ライフサイエンスコーパス: be compromised by

1 were similar to flight TA muscles, yet power was compromised by 40% following flight.

2 nfection and the time of its occurrence have been compromised by a lack of systematic screening and t

3 cular epidemiological mapping of cholera has been compromised by a reliance on sub-genomic regions su

4 In diabetes, HIF-1alpha function is compromised by a high glucose-induced and reactive ox

5 of live-attenuated oral poliovirus vaccines is compromised by a high prevalence of diarrhoea and oth

6 orter in Muller cells of the diabetic retina is compromised by a mechanism involving oxidation.

7 trans-SNARE-regulating function of Munc18-1 is compromised by a mutation associated with Ohtahara Sy

8 In over half of human cancers, p53 function is compromised by a mutation in its gene.

9 tion or orientation of the C-terminal domain is compromised by a proline residue at position 572 or 5

10 ADR1-TADIV to activate transcription in vivo was compromised by a mutation in TAFII130/145.

11 GK1 upregulation and cell survival functions were compromised by a pharmacological SGK1 inhibitor.

12 Thus, neuromuscular transmission is compromised by AChR deficiency, fast channel kinetics

13 nst the T790M mutant, but their efficacy can be compromised by acquired mutation of C797, the cystein

14 e found that the induction of endogenous p21 is compromised by AD1-deficient p53 (p53(AD1(-))), AD2-d

15 In cells where AGT function was compromised by addition of the AGT inhibitor O(6)-be

16 hether the expression or function of PLCzeta is compromised by advancing male age.

17 iotics, which target the bacterial ribosome, is compromised by adverse effects related to limited dru

18 enetically determined drive for fetal growth is compromised by adverse intrauterine conditions.

19 that protects against daptomycin, which can be compromised by Agr-triggered toxin production or an e

20 e with surgery or radiation does not seem to be compromised by an initial trial of surveillance.

21 A clear interpretation of these studies has been compromised by an incomplete understanding of the s

22 mutagenesis with N-ethyl-N-nitrosourea (ENU) is compromised by an inability to monitor mutation effic

23 cern if the quality of an infant's milk diet is compromised by an inadequate or lack of supplemented

24 an initial period, when LNCaP cell survival was compromised by an arising population of neuroendocri

25 han in countries where immunisation programs were compromised by anti-vaccine movements.

26 cause disease only when the commensal flora is compromised by antibiotic therapy.

27 with lysine results in a catalytic rate that is compromised by at least 20-fold.

28 cted group of patients whose quality of life is compromised by atrial fibrillation, the recommended p

29 In other areas of Pakistan, SIAs have been compromised by attacks targeting polio workers, whi

30 However, the activity of DP can be compromised by binding to the acute phase serum prote

31 osis, unless its ceramide-induced activation is compromised by binding to PAR-4.

32 The stability of the vaccine was compromised by both high temperatures and dilution.

33 observation that the BRCA2/APRIN interaction is compromised by BRCA2 missense variants of previously

34 ause the digestive system of infected snails is compromised by C. lingua infection.

35 se polysaccharide biosynthetic machinery had been compromised (by carbon starvation, respiratory inhi

36 If caregivers' well-being is compromised by caregiving, it may bode poorly for tra

37 entiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-exp

38 tunately, the long-term use of these devices is compromised by cellular encapsulation.

39 Many innovative studies have been compromised by challenges in recruiting sufficient

40 apacity to survive future climate change may be compromised by changes in the fire regime.

41 However, therapeutic consistency was compromised by chromosomal position effects on vecto

42 the proliferation of cultured diploid cells is compromised by chromosome missegregation.

43 ter hematopoietic cell transplantation (HCT) is compromised by chronic GVHD.

44 However, benefits of HIV PIs are compromised by clinically important adverse effects,

45 Sexual function could be compromised by clitoral surgery.

46 dent spindle assembly using mitotic extracts was compromised by cohesin depletion, and it was rescued

47 buprenorphine-induced antinociception might be compromised by concomitant activation of ORL-1 recept

48 olerability of some prostacyclin analogs may be compromised by concomitant activation of the E-prosta

49 stage intermediate en route to kealiiquinone was compromised by concomitant O-demethylation upon trea

50 es essential when activity of these subunits is compromised by conditional mutations.

