ライフサイエンスコーパス: be confirmed by

1 The positions of the bromine substituents were confirmed by 2D-NMR spectroscopic analysis and the

2 between isotopically distinct Cd end-members was confirmed by a Bayesian modeling approach.

3 stallographically observed binding interface was confirmed by a comprehensive cell-based binding assa

4 The mode of interaction with Ctf4 was confirmed by a crystal structure of the stapled Sld5

5 oma in an adult woman, in whom the diagnosis was confirmed by a CT-guided biopsy.

6 Interaction between miR-423-5p and HCN4 was confirmed by a dose-dependent reduction in HCN4 3'-u

7 very low-density lipoprotein receptor); this was confirmed by a RELN-binding assay.

8 r strongly stimulated the chlorination rates was confirmed by a second independent experiment showing

9 Local recurrence and inflammation were confirmed by a biopsy.

10 The formation of the oxide films were confirmed by a combination of powder X-ray diffract

11 The effect of cAMP on Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodi

12 A2AR signaling in these pathological changes was confirmed by alleviation of the impairment of AQP4 p

13 with evidence of deletion, parasite presence was confirmed by amplifying three independent genes.

14 The predictive ability of the models was confirmed by an external validation procedure with a

15 sent evidence that our experimental findings are confirmed by analyses of 1 million actual hospitalit

16 d predictive power of these genetic features were confirmed by analyses of common epialleles in natur

17 NLRP1 expression in melanoma was confirmed by analysis of 216 melanoma tumors and 13

18 Accuracy was confirmed by analysis of a standard reference materi

19 The validation method was confirmed by analysis of rice flour certified refere

20 Furthermore, the universality of the assay was confirmed by analyzing different strains of influenz

21 The accuracy of the method was confirmed by analyzing the standard reference materi

22 g inflammasome to be targeted by ZIKV, which was confirmed by analyzing the transcript levels of the

23 The results of potentiometric measurements were confirmed by argentometric titration.

24 HBc particle morphology was confirmed by Atomic Force Microscopy (AFM).

25 The identity of seven substances was confirmed by authentic reference standards, all of w

26 al pure primary ovarian choriocarcinoma that was confirmed by beta human chorionic gonadotropin (beta

27 LRRK2 carrier status was confirmed by bidirectional Sanger sequencing.

28 Here, this genomic-based target assignment is confirmed by biochemical assays, chemical proteomics

29 Seventy-five Nm urethritis cases were confirmed by biochemical and polymerase chain react

30 Disease progression was confirmed by biopsy for all patients in the case of

31 The eVP40-WWP1 interaction was confirmed by both peptide pulldown and coimmunopreci

32 HIV provirus gene-editing were confirmed by cell genomic DNA PCR and fluorescent m

33 due to their structural rearrangement, which was confirmed by changes in Q band of VIS spectra.

34 perturbations expected from such modulation are confirmed by chemical shift changes in both observed

35 The reduction was confirmed by chemical studies that enabled the compl

36 ucts formed from 8,9-EET in this COX pathway were confirmed by chemical synthesis: ct-8,9-epoxy-11-hy

37 suggested a novel mechanism of action, which was confirmed by chemoproteomic analysis leading to the

38 This was confirmed by ChIP-seq and RNA-seq analyses, showing

39 unctions of ferritin based bionanocages have been confirmed by chronoamperometry (CA) and open circui

40 , heat shock cognate 70-kDa protein, and OGT were confirmed by co-immunoprecipitation.

41 The partnership of UGT1A_i2 and PKM2 was confirmed by coimmunoprecipitation in the HT115 colo

42 and the genome terminal protein (P4), which was confirmed by coimmunoprecipitation of recombinant pr

43 of cancer cells in vitro and in vivo, which were confirmed by colony formation assay, transwell inva

44 ction overlap between the host and the guest is confirmed by combined molecular dynamics and density

45 and predictive ability of the proposed model are confirmed by comparing the results of calculations w

46 This is confirmed by comparing input versus pulldown high-thr

47 The specificity of (64)Cu-CBP7 for collagen was confirmed by comparison with a nonbinding isomer.

48 rometry (GC x GC-TOF-MS), and their identity were confirmed by comparison with authentic standards an

49 This is confirmed by computational simulation, suggesting tha

50 The differential reactivity was confirmed by computational modeling of the electroni

51 t of the fluids down the microchannel, which were confirmed by computational fluid dynamics.

