ライフサイエンスコーパス: be critical for

1 matter microstructure in the normative brain is critical for a neuroscientific approach to both typic

2 Mode control in a laser cavity is critical for a stable single-mode operation of a ring

3 ice in these models and confirm that GSTO1-1 is critical for a TLR4-like pro-inflammatory response in

4 the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes.

5 ection of cultured lung epithelial cells and was critical for AA release from membrane phospholipids.

6 manage the ongoing microbial challenge will be critical for achieving the United Nations Sustainable

7 The identification of LTR-RTs is critical for achieving high-quality gene annotation.

8 Understanding these interactions is critical for achieving the greatest diffusion of publ

9 Rather, it is critical for activating endosomal toll-like receptors

10 , contain extensive secondary structure that is critical for activity.

11 is of RCAR1 showed that its tyrosine residue is critical for AHG1 interaction and regulation.

12 Thus, we hypothesized that Cav-1 may be critical for albumin uptake in tumors and perhaps det

13 vations demonstrate that tyrosine 470 and 88 are critical for allosteric modulatory effects of SRI-co

14 lume at the Phe position in the alpha1-helix is critical for alphaLbeta2 activation because trimming

15 essing and the BACE1 cleavage site selection is critical for amyloidogenesis in AD pathogenesis, and

16 ssing, and the BACE1 cleavage site selection is critical for amyloidogenesis in AD pathogenesis, and

17 n/deacylation cycles and vesicular transport are critical for an adequate subcellular distribution of

18 r major energy fluxes (growth, reproduction) is critical for any general theory of organismal energet

19 Risk estimation is critical for appropriate informed consent and varies

20 PfCDPK1 is critical for asexual development of Plasmodium falcip

21 ified the disulfide bonds in IL-12alpha that are critical for assembly-induced secretion and biologic

22 orough understanding of core-shell formation is critical for atomic-scale design and control of the p

23 TRIM23 was critical for autophagy-mediated restriction of multi

24 lic electron flow around photosystem I (CEF) is critical for balancing the photosynthetic energy budg

25 Named entity recognition is critical for biomedical text mining, where it is not

26 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and pota

27 sis is a complex, multicellular process that is critical for bone development and generation.

28 t to demonstrate that the left angular gyrus is critical for both episodic simulation and episodic me

29 ll-type-specific transcription of genes that are critical for brain function.

30 Nutrition during the first 1000 d is critical for brain development.We evaluated the effec

31 Sporulation is critical for C. perfringens type A food poisoning sin

32 uch cross-talk on tumor cell phenotypes that are critical for cancer initiation and progression.

33 corated by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape

34 eir cell surface G protein-coupled receptors are critical for cell migration, not only in many fundam

35 of FtsZ protofilaments into dynamic clusters is critical for cell division, but the interactions betw

36 KLF4 is critical for cell fate decision and has an ambivalent

37 The cellular response to hypoxia is critical for cell survival and is fine-tuned to allow

38 Recovery from checkpoint activation is critical for cell survival following DNA damage.

39 tion of phospholipid synthesis in eukaryotes is critical for cellular homeostasis.

40 that an increase in the E/P4 signaling ratio is critical for cervical ripening.

41 We found that conserved subdomains generally are critical for channel function and are enriched with

42 trol of FANCD2:FANCI monoubiquitination that is critical for chemotherapy responses and prevention of

43 re, nsP3 mono(ADP-ribosyl)hydrolase activity is critical for CHIKV replication in both vertebrate hos

44 Repair of the alveolar epithelium is critical for clinical recovery; however, mechanisms u

45 s consistent with the notion that the S-loop is critical for cofactor binding, allosteric activation

46 crostructure and neural synchronization that is critical for cognitive processing.

47 t commonly mutated genes in human tumors and are critical for conferring and maintaining the oncogeni

48 The formation of this subcomplex was critical for conferring stability to the NEFs, helpe

49 threatened species, for release to the wild, is critical for conservation.

