ライフサイエンスコーパス: be directed against

1 he major cytolytic activity of the donor CTL was directed against 2 HLA-A11-restricted epitopes in th

2 c challenge, MHC-restricted T cell responses are directed against a few dominant antigenic epitopes.

3 nding CD8+ T cells use Vbeta10 or Vbeta8 and are directed against a single glycoprotein B (gB498-505)

4 hat spontaneous TRAG-3-specific CD4+ T cells are directed against a single immunodominant epitope and

5 ospholipid antibodies found in this syndrome are directed against a variety of phospholipid binding p

6 es to mitochondria, the hallmark of disease, are directed against a very conserved site of pyruvate d

7 a prominent lymphoproliferative response to be directed against a 62-kDa component.

8 alizing humoral responses that, in part, may be directed against a novel epitope(s) found on the HIV-

9 TB patients show significant homogeneity in being directed against a well-defined subset of antigens

10 Whether this oligoclonal and polyclonal IgG is directed against a disease-relevant antigen remains u

11 The CF antibody response is directed against a heat-labile antigen that has chiti

12 a monoclonal chimeric antibody fragment that is directed against a protein expressed on the surface o

13 e effect upon the immune response because it is directed against a single epitope.

14 tract epithelial cells, and a response that is directed against a virus that continuously undergoes

15 rom schistosome-infected C57BL/6 (BL/6) mice was directed against a 62-kDa component of SEA.

16 from one of the two responder rhesus monkeys was directed against a 9-residue peptide, GELMTLATW, at

17 Immunoblots revealed that the blocking IgG was directed against a meningococcal Ag called H.8.

18 The antibody was directed against a recombinant fusion protein consis

19 One was directed against a recombinant molecule containing a

20 This screen was directed against a variety of coregulators, transcri

21 The vaccine-induced T-cell reactivities were directed against a broad set of renal tumor-associa

22 e xenograft was present in the recipient and were directed against a large number of pig proteins.

23 i-HIV-1 NAbs produced between weeks 7 and 13 were directed against a neutralization-sensitive virus s

24 arkably, up to one fourth of the CD8 T cells were directed against a single minor antigen, H60.

25 oped a novel targeted fibrinolytic drug that is directed against activated platelets.

26 Responses were directed against all 10 peptides tested and were re

27 odies to peptides designated PR-15 and DK-12 were directed against amino acid residues 103-117 and 12

28 1996 elicited pH1N1 antibody responses that are directed against an epitope near the HA receptor-bin

29 ain of BPAg2 and that the IgA autoantibodies are directed against an epitope within or adjacent to a

30 antiidiotypic approach which was designed to be directed against an amiloride binding domain on the e

31 utoimmune thrombocytopenia in which antibody is directed against an immunodominant epitope of the bet

32 and that a subset of autoantibodies in IDDM is directed against an integral membrane protein of insu

33 In BALB/c (H-2d) mice, the dominant response is directed against an Ld-restricted peptide in the nucl

34 m3D6, which is directed against an N-terminal domain of Abeta (amino

35 The immunodominant response was directed against an epitope present in the viral M p

36 t was believed earlier that these antibodies were directed against anionic phospholipids.

37 e data suggest that allogeneic responses can be directed against antigenic determinants of low abunda

38 we found that the majority of these T cells were directed against antigenic peptides residing within

39 ANCA are directed against antigens expressed on the surface o

40 edominant immune responses stimulated by BCG were directed against antigens present in mycobacterial

41 Many antibiotics are directed against bacterial ribosomes, and mutations

42 Most pathogenic APLAs are directed against beta2-glycoprotein I (beta2GPI), a

43 Therefore, in many cases treatment must be directed against both the tumor and the hormone-exces

44 d efficacy of the dual nanobioconjugate that is directed against both CK2 and EGFR.

45 Peptide-specific IFN-gamma responses were directed against both the class I and class II MHC-

46 esults showed that some patients' antibodies were directed against both the domain containing the gam

47 Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this

48 3) of hemophiliacs treated with plasma fVIII were directed against C2 and another LCh epitope within

49 Much of the immunity to the parasite is directed against carbohydrate determinants in both gl

50 he rD-mPGPtide in this transplantation model was directed against CD4+ T cells and was exclusively sp

51 Myositis-specific autoantibodies (MSAs) are directed against cell machinery proteins such as ami

52 All the antibodies identified were directed against class I antigens.

53 und in high titers in most patients, seem to be directed against conformational forms of GAD.

54 hannel activation by DeltaP when the Deltapi was directed against DeltaP.

55 PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodi

56 chniques to determine whether the antibodies were directed against donor mismatches.

57 -bovine reassortant rotavirus vaccine (HBRV) is directed against each of the most prevalent rotavirus

58 Bulk T-cell responses were directed against either Hantaan virus nucleocapsid

59 c T cell responses, elicited by all vectors, were directed against Env, rather than Gag, determinants

60 amers can function as anticoagulants if they are directed against enzymes of the coagulation cascade.