51 ementation of such a multimodal approach can be compromised by conflicting requirements to optimize e

52 nd engineered auxotrophies, these approaches are compromised by cross-feeding of essential metabolite

53 bserved when the peroxidase activity of Prx1 is compromised by Cys52 overoxidation or in the presence

54 on, repetitive DNA stability, and DNA repair are compromised by decreasing cohesin levels to 30% of w

55 However, p53 function could be compromised by defective signaling in the p53 pathway

56 egative stimuli E. coli LPS or P. aeruginosa was compromised by deficiency of CD18.

57 kemia, the BACH2-mediated checkpoint control is compromised by deletions, rare somatic mutations and

58 The survival of HSV-IL-2-infected mice was compromised by depletion of either IL-2, CD4(+), or

59 irectly influenced by Emx2 and that polarity is compromised by developmental defects in the sensory p

60 e and level differences (ITDs and ILDs), can be compromised by device processing.

61 nstrate that muscle mitochondrial efficiency is compromised by diet-induced obesity and is subsequent

62 erall performance of protein microarrays can be compromised by diffusion-limited kinetics.

63 or from degenerating SER whose function has been compromised by dilation.

64 ays, as well as their efferent counterparts, are compromised by disease or injury resulting in signif

65 ent-control protein modules (CCPs 1-20), may be compromised by disease-linked mutations.

66 This action is compromised by disease states affecting anatomical si

67 ng in protoplast transient expression assays is compromised by disruption of F-actin.

68 its function in controlling growth polarity was compromised by disruption of ROP1-dependent F-actin

69 est that the protective function of DJ-1 can be compromised by diverse perturbations in its structura

70 evels and restored fetal growth in mice that was compromised by DL-propargylglycine treatment, demons

71 Genomic integrity is compromised by DNA polymerase replication errors, whi

72 Computers can be compromised by encoding malware in DNA sequences, and

73 r step toward realizing a world where no one is compromised by epilepsy.

74 ructions based on carbon isotope proxies may be compromised by episodic outbursts of isotopically lig

75 Both steps might be compromised by excluded volume conditions that would

76 ty in fish to nC60 based on methods shown to be compromised by experimental artifacts.

77 nolayers terminates in a critical point have been compromised by experimental difficulties with Langm

78 ffects on epitope-tagged GLUT4 translocation were compromised by expression of T410A-PKC-zeta, T560A-

79 critical virulence factor, listeriolysin O, was compromised by FA modulation, suggesting that FAs pl

80 erentiated ES cells, p53 checkpoint pathways are compromised by factors that affect the nuclear local

81 gens, which have greater B cell involvement, is compromised by fetal growth retardation.

82 yzed inhibition of factor Xa by antithrombin is compromised by fibrinogen to a greater extent when Zn

83 One-carbon metabolism is compromised by folate deficiency and common genetic p

84 nction and that the function of beta-catenin is compromised by fusion to a transcriptional repressor

85 promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity.

86 o LTA-treated human aortic endothelial cells was compromised by gelsolin.

87 forms whose internalization properties have been compromised by genetic perturbations within the car

88 hypothesize that the bona fide pattern might be compromised by heterogeneity of multiple structural d

89 zing genomic analysis, but this analysis can be compromised by high rates of missing true variants.

90 however, compliance with these measures can be compromised by high staff turnover and heavy workload

91 he province of the private sector, have long been compromised by high rates of attrition (failure dur

92 lts suggest that the normal function of MLK3 is compromised by HIV-1 neurotoxins (Tat, gp120), result

93 raft survival after intraportal implantation is compromised by host innate immune responses and the p

94 ic treatments of micrometastatic disease may be compromised by hypoxic resistance.

95 g-term survival and function of islet grafts is compromised by immune rejection-related factors.