50 Formation and expression of memories are critical for context-dependent decision making.

51 properties of materials at reduced dimension is critical for continuous advancement of modern electro

52 d transformations of Fe(III)-(oxyhydr)oxides is critical for correctly interpreting stable isotopic d

53 Although it has been critical for decades in microbial physiology to cha

54 curate interpretation of pathogenic variants is critical for delivering solid clinical molecular diag

55 his contribution provides understanding that is critical for designing perovskite devices capable of

56 new environments and acquire new phenotypes is critical for developing comprehensive responses to ou

57 Nuclear movement is critical for developmental events, cell polarity, and

58 d by CRF and that CRFR1 signaling in the CeA is critical for discriminative fear.

59 bout the aroma given off by the fruit, which is critical for dissecting sensory properties and qualit

60 of BAZ1A and BAZ1B, even when non-standard, are critical for DNA damage recovery in part by regulati

61 PCNA) and Replication Protein A (RPA), which are critical for DNA replication and repair.

62 t timely exit of these proteins from the TGN is critical for effective pre-invasive immune responses

63 oduced by intratumoral Batf3 dendritic cells are critical for effector T cell recruitment.

64 RAD51 mediator proteins (i.e. paralogs) are critical for efficient HR in mammalian cells.

65 al infection, indicating that the Ub pathway is critical for ehrlichial intracellular replication and

66 rted state of SecA is still lacking and will be critical for elucidating the bacterial protein transp

67 during their developmental dispersal, which is critical for embryogenesis.

68 Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing,

69 ng along the vessels of the microcirculation is critical for endothelial homeostasis and inflammation

70 interneurons into nascent cortical circuits is critical for ensuring normal information processing w

71 Histone H3 lysine 36 methylation (H3K36me) is critical for epigenetic regulation and mutations at o

72 The hippocampus is critical for episodic memory, and synaptic changes in

73 otility receptor RHAMM by the RB/E2F pathway was critical for epithelial-mesenchymal transition, moti

74 propose that host interactions with microbes are critical for establishing the immune landscape of th

75 gradients drive co- and countertransport and are critical for establishing the membrane potential.

76 t is FGFR1, expressed by all ICM cells, that is critical for establishment of a PrE identity.

77 Acetylcholine in the neocortex is critical for executive function [1-3].

78 -channel dependent activation of BK channels is critical for feedback control of both calcium influx

79 ial oxidative stress in alveolar macrophages is critical for fibrosis development.

80 ing to a strong spatial structuring that can be critical for fitness.

81 to AMO(+) NAO(+) and AMO(-)NAO(-) phases as being critical for forest productivity, likely due to de

82 is produced abundantly during infection and is critical for GAS pathogenesis.

83 an essential internal RNA modification that is critical for gene expression control in most organism

84 not spatial variation in population density, were critical for generating fine-scale variation in hom

85 f the Lck kinase with CD4 or CD8 coreceptors is critical for generation of MHC specificity.

86 annel accrual, while disengagement from ZO-1 is critical for GJ channel closure and transitioning GJ

87 within the GTPase domain of the protein that are critical for GTP and receptor binding.

88 This research is critical for guiding treatment and policies in Africa

89 GW182 reveals a "gate"-like interaction that is critical for GW182 docking into one of hAgo1's trypto

90 Their metabolism is critical for health and mis-metabolism can be lethal.

91 tion of optimal dosing and treatment content is critical for health care providers, payers, and polic

92 Thyroid and glucocorticoid hormones are critical for heart maturation.

93 red to improve exposure of specific epitopes is critical for HIV-1 vaccine development.

94 The host immune response is critical for homeostasis; however, when chronic low l

95 lectively referred to as their "microbiome," are critical for host health, but the mechanisms that go

96 ino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highl

97 hes demonstrates that this adaptive response is critical for HRas-induced proliferation.

