ライフサイエンスコーパス: be critical to

1 n the context of macroscale tissue structure is critical to a deeper understanding of diverse biologi

2 ration and sorting of bioparticles and cells is critical to a variety of biomedical processing steps

3 modeling, two features of alpha oscillations are critical to account for the observed effects on long

4 terostructures, the design of multijunctions is critical to achieve carrier confinement.

5 Shared decision making is critical to achieve value-concordant treatment decisi

6 he context in which these decisions are made is critical to achieving a safe strategy for imparting p

7 rain owing to their dense PEG coating, which was critical to achieving widespread transgene expressio

8 Furthermore, HMGB1 is critical to activate the particle-induced pro-inflamm

9 The sulfonamide linker is critical to activity, substitutions at position 4 of

10 ification of effective combination therapies is critical to address the emergence of drug-resistant c

11 its interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesi

12 his pathway in the context of motor learning is critical to advancing the efficacy of neurorehabilita

13 The fine-scale regulation of R genes is critical to alleviate the burden of their expression,

14 burden of community-acquired pneumonia (CAP) is critical to allocate resources for prevention, manage

15 ts, these data suggest that daily dosing may be critical to allow for development of robust gamma osc

16 ate of outcomes-driven quality reporting, it is critical to appropriately risk stratify patients usin

17 Ascertainment of hospitalizations is critical to assess quality of care and the effectiven

18 urs between companion animals and humans, it was critical to assess the relative risk of this novel v

19 , effective investment of precious resources is critical to assure that the organization delivers hig

20 ing behavior when those contingencies change is critical to behavioral flexibility.

21 tiation, and function of human lung NK cells is critical to better understand their role in diseases

22 17 immune responses, but some proteins might be critical to both diseases.

23 Sensitive detection of T4 PNK activity is critical to both clinical diagnosis and therapeutics.

24 and precise ages of large silicic eruptions are critical to calibrating the geologic timescale and g

25 Intracellular pH (pHi) is critical to cardiac excitation and contraction; uncom

26 carry out numerous metabolic reactions that are critical to cellular homeostasis.

27 ll interleukin 4 production and GC migration were critical to cGVHD reversal.

28 Quantifying the effects of inbreeding is critical to characterizing the genetic architecture o

29 It is critical to choose the appropriate treatment for prec

30 mprise a diverse subpopulation of cells that are critical to circuit function.

31 urated sets of pathology image features will be critical to clinical studies that aim to evaluate and

32 n complex function and virus assembly, which is critical to completion of the virus life cycle.

33 flict situations (e.g., police officers), it is critical to consider the role that restricted sleep m

34 n of regulatory Treg (Treg) in the periphery is critical to control inflammatory processes.

35 Inter-tissue communication is critical to control organismal energy homeostasis in

36 the intestine-specific homeobox protein ISX is critical to control the metabolic flow of beta-carote

37 ive antibody response.IMPORTANCE Our results are critical to current work in the HIV-1 vaccine field

38 It is critical to define the proteins and their properties

39 These results are critical to design of appropriate therapeutic strate

40 nical trials in patients with lymphoma, will be critical to determine how best to deploy MRD testing

41 expanded use of RTS,S/AS01 continue, it will be critical to determine the performance of the vaccine

42 Thus it is critical to determine the particular role for ciliary

43 ase of emerging infectious diseases, it will be critical to develop platforms that are able to produc

44 It is critical to develop a highly efficient template-free

45 ance after lifestyle-induced weight loss, it is critical to develop approaches that distinguish succe

46 atteries usable under ambient conditions, it is critical to develop highly efficient catalysts for th

47 nd MR images along with outcomes from trials is critical to develop improved methods of assessment.

48 the physics of such motor-filament materials is critical to developing a physical model of the cytosk

49 uretic resistance (DR) in heart failure (HF) is critical to developing targeted treatment strategies.

