural proteins (GFAP and AQP4) was compromised.

53 development was established, but maintenance was compromised.

54 re defects (NTDs) arose and dorsal extension was compromised.

55 ygotes and found that blastocyst development was compromised.

56 O-GlcNAc, IL-2 production and proliferation were compromised.

57 ined under conditions in which the cytonemes were compromised.

58 y after the cessation of cuprizone treatment were compromised.

59 confirmed that the cellular p53 oscillations are compromised after miR-192 perturbations, matching we

60 phages, which provide an immune barrier that is compromised after liver injury.

61 we report that the DNA ligation step of BER is compromised after pol beta insertion of oxidized puri

62 e induction of phosphorylated Stat3 and RelA was compromised after IMQ treatment in the knockout mice

63 perties of the constituent conformations can be compromised and inaccurate, despite exhibiting high c

64 of areas where the intestinal epithelium had been compromised and demonstrated the potential use of t

65 t of this model, mechanical force production is compromised and cell proliferation is reduced in Yap

66 lpha/IL-13Ralpha1 (13R) heteroreceptor (HR), is compromised and determined whether the lack of signal

67 When mitochondrial quality is compromised and homeostasis is not re-established, my

68 ises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas, p

69 lypican when the SLT-1/slit guidance pathway is compromised and that LON-2/glypican functions in both

70 In aged flies, respiratory activity is compromised and the production of peroxide radicals i

71 MukBEF is impaired when MukB ATP hydrolysis is compromised and when MatP is absent, leading to a sta

72 s were sustained in states in which security was compromised and the risk of polio was high, partly o

73 Survival after CVD onset is compromised, and CVRFs are independent modifiers of C

74 Various human diseases occur if DNA repair is compromised, and most of these impact the nervous sys

75 oph, the production of key virulence factors is compromised, and the ability to infect nematodes and

76 of the MBF complex to its cognate promoters is compromised, and the induction of MBF target genes in

77 d with oxidized Kar2, although these alleles are compromised as an ATPase.

78 Islet function and survival may be compromised as a consequence of an incomplete islet B

79 nally, the viability of species with TSD may be compromised as climate gets warmer.

80 ity changes in conventional diffusometry can be compromised at low-abundance antigens because protein

81 ystems and explore how crystalline structure is compromised at elevated temperatures.

82 They were both precise, but trueness was compromised at the highest tested level with the Eva

83 equilibrium with the host, but when the skin is compromised, bacteria can colonize the wound and impa

84 n proteasome function, VCP, or gp78 activity is compromised, BOK is stabilized to induce MOMP and apo

85 during replication stress when CHK1 function is compromised but does not appear to be essential for r

86 nd engineered auxotrophies, these approaches are compromised by cross-feeding of essential metabolite

87 plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across

88 Those functions are compromised by mounting pressures on marine biodiver

89 (PPARgamma), but their therapeutic benefits are compromised by severe side effects.

90 f age coinfected with HIV or malaria, or who are compromised by sickle cell disease or severe malnutr

91 nst the T790M mutant, but their efficacy can be compromised by acquired mutation of C797, the cystein

92 that protects against daptomycin, which can be compromised by Agr-triggered toxin production or an e

93 apacity to survive future climate change may be compromised by changes in the fire regime.

94 olerability of some prostacyclin analogs may be compromised by concomitant activation of the E-prosta

95 ementation of such a multimodal approach can be compromised by conflicting requirements to optimize e

96 e and level differences (ITDs and ILDs), can be compromised by device processing.

97 ent-control protein modules (CCPs 1-20), may be compromised by disease-linked mutations.

98 Computers can be compromised by encoding malware in DNA sequences, and

99 eonatal host defense against infection could be compromised by immunosuppressive CD71(+) erythroid sp

100 te determination of metal concentrations can be compromised by microheterogeneity commonly referred t

101 t a low rate; the utility of avibactam might be compromised by mutations that increase this deactivat

102 However, their therapeutic efficacy can be compromised by NA changes that emerge naturally and/o

103 arantee that children's development will not be compromised by other hazards as they grow older.

104 erse transcriptase inhibitors (NtRTIs) might be compromised by resistance.