98 e findings indicate that the GERAMT sequence is critical for hsp70-mediated regulation of SOD2 and th

99 The ATPase activity of MORC2 is critical for HUSH-mediated silencing, and the most co

100 JNK activity was critical for ICAM-1-induced F-actin rearrangements.

101 biomarkers and mechanistic explorations will be critical for identifying appropriate patients for fut

102 reased understanding of how this is achieved is critical for identifying or improving therapeutic int

103 stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression dur

104 he substrate specificity of protease enzymes is critical for illuminating the molecular basis of thei

105 ration and decreases levels of proteins that are critical for immune suppressive activities of myeloi

106 hat mobility and supramolecular organization are critical for immunity.

107 uptake and transport in staple cereal crops is critical for improving both Zn content and tolerance

108 praglacial DOM and their cycling by microbes is critical for improving our understanding of supraglac

109 The vascular endothelium is critical for induction of appropriate lineage differe

110 Plasmablast production of IL-6 is critical for initiation of T follicular helper cells

111 We demonstrate that Rac3 GTPase is critical for integrating the adhesion of invadopodia

112 in the posterior dorsomedial striatum (pDMS) are critical for interlacing new and existing action-out

113 the structure of the notochord during aging is critical for investigations relating to IVD function

114 on and the features of the PPT sequence that are critical for its recognition by HIV-1 RT remain uncl

115 phorylates PAGE4 at S9 and T51, but only T51 is critical for its activity.

116 Viperin's iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many diff

117 the stable interaction of H3K36M with SETD2 is critical for its inhibitory effects.

118 vertase cleavage of protein C in hepatocytes is critical for its thrombin activation.

119 f this site plays a role in AR stability and is critical for its transcriptional activity.

120 , the fundamental unit in neuronal circuits, are critical for learning and memory, perception, thinki

121 eurons in the human brain and are thought to be critical for learning.

122 The cerebellum is critical for learning the appropriate timing of senso

123 ates 5-phosphate/3-hydroxyl DNA termini that are critical for ligation by the NHEJ DNA ligase, LigIV.

124 the field of LTP is why different molecules are critical for long-lasting forms of LTP induced by di

125 lung cancer tissues and its expression level is critical for lung cancer cell proliferation, which ma

126 Intravital microscopy revealed that CX3CR1 is critical for Ly6Clo monocyte transmigration across th

127 2+) release-activated Ca(2+) (CRAC) channels is critical for lymphocyte function and immune responses

128 Therefore, efficient Cxcr4 desensitization is critical for lymphoid differentiation of HSPCs, and i

129 d activity of these ligase-adaptor complexes is critical for main-tenance of optimal plasma membrane

130 e, we found that the GTPase activity of OPA1 is critical for maintaining cristae tightness and thus e

131 te GA signaling in the somatic anther tissue is critical for male meiotic cell wall formation and thu

132 ulsatile release of luteinizing hormone (LH) is critical for mammalian fertility.

133 Accurate and timely diagnostics are critical for managing bacterial infections.

134 the medial preoptic area (MPOA) is known to be critical for maternal behavior, the specific role of

135 ese results demonstrate that NKG2D signaling is critical for maximal TNF-alpha release by NK cells.

136 nd that monocarboxylate transporter-4 (MCT4) is critical for mediating GSC signaling in hypoxia.

137 d scarring or are known to the health system was critical for meeting elimination criteria of blindin

138 the hydrophobic face of two alpha-helices to be critical for membranous localization.

139 the cortical slow oscillations-is thought to be critical for memory consolidation during sleep, the r

140 s via lysosomal degradation called mitophagy is critical for mitochondrial homeostasis and cell survi

141 Accurate mitotic spindle assembly is critical for mitotic fidelity and organismal developm

142 rming minerals transform under shock loading is critical for modeling collisions between planetary bo

143 key parasite nutrient-sensing mechanism that is critical for modulating parasite replication and viru

144 in methylome studies, enrichment methods may be critical for moving the field forward.

145 ion assays reveal that this interaction mode is critical for MT binding and facilitates MT nucleation

146 We demonstrate, that like PABPN1, MATR3 is critical for myogenesis.

147 prisingly, the third stage, which appears to be critical for neural fate commitment, depends almost e

148 Mitochondrial transport in axons is critical for neural circuit health and function.

149 ication analyses suggest that the TF protein is critical for neurological disease.