50 ns between small molecules and nucleic acids is critical to discover lead compounds and design novel

51 elic profiling and (epi)genome editing] will be critical to dissect the molecular genetics of T2DM pa

52 le DNA molecules through a nanoscale channel is critical to DNA sequencing and mapping technologies t

53 lation experiments show that EMF communities are critical to drought tolerance.

54 Tongue protrusion-retraction is critical to early nutrition but is also a gustatory-o

55 Therefore, Piezo2 is critical to EC cell mechanosensitivity and downstream

56 microglial/macrophage demyelinating response is critical to effectively target therapeutics.

57 to generate a relevant hepatocyte will also be critical to efforts to build complex multicellular mo

58 stand Treg biology in health and disease, it is critical to elucidate factors that affect Treg homeos

59 structural, and evolutionary mechanisms and is critical to elucidating how genome variation contribu

60 nding how guppy diets vary among communities is critical to elucidating the role of niche shifts in m

61 hat in addition to tanning bed avoidance, it is critical to emphasize sun protection and skin cancer

62 ethods to predict missing methylation states are critical to enable genome-wide analyses.

63 en morphogenesis during pancreas development is critical to endocrine and exocrine cell fate.

64 h the glucagon-like peptide-1 (GLP-1) system is critical to energy balance control and is a target fo

65 es and a high fraction of Sn/Li2 O interface are critical to enhance the coulombic efficiency and cyc

66 nervate tissues or regenerate small injuries is critical to enhance material-based interventions to r

67 t activate some genes while silencing others are critical to ensure precision in lineage specificatio

68 Rapid learning can be critical to ensure elite performance in a changing wo

69 consideration of production lead times will be critical to ensure sufficient supply throughout to ac

70 er expression of nephrin on the cell surface is critical to ensure integrity of the blood filtration

71 mprove the efficiency of target/DNA cleavage is critical to ensure the success of CRISPR screens.

72 immunosuppressive medications posttransplant is critical to ensuring graft survival.

73 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival.

74 Moving forward, it will be critical to evaluate the clinical use of RHL30 in the

75 Further information from randomized trials is critical to evaluate clinical outcomes with BVS on co

76 oyed in the surface modification process, it is critical to evaluate different purification strategie

77 ses to warming-induced environmental changes is critical to evaluating their influences on soil bioge

78 ly significantly on rain-fed agriculture, it is critical to examine climate variability and food inse

79 le Care Act and Medicaid program unclear, it is critical to examine the geographic availability of sp

80 tin-4 shedding in ovarian cancer progression is critical to facilitate its development as both a seru

81 gon-like peptide-1 receptors (GLP-1R), which are critical to feeding and body weight control, we test

82 Thus, it is critical to find new target-specific therapeutic moda

83 es among sites in their species compositions-is critical to forecast communities in the Anthropocene.

84 elical and strand conformations in caspase-6 is critical to fully assess its unique function and regu

85 evident, to better understand the subsurface is critical to further understanding the Earth, life, th

86 elements (a common source of abiotic stress) is critical to gaining insights into the accumulation of

87 election of a strain-matched H chain isotype are critical to generate ideal surrogate Abs for testing

88 spatial summation over a moving sensor array is critical to generating population codes of sensory sp

89 aintenance of whole-body glucose homeostasis is critical to glycemic function.

90 The appropriate choice of RGE is critical to guarantee satisfactory normalization of R

91 Population-level disease metrics are critical to guide the distribution of resources and

92 cognizing motivationally salient information is critical to guiding behaviour.

93 To improve preparedness, it is critical to have some understanding of how CSF would

94 Proper execution of asymmetric organogenesis is critical to health, making furthering our understandi

95 to sites of pathogen growth or tissue damage is critical to host defense and organ homeostasis.

96 o understand why others feel the way they do is critical to human relationships.

97 solid organs for transplant, future studies are critical to identify and target modifiable risk fact

98 he rise of ChR2 use in optogenetics, it will be critical to identify residues that contribute to O1 o

99 Obtaining a detailed family history is critical to identify families who will benefit from g

100 similarity between native and invaded areas is critical to identifying niche shifts during species i

101 allosteric coupling to identify regions that are critical to IGPS function.

