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1               To date, anti-HIV-1 gRNAs have been designed to account for off-target activity, howeve
2            Moreover, CRISPR interference can be designed to achieve selective knockdown of any of the
3                                    The trial was designed to achieve a 20% improvement in 2-year cont
4 gainst risk of nephrotoxicity the algorithms were designed to achieve target attainment rates of >80%
5 icrofluidic point-of-care (POC) devices have been designed to address these needs, but they are not a
6                                      CONFETI is designed to address two conflicting issues when searc
7                             The Sister Study was designed to address gaps in the study of environment
8 ency criterion to identify polymers that can be designed to adopt a predetermined structure and show
9 rees filament orientation on the top surface was designed to align with the direction of the first fl
10 interactions with Rosetta, Foldit Standalone is designed to allow easy, real-time, direct manipulatio
11 nd a minor groove binding (MGB) TaqMan probe were designed to amplify the 81bp region on the cyt b ge
12                  However, current approaches are designed to analyze a biological system assuming tha
13           Current spliced alignment software is designed to analyze each sample separately.
14                            The current study was designed to answer the fundamental question of how s
15  leveraging microscale techniques, the model is designed to approximate the structure of the human br
16                             ChimerSeq module is designed to archive the fusion candidates from deep s
17                              Although trials are designed to assess efficacy and effectiveness and in
18                        Future studies should be designed to assess whether increases in suicidality r
19           The patient-pathway analysis (PPA) is designed to assess the alignment between tuberculosis
20                                    The study was designed to assess modified retro colic retro gastri
21                              The star rating was designed to assess overall quality of the institutio
22 nt data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided tr
23                                   This study was designed to assess the effects of high-flow nasal ca
24 ase II studies, a randomized phase III trial was designed to assess the efficacy of adding bevacizuma
25 trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein harv
26                                   This study was designed to assess the potential of improving hCPC f
27                          This European trial was designed to assess the safety and effectiveness of a
28                Purpose The KEYNOTE-028 trial was designed to assess the safety and efficacy of pembro
29                                       SCORE2 was designed to assess whether intravitreal bevacizumab
30 inational SMS (Substrate Modification Study) was designed to assess whether prophylactic ablation of
31                        The CONCORD programme was designed to assess worldwide differences and trends
32 n two countries (New Zealand and China), and were designed to assess type of control strain, diet, pr
33 ductor films with vertical compositions that are designed to atomic-scale precision provide the found
34 Cu) deficient (Cu/In + Ga = 0.76) CIGS films were designed to avoid the rather dangerous KCN treatmen
35                   Pseudoisochromatic figures are designed to base discrimination of a chromatic targe
36 pled covalently through peptide linkers that are designed to be cleaved by intracellular macrophage p
37             The custom hardware and software are designed to be easy to use.
38                      These organic particles are designed to be non-toxic and highly water-soluble.
39 ero-footprint viewer for image analysis that is designed to be extensible as well as capable of being
40                                 Although 1C8 was designed to be a structural mimic of the fused tetra
41 ly in the subtype of tumor where the therapy was designed to be active.
42 rescent [60]fullerene derivative (C60-serPF) was designed to be an amphiphilic nanostructure, which i
43                             The VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal c
44                                    Opicapone was designed to be effective without the adverse effects
45 covalent organic framework (sp(2)c-COF) that was designed to be fully pi-conjugated and constructed f
46 ches to support research and education, that are designed to better position AMCs to compete and face
47 uld be treated with endocrine therapy, which is designed to block ERalpha signaling.
48 er to vascular injury in primary hemostasis, is designed to capture platelets under the high shear st
49                                     Softness is designed to capture the hidden patterns in relative p
50 an integrated, self-driven microfluidic chip was designed to carry out digital LAMP.
51  are formed using DNA origami approaches and are designed to change conformations in response to a bi
52 of red blood cell production and destruction was designed to characterise primaquine-induced haemolys
53                                   This study was designed to characterize lipid droplet (LD) formatio
54                 Three types of surfaces have been designed to combat biofilm formation, while attempt
55 then discuss how engineered immune cells are being designed to combat cancer, focusing on how new syn
56    Because aztreonam inhibits AmpCs, a study was designed to compare ESBL detection by the CLSI disk
57 multiple, independent data sources.The study was designed to compare relevant data published by the F
58                                   This study was designed to compare rosehips of the two roses specie
59   The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral interna
60 ensive Nutrition in Acute Lung Injury Trial) was designed to compare the impact of feeding from acute
61  stainless steel capillary and DC ion optics was designed to conduct ions into the mass spectrometer.