61 nfirming the VirB9-specific T-cell responses are directed against epitopes in the native protein.

62 Most of the inhibitory activity is directed against epitopes in the A2 and C2 domains.

63 e viral M protein, and subdominant responses were directed against epitopes present in the P, F, and

64 The most frequent and robust responses were directed against epitopes within the Gag and Nef pr

65 known transgenerational silencing responses are directed against foreign DNA introduced into the org

66 broside sulfate (sulfatide); and RMAb, which is directed against galactocerebroside (GC).

67 ned with monoclonal antibodies: MAbO4, which is directed against galactocerebroside sulfate (sulfatid

68 ned which HSV entry glycoproteins these PAbs were directed against: glycoproteins gB, gD, and gC were

69 odies elicited during natural infection that are directed against gp120 epitopes that overlap the bin

70 neither these autoAbs nor the receptor they are directed against have been convincingly implicated i

71 induce the expression of defense genes that are directed against herbivores, as found in tobacco and

72 mental design of vaccine candidates that may be directed against HIV-1 subtype C.

73 Current malaria vaccine candidates are directed against human and mosquito stages of the pa

74 a different antiviral activity of ZAPL that is directed against influenza A virus.

75 Responses appeared to be directed against intracellular proteins involved in c

76 mobility shift assays using antibodies that are directed against known RNA-binding proteins.

77 l antibodies (bnMAbs), 2F5, 4E10, and Z13e1, are directed against linear epitopes mapped to the MPER,

78 rase activity in vivo and that this activity is directed against Lys(9) of histone H3.

79 se mAbs, like those from a previous patient, were directed against mature Dsg1 (matDsg1) on the cell

80 The GVL effect is directed against minor histocompatibility antigens sh

81 e rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens.

82 T cells were directed against modifications of a chemically domi

83 ts may be a serious problem when CTL therapy is directed against more unstable tumor cell-derived tar

84 that new, nonantibiotic therapeutics need to be directed against multiple targets.

85 ating HIV-1, the CTL response is polyclonal, is directed against multiple HIV-1 proteins, including h

86 The Abs were directed against multiple FH epitopes located at th

87 markably, immunodominant T cell reactivities were directed against mutated neoantigens or a cancer ge

88 tivity of some "histone deacetylase" enzymes is directed against non-histone substrates.

89 ve epitopes, since only 2-5% of these titers were directed against nonprotective de-O-acetylated GXM

90 ective bactericidal antibodies and appear to be directed against nonsialylated bacterial epitopes.

91 odies consisted of classes IgA and/or IgM or were directed against NR1a/NR2b (not against NR1a alone)

92 of pathogenic autoantibodies, many of which are directed against nuclear antigens, in particular dou

93 ate a CD8(+) T-cell response in the CNS that is directed against one dominant (VP3(159-166)) and two

94 nd suggest that future brain therapies might be directed against paracrine factors produced by cells

95 o acid 57 and amino acid 113 but no antibody was directed against peptides representing the hypervari

96 The majority of APLAs are directed against phospholipid-binding proteins, part

97 art by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage

98 ups, the majority of antibodies against AMA1 were directed against polymorphic epitopes.

99 ggesting that responses against both vectors were directed against preformed components of the viral

100 tion of the MHC class II-restricted response was directed against proteasome-dependent epitopes.

101 In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxida

102 litis seen in Wegener's granulomatosis (WG), are directed against proteinase-3 (PR-3), a serine prote

103 atory assays for antiphospholipid antibodies are directed against prothrombin and beta2-glycoprotein

104 Antibody to peptide KD-14 was directed against residues 206-219 of the first extra

105 suggested that the negative function of SOG is directed against SCW, we present data that suggests t

106 didate, PorB induces antibody responses that are directed against six variable surface-exposed loops

107 The IgE response is directed against specific components from an allergen

108 led plasma IgE from DOCK8-deficient patients is directed against staple food antigens but not house d

109 Correspondingly, vaccines may be directed against "stealth" epitopes, overriding viral

110 Treatment of uncomplicated cellulitis should be directed against Streptococcus and methicillin-sensit

111 e target the inflammatory process and others are directed against structural cells.

112 A from multiple strains of S. pneumoniae and were directed against surface-exposed epitopes.

113 that a proportion of neutralizing antibodies are directed against the Ad5 fiber.

114 ments in development for Alzheimer's disease are directed against the amyloid-beta (Abeta) peptide.

115 ayed allergic reactions where IgE antibodies are directed against the carbohydrate alpha-Gal epitope.

116 he 375 S/W mutant by CD4BS antibodies, which are directed against the CD4-binding region of gp120, wa

117 s an autoimmune disorder in which antibodies are directed against the desmosomal adhesion molecule Ds

118 tering disease in which autoantibodies (IgG) are directed against the desmosomal cadherin desmoglein

119 The associated autoantibodies are directed against the extracellular domains of cell-s

120 n the detection of antibodies, most of which are directed against the immunodominant regions (IDR) of

121 A group of specific therapies are directed against the influx of inflammatory cells in

122 Several specific therapies are directed against the influx of inflammatory cells in

123 gated humanized antiTac Fab fragments, which are directed against the interleukin-2 receptor, with gl

124 gical hallmark of primary biliary cirrhosis, are directed against the lipoyl domain of the E2 subunit

125 hould devise empiric treatment regimens that are directed against the most common local pathogens.