102 ent of a membrane bound receptor (CD40) that is critical to immune regulation in colon biopsies colle

103 d a formal part of the immune system, but it is critical to immunity.

104 tive to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms

105 to management of the older surgical patient is critical to improve postoperative cognitive outcomes

106 nge and nitrogen deposition in these systems is critical to improve predictive abilities for future c

107 enetic basis of variation in leaf morphology is critical to improving agricultural productivity.

108 rmacologic asthma therapies expands, it will be critical to include elderly asthmatics in large clini

109 Research also is critical to increasing basic understanding of the neu

110 dentification of emerging antigenic variants is critical to influenza vaccine design.

111 to help infer influenza antigenicity, which is critical to influenza vaccine development.

112 mune tolerance in hematological malignancies is critical to inform the development of future immunoth

113 ggest that programmed death 1 (PD-1) pathway is critical to inhibit immune surveillance in CLL.

114 one located between two tryptophan residues, are critical to insoluble and soluble glucan recognition

115 This temporal patterning is critical to interpreting the stimulus.

116 ding uncertainties in land cover projections is critical to investigating land-based climate mitigati

117 Diffusion in complex oxides is critical to ionic transport, radiation damage evoluti

118 ding factors that contribute to their spread is critical to its control.

119 large-scale and facile production of SiC NWs is critical to its successful application.

120 development and suggest that Neto2 assembly is critical to KAR modulation of DRG neuron process outg

121 obust ribonucleotide excision repair pathway is critical to keeping incorporation levels low in wild-

122 se of antifungals via antifungal stewardship is critical to limit multidrug resistance emergence.

123 utosomal homolog 1), an RNA-binding protein, are critical to maintain proper cardiac muscle function;

124 ommunication between neighbouring cells, and are critical to maintain various physiological processes

125 Here we show that the metabolic sensor LKB1 is critical to maintain cellular metabolism and energy h

126 this novel myokine-dependent hormone module is critical to maintain diurnal rhythms in circulating l

127 -specific transcripts during development, it is critical to maintain genes required for other lineage

128 During medical treatment it is critical to maintain the circulatory concentration of

129 ppression of TGFbeta/Smad signaling in vitro is critical to maintaining characteristic features of mo

130 Nutrition management is critical to maintaining glycemic control, yet it is d

131 anding the link between ethnicity and health is critical to making appropriate public policy decision

132 The most prominent example, which is critical to mammalian survival, is that of pancreatic

133 ast ingestion of the NOAC and renal function is critical to managing these patients given that labora

134 tegies to increase accrual of older patients are critical to meaningfully change the evidence base fo

135 g and EMT-inducing transcription factor ZEB1 are critical to mediate these effects of GM-CSF.

136 Precise timekeeping is critical to metrology, forming the basis by which sta

137 lecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's

138 f patients, early identification of risk may be critical to minimizing effects on future health.

139 e health effects through inhalation exposure is critical to mitigating its potential impact on public

140 When a new vaccine is introduced, it is critical to monitor trends in disease rates to ensure

141 ablishing the burden of undiagnosed diabetes is critical to monitoring public health efforts related

142 ntracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processe

143 data from electronic data research networks is critical to national research initiatives and learnin

144 array of new functions that are proposed to be critical to neuronal-glial interactions through the m

145 sfunction of a Slo2 potassium channel, which is critical to neuronal function.

146 ase to meet the demands of neuronal activity is critical to neurotransmission.

147 d width) variance, it is the mean delay that is critical to noise performance.

148 size, indicating that this pro-drug approach was critical to obtain the desired activity in vivo.

149 standing of middle ear cilia properties that are critical to OM susceptibility, however, is limited.