62                                           It is designed to connect miRNA molecules end to end, formi
63                             Because the EDSP was designed to consider mode of action, toxicity pathwa
64 f the Au nanoparticles/graphene-chitosan has been designed to construct an impedimetric immunosensor
65     Fluorescent probes for signal generation were designed to consume products of the catalytic react
66 -gap conjugated polymer PhF2,5 (Eg = 1.9 eV) is designed to contain alternating cyclopentadithiophene
67                  The stereodynamic molecules were designed to contain a pair of redox-active substitu
68    Therefore, rabbit recombinant PrP mutants were designed to contain every single amino acid substit
69         A new class of architected materials is designed to control the propagation of sound.
70 ed hybridization/displacement reactions that are designed to convert a given amount of RNA molecules
71 y-based approach to detect miRNA loci, which is designed to cope with the high sequencing depth of cu
72 he 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and evaluated in
73  a non-uniform system of gyroscopic spinners is designed to create a unidirectional wave pattern, whi
74                            Neural interfaces are designed to decode motor intent and evoke sensory pr
75                                   This study was designed to define a dynamic composite prognostic AB
76                                        Teeth are designed to deliver high forces while withstanding t
77  thousands of nanoparticle formulations have been designed to deliver nucleic acids, most nanoparticl
78    Thus, the downstream purification process is designed to demonstrate robust removal of these impur
79 t target recognition step, the target enzyme is designed to destabilize detection probe derived from
80 lts suggest that genetic tests for AMD might be designed to detect common and rare genetic variants,
81 hanide-based paramagnetic shift reagents can be designed to detect important metabolites by CEST MRI
82            Trials published to date have not been designed to detect differences in clinical outcomes
83                                           It is designed to detect specific metabolites of interest w
84                                    The study was designed to detect a difference of 10% in accuracy b
85 developed a novel Remodeling Index (RI) that was designed to detect an exaggerated hypertrophic respo
86                                    The study was designed to detect at least a 50% reduction in 3-yea
87                                    The study was designed to detect at least a 50% reduction in 3-yea
88                         Ebola padlock probes were designed to detect a specific L-gene sequence prese
89                              Sample analyses were designed to detect driver mutations, chromosome cop
90     Current differential correlation methods are designed to determine molecular feature pairs that h
91                                   This study is designed to determine impact of different F. nucleatu
92                 Therefore, the present study was designed to determine the impact of fingolimod (FTY7
93                                    The study was designed to determine the role of long noncoding RNA
94                                   This study was designed to determine whether a preventive intervent
95                                   This study was designed to determine whether gelatin supplementatio
96                                 This project was designed to determine whether radiomics features mea
97  functional magnetic resonance imaging tasks were designed to differentiate between activation relate
98                               Protocols have been designed to direct the assembly of hundreds of dist
99  over time in many species, few studies have been designed to directly compare process-level differen
100                            The nanoparticles were designed to disassemble into free native peptides v
101                       The metasurface device is designed to display two asymmetrically distributed of
102                  A holistic in vivo approach was designed to display the link between the entry and a
103  high levels of specificity and sensitivity, were designed to distinguish allelic products based upon
104         Six multiplex-compatible PCR primers were designed to distinguish Streptococcus pneumoniae se
105     Several error correction algorithms have been designed to efficiently reduce the error rate to 1%
106                             Theatrical magic is designed to elicit negative emotions such as feelings
107  In other words, first and second approaches were designed to employ nanomaterials while third and fo
108 ere, we present two computational tools that are designed to enable rapid and high-throughput analyse
109 isoindoline (BPI) ligands of these complexes were designed to enable multielectron redox events.
110                                  These tools are designed to encourage exploration and critical evalu
111                          Dyes must therefore be designed to encourage these interfacial interactions,
112 d Ethnic Diversity in the Oncology Workforce is designed to enhance existing programs and create new
113 nhibitor 5-(tetradecyloxy)-2-furoic acid and was designed to enhance delivery in vivo.