52 The recommendations were confirmed by confidential electronic voting; approv

53 This result was confirmed by confocal microscopy experiments.

54 ecessive model of inheritance, and causation was confirmed by CRISPR/Cas9 gene targeting.

55 development in zebrafish, and these results were confirmed by CRISPR knockout.

56 The diagnosis was confirmed by CT-guided biopsy.

57 A, and interferon regulatory factor 2 (IRF2)-were confirmed by custom assays.

58 This organization is confirmed by cysteine cross-linking in full-length re

59 The basophil-targeting effect of ibrutinib was confirmed by demonstrating that IgE-dependent histam

60 be elicited by host immune responses, which is confirmed by depletion studies of human immunoglobuli

61 Virus growth was confirmed by detailed electron microscopic studies t

62 position of the phenol structure of THC-COOH was confirmed by detection of monochlorinated byproduct

63 ally confirmed pneumococcal pneumonia (MCPP) was confirmed by detection of pneumococcus in a relevant

64 The NMR experimental data obtained were confirmed by DFT quantum chemical calculations and

65 The AuNPs-rGO nanocomposite was confirmed by different physicochemical characterizat

66 ic, were conserved across species, and could be confirmed by differential migration behavior of prote

67 d in catecholamine-treated TTS-iPSC-CMs, and were confirmed by differentially expressed lipid transpo

68 of interaction between PvTRAg38 and basigin was confirmed by direct interaction where basigin was sp

69 nteraction with the endocytic pathway, which was confirmed by direct measurement of fluid-phase endoc

70 ed 17 additional pathogens, 7 of which could be confirmed by discrepant testing.

71 of arxA in photosynthetic arsenite oxidation was confirmed by disrupting the gene in a representative

72 Hen's egg allergy (secondary outcome) was confirmed by double-blind, placebo-controlled food c

73 ysate by Western blot and mass spectrometry, was confirmed by dual immunohistochemical staining using

74 This was confirmed by duodenoscopy with simultaneous injectio

75 At week 6, PH status was confirmed by echocardiography, and rats were randoml

76 f interictal and ictal epileptiform activity was confirmed by either stereo-electroencephalography or

77 This equilibrium is confirmed by electron interchange reactions between n

78 ion of Au25 (SG)18 in the two nanocomposites is confirmed by electron microscopy, and the accessibili

79 ated envelope abnormalities, that is, blebs, were confirmed by electron microscopy and immunofluoresc

80 in an unbiased small molecule screen, which was confirmed by electrophysiological analysis.

81 The predictions were confirmed by electrophysiological experiments, reve

82 Rescue of visual function was confirmed by electroretinography.

83 tability of the XB capsules in the gas phase was confirmed by electrospray ionization mass spectromet

84 Chelator conjugation was confirmed by electrospray ionization-mass spectromet

85 The proportion of Li(+) ions has also been confirmed by elemental analysis, whereas powder X-r

86 Binding of IgE and IgG to BGG was confirmed by ELISA and completely abolished after pr

87 This was confirmed by ELISA-based analysis of the TREM2-TYROB

88 Compounds of interest were confirmed by eluting zones using a TLC-MS interface

89 The purity and phase composition were confirmed by energy dispersive X-ray spectroscopy a

90 ailable standards, while the other compounds were confirmed by exact mass search of their deprotonate

91 The PMF results were confirmed by examining three samples that contained

92 e top prediction results for the new dataset are confirmed by experimental studies or supported by ot

93 This is confirmed by experimental and theoretical evidence of

94 The theoretically expected migration order was confirmed by experimental results with selected Ag N

95 A part of this network was confirmed by experimental work in the original paper

96 This finding was confirmed by experimentally determined folding and u

97 This prediction was confirmed by expression in cell models, which showed

98 This scenario is confirmed by extensive numerical simulations and vali

99 Membranous location was confirmed by flow cytometry of viable non-permeabili

100 phage on carbon nanotube-modified electrode was confirmed by fluorescence microscopy.

101 The role of this NLS was confirmed by fluorescent imaging of wild-type and NL

102 Integration of (f)Si NP with cells was confirmed by FT-IR analysis.

103 presence of BLEO components in treated juice was confirmed by FTIR spectroscopy.