96 eonatal host defense against infection could be compromised by immunosuppressive CD71(+) erythroid sp

97 that sleep homeostatic and circadian factors are compromised by impairment of the automaticity and pl

98 channel, ClC-1, in Huntington disease muscle was compromised by improper splicing and a corresponding

99 Their expression was compromised by in vivo RNA interference (RNAi) deple

100 examination within 1 year was that the first was compromised by inadequate bowel preparation or incom

101 mechanical integrity of these materials may be compromised by inadvertent "sharp" contacts.

102 tency against multidrug-resistant cell lines was compromised by increased polarity.

103 The (18)F-SiFA-Z(HER2:2891) conjugate was compromised by increasing bone retention over time (

104 ntation for liver failure or dysfunction but are compromised by inefficient engraftment, cell dispers

105 p51 C terminus in nucleic acid binding that is compromised by inhibitor binding.

106 -independent survival to hematopoietic cells was compromised by inhibitors of PI3-kinase, as well as

107 of the colloidosmotic hypothesis appeared to be compromised by initial conflicts between model volume

108 However, this is compromised by insufficient information about the eff

109 r warning signal that the analytical results are compromised by interferences.

110 ic inheritance of stable gene expression can be compromised by interruption of DNA replication.

111 s, or the enzymatic siderophore pipeline may be compromised by intracellular superoxide stress or dam

112 reversed when the partial occlusion percept was compromised by introducing a small gap between the c

113 es of ligand interactions with human IFNAR-1 are compromised by its low affinity.

114 patients with gastrointestinal cancer could be compromised by its intrinsically low uptake by tumors

115 The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mis

116 wever, its use as a nutraceutical ingredient is compromised by its low water solubility, chemical sta

117 brain, and chronic treatment with bumetanide is compromised by its potent diuretic effect.

118 Unexpectedly, the topoisomerase activity is compromised by K391/K436 SUMOylation, and this provid

119 plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across

120 ng highly transparent, but this transparency is compromised by light that is scattered and reflected

121 al mediator of immunosurveillance, which can be compromised by locally sustained ligand expression bu

122 However, the interpretation of these results is compromised by long-term compensatory adaptation occu

123 y of multi-subunit coactivator complexes can be compromised by loss of a single subunit, underscoring

124 This impact can be compromised by low quality of probes within arrays, w

125 The redox stability of myoglobin (Mb) is compromised by many factors, including lipid oxidatio

126 lp maintain fetal growth when its own growth is compromised by maternal undernutrition.

127 as elevated and blood/brain barrier function was compromised by MCAO in WT mice.

128 e therapeutic efficacy of such compounds may be compromised by MDMX overexpression.

129 tact perirhinal (pRh) cortex function, which is compromised by meth-induced downregulation of GluN2B-

130 te determination of metal concentrations can be compromised by microheterogeneity commonly referred t

131 otochemical consumption or the oxygen supply is compromised by microvascular damage.

132 tion of 1-tert-butyl-2-methylenecyclopentane was compromised by migration of the double bond prior to

133 anoparticles increases as the pore structure is compromised by mild aging in phosphate-buffered solut

134 aser speckle contrast imaging (LSCI) systems is compromised by motion artefacts.

135 Those functions are compromised by mounting pressures on marine biodiver

136 r implicated in BAT thermogenesis that could be compromised by MSG treatment.

137 Therefore, translation of RVFV mRNAs is compromised by multiple mechanisms during infection.

138 lding of a larger protein, Rubisco (51 kDa), was compromised by multiplication, whereas that of a sma

139 Lateral rectus function sometimes is compromised by muscle attachment to the lateral orbit

140 y, positive regulator of DKF-1 activity that is compromised by mutation of Lys(298) or Trp(396).

141 Where gene function is compromised by mutation, the presence of multiple iso

142 the chain-terminating thioesterase reaction was compromised by mutation of the (active-site) serine

143 promoting complex/cyclosome (APC/C) function was compromised by mutation, and specifically inhibited

144 While protein stability was compromised by mutation, the specific activities of

145 ation status when the STUbL or Ufd1 pathways are compromised by mutations.