114                        Although chemotherapy is designed to eradicate tumor cells, it also has signif
115                                   This trial was designed to establish (with 90% power and an alpha o
116                                   This study was designed to estimate changes over time (2000 to 2010
117          This double-masked randomized study is designed to evaluate the potency of a combination of
118          A case-control study of 40 patients was designed to evaluate 1) the differences in biomarker
119                                   This study was designed to evaluate serum lipid metabolite changes
120                                   This study was designed to evaluate the association between glaucom
121         In line with this approach, this wok was designed to evaluate the effects of electron-beam an
122                                   This study was designed to evaluate the predictive ability of renal
123        Here, a predictive modeling framework was designed to evaluate the roles of transport limitati
124 DS AND HIV Vaccine Trials Network (HVTN) 104 was designed to evaluate the safety and tolerability of
125                          The current studies were designed to evaluate how many patients with idiopat
126                                   This study was designed to examine roles of the endogenous hydrogen
127                            The present study was designed to examine the influence of ibudilast on su
128                                   This study was designed to examine the resistance and virulence of
129          Only 2 randomized controlled trials were designed to examine fracture outcomes.
130                   In this study, experiments were designed to examine whether supplementation of anti
131 able after a simple cleaning process and can be designed to exhibit different geometrical arrangement
132          These brochosome coatings (BCs) can be designed to exhibit strong omnidirectional antireflec
133 ork of inductor-capacitor transmission lines is designed to experimentally realize the transformation
134                            The current study was designed to explore the biological function and epig
135                                   This study was designed to explore whether Chinese medicine xin-mai
136                 Self-assembled materials can be designed to express useful optoelectronic properties;
137                            The present study was designed to extend these findings by testing the hyp
138 scientific community via a Web platform that is designed to facilitate exploration and analysis of hi
139 yAn) that differ in their binding geometries were designed to find the best complementary fit to the
140 eet, but does not prescribe how patterns can be designed to fit target shapes.
141                      The analysis conditions were designed to fit the requirements of both affinity L
142                              The flow system was designed to focus on automation and miniaturization
143                             Novel immunogens were designed to focus the antibody response of rabbits
144              An aromatic oligoamide sequence was designed to fold and self-assemble into a double hel
145 on due to the simplicity with which they can be designed to form discrete structures and programmed t
146                                  This review is designed to foster the discussion regarding the viabi
147 The Safe Surgery 2015 South Carolina program was designed to foster state-wide engagement of hospital
148  Fully bioresorbable coronary scaffolds have been designed to function transiently to prevent acute r
149                         Modern vaccines must be designed to generate long-lasting, high-affinity, and
150                                   This study was designed to generate a more faithful model of Parkin
151 PSMA-ligand PET and morphologic imaging have been designed to guide image interpretation.
152 ace (GUI) version of MOSFLM (called iMosflm) is designed to guide inexperienced users through the ste
153                        Elastomeric materials are designed to have load bearing properties whereas hyd
154 dely used materials and, in most cases, they are designed to have long life times.
155                               The nitroxides are designed to have the methyl groups further away from
156 In multivariable sensors, a sensing material is designed to have diverse responses to different gases
157                      The microfluidic device was designed to have a bilaterally converging channel to
158                                 A classifier was designed to identify imaging biomarkers related to c
159                        Therefore, this study was designed to identify miRNAs involved in elevated FSS
160              Perioperative care bundling has been designed to improve processes of care surrounding c
161 ve Microbiome in New-Onset Crohn's Disease," was designed to improve our understanding of the microbi
162                                    The trial was designed to include 260 patients.
163 alent pneumococcal conjugate vaccine (PCV13) was designed to include disease-causing serotypes that a
164 t DLBCL and FL management if clinical trials are designed to incorporate such tests.