150 Orofacial stereotypies are critical to optimizing food rejection.

151 Macrophages are critical to organ structure and function in health a

152 Antibody-antigen interactions are critical to our immune response, and understanding t

153 distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia func

154 Therefore, understanding synaptic dynamics is critical to our understanding of sensory encoding.

155 at the voltage-gated sodium channel, Nav1.7, is critical to pain sensation in mammals, pharmacologica

156 While mitophagy is critical to pancreatic beta-cell function, the posttr

157 Although adequate postoperative pain control is critical to patient and surgeon success, the optimal

158 romoter proximal cis-regulatory element that is critical to PD-1 expression in vitro, responds to NFA

159 Attention is critical to perception, serving to select behaviorall

160 PCa detection is critical to personalized medicine and varies consider

161 ics experiment, accurate orthology inference is critical to phylo-transcriptomics.

162 lin (CaM) and calmodulin-like (CML) proteins is critical to plant immunity.

163 nic carbon (SOC) decomposition under warming is critical to predict carbon-climate feedbacks.

164 The ability to predict leaf area development is critical to predict crop growth, particularly under c

165 ng ability and architecture of woody plants, are critical to predicting encroachment over the next ce

166 ding the factors controlling SSA composition is critical to predicting aerosol impacts on clouds and

167 mics of the intracellular Mtb sub-population is critical to predicting clinical TB treatment duration

168 the demographic rates of different ecotypes is critical to predicting shifts in species distribution

169 diabetes, early diagnosis and interventions are critical to prevent this disease and can postpone or

170 g silo discharge, the understanding of which is critical to preventing destructive instabilities and

171 (MI), time-dependent leukocyte infiltration is critical to program the acute inflammatory response.

172 ren with mental disorders in school settings is critical to promote academic achievement and long-ter

173 hastic motion on the surface of living cells is critical to promote molecular encounters that are nec

174 eurons and glia from radial glia progenitors is critical to proper neocortical development but the me

175 gh freshwater landscapes in the Anthropocene is critical to protecting and restoring aquatic ecosyste

176 early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, partic

177 hese lesions and the repair pathways engaged is critical to realizing the full potential of this tech

178 It is critical to recognize the early signs of cerebral ede

179 the epidermal growth factor receptor (EGFR), is critical to recovery from SARS-CoV-induced tissue dam

180 direct appropriate therapy has been shown to be critical to reduce mortality rates.

181 anding of our field's environment impact, it is critical to refine what can be made to what should be

182 pposite: instantaneous frequency modulations are critical to regulate phase relations and synchroniza

183 lative stoichiometry of the two proteins may be critical to regulated endocytic fission.

184 anterior insular cortex to central amygdala is critical to relapse after the cessation of contingenc

185 Resolving this apparent contradiction is critical to representing nutrient dynamics in predict

186 In order to understand this mechanism, it is critical to resolve the evolution of the exciton's bi

187 n of Mrc1 facilitated by the SCFDia2 complex is critical to restart stalled replication forks during

188 orphology and function following tissue loss is critical to restore normal physiology, yet few cases

189 To determine why MerTK is critical to RPE function, we examined visual cycle in

190 s feature might be important when the timing is critical to send signals to external devices before t

191 following a train of action potentials that are critical to shaping the firing patterns of these cel

192 that the correct parameterization of sigma w is critical to simulate realistic cirrus properties.

193 , or actuate in response to external stimuli are critical to soft robots, programmable matter, and sm

194 urium, a byproduct of copper refining, which is critical to solar photovoltaics, is chosen as a case

195 rial baroreceptors, and C1 neuron activation is critical to stabilize BP under hypoxia or anesthesia.

196 Cellular mitochondria are critical to successful neurogenesis and are a major

197 how that groundwater availability would have been critical to supporting isolated networks of hydro-r

198 Behavioral responses to threat are critical to survival.

199 Successful social integration may be critical to survival and reproduction for highly soci

200 ts, we anticipate that cellular context will be critical to synthetic-lethal therapies.