146 t a low rate; the utility of avibactam might be compromised by mutations that increase this deactivat

147 om mammalian cells, ESE function in S. pombe is compromised by mutations and increased distance from

148 The expansion mechanism is compromised by mutations that decrease the processivi

149 consequently promote cellular proliferation, is compromised by mutations within the PWWP domain that

150 However, their therapeutic efficacy can be compromised by NA changes that emerge naturally and/o

151 of a PIN that functions as a bistable switch is compromised by neglecting enzyme-substrate intermedia

152 thors studied this interaction when 1 system was compromised by neurological disease.

153 described here and specifically how they may be compromised by nonsteroidal anti-inflammatory drugs a

154 ay not be true when the blood-ocular barrier is compromised by ocular inflammation.

155 on process, and we show that this networking is compromised by off-target, bioenergetic effects of so

156 stimate strengths in excess of salt-bridges, are compromised by omission of the relevant anion in the

157 We also discuss how receptor regulation is compromised by oncogenic mutations and the structural

158 s, because survival of endothelial cells can be compromised by opening of the mitochondrial permeabil

159 arantee that children's development will not be compromised by other hazards as they grow older.

160 pe p53, the p53 transactivation activity may be compromised by other mechanisms.

161 cess of periodontal regenerative therapy may be compromised by our limited understanding of the wound

162 y cGMP-stimulated signaling events in tubule are compromised by overexpression of PDE5.

163 tion-mediated MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor

164 wever, the viability of iron-deficient flies is compromised by overexpression of mitochondrial ferrit

165 SGN survival is compromised by overexpression of the proapoptotic reg

166 us trans-Golgi compartment, a mechanism that was compromised by overexpression of GODZ.

167 on the epithelium and that these roles could be compromised by P. aeruginosa proteases.

168 Resistance is compromised by pad3 or coi1 mutations, suggesting tha

169 ntry, but reversal of the S-phase checkpoint is compromised by pairwise cyclin knockdown.

170 ves as a barrier to lumenal bacteria and can be compromised by pathologic Fas-mediated epithelial apo

171 rmation integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is

172 , the final visual and anatomic outcomes may be compromised by persistent retinal detachment, seconda

173 with cultured cells show that KIT activation is compromised by point mutations in amino acids critica

174 rt, highly conserved sequence whose activity was compromised by point mutations.

175 The yields are compromised by polymerization of the alpha-methylsty

176 Interpretation of many experiments is compromised by possible effects of the 3' structures

177 aser anterior capsulotomy integrity seems to be compromised by postage-stamp perforations and additio

178 Specifically, they were compromised by potentially biased patient recall.

179 shortened survival and their quality of life is compromised by progressive anemia, marked hepatosplen

180 Furthermore, the potency of some activators is compromised by proteasome inhibition, leading to the

181 es from ionization of C75, and DM reactivity is compromised by protonation of C41.

182 ndicating that damage-induced S-phase arrest was compromised by Rad1 loss.

183 Effective MPR-mediated delivery may be compromised by rapid clearance of infused enzyme by t

184 nction of the inflamed intestinal mucosa can be compromised by reactive oxygen metabolites that incre

185 When S phase is compromised by reducing the activity of dE2F-dDP by e

186 ent when Cdk1-cyclin B activation at the SPB is compromised by reduction of Cut12 function.

187 glucose-dependent vagal afferent signalling is compromised by relatively short periods of exposure t

188 ave shown that clearance of extracellular K+ is compromised by removal of the perivascular pool of th

189 ese oxygen atoms in the normal reaction that are compromised by replacement of oxygen with sulfur.

190 ity of its activated product, plasmin (hPm), are compromised by replacing these two amino acids by th

191 d on the role of Asp301 in substrate binding are compromised by reports of catalytic activity toward

192 Stability was compromised by repulsive electrostatic forces origin

193 Yet current drug therapies are compromised by resistance.

194 bal health burden and current drug therapies are compromised by resistance.

195 erse transcriptase inhibitors (NtRTIs) might be compromised by resistance.

196 oguanil, the clinical efficacy of which have been compromised by resistance arising through mutations

197 ge complexes, but their clinical utility has been compromised by resistance.