165             Synthetic diblock copolypeptides were designed to incorporate oppositely charged ionic se
166               HIV(NL4-3) 5'UTR substitutions were designed to individually stabilize the dimer-prone
167                              The TALEN pairs were designed to induce double-strand DNA break near the
168 hosphonates stimulate gammadelta T cells but were designed to inhibit bone resorption rather than tre
169 emonstrate that an sxRNA "bait" sequence can be designed to interact with a specific microRNA "trigge
170 ential small-molecule pan-RAS ligands, which were designed to interact with adjacent sites on the sur
171        This study suggests that agents could be designed to interfere with internalization of Yersini
172  field, novel in vitro and mouse models that are designed to interrogate complex genetics and functio
173       Genome-wide association studies (GWAS) are designed to investigate single nucleotide polymorphi
174 condly, an array of magnetic induction coils are designed to investigate the feasibility of a tomogra
175     The spatial Principal Component Analysis is designed to investigate non-random spatial distributi
176                            The present study is designed to investigate the adjunctive effects of sub
177                               The GuLF STUDY was designed to investigate relationships between oil sp
178                            The present study was designed to investigate the effect of a genetic risk
179                                   This study was designed to investigate the effect of adding 40 g fr
180                            The present study was designed to investigate the effects of chronic dieta
181                                   This study was designed to investigate the frequency and pattern of
182                              The tAnGo trial was designed to investigate the potential role of gemcit
183                                   This study was designed to investigate the role of octreotide in AK
184                            The current study was designed to investigate the role of the Protein Regu
185                            The present study was designed to investigate the specific role of MC1-R i
186 armacokinetic variability, the current study was designed to investigate the temporal relationship be
187                                   This study was designed to investigate whether Chrna7 deficient mic
188                            The present study was designed to investigate whether different sets of ac
189     This systematic review and meta-analysis was designed to investigate whether maternal psychologic
190                                Our algorithm was designed to iteratively solve a pair of integer prog
191     We argue that human-like machines should be designed to make decisions in transparent and compreh
192                       The present experiment was designed to match the two primary approaches to stud
193 airs(12,13) and molecular rotors(14-16) have been designed to measure intracellular stresses; however
194  are that the primary objective of the trial was designed to measure efficacy and not haemolysis in r
195                      The [Formula: see text] was designed to measure the dissimilarity between two lo
196 ditional modification or formulation and can be designed to mediate sequence-specific cleavage of dif
197                          The methodology has been designed to meet specifications for GMP production,
198                           Current inhibitors are designed to mimic the tripeptide sequence (arginine-
199                        The second experiment was designed to mimic a lesion-focused analysis to ident
200                         The first experiment was designed to mimic an IPCA situation, with images of
201 veraged an offline "feed frame table," which was designed to mimic the full process from a NIR measur
202                        Benzotriazepin-2-ones were designed to mimic the suggested bioactive gamma-tur
203      Microfluidic and CFD circulation models were designed to mimic tumor progression by escalating f
204                  Novel peptidylated surfaces were designed to minimise interferences when electrochem
205  efficiency, advanced combustion engines are being designed to minimize the amount of heat wasted in
206                           A robust procedure is designed to minimize the bias introduced by DEGs in t
207                               This structure is designed to mitigate the rapid decomposition of the r
208                                      Our MCF is designed to mode match a standard single mode optical
209  cross-organism functionality, these systems are designed to operate orthogonally to native control m
210 ed circuits, where particular circuits/chips are designed to optimally perform particular functionali
211                                        miTNM is designed to organize findings in comprehensible categ
212                                           It was designed to overcome the spectral congestion and lin
213                        Each colouring strand is designed to pair with an extended triangle strand by
214                                    The robot is designed to perform a random walk without any energy
215                   A hetero-[4]pseudorotaxane was designed to perform a molecular machine function of
216             The Oncology Grand Rounds series is designed to place original reports published in the J
217                         The novel air filter was designed to possess the synergistic advantages of po
218           Several computer programs have now been designed to predict RNA modules.
219 l that, even though synthetic network models are designed to present structural properties similar to
220 ccharide-conjugate and subunit vaccines that were designed to prevent S. aureus infection in patients
221 disease states, and increasingly studies are being designed to probe the functional consequences of s
222 s illustrates how self-assembly kinetics can be designed to produce structures with a desired physica
223  new machine learning method (RiskSLIM) that is designed to produce accurate, risk-calibrated scoring
224                    A computational algorithm was designed to produce a measure of DW image distortion
225                  The result of these efforts is designed to promote telehealth models that ensure bet
226                       CALGB 30801 (Alliance) was designed to prospectively confirm that finding.
227                             The polymer coat was designed to protect the particles from decomposition
228                            NMIBC trials must be designed to provide the most clinically relevant data
229     A publicly available web application has been designed to provide all Tox21-ToxCast dose-likeliho
230                                  The article is designed to provide an introductory level of technica
231                                   This study was designed to provide insight into the results of a la
232 , and a custom-made RDE/RRDE working station was designed to provide unique means by which to in situ
233                      However, current models are designed to quantify growth under conditions for whi
234 ll, a high-temperature single-molecule assay was designed to quantitatively measure long-range DNA un