201 , scattering signature, and crosstalk, which are critical to system miniaturization, diversity in fun

202 urces and demands are spatially variable, it is critical to take into account the location of activit

203 Because GBPs are critical to target vacuolar bacteria, we determined

204 Mechanistic details of catalytic reactions are critical to the development of improved catalysts.

205 tations within the antibody variable domains are critical to the immense capacity of the immune reper

206 Because type I and II IFNs are critical to the immune-mediated activity of anti-Erb

207 nd innate and adaptive immune responses that are critical to the induction of disease, persistence of

208 CDPK1 controls multiple processes that are critical to the intracellular replicative cycle of T

209 athways that restrict cell cycle progression are critical to the maintenance of functional HSCs.

210 s of connectivity among large-scale networks are critical to the neurobiology of reward dysfunction a

211 and sub-cortical neurogenesis during infancy are critical to the pathophysiology of ID.

212 Observation and description are critical to the practice of medicine, and to ophthal

213 between organic matter and mineral matrices are critical to the preservation of soil and sediment or

214 apies that target known mechanisms of action are critical to the success of proposed treatments.

215 mation induces various innate responses that are critical to the survival of the individual and for t

216 Interleukin-23 is thought to be critical to the pathogenesis of psoriasis.

217 his locus, SNAP29, AIFM3, and CRKL appear to be critical to the phenotype, with haploinsufficiency of

218 hieving a high number of CD8(+) T cells will be critical to the success of a cell-mediated vaccine ag

219 netic properties, and how these efforts have been critical to the discovery, design, and subsequent d

220 The H(-) anion is also believed to have been critical to the formation of molecular hydrogen in

221 Regulating gene expression during infection is critical to the ability of pathogens to circumvent th

222 e about the dietary sources of sodium intake is critical to the development of effective reduction st

223 Understanding the underlying mechanisms is critical to the development of strategies to control

224 drugs, for which no target is characterized, is critical to the development of their second-generatio

225 Collective cell movement is critical to the emergent properties of many multicell

226 in the heme-copper oxidase (HCO) superfamily is critical to the enzymatic activity of reducing O2 to

227 he enzyme's mechanism demonstrating that H42 is critical to the enzyme's activity and that the reacti

228 efined nanostructures with tunable functions is critical to the exploitation of nanoscience and nanot

229 d orientation of the bipolar mitotic spindle is critical to the fidelity of cell division.

230 aptic connections between developing neurons is critical to the formation of functional neural circui

231 DHA) is an essential omega-3 fatty acid that is critical to the formation of neuronal synapses and me

232 the mechanisms underlying bacterial adhesion is critical to the formulation of membrane biofouling co

233 the complex architecture of African genomes is critical to the global effort to understand human his

234 Halide passivation is critical to the growth of these (100) face-dominated

235 The removal of macroalgal biomass is critical to the health of coral reef ecosystems.

236 cross-presentation in dendritic cells (DCs) is critical to the initiation of most cytotoxic immune r

237 -self RNA sensors, including RIG-I and MDA5, is critical to the initiation of the innate immune respo

238 in in the extracellular matrix in humans and is critical to the integrity and function of many muscul

239 owledge of the positions of the fluorophores is critical to the interpretation of fluorescence resona

240 Spatial information is critical to the interrogation of developmental and ti

241 A hypoxic state is critical to the metastatic and invasive characteristi

242 Caspase-6 is critical to the neurodegenerative pathways of Alzheim

243 AhR as a novel target on donor T cells that is critical to the pathogenesis of aGVHD.

244 a timely and complete resection of the tumor is critical to the patient's tumor recurrence-free survi

245 , it has been assumed that this localization is critical to the protein's function.

246 Patient safety is critical to the provision of quality health care and

247 ion between the JAK1-STAT3 and SMAD pathways is critical to the roles of TGF-beta in liver fibrosis.