105 In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic

106 ell penetrating peptides and bioportides may be compromised by the general capacity of polycationic p

107 e in the case of Flp but not Cre, appears to be compromised by the pentad mutations.

108 RISPR-Cas9 and TALENs for genome editing may be compromised by their off-target activity.

109 roviding mycobacterial resistance that could be compromised by TNF neutralization.

110 forms whose internalization properties have been compromised by genetic perturbations within the car

111 ge complexes, but their clinical utility has been compromised by resistance.

112 The AASK-N repository urine samples have been compromised by the acetic acid preservative.

113 In diabetes, HIF-1alpha function is compromised by a high glucose-induced and reactive ox

114 trans-SNARE-regulating function of Munc18-1 is compromised by a mutation associated with Ohtahara Sy

115 hether the expression or function of PLCzeta is compromised by advancing male age.

116 Genomic integrity is compromised by DNA polymerase replication errors, whi

117 However, this is compromised by insufficient information about the eff

118 wever, its use as a nutraceutical ingredient is compromised by its low water solubility, chemical sta

119 Unexpectedly, the topoisomerase activity is compromised by K391/K436 SUMOylation, and this provid

120 ng highly transparent, but this transparency is compromised by light that is scattered and reflected

121 tact perirhinal (pRh) cortex function, which is compromised by meth-induced downregulation of GluN2B-

122 aser speckle contrast imaging (LSCI) systems is compromised by motion artefacts.

123 Therefore, translation of RVFV mRNAs is compromised by multiple mechanisms during infection.

124 Lateral rectus function sometimes is compromised by muscle attachment to the lateral orbit

125 consequently promote cellular proliferation, is compromised by mutations within the PWWP domain that

126 We also discuss how receptor regulation is compromised by oncogenic mutations and the structural

127 ent when Cdk1-cyclin B activation at the SPB is compromised by reduction of Cut12 function.

128 glucose-dependent vagal afferent signalling is compromised by relatively short periods of exposure t

129 s in patients with peripheral artery disease is compromised by restenosis and risk of stent fracture

130 However, its activity in saliva is compromised by salivary protease-mediated degradation

131 The accuracy of these assays is compromised by several issues including substrate ins

132 of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the con

133 glucose-dependent vagal afferent signalling is compromised by short periods of exposure to HFD well

134 Unfortunately, their utility is compromised by significant nephrotoxicity and polymyx

135 etal-coordinating C4C4 motif in RTEL1, which is compromised by the Hoyeraal-Hreidarsson syndrome (HHS

136 mer, the binding of HD1 and NU172 properties is compromised by thrombin inhibitors alone, as well as

137 Interim performance of the resource is compromised by variable sequence overlap and modest i

138 Cognition is compromised by white matter (WM) injury but the neuro

139 an initial period, when LNCaP cell survival was compromised by an arising population of neuroendocri

140 The stability of the vaccine was compromised by both high temperatures and dilution.

141 tency against multidrug-resistant cell lines was compromised by increased polarity.

142 us trans-Golgi compartment, a mechanism that was compromised by overexpression of GODZ.

143 Stability was compromised by repulsive electrostatic forces origin

144 phosphorylation-dependent channel activation was compromised by the introduction of disease-causing m

145 ape macerate, although accuracy for linalool was compromised by the presence of interferences.

146 Tumor angiogenesis in mouse PCa tissues was compromised by tissue-specific ablation of Frs2alpha

147 GK1 upregulation and cell survival functions were compromised by a pharmacological SGK1 inhibitor.

148 genic repeat elements and 5' distal VH genes were compromised by the Setd1a-cKO.

149 rived stem cells (ASCs) from visceral depots are compromised compared with those of ASCs from subcuta

150 it was assumed that their antitumor immunity was compromised compared with immunocompetent patients.

151 In the absence of PLST-1, polarization was compromised, cytokinesis was delayed or failed, and

152 If this interaction is compromised, cytokinetic precursors are asymmetricall

153 he transcriptional activity of wild-type p53 is compromised, despite its high expression level.

154 ia-smooth endoplasmic reticulum interactions are compromised due to decreased associations and decrea

155 not be examined and prediction accuracy may be compromised due to sampling.