104 Formation of metal-chlorophylls complexes was confirmed by FTIR spectroscopy.

105 ions between polymer chains and antioxidants were confirmed by FTIR where spectra displayed a shift o

106 Identity was confirmed by full-genome sequencing and was not attr

107 f this domain to Importin alpha1 (Impalpha1) was confirmed by gel filtration and NMR studies.

108 Plastid transformation was confirmed by GFP accumulation from the second open r

109 Accuracy was confirmed by good correlation between patient serum

110 O mutant has a metabolic disadvantage, which was confirmed by growth pattern analysis using phenotype

111 C activation on epithelial barrier leakiness was confirmed by HDAC inhibition, which improved barrier

112 This distribution is confirmed by high-resolution numerical modeling outpu

113 Muscle structural differences were confirmed by histological analyses of the gastrocne

114 d true-positive if the positive primary site was confirmed by histology or follow-up imaging.

115 atom and cyanobacterial photopigments, which were confirmed by HPLC-analysis.

116 ommon organic solvents, and their identities were confirmed by HRMS and detailed 1D and 2D NMR spectr

117 Gene expression was confirmed by IHC for GAGE, SOX9, AMH, CYP17A1, LIN28

118 mouse xenograft models using (124)I-CLR1404 was confirmed by imaging.

119 The expression of KCa3.1 in vivo was confirmed by immunofluorescence staining on multinuc

120 essing of human renin in dense core granules was confirmed by immunogold labeling.

121 Detection of membrane-bound TLN was confirmed by immunohistochemistry and fluorescence a

122 ization of gamma-tubulin-1 in mature neurons was confirmed by immunohistochemistry and immunofluoresc

123 arget expression in tumor, lung, and stomach was confirmed by immunohistochemistry.

124 ning set established weighted factors, which were confirmed by immunohistochemistry.

125 These results were confirmed by immunohistochemistry.

126 The exposure of PS on the HCV envelope was confirmed by immunoprecipitation of HCV particles wi

127 The diminished scratching behaviour was confirmed by impaired response to several pruritogen

128 ynaptojanin-1 by R1441C hLRRK2 could further be confirmed by in vitro kinase assays.

129 Coincident virologic clearance was confirmed by in situ hybridization and a failure of

130 The down regulation was confirmed by in situ hybridization histochemistry fo

131 in vivo P640L variant's ethosuximide effect was confirmed by in vitro electrophysiological studies.

132 KSHV infection of neurons was confirmed by in vitro infection of primary human neu

133 o mediate GM-CSF and IL-17 mRNA decay, which was confirmed by in vitro luciferase assay.

134 This was confirmed by in vitro measurement of IFN-gamma produ

135 and IL-22 occurred at the level of PGE2 This was confirmed by in vivo cyclooxygenase 2 inhibition, wh

136 These observations were confirmed by in vivo animal studies showing prefere

137 Inflammation in MG and conjunctiva was confirmed by increased cytokine gene and protein exp

138 Local T-cell activation was confirmed by increased tumor infiltration with CD103

139 Covalent bond formation to Cys-154 was confirmed by incubation of the inhibitors with wild-

140 t not extensive replication of the pathogen, was confirmed by infections with SCHU S4 DeltapurMCD, a

141 f secondary structure in the silk constructs was confirmed by infrared spectroscopy and X-ray diffrac

142 The immobilization was confirmed by intensity changes in the main near band

143 The structure of [(Ph3P)6Cu6H5](+) has been confirmed by its conversion back to (Ph3P)6Cu6H6 an

144 Function of one such lead compound was confirmed by its activity in suppressing influenza v

145 This was confirmed by its major metabolite norfluoxetine whos

146 Shc activation was confirmed by its tyrosine phosphorylation.

147 (35%) cases, congenital Zika virus infection was confirmed by laboratory tests and no controls had co

148 For primary analysis, cases were confirmed by laboratory isolation or detection of N

149 If these results can be confirmed by larger and well-controlled studies, it m

150 sition of oxidized form of Clark I and/or II was confirmed by LC-HESI/HRMS.

151 o two hours and the structures of hydrazones were confirmed by LC-MS for the first time.