150 nsport of cargoes within axons and dendrites is critical for neuronal function.

151 hrome b5 reductase 3 expression and activity is critical for NO-stimulated cGMP production and vasodi

152 Molecular imaging of cancer biomarkers is critical for non-invasive accurate cancer detection a

153 KCNQ2 potassium channels are critical for normal brain function, as both loss-of-

154 munication between neural and vascular cells is critical for normal brain development and function.

155 Thyroid hormone is critical for normal brain development.

156 he blood brain barrier and into neural cells is critical for normal cerebral physiologic function.

157 SREBP-1 is critical for OGT-mediated regulation of cell survival

158 ed that careful catalyst and solvent pairing is critical for optimal yield and selectivity; proper ch

159 Evaluation of microcirculation perfusion is critical for optimization of microvascular perfusion

160 our results show that dynamics of CA and SP1 are critical for orderly HIV-1 maturation and that small

161 he cerebellum and the motor cortex appear to be critical for our ability to learn physics, allowing u

162 Continued research on CRF mutations will be critical for our future understanding of cancer biolo

163 mechanisms controlling cardiac specification is critical for our understanding of how heart formation

164 However, the PEPD-p53 complex is critical for p53 response to stress, as stress signal

165 ndicate that Panx1 expressed in immune cells is critical for pain-like effects following nerve injury

166 Z-nucleic acid binding (Zalpha) domain that is critical for pathogenicity in mice.

167 and extent of breast cancer by a pathologist is critical for patient management for tumor staging and

168 sted the hypothesis that human dentate gyrus is critical for pattern separation, whereas, CA3 underpi

169 he paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth an

170 BD2 and BD4, suggesting that individual BDs are critical for PBRM1 function.

171 ), a core hub of the "salience network" that is critical for perception of interoceptive signals and

172 While T cells are critical for performing appropriate effector functio

173 ecific diversity of mycorrhizal fungi, which are critical for plant fitness, biogeochemical cycling a

174 zone of soil influenced by a plant root and is critical for plant health and nutrient acquisition.

175 The coordination of shoots and roots is critical for plants to adapt to changing environments

176 rstandings of contemporary forest cover loss are critical for policy but have come at the expense of

177 trate that targeting mTOR-dependent M2 cells is critical for preventing chronic allograft rejection,

178 Mitotic rounding during cell division is critical for preventing daughter cells from inheritin

179 Elucidation of involved neural systems is critical for prevention.

180 We demonstrate that one of these motifs is critical for PrimPol's recruitment to stalled replica

181 ance and the almost instantaneous activation are critical for producing these effects, the INaP is an

182 The hippocampus is critical for producing stable representations of fami

183 zymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required

184 IGNIFICANCE STATEMENT Neuronal energy levels are critical for proper CNS function, but the relative r

185 Thus, timely and accurate species counts are critical for proper conservation and management.

186 tivity to form exclusively crossovers, which are critical for proper homolog segregation in Meiosis I

187 -hindbrain boundary constriction (MHBC), and are critical for proper MHB formation.

188 w that the short 310-helix from D580 to S584 is critical for proper biogenesis of the A2 domain and F

189 BCD suggested that the ARL2-TBCD interaction is critical for proper maintenance of microtubule densit

190 rect-pathway spiny projection neurons (SPNs) is critical for proper movement.

191 molecules to the correct subcellular locales is critical for proper physiological function.

192 strate that the adjuvanted Env protein boost is critical for protecting against high-dose SIVsmE660 c

193 ssess multiple antimicrobial mechanisms that are critical for protection of the host against infectio

194 nosine generated by cells at the injury site is critical for protection from IRI through bone marrow-

195 Proper extraction and analytical methods are critical for quantification.

196 ional control by small regulatory RNA (sRNA) is critical for rapid adaptive processes.

197 anterior thalamic nucleus (AN) complex would be critical for recollection while the Mediodorsal nucle

198 C proliferation and migration responses that are critical for regeneration by targeting proregenerati

199 al for the control of cellular functions and are critical for regulation of the immune system.