156 itical circumstances, when the image quality is compromised due to high background scattering, high a

157 the absence of ALADIN, polar body extrusion is compromised due to problems in spindle orientation an

158 s, against intracellular pathogenic bacteria is compromised due to their inability to traverse eukary

159 ons in animals whose cross-modal experiences are compromised during early life fail to develop the ab

160 that communication between conspecifics may be compromised during critical biological periods.

161 at the integrity of germline DNA methylation is compromised during the aging process.

162 el of Parkinsonism, this nigro-vagal pathway was compromised during the early stages of motor deficit

163 dvantage when the respiratory control system is compromised (e.g., sleep apnea, apnea of prematurity,

164 in animals whose visual-auditory experience is compromised early in life by noise-rearing can develo

165 t (Dysf(-/-)) mice, in which membrane repair is compromised, either by transgenic expression of folli

166 ficient metabolism of this phytochemical may be compromised energy production.

167 ly vulnerable, disappearing when the cochlea is compromised even slightly.

168 vival of C. neoformans in a host environment was compromised even with the addition of exogenous aden

169 bility to decode memory on individual trials was compromised, even reversing, during attempts to conc

170 ical challenge to body fluid homeostasis may be compromised following RDN.

171 time-course dataset, and the performance may be compromised for datasets with a limited number of sam

172 Because the BBB can be compromised for days after stroke and thus further ex

173 ment to stalled replication forks, but which is compromised for the intra-S phase checkpoint.

174 beyond which tissue homeostasis and immunity is compromised for the long-term.

175 The T585P mutant was compromised for binding to OriP in vivo as well as f

176 After adjustment, OS was compromised for patients with nodal metastases compa

177 In contrast, the sensor performance was compromised for planar gold electrodes in the same c

178 We also found that the mutant proteins were compromised for peptide binding.

179 has a valid type I error rate, but the power is compromised given that all subjects are used for esti

180 ng declarative memory formation and how they are compromised in age-related memory loss remain hypoth

181 embly and alphaM/beta2 integrin localization are compromised in Arpc2(-/-) cells.

182 at Hdac8-deficient hematopoietic progenitors are compromised in colony-forming cell serial replating

183 lar integrity in the RPE and asked how these are compromised in models of macular degeneration.

184 o the cognitive and affective processes that are compromised in neurodegeneration as well as the prac

185 Arabidopsis pck1 and ppdk mutants are compromised in seed-storage reserve mobilization and

186 nvestigation revealed that phagocyte numbers are compromised in Sod2-deficient zebrafish.

187 ral connectivity among the DMN nodal regions are compromised in T2DM.

188 rupting NAC78 and its closest relative NAC53 are compromised in the activation of this regulon and no

189 agy-lysosome flux and mitochondrial function are compromised in the Drosophila nervous system and SRS

190 rylation-defective mutants of R-Ras and TC21 are compromised in their ability to promote cancer cell

191 where neurons with reduced levels of sacsin are compromised in their ability to recruit or retain Dr

192 of microglia to adequately produce IL-10 may be compromised in ALS.

193 ntial process of learning and memory and may be compromised in degenerative diseases, such as Alzheim

194 in early postnatal life whose functions may be compromised in human neurological disorders.

195 ways termed the glymphatic system, which may be compromised in the aging brain.

196 This proresolution system appears to be compromised in type 2 diabetes (T2D).

197 phagocytic activity of systemic immune cells is compromised in a Drosophila melanogaster model of Fra

198 red light induced but the induction of SPCH is compromised in a GATA gene mutant background, we hypo

199 SNpc, and to determine whether this pathway is compromised in a rat model of Parkinsonism.

200 GluR-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fra

201 Adherence to social norms is compromised in a variety of neuropsychiatric conditio

202 e systems, the NRF2-mediated stress response is compromised in aging and neurodegenerative diseases.

203 Such protective function is compromised in AGS patients and may be linked to unsc

204 ed DNAJB2a/HSP70 heat shock response pathway is compromised in amyotrophic lateral sclerosis.

205 and prevent new infections during pregnancy is compromised in areas with >90% prevalence of Pfdhps-K

206 small resistance adipose arteries, and this is compromised in arteries from diabetic patients.