152 The apoptotic potential of TRAIL-R2 on hHSC was confirmed by lentiviral-mediated knockdown.

153 gLASSO, UBE2S, SALL2, XBP1 and KIAA0922 have been confirmed by literature survey to be highly relevan

154 terestingly, 13 (out of the 15) associations were confirmed by literature mining.

155 in-orbit torque on the CoNiCo magnets, which is confirmed by macrospin calculations and micromagnetic

156 s to a large ground spin state (ST =16) that is confirmed by magnetization studies up to 20 Tesla.

157 The presence of native acrylamide was confirmed by mass analysis at m/z=71 ([C3H5NO](+)) a

158 The presence of SI was confirmed by mass spectrometry.

159 More importantly, correct pairing was confirmed by mass spectrum.

160 The diagnosis of influenza infection was confirmed by means of RT-PCR assay and culture of na

161 These observations were confirmed by measurement of electron transfer rates

162 vity for diagnosing pertussis; the diagnosis is confirmed by measuring serum anti-pertussis toxin (an

163 acy of application-detected hospitalizations was confirmed by medical record review as the reference

164 566 incident endometrial cancer occurrences were confirmed by medical record review.

165 Incident invasive breast cancer cases were confirmed by medical record review.

166 vanced AMD cases (primarily neovascular AMD) were confirmed by medical record review.The multivariabl

167 inity of the transition state barrier, which is confirmed by microcanonical statistical theory that i

168 This was confirmed by mitochondrial electron transporter chai

169 Their greater dough strength and stability were confirmed by mixograph and were associated with hig

170 The experimental evidence from these studies is confirmed by molecular dynamics (MD) simulation in th

171 termediates from one transition state, which is confirmed by molecular dynamics simulations.

172 ase of these nanoparticles into the solution was confirmed by monitoring their catalytically amplifie

173 The structures of the compounds were confirmed by MS, FTIR &(1)H NMR; and their properti

174 functional roles in the germination process were confirmed by mutant analysis.

175 Ester bond formation was confirmed by nuclear magnetic resonance technique th

176 Species and subgroup identifications were confirmed by nucleic acid-based methods and include

177 tracellular recognition of SVLP TLR2 ligands was confirmed by observing SVLPs' association with inter

178 A cervical basis for the parturition delay was confirmed by other ex vivo tests including decreased

179 In 14 cases (87.5%), bleeding was confirmed by other methods.

180 s the observed GPP well (R(2) = 0.79), which was confirmed by other model performance checks that com

181 RNA Gas5 that blocks c-Myc expression, which was confirmed by overexpression studies.

182 n the one cultivated at 96h, these behaviors were confirmed by PCA analyses.

183 ts of miRNA-targeted ARFs in C. roseus cells was confirmed by Poly(A) Polymerase-Mediated Rapid Ampli

184 The two-dimensional kagome structure has been confirmed by powder X-ray diffraction, high-resolut

185 Results were confirmed by propensity score analysis.

186 eraction between ATP5alpha and FANCD2, which was confirmed by protein docking analysis.

187 of these genes have RNA-seq evidence and 87% were confirmed by proteomics.

188 NLS-CSU when compared with HCs, 31 (79.48%) were confirmed by qPCR corresponding to genes involved i

189 n in response to the aforementioned stresses was confirmed by qRT-PCR analysis in distinct Arachis ge

190 Results were confirmed by qualitative pollen analysis.

191 ression patterns in the venom gland and this was confirmed by quantitative real-time PCR (qPCR) analy

192 ignificant up-regulation of 31 and 30 miRNAs was confirmed by quantitative reverse transcriptase PCR

193 This was confirmed by quantitative reverse transcriptase PCR

194 n situ identification of PTX3 in skin lesion was confirmed by quantitative reverse-transcription poly

195 X7, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, and P2Y13 was confirmed by quantitative RT-PCR and immunocytochemi

196 2D NMR spectroscopic data and the assignment was confirmed by quantum mechanics-based NMR chemical sh

197 i-layer h-BN film with a thickness of 5-6 nm is confirmed by Raman spectroscopy, scanning electron mi

198 This theoretical prediction is confirmed by real-time transmission electron microsco

199 miR-21, miR-146b, miR-155 and miR-132, which were confirmed by real-time polymerase chain reaction an