200 mino acid region of the C-terminal extension is critical for relieving the auto-inhibition of full-le

201 est that voltage-gated Ca(2+) influx in OPCs is critical for remyelination.

202 Convenient and intuitive data interfaces are critical for researchers to easily upload, analyze a

203 Ventral tegmental area (VTA) activity is critical for reward/reinforcement and is tightly modu

204 Collectively, our data indicate that gdf3 is critical for robust Nodal signaling at multiple stage

205 Furthermore, TLR2 but not TLR4 was critical for sensing of cell wall extracts and whole

206 ina and the retinal pigment epithelium (RPE) is critical for several processes, including visual pigm

207 Recent work has consistently shown XIAP to be critical for signaling downstream of the Crohn's dise

208 Assembly of the ASC speck is critical for signaling by the inflammasome.

209 Mitochondrial health is critical for skeletal muscle function and is improved

210 Both social environment and genetic factors are critical for smoking initiation and nicotine addicti

211 cetylase-2 (HDAC2), an epigenetic regulator, is critical for stress-induced cardiac hypertrophy.

212 n LMP1 constitutively activates NFkappaB and is critical for survival of EBV-immortalized B cells.

213 that the presence of SOS1/EPS8/ABI1 complex is critical for sustained EMT traits of ovarian cancer c

214 e neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation of

215 Signaling through the T-cell receptor (TCR) is critical for T-cell development and function.

216 genesis of the pore residues shows that they are critical for TA protein extraction in vitro and for

217 s around the viral replication proteins that is critical for TBSV replication.IMPORTANCE One intrigui

218 previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation

219 Neutrophil extracellular traps (NETs) are critical for the clearance of large pathogens and ar

220 n fast transduction elements at synapses and are critical for the expression of plasticity.

221 Notably, CSCs are critical for the formation and maintenance of liver

222 in (TMD) of the GluA2 subunit of AMPARs that are critical for the function of AMPAR auxiliary subunit

223 timulation, indicating that these activities are critical for the in vivo function of STN1.

224 Strategies to resolve replication blocks are critical for the maintenance of genome stability.

225 ls expressing the transcription factor Foxp3 are critical for the prevention of autoimmunity and the

226 Substrate recognition and binding are critical for the regulation of this reaction.

227 Tumor-host interactions are critical for the survival and proliferation of cance

228 These polymorphisms may be critical for the development of specialized plant fee

229 riate radiographic interpretation would thus be critical for the early detection of TMJOA.

230 tion factor Foxh1, in part through Eomes, to be critical for the formation of FLK1(+) mesoderm, from

231 eins form a coiled-coil interaction known to be critical for the formation of NuRD.

232 These genes may be critical for the generation of hybrid vigor.

233 Understanding physiological acclimation will be critical for the large carbon stores in these ecosyst

234 a daunting challenge for clinicians but will be critical for the success of disease-modifying therapi

235 f the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal ca

236 incretin effect after nutrient ingestion and is critical for the actions of dipeptidyl peptidase 4 in

237 of mutant enzymes showed that residue W1065 is critical for the activity of GTF180-DeltaN.

238 ons, a currently understudied cell type that is critical for the brain's reward circuit, and how Delt

239 Here we report that PI3K signaling is critical for the control of West Nile virus (WNV) inf

240 indicate that AMPK activity in the NAc core is critical for the cue-induced reinstatement of cocaine

241 nterleukin-15 is a pleiotropic cytokine that is critical for the development and survival of multiple

242 ntamoeba histolytica drives gut inflammation is critical for the development of improved preventive a

243 of fluid transport through porous materials is critical for the development of lateral flow assays a

244 This is critical for the development of microfluidic chemosen

245 es in the resolution of bacterial infections is critical for the development of new therapeutic strat

246 itigating the risk of product immunogenicity is critical for the development these products.

247 rate that regulated SRF expression, in turn, is critical for the effects of cocaine on dendritic spin

248 ich the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription.