207 inogenesis only occurs when Atp1b1a function is compromised in both the overlying periderm (resulting

208 integrin LFA-1 to the immunological synapse is compromised in Cav1-knockout T cells, as is the abili

209 w that autophagy lysosomal reformation (ALR) is compromised in cells lacking functional GCase.

210 e Deacetylase 6) and that FGFR3 accumulation is compromised in cells lacking HDAC6 or following treat

211 Sensory organisation of balance control is compromised in children with developmental coordinati

212 tic cell clearance activity or efferocytosis is compromised in diabetic wound macrophages.

213 key role in stability of mushroom spines and is compromised in different mice models of Alzheimer's d

214 e PKD proteins polycystin-1 and polycystin-2 is compromised in DZIP1L-mutant cells.

215 is revealed that antioxidant gene expression is compromised in flies with reduced Cdk12 function, whi

216 ized for the repair of oxidative DNA damage, is compromised in Foxo3(-/-) primitive hematopoietic cel

217 xpression of NMI (N-myc and STAT interactor) is compromised in invasive breast cancers.

218 ith the RNA-induced silencing complex (RISC) is compromised in MDD.

219 rons because of evidence that their function is compromised in MDD.

220 ontinues genome-wide when Mediator integrity is compromised in med17 temperature-sensitive (ts) yeast

221 Physical performance is compromised in mice which lack endothelial Piezo1 and

222 6)A target, and female-specific Sxl splicing is compromised in multiple m(6)A pathway mutants.

223 a and ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders, many o

224 al cortical recruitment in healthy subjects, is compromised in neuropsychiatric disorders.

225 ly implicated target genes, whose expression is compromised in Nfe2-null cells, and many other genes

226 Furthermore, this MI checkpoint is compromised in oocytes from aged mice.

227 REDD1 induction is compromised in ovarian cancer cells that do not respo

228 ngiogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral scle

229 ugs are injurious and hermaphrodite activity is compromised in plep-1 mutants, so the allele might be

230 ion is higher and the immunity to B. cinerea is compromised in pmei10, pmei11, and pmei12 mutants wit

231 clearance of aggregation-prone proteins that is compromised in R47H carriers and may accelerate the c

232 NA-protein crosslinks in vivo whose function is compromised in Ruijs-Aalfs syndrome patients.

233 sponses, develops in a protracted manner and is compromised in several prevalent neurodevelopmental d

234 ver, the magnitude of the therapeutic effect is compromised in smokers compared with non-smokers.

235 owever, protection against end fusions in G1 is compromised in the absence of Rap1.

236 achyrhizi and Blumeria graminis f.sp. hordei is compromised in the Arabidopsis cam7 and pen3 cam7 mut

237 (SARD1) because induction of these TF genes is compromised in the che-2 mutant.

238 This population of endothelial cells is compromised in the double mutant, whereas excessive p

239 , the generation of ROS upon flg22 treatment is compromised in the PLC2-defficient plants, suggesting

240 yelin perturbations, the blood-nerve barrier is compromised in the presence of ectopic OPCs.

241 reported that ischemia-induced angiogenesis is compromised in type 2 diabetic mice.

242 g-radiation-induced DNA double-strand breaks is compromised in XRCC4 cells.

243 efficient Cse4 turnover as Cse4 degradation is compromised in yeast cells lacking RCY1 Excessive Cse

244 use the health of upwardly mobile minorities is compromised in young adulthood.

245 P1V3 eosinophils, monocytes, and lymphocytes was compromised in a platelet-dependent manner, and airw

246 However, coumarin exudation was compromised in abcg37 mutants only with respect to c

247 eration of small intestinal epithelial cells was compromised in an SseF/SseG-dependent manner, sugges

248 dritic cells by agonistic anti-CD40 antibody was compromised in chronically infected mice.

249 Reestablishment of tight junctions was compromised in EM and CX epithelial cells even after

250 6 in Arabidopsis, and immunity to Pma ES4326 was compromised in gae6 and gae1 gae6 mutant plants.