200 disuse atrophy together with Trim63 (MuRF1), were confirmed by real-time quantitative RT-PCR, and DNA

201 the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic par

202 , implicating early pregnancy factors, which was confirmed by reduced expression of BAT markers in pr

203 tion of excess CHOP to this ER stress injury was confirmed by reduction in TM-induced cell death when

204 Removal of cells and antigens was confirmed by reduction of DNA and antigen markers ne

205 ericardial AT in mediating all these effects was confirmed by removal of pericardial AT and ex vivo c

206 An excellent precision was confirmed by repeatability (RSD (%)=0.30) and interm

207 f incident AMD during follow-up through 2007 were confirmed by reports from participants' physicians

208 Specificity of antibodies toward TraM was confirmed by results of an opsonophagocytic inhibiti

209 1 is involved in regulating CDKN2A This idea was confirmed by RNAi-mediated suppression or genetic de

210 he downregulation of individual transporters was confirmed by RT-PCR.

211 ought and in different genotypes and organs, were confirmed by RT-qPCR Corresponding target transcrip

212 for the creation of the 2D block co-micelles was confirmed by selected area electron diffraction anal

213 The efficacy of the enzymatic pretreatment was confirmed by SEM and FTIR.

214 The tumour-specific origin of HBB is confirmed by sequence polymorphisms within human xeno

215 Positive results were confirmed by sequencing.

216 cancer activity was apoptosis-dependent that was confirmed by severe alterations in cellular morpholo

217 relevance of the observed motional quenching is confirmed by significant reductions in glutaminase ki

218 This was confirmed by silencing STAT3 in macrophages.

219 emission rates and terrain elevations, which are confirmed by similar correlations between satellite-

220 These analytical results are confirmed by simulation.

221 The power of the proposed framework was confirmed by simulation and a Populus szechuanica va

222 part of the Li(+) ions in the new CD-MOF has been confirmed by single-crystal X-ray analysis by deter

223 The magnetic origin of the long-lived states is confirmed by single-atom electron spin resonance on a

224 h AgNPs and dissolved silver in the extracts was confirmed by single particle (SP)-ICPMS analysis.

225 This was confirmed by single value decomposition of CD and UV

226 Destabilization of the SRX by piperine was confirmed by single-nucleotide turnover measurements

227 parisons of Tag-seq and RNA-seq data, and 44 were confirmed by single cell RNA-seq.

228 The structures of 5 and 6 were confirmed by single crystal X-ray diffraction measu

229 IAS tone; these tissue contractile responses were confirmed by single-cell contraction using magnetic

230 actions in both the solid and solution state were confirmed by single-crystal X-ray analyses and thei

231 The key structures were confirmed by single-crystal X-ray diffraction.

232 yl-pyran in the pore lumen, which could both be confirmed by site-directed mutagenesis and electrophy

233 The structure is confirmed by site-directed mutagenesis and provides a

234 t biological function of these binding sites was confirmed by site-directed mutagenesis.

235 This was confirmed by specific LCK gene silencing and ex vivo

236 ructures of phenoylated phosphatidylcholines were confirmed by spectral analysis.

237 The unusual secondary structure of 1 was confirmed by spectroscopic approaches including solu

238 n as a high affinity molecular target, which was confirmed by SPR and crystallography.

239 This was confirmed by SQUID monitoring during H2 release from

240 Diagnosis of MCC was confirmed by staining positive for cytokeratin 20 (C

241 Results of RT-PCR and sequencing were confirmed by staining cell cultures with a panel of

242 The physical mechanism of the SHGs is confirmed by studying the dependences of the output p

243 toxicity sparing, but this has only recently been confirmed by substantial clinical data.

244 agnosis of MD or mixed IPMN and in whom IPMN was confirmed by surgical pathologic findings at a singl

245 naphtho[2,1,8-def]chromen-2-one (NCO), which was confirmed by synthesis.

246 th human mesenchymal stem cells, and results were confirmed by targeted analysis with multiple reacti

247 The existence of the unintentional donor is confirmed by temperature dependent admittance spectro

248 simulant and excised neonatal porcine skin) were confirmed by texture analysis and optical coherence

249 This is confirmed by the distribution of the AQP1 water chann

250 rent active site requirement for WGS and DRM is confirmed by the experimental evaluation of the activ

251 pacities increase after bio-treatment, which is confirmed by the increase of micropore surface area.