198 The use of beta-lactam antibiotics is compromised by resistance, which is provided by beta-

199 s in patients with peripheral artery disease is compromised by restenosis and risk of stent fracture

200 However, its activity in saliva is compromised by salivary protease-mediated degradation

201 ness of the test-and-slaughter policy may be being compromised by selection for cattle that are genet

202 In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic

203 The accuracy of these assays is compromised by several issues including substrate ins

204 (PPARgamma), but their therapeutic benefits are compromised by severe side effects.

205 We hypothesized that SL would be compromised by severe TBI.

206 of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the con

207 glucose-dependent vagal afferent signalling is compromised by short periods of exposure to HFD well

208 f age coinfected with HIV or malaria, or who are compromised by sickle cell disease or severe malnutr

209 Unfortunately, their utility is compromised by significant nephrotoxicity and polymyx

210 We found that Pto-mediated resistance was compromised by silencing of genes encoding two mitog

211 However, most reported studies have been compromised by small sample sizes and short observa

212 in "normal" liver tissue, but these studies were compromised by small sample size, limited age range

213 plastic deformation of bulk metallic glasses is compromised by strain softening and shear localizatio

214 owever, the efficacy of these approaches may be compromised by suboptimal adherence, decreased drug c

215 sides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in parti

216 ilament structure and how this stability can be compromised by subtle changes in macrolactone ring co

217 trials, but their therapeutic value seems to be compromised by systemic toxicity.

218 lization and drug-resistant activity of BCRP were compromised by T362A mutation.

219 ide the first evidence that Hh signaling can be compromised by targeting the HSC for disruption.

220 ble mRNAs in yeast when the decapping enzyme is compromised by temperature-sensitive alleles of eithe

221 While repressive functions of the ICR are compromised by the deletion regardless of tissue typ

222 IA methods are sensitive but are compromised by the lack of adequate specificity.

223 Scans late in the experiment are compromised by the loss of a defined plateau region

224 e the activities of several nuclear proteins are compromised by the polyQ mutation.

225 ut requires coherent illumination, which can be compromised by the complex high-pressure sample envir

226 T cell diversity may be compromised by the declining thymic output of new T c

227 However, the usefulness of oseltamivir can be compromised by the emergence and spread of drug-resis

228 ese synthetic antibiotics does not appear to be compromised by the existing resistance mechanisms, as

229 ell penetrating peptides and bioportides may be compromised by the general capacity of polycationic p

230 inflammatory conditions; its activity might be compromised by the IL-13 decoy receptor (IL-13Ralpha2

231 essed concern that any advantage in CR would be compromised by the observed on-study mortality, and e

232 e in the case of Flp but not Cre, appears to be compromised by the pentad mutations.

233 Such measurements can be compromised by the presence of a significant noninter

234 utics based on mini- or micro-constructs may be compromised by the presence of non-native protein jun

235 stly discriminate chromosomal position might be compromised by the propensity of oocyte kinetochores

236 regulate a number of rhythmic processes may be compromised by the time females reach middle age.

237 n after the study has been completed, it may be compromised by the unavailability of tissue specimens

238 rategy for AIDS chemotherapy that should not be compromised by the unusual genetic diversity of HIV-1

239 The AASK-N repository urine samples have been compromised by the acetic acid preservative.

240 indicate that water column structure has not been compromised by the degassing and local stability is

241 e original randomly assigned groups may have been compromised by the exclusion of 20.7% of women from

242 The single previous human study may have been compromised by the fixation method used and the pos

243 n hepatocytes, research in small animals has been compromised by the frailty of the current mouse xen

244 screening for novel tumor-specific drugs has been compromised by the lack of appropriate control cell

245 s, along with certain cancer treatments, has been compromised by the presence of multidrug transporte

246 ainst community Escherichia coli strains has been compromised by the spread of CTX-M beta-lactamase-p

247 their sensitivity and specificity have often been compromised by the use of complex mixtures of undef

248 rain function, not brain development per se, is compromised by the absence of MeCP2.