251 translocation of the NF-kappaB subunit c-Rel was compromised in gamma-secretase inhibitor-treated and

252 In addition, polar auxin transport was compromised in gsnor1-3, which was correlated with u

253 Instead, GC treatment was compromised in mice expressing a defective GR in the

254 rillary acidic protein-expressing astrocytes was compromised in the absence of testes and testosteron

255 tration by granulated activated carbon (GAC) was compromised in the presence of HA.

256 We found that TRPML1-mediated Ca(2+) release was compromised in these LSDs.

257 Mechanistically, IL-2 production was compromised in weakly stimulated T cells, affecting

258 fter 12 weeks of an HFD, blood flow recovery was compromised in WT mice, whereas it was fully recover

259 sing TNT-active GSTs AtGST-U24 and AtGST-U25 were compromised in biomass production when grown in the

260 rns in wild-type mice, but all these changes were compromised in CKO mice.

261 e other hand, cardiac structure and function were compromised in response to aortocaval shunt in both

262 t and glycolysis in activated CD4(+) T cells were compromised in the absence of the INSR, which was a

263 DR3(-/-) mice were compromised in their ability to maintain adequate n

264 oint triggered when TOG5-microtubule binding was compromised, indicating that TOG5 is essential for s

265 resulting niche, but stromal cell maturation is compromised, leading to a niche that is unable to sup

266 imer's disease, the microtubule cytoskeleton is compromised, leading to neuronal dysfunction and even

267 e increases, working memory (WM) performance is compromised more by distractors presented during WM m

268 TPs in vivo, and the activity of Pol epsilon is compromised more than lagging-strand polymerase Pol d

269 Interestingly, the observed induction of TH was compromised on silencing of MTA1.

270 c lupus erythematosus (SLE), this cross-talk was compromised; pDCs promoted plasmablast differentiati

271 When fetal growth is compromised, placental insufficiency must be distingu

272 ve cognitive performance when SCN timing has been compromised, possibly by coordinating activity in t

273 ed perfusion, the delivery of (18)F-FAZA may be compromised, potentially disturbing the association b

274 teoblast differentiation when glucose uptake is compromised, raising blood glucose levels restores co

275 , the nutritional value of the final product is compromised requiring double portion sizes, as compar

276 g sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction.

277 tained normally and neuronal differentiation is compromised: rx3-derived ff1b+ neurons, implicated in

278 l conditions, however, erythrocyte life span is compromised severely, which threatens the organism wi

279 ntial if the early Golgi syntaxin SedV(Sed5) is compromised, showing that the Golgi can function with

280 ch constitutes a fluid-filled porous medium, is compromised; straight-swimming cells unable to tumble

281 When RNase H2 is compromised, such as in Aicardi-Goutieres patients, g

282 in states or diseases where muscle function is compromised, such as myopathies, muscular dystrophies

283 When ATL function is compromised, the morphology of the endoplasmic reticu

284 ever, their utility in biological fluids can be compromised through denaturation induced by physiolog

285 Accumulation of PSII core proteins is compromised under these conditions in the presence of

286 In this model, barrier function is compromised upon exposure to inflammatory factors suc

287 ument protein pp150 and the formation of vAC was compromised upon endocytic inhibition.

288 cordingly, the viability of an frmRAB mutant was compromised upon exposure to TMAO.

289 ide insights into protective mechanisms that are compromised when nonhibernating species, such as hum

290 l that a proportion of maternal mitochondria are compromised when they fail to fuse normally, leading

291 ead of pathogens via hosts, this barrier may be compromised when host species are mobile.

292 n academic labs, persistence of the software is compromised when developers graduate, funding ceases,

293 ndependent of known nucleophagy pathways but is compromised when nuclear protein export is blocked.

294 particularly for infrequently mutated genes, is compromised when subjects carry different combination

295 kpoint blockade immunotherapy for metastases was compromised when NK cells lacked heparanase.

296 A major pathway that was compromised, when TCR signaling was suboptimal, was

297 nteracting domain formed by omega6 and core1 is compromised, which may be responsible for the entropi

298 etabolic processes and protein synthesis may be compromised, while genes involved in acid-base regula

299 ALT-activity assays may be compromised with co-existing vitamin B-6 deficiency.

300 e proximal and distal interphalangeal joints were compromised, without interphalangeal instability.