252 ulk superconductivity at about 0.25 K, which is confirmed by the zero resistivity, AC magnetic suscep

253 e at 485 and 780 cm(-1), respectively, which was confirmed by the 1.83 A Fe-O bond observed by XAS.

254 amount of lycopene in soluble fraction which was confirmed by the appearance of lycopene crystals whe

255 ignificant artifacts were observed, and this was confirmed by the comparison of depth profiles obtain

256 This estimate was confirmed by the G-PhoCS estimates of divergence tim

257 iciency of viral isolation from swab samples was confirmed by the limit of detection (as low as 0.1 P

258 This prediction was confirmed by the natriuretic response to diuretics t

259 This prediction was confirmed by the natriuretic response to diuretics.

260 The configuration of the products was confirmed by the observation of through-space (13)C-

261 The clinical relevance of the result was confirmed by the significant interaction between LHP

262 ing the onset of apoptosis of LX-2 cells, as was confirmed by the terminal deoxynucleotidyl transfera

263 ed-dose and partial-breast radiotherapy, and was confirmed by the test against the critical HR being

264 This observation was confirmed by the X-ray structure of 11m bound to Glu

265 from the molecularly imprinted polymer (MIP) was confirmed by the XPS analysis.

266 circled DDA on the MPA and cysteamine layers were confirmed by the increased redox reaction.

267 Striatal ROI outcomes were confirmed by the voxel-based analyses that addition

268 enberger-Horne-Zeilinger and W states, which is confirmed by tomographical reconstruction of single-p

269 The characterization was confirmed by transmission electron microscopy, X-ray

270 Formation of core-shell type nanostructures was confirmed by transmission electron microscopy.

271 within the injured xiphoid cartilage, which was confirmed by TUNEL assay.

272 This is confirmed by two-dimensional Particle-in-Cell (2D3V P

273 Refolding was confirmed by ultrafast broadband transient absorptio

274 lization of excitons in the shell domain, as was confirmed by ultrafast transient absorption and emis

275 The mechanism of AAC was confirmed by ultrasound biomicroscopy.

276 Efficient lineage-specific differentiation was confirmed by uniform NCAM1 and myosin heavy chain ex

277 Recent ZIKV infection was confirmed by urine reverse-transcription polymerase

278 The generic design rationale is confirmed by using nonspherical particles, which deve

279 The pathway was confirmed by using cultured neurons treated with rec

280 Binding to native M. tuberculosis proteins was confirmed by using M. tuberculosis culture filtrate

281 The robustness of the study results was confirmed by using various immune metagenes in the s

282 nd mycobacteria growth indicator tube (MGIT) were confirmed by using rpoB gene sequencing, which rais

283 photon response and photo-absorption, which were confirmed by UV/Vis-NIR diffuse reflectance spectra

284 able positioning using the fluke and flipper was confirmed by video data for both the downward and up

285 This finding was confirmed by visualising FLS2 and BRI1 within distin

286 tly of age, gender and infarct volume, which was confirmed by voxel-based lesion-symptom mapping.

287 OPN expression was confirmed by Western blot and ELISA, and OPN was pur

288 lipid rafts with HCV-induced autophagosomes was confirmed by Western blotting, immunofluorescence mi

289 expression of LSA3 in blood-stage parasites was confirmed by western blotting.

290 Targets of miRNA-31-3p were confirmed by Western blot analysis and luciferase r

291 Protein specificity and secondary structure were confirmed by Western Blot and Circular Dichroism (C

292 The alternations of the TRIM proteins were confirmed by Western blot.

293 Structures of 1 and 2 are confirmed by X-ray crystallography.

294 The structures of key products are confirmed by X-ray crystallography.

295 presence of the ligand-centered radical has been confirmed by X-ray crystallography and SQUID magnet

296 tiate antibody surface immobilization, which was confirmed by X-ray Photoelectron Spectroscopy, Atomi

297 The formation of the SAM was confirmed by X-ray photoelectron spectroscopy, scann

298 uodenum and ileum was inserted, and position was confirmed by X-ray.

299 The structures of the key products were confirmed by X-ray crystallography.

300 Binding of PHR1 and PHL1 factors to P1BS was confirmed by Y1H, electrophoretic mobility assay and