249 strate that the adhesive function of BT-R(1) is compromised by the Cry1Ab toxin, which acts as a sele

250 eptionally effective analgesic whose utility is compromised by the development of tolerance and depen

251 t that an Akt-mediated cell survival pathway is compromised by the diminished availability of PIP2 el

252 iable class of antibiotics, the carbapenems, is compromised by the growth, primarily in intensive car

253 etal-coordinating C4C4 motif in RTEL1, which is compromised by the Hoyeraal-Hreidarsson syndrome (HHS

254 DNAJB6 itself, suggest that DNAJB6 function is compromised by the identified G/F domain mutations.

255 and factors involved in overhang processing is compromised by the inability to easily and accurately

256 e performance of PCR-based assays in general is compromised by the inadequacy of experimental control

257 ment to patients with radiorecurrent disease is compromised by the lack of diagnostic tests with suff

258 delta in preserving genome stability, which is compromised by the loss of WRN in Werner syndrome.

259 iotic function in human spermatogenesis that is compromised by the mutant protein via dominant negati

260 ver, the clinical feasibility of this method is compromised by the necessity of arterial blood sampli

261 m for such studies is that statistical power is compromised by the need to control the false-positive

262 Diagnosis of MAC-based diseases is compromised by the need to cultivate these fastidious

263 ve, 25-NBD-cholesterol, has a structure that is compromised by the presence of a bulky NBD group and

264 galovirus (HCMV) following natural infection is compromised by the presence of immune modulation gene

265 alein, and their potency against cell growth is compromised by the presence of P-gp 170, suggesting t

266 t PM hERG structural and metabolic stability is compromised by the reduction of extracellular or intr

267 e maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the hu

268 etic recording media at ultra-high densities is compromised by the thermal 'flips'--magnetic spin rev

269 However, the utility of the SF-AP view is compromised by the variation in x-ray penetration in

270 Moreover, when biosynthesis was compromised by the absence of a fully functional DHP

271 d enzyme was dependent on Ca(2)+ content and was compromised by the calmodulin antagonist N-(6-aminoh

272 phosphorylation-dependent channel activation was compromised by the introduction of disease-causing m

273 ape macerate, although accuracy for linalool was compromised by the presence of interferences.

274 und that motility in an agar migration assay was compromised by the simultaneous absence of four enzy

275 e antiholin function of the deletion protein was compromised by the substitution of early-lysis misse

276 slation and NB-LRR-mediated virus resistance were compromised by the downregulation of Argonaute4-lik

277 sly, the stability and robustness of the ICP were compromised by the entrainment of air, N2, or gas m

278 nditions in aged transgenic and control mice were compromised by the profound differences in field po

279 genic repeat elements and 5' distal VH genes were compromised by the Setd1a-cKO.

280 diseases of some classes of antioxidants may be compromised by their autophagy-blocking properties.

281 RISPR-Cas9 and TALENs for genome editing may be compromised by their off-target activity.

282 , yet the biological potency of many analogs is compromised by their inefficient activation through c

283 T-DNA insertion mutant lines of Arabidopsis is compromised by their propensity to trigger transcript

284 essions will reduce blood flow, survival may be compromised by these interruptions.

285 tes that transcription of 17% of yeast genes are compromised by this mutation.

286 of RTX by measuring the CD19+ cell count may be compromised by this activity.

287 mer, the binding of HD1 and NU172 properties is compromised by thrombin inhibitors alone, as well as

288 Tumor angiogenesis in mouse PCa tissues was compromised by tissue-specific ablation of Frs2alpha

289 roviding mycobacterial resistance that could be compromised by TNF neutralization.

290 tes NO disproportionation to give 3 may have been compromised by traces of air in the nitric oxide so

291 ediated proximal and distal signaling events were compromised by TRAF3 deficiency.

292 st arterial phases that would otherwise have been compromised by transient motion.

293 rvival of patients with t(8;21)(q22;q22) may be compromised by treatment approaches that do not inclu

294 However, the specificity of the test is compromised by vaccination with the Mycobacterium bov

295 Postoperative alignment may be compromised by variability in preoperative measuremen

296 Interim performance of the resource is compromised by variable sequence overlap and modest i

297 xtinctions and postextinction recoveries may be compromised by variations in preservation and samplin

298 ctive APC function and T-cell activation can be compromised by viral immune evasion strategies, inclu

299 Cognition is compromised by white matter (WM) injury but the neuro

300 However, protein crystallography data may be compromised by x-ray photoreduction (XRP).