248 ntified ribonucleoprotein (RNP) complex that is critical to the specificity of these small molecules

249 f 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables faci

250 The matrix is critical to the success of biofilms in diverse habita

251 s of antifungal-resistant Candida infections is critical to the successful management of patients wit

252 (TPL), composed of three introns (TPL 1-3), is critical to the translation of HAdV late mRNA.

253 is still an unresolved issue, even though it is critical to the understanding of the functional prope

254 rm storage of stable nanoparticulate systems is critical to the utilization of nanotechnology in biom

255 Knockout analysis suggested Gfi-1 and PPARg were critical to the ATRAinduced differentiation program

256 where increases in cellular compound potency were critical to the development of probes or drugs.

257 The stability of folded proteins is critical to their biological function and for the eff

258 The connectivity amongst photoreceptors is critical to their function, as it underpins lateral i

259 Such strain hardening is critical to their function, especially for materials

260 A conserved motile system is critical to their life cycles and drives directional

261 without compromising thermodynamic stability is critical to their natural function.

262 or some of these proteins the disulfide bond is critical to their stability and function.

263 Reactivating quiescent cells to proliferate is critical to tissue repair and homoeostasis.

264 creasing the covalency of metal-oxygen bonds is critical to trigger lattice-oxygen oxidation and enab

265 led receptors (GPCRs) to specific G proteins is critical to trigger the appropriate physiological res

266 ible for this complex vesicular sorting will be critical to understand VGLUT's involvement in normal

267 Therefore, it is critical to understand CSC biology to develop novel C

268 unraveling the wiring of organelle networks is critical to understand how biological systems are bui

269 Thus, it is critical to understand how cells orient the cytoskele

270 h 34 times the warming potential of CO2 , it is critical to understand how factors associated with gl

271 f opioid-related morbidity and mortality, it is critical to understand how preoperative opioid use im

272 Consequently, it is critical to understand the mechanisms by which organi

273 As flammability standards are updated, it is critical to understand their impact on exposure and h

274 neration, differentiation, and disappearance are critical to understanding both steady-state homeosta

275 ses and dissecting the underlying mechanisms are critical to understanding brain development and impr

276 e human protein-protein interaction networks are critical to understanding cell biology and interpret

277 properties and switching mechanisms of MTJs are critical to understanding device operation and to en

278 We suggest that multi-region investigations are critical to understanding intra-patient heterogeneit

279 ties associated with phase-separated systems are critical to understanding the unusual behaviours of

280 mental plant-water feedback pathway that may be critical to understanding plant-mediated global chang

281 ts formation on the Sun remains elusive, yet is critical to understanding a broad spectrum of phenome

282 of the basic crystallographic modes of slip is critical to understanding and analyzing the plastic d

283 High-resolution optical imaging is critical to understanding brain function.

284 a subset of individuals to become depressed is critical to understanding depression on a basic level

285 related to other components of their fitness is critical to understanding disease impacts at a popula

286 the factors governing investment in immunity is critical to understanding host-pathogen ecological an

287 This information is critical to understanding how local processing in V1

288 ies and how they are tethered within the MOF is critical to understanding how these components couple

289 Constraining the H2 cycle is critical to understanding its role in atmospheric che

290 ffness and ultrastructure for TMJ components is critical to understanding joint function and for the

291 ring phytoplankton classes in river networks is critical to understanding phytoplankton dynamics and

292 n varies across populations and through time is critical to understanding speciation and hybridizatio

293 topathological analysis of autopsy specimens is critical to understanding the cellular mechanisms und

294 ioinformatics because knowledge of structure is critical to understanding the functions of RNA sequen

295 n addition to those of the invasive species, is critical to understanding the impacts of invasion on

296 Future research is critical to understanding the long-term consequences

297 Elucidation of this process is critical to understanding the pathophysiology of nonc

298 complex pharmacology of these receptors will be critical to unlocking their ultimate therapeutic pote

299 the maturation pathways in BNAb development is critical to vaccine design efforts to recapitulate th

300 nal role of translation machinery components are critical to viability.