249 Thermosensing is critical for the expression of virulence genes in pat

250 ich is the site of thermoregulatory neurons, is critical for the febrile response to peripheral infla

251 Pigment regeneration is critical for the function of cone photoreceptors in b

252 position occupied by W972 within WT Arkadia is critical for the function of RING and that it depends

253 that the STING-dependent type I IFN pathway is critical for the GBP-mediated release of Brucella DNA

254 ng of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune respon

255 ways to inactivate pathogens in human waste is critical for the improvement of worldwide access to s

256 t of the viral 5' untranslated region (UTR), is critical for the initiation of dengue virus replicati

257 gether, our data indicate that ROS signaling is critical for the loss of barrier function following g

258 Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis

259 Mitochondrial division is critical for the maintenance and regulation of mitoch

260 that RNA topology, in addition to sequence, is critical for the molecular recognition of RNA.

261 Recruitment via settlement of pelagic larvae is critical for the persistence of benthic marine popula

262 Examination of vvDeltaB1 revealed that B1 is critical for the production of infectious virions in

263 show that loss of dysregulated Wnt signaling is critical for the progression of disseminated CRCs.

264 The androgen receptor (AR) is critical for the progression of prostate cancer to a

265 nts of both sexes, we show that dystroglycan is critical for the proper migration, axon guidance, and

266 The Mre11-Rad50-Nbs1(Xrs2) (MRN/X) complex is critical for the repair and signaling of DNA double s

267 Intact presynaptic mitochondrial function is critical for the short-term dynamics of mossy fibre t

268 ment and governance at the river basin scale is critical for the sustainable development of rural agr

269 Therefore, 66Y in the stalk domain of N1 NA was critical for the stability of the NA tetramer and, s

270 ve changes observed in group M Vpus (M-Vpus) were critical for the acquisition of its anti-tetherin a

271 in growth and physiology during development are critical for their spawning success.

272 h a rich repertoire of robust behaviors that are critical for their survival.

273 ory assessment, with a goal toward licensure is critical for these products.

274 terference hedgehog (Ihog) and the glypicans are critical for this cell-cell cytoneme mediated intera

275 nicotinic acetylcholine receptors in the NAc are critical for this effect.

276 f H2O2 A conserved cysteine residue in OxyR2 is critical for this function.

277 revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in

278 of JNK1 in hematopoietic innate immune cells was critical for this effect.

279 vate the contact system and that this system is critical for thrombus stabilization and growth have i

280 In adult animals, the secreted Wnt proteins are critical for tissue regeneration and frequently cont

281 HR)-mediated DNA repair, which is thought to be critical for tumor suppression.

282 Functionally, repression of CPT1A is critical for tumor formation, as elevated CPT1A expre

283 e to varying environmental conditions, which are critical for understanding plant energy storage and

284 Studies of protein unfolding mechanisms are critical for understanding protein functions inside

285 telomere-terminal haplotypes in individuals, are critical for understanding telomere function and its

286 tion-state supramolecular structure" control is critical for understanding and optimization of the th

287 pheric carbon dioxide concentration ([CO2 ]) is critical for understanding and predicting the consequ

288 work (DMN) is a complex dynamic network that is critical for understanding cognitive function.

289 f disease-associated miRNAs (disease miRNAs) is critical for understanding disease etiology and patho

290 racterization of tumor genetic heterogeneity is critical for understanding how cancers evolve and esc

291 actions of complex glycoligands and proteins is critical for understanding important biological proce

292 s, the study of protein acetylation dynamics is critical for understanding of how this modification i

293 es under reaction conditions at atomic scale is critical for understanding reactivity.

294 g specificity of transcription factors (TFs) is critical for understanding the principles of gene reg

295 distributions, and patterns of connectivity is critical for understanding the properties of neural c

296 cting the evolutionary history of metastases is critical for understanding their basic biological pri

297 the N domain with cognate viral proteins may be critical for virion assembly.IMPORTANCE Poxviruses ar

298 gulation of virulence factors, PASTA kinases are critical for virulence due to their roles in regulat

299 particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with

300 g, suggesting that the duration of the night is critical for wheat photoperiodic response.