235           Here, an immunocompetent rat model was designed to recapitulate the human IgE-Fcepsilon rec
236                            The current study was designed to reconcile these discrepancies.
237 elaxation of nondiseased vessels, this study was designed to reinvestigate the mode of action in grea
238                                   Each donor is designed to release COS/H2S after the activation of a
239                             This formulation is designed to release ivermectin, a mosquito-killing dr
240                               A slurry doser was designed to replace the plastic extruder of an open-
241                 Most neuron models, however, are designed to reproduce certain small sets of empirica
242                      Neuroprosthetic devices are designed to restore lost function and could be used
243                              Doxil liposomes are designed to retain doxorubicin in circulation, minim
244                                       Probes were designed to retain biological activity and alkylate
245 velopment of novel therapeutics: These would be designed to reverse lymphatic dysfunction, either pri
246 midity-induced, bendable smart clothing have been designed to reversibly adapt their thermal insulati
247      DGT (Diffusion Gradients in Thin films) was designed to sample trace metals in situ at their nat
248                                   This study was designed to screen the vitamin D pathway genes for p
249               Antibody-drug conjugates (ADC) are designed to selectively bind to tumor antigens via t
250 ar weight and hydrophilicity, this conjugate is designed to selectively release morphine in injured t
251 hly programmable nanoscale material that can be designed to self-assemble into 3D structures that are
252 , N3-Ala-Val-NHCH2-C identical withCH, which is designed to self-assemble through intermolecular hydr
253 Relative Citation Ratio (RCR), a metric that was designed to serve in that capacity, measures the inf
254 els of LINCS L1000, every two landmark genes are designed to share a single channel.
255                              Since the trial was designed to show superiority of once-daily radiother
256              Therefore, an animal experiment was designed to simulate the transfer of Sudan I to eggs
257                      An automated method has been designed to simultaneously estimate the diffusion c
258         Furthermore, a smart dancing blanket is designed to simultaneously convert biomechanical ener
259       A new efficient optimization algorithm is designed to solve the objective function.
260 tes is reduced, while the I-TASSER-MR server is designed to solve the phase problem for proteins that
261 cting groups inspired by pincer ligands have been designed to stabilize otherwise kinetically and the
262 dataBase of Bacterial Quality scores (dBBQs) was designed to store and retrieve quality scores.
263 5X) and d(XC5XGiX) (X = A, T or none; i < 5) are designed to study the impact of G-repeats on the for
264                  A molecular torsion balance was designed to study and measure OH-pi interactions bet
265                                         MESA was designed to study progression of subclinical disease
266   A series of N-arylimide molecular balances were designed to study and measure fluorine-aromatic (F-
267            Repeated Prisoner's Dilemma games were designed to study how costly punishment, diversity,
268 tion of ACC activity in the sebaceous glands is designed to substantially affect sebum production, be
269                                 The platform is designed to support identification and prioritization
270                                 Our taxonomy is designed to support the development and design of fut
271 rom Withania somnifera and the present study is designed to systemically investigate the anti-HCC eff
272                This quasi-experimental study was designed to take place during routine service appoin
273              Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane.
274 icles that either naturally accumulate in or are designed to target tumours.
275 ion of NPs, and suggest that NP coatings can be designed to target NPs to specific parts of plants.
276 e, an engineered version of Cre recombinase, was designed to target a 34-bp sequence within the HIV-1
277                            The shRNA library was designed to target a subset of genes previously iden
278 igopyridylamide based alpha-helical mimetics was designed to target the central alpha-helix subdomain
279 s tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease i
280                                PCR protocols were designed to target 5 sequences unique to the M. gal
281 e fragments of double-stranded RNAs (dsRNAs) were designed to target different regions of the sequenc
282                                  New primers were designed to target the 16S rRNA gene, as a universa
283                                 The TRI_tool is designed to test up to 100 potential interactions wit
284                            The current study was designed to test if TASK channels contribute to thei
285                               Our experiment was designed to test predictions corresponding to the ev
286                                    The study was designed to test the effects of substituting full-fa
287                           This phase 2 study was designed to test the efficacy and safety of pembroli
288                            The present study was designed to test the latter hypothesis.
289 cept patients with genotype 3 and cirrhosis, was designed to test the noninferiority of 8 weeks of so
290                            The current study was designed to test whether patient age at diagnosis is
291 f bifunctional chelators (BFCs), L1-L5, that were designed to tightly bind (64)Cu and shown to intera
292 e current analytical framework of resilience is designed to treat low-dimensional models with a few i
293                              The experiments were designed to unambiguously separate the electroporat
294 residents of Framingham, Massachusetts, that was designed to uncover the determinants and natural his
295                                 The software is designed to use as input data from real or previously
296                                     RolyPoly is designed to use expression data from either bulk tiss
297 , where a structure-based prior distribution is designed to utilize the phylogenetic tree.
298               In this study, an immunosensor was designed to utilize for the detection of prostate sp
299                      Current genome browsers are designed to work via graphical user interfaces (GUIs
300                                         iJRF is designed to work under the high-dimension low-sample-

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