126 g monoclonal antibodies, 7A12 and 2G4, which are directed against the SA-binding site within VP8* and

127 Campath-1 antibodies are directed against the surface antigen CD52 that is ex

128 ls for growth, and many new cancer therapies are directed against the tumor vasculature.

129 ls, and that CTL immunotherapy of JMML could be directed against the gamma-globin-derived epitope g10

130 tection induced by these peptides appears to be directed against the infected hepatocytes.

131 the pathologic auto-antibodies are shown to be directed against the plasma protein beta(2)-glycoprot

132 Two of these mAbs appeared to be directed against the same epitope site within this re

133 that diverse immune responses in humans can be directed against the same protein.

134 but the responses in both cases appeared to be directed against the same region of gp120.

135 mster ovary (CHO) cells of 5C12 HuMAb, which is directed against the A subunit of Stx2.

136 The anti-Tac dsFv is directed against the alpha subunit of the interleukin

137 of the autoreactive CD4(+) T cell repertoire is directed against the B:9-23 segment of the insulin B

138 Anti-APP is directed against the beta-amyloid precursor protein a

139 chronic varicella zoster virus vasculopathy is directed against the causative virus.

140 ll resistance to the IgG1b12 antibody, which is directed against the CD4 binding site.

141 However, m266.2, which is directed against the central domain of Abeta (amino a

142 response in primary biliary cirrhosis (PBC) is directed against the E2 component of pyruvate dehydro

143 atients with primary biliary cirrhosis (PBC) is directed against the E2 component of the pyruvate deh

144 nergy landscape, whereby the photonic energy is directed against the E2 loop by the C13-methyl group,

145 mAb 12G3H11, used here as a model, is directed against the human receptor tyrosine kinase E

146 m autoantibodies, the immunodominant epitope is directed against the inner lipoyl domain of PDC-E2.

147 The monoclonal antibody (MAb) 13D6, which is directed against the K1 capsule from A. baumannii, wa

148 nt CD4(+) T-cell response in MSP1 vaccinates is directed against the MSP1a subunit.

149 The principal effect of anti-CTLA4 is directed against the naive, not regulatory, T cell po

150 An antiserum has been derived that is directed against the NH2-terminal 17 amino acids of t

151 evelopment and use of such an antibody which is directed against the optimal phosphorylation motif of

152 This immunity is directed against the Plasmodium spp. parasite develop

153 d the FG-3019 monoclonal antibody (mAb) that is directed against the pleiotropic matricellular signal

154 ence the TipA multidrug resistance mechanism is directed against the same chemical motif that inhibit

155 ing the greatest in vivo protective efficacy was directed against the A chain.

156 ains, a portion of the bactericidal antibody was directed against the highly conserved protein, neiss

157 In three patients, immunoreactivity was directed against the Ig domains of contactin and was

158 Strikingly, very little reactivity was directed against the N-terminal domain (aa 1-213) by

159 tibody-mediated macrophage killing mechanism was directed against the spore itself or the vegetative

160 One arm of the diabody was directed against the target antigen, and the other a

161 significant fraction of the gB AD-5 response was directed against the YNND epitope, further argued th

162 The most active ODNs were directed against the 3'-poly adenylation signal sit

163 IgA antibodies in primary infection were directed against the Bam Z Epstein-Barr replication

164 Some of these activities were directed against the CD4 binding site (CD4bs).

165 The responses were directed against the donor HLA-class I antigens.

166 Sera isolated from these animals were directed against the HA epitope involving amino aci

167 conjugated monoclonal antibodies (mAbs) that were directed against the IL-2R alpha, IL-2R beta, and g

168 rylated, showing that these three antibodies were directed against the phosphate group(s) on Ser23 an

169 CD4(+) T cells that were directed against the type 1 diabetes-associated aut

170 Of the linear binding IgG responses, most were directed against the V3 loop in all immunization gr

171 ls are of antibodies and memory B cells that are directed against these conserved epitopes.

172 onally designed targeted agents that are now being directed against these pathways, with early eviden

173 To examine whether immunity to P. vivax is directed against these polymorphic regions of DBPII,

174 e data demonstrate that an antibody response is directed against these virulence-associated factors d

175 tumor antigen (Tag) in C57BL/6 (H2(b)) mice is directed against three H2-D(b)-restricted epitopes, I

176 nduction of robust immune responses that may be directed against tumor-associated antigens.

177 and chronic skin blistering, autoantibodies are directed against type VII collagen.

178 the greatest frequency of responses (by ORF) being directed against UL39, UL25, UL27, ICP0, UL46, and

179 of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodef

180 luated the extent to which Ad5-specific NAbs are directed against